Intermediate filaments in the heart: The dynamic duo of desmin and lamins orchestrates mechanical force transmission
Curr Opin Cell Biol. 2023 Nov 14;85:102280. doi: 10.1016/j.ceb.2023.102280. Online ahead of print.ABSTRACTThe intermediate filament (IF) cytoskeleton supports cellular structural integrity, particularly in response to mechanical stress. The most abundant IF proteins in mature cardiomyocytes are desmin and lamins. The desmin network tethers the contractile apparatus and organelles to the nuclear envelope and the sarcolemma, while lamins, as components of the nuclear lamina, provide structural stability to the nucleus and the genome. Mutations in desmin or A-type lamins typically result in cardiomyopathies and recent studies...
Source: Current Opinion in Cell Biology - November 16, 2023 Category: Cytology Authors: Gun West Sogol Sedighi Giulio Agnetti Pekka Taimen Source Type: research
Intermediate filaments in the heart: The dynamic duo of desmin and lamins orchestrates mechanical force transmission
Curr Opin Cell Biol. 2023 Nov 14;85:102280. doi: 10.1016/j.ceb.2023.102280. Online ahead of print.ABSTRACTThe intermediate filament (IF) cytoskeleton supports cellular structural integrity, particularly in response to mechanical stress. The most abundant IF proteins in mature cardiomyocytes are desmin and lamins. The desmin network tethers the contractile apparatus and organelles to the nuclear envelope and the sarcolemma, while lamins, as components of the nuclear lamina, provide structural stability to the nucleus and the genome. Mutations in desmin or A-type lamins typically result in cardiomyopathies and recent studies...
Source: Current Opinion in Cell Biology - November 16, 2023 Category: Cytology Authors: Gun West Sogol Sedighi Giulio Agnetti Pekka Taimen Source Type: research
Exploring the dynamic behavior of leukocytes with zebrafish
Curr Opin Cell Biol. 2023 Nov 11;85:102276. doi: 10.1016/j.ceb.2023.102276. Online ahead of print.ABSTRACTCell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligne...
Source: Current Opinion in Cell Biology - November 13, 2023 Category: Cytology Authors: Cassia Michael Sofia de Oliveira Source Type: research
Exploring the dynamic behavior of leukocytes with zebrafish
Curr Opin Cell Biol. 2023 Nov 11;85:102276. doi: 10.1016/j.ceb.2023.102276. Online ahead of print.ABSTRACTCell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligne...
Source: Current Opinion in Cell Biology - November 13, 2023 Category: Cytology Authors: Cassia Michael Sofia de Oliveira Source Type: research
Exploring the dynamic behavior of leukocytes with zebrafish
Curr Opin Cell Biol. 2023 Nov 11;85:102276. doi: 10.1016/j.ceb.2023.102276. Online ahead of print.ABSTRACTCell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligne...
Source: Current Opinion in Cell Biology - November 13, 2023 Category: Cytology Authors: Cassia Michael Sofia de Oliveira Source Type: research
Exploring the dynamic behavior of leukocytes with zebrafish
Curr Opin Cell Biol. 2023 Nov 11;85:102276. doi: 10.1016/j.ceb.2023.102276. Online ahead of print.ABSTRACTCell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligne...
Source: Current Opinion in Cell Biology - November 13, 2023 Category: Cytology Authors: Cassia Michael Sofia de Oliveira Source Type: research
Cadherin-linked morphogen gradient actualizes robust tissue patterning
Curr Opin Cell Biol. 2023 Nov 6;85:102275. doi: 10.1016/j.ceb.2023.102275. Online ahead of print.ABSTRACTMorphogen gradients govern tissue patterning. These gradients provide positional information, instructing cells to adopt distinct fates. Over the past few decades, extensive studies have revealed the detailed mechanisms by which morphogens generate tissue patterns. However, the communication between morphogen-receiving cells is still poorly understood. Here, I describe how cadherin-mediated cell competition ensures robust morphogen-gradient formation. In normal zebrafish embryos, unfit cells with abnormal Wnt signaling ...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Tohru Ishitani Source Type: research
Roles of ESCRT-III polymers in cell division across the tree of life
Curr Opin Cell Biol. 2023 Nov 7;85:102274. doi: 10.1016/j.ceb.2023.102274. Online ahead of print.ABSTRACTEvery cell becomes two through a carefully orchestrated process of division. Prior to division, contractile machinery must first be assembled at the cell midzone to ensure that the cut, when it is made, bisects the two separated copies of the genetic material. Second, this contractile machinery must be dynamically tethered to the limiting plasma membrane so as to bring the membrane with it as it constricts. Finally, the connecting membrane must be severed to generate two physically separate daughter cells. In several or...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Jeremy Graham Carlton Buzz Baum Source Type: research
Cadherin-linked morphogen gradient actualizes robust tissue patterning
Curr Opin Cell Biol. 2023 Nov 6;85:102275. doi: 10.1016/j.ceb.2023.102275. Online ahead of print.ABSTRACTMorphogen gradients govern tissue patterning. These gradients provide positional information, instructing cells to adopt distinct fates. Over the past few decades, extensive studies have revealed the detailed mechanisms by which morphogens generate tissue patterns. However, the communication between morphogen-receiving cells is still poorly understood. Here, I describe how cadherin-mediated cell competition ensures robust morphogen-gradient formation. In normal zebrafish embryos, unfit cells with abnormal Wnt signaling ...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Tohru Ishitani Source Type: research
Roles of ESCRT-III polymers in cell division across the tree of life
Curr Opin Cell Biol. 2023 Nov 7;85:102274. doi: 10.1016/j.ceb.2023.102274. Online ahead of print.ABSTRACTEvery cell becomes two through a carefully orchestrated process of division. Prior to division, contractile machinery must first be assembled at the cell midzone to ensure that the cut, when it is made, bisects the two separated copies of the genetic material. Second, this contractile machinery must be dynamically tethered to the limiting plasma membrane so as to bring the membrane with it as it constricts. Finally, the connecting membrane must be severed to generate two physically separate daughter cells. In several or...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Jeremy Graham Carlton Buzz Baum Source Type: research
Cadherin-linked morphogen gradient actualizes robust tissue patterning
Curr Opin Cell Biol. 2023 Nov 6;85:102275. doi: 10.1016/j.ceb.2023.102275. Online ahead of print.ABSTRACTMorphogen gradients govern tissue patterning. These gradients provide positional information, instructing cells to adopt distinct fates. Over the past few decades, extensive studies have revealed the detailed mechanisms by which morphogens generate tissue patterns. However, the communication between morphogen-receiving cells is still poorly understood. Here, I describe how cadherin-mediated cell competition ensures robust morphogen-gradient formation. In normal zebrafish embryos, unfit cells with abnormal Wnt signaling ...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Tohru Ishitani Source Type: research
Roles of ESCRT-III polymers in cell division across the tree of life
Curr Opin Cell Biol. 2023 Nov 7;85:102274. doi: 10.1016/j.ceb.2023.102274. Online ahead of print.ABSTRACTEvery cell becomes two through a carefully orchestrated process of division. Prior to division, contractile machinery must first be assembled at the cell midzone to ensure that the cut, when it is made, bisects the two separated copies of the genetic material. Second, this contractile machinery must be dynamically tethered to the limiting plasma membrane so as to bring the membrane with it as it constricts. Finally, the connecting membrane must be severed to generate two physically separate daughter cells. In several or...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Jeremy Graham Carlton Buzz Baum Source Type: research
Cadherin-linked morphogen gradient actualizes robust tissue patterning
Curr Opin Cell Biol. 2023 Nov 6;85:102275. doi: 10.1016/j.ceb.2023.102275. Online ahead of print.ABSTRACTMorphogen gradients govern tissue patterning. These gradients provide positional information, instructing cells to adopt distinct fates. Over the past few decades, extensive studies have revealed the detailed mechanisms by which morphogens generate tissue patterns. However, the communication between morphogen-receiving cells is still poorly understood. Here, I describe how cadherin-mediated cell competition ensures robust morphogen-gradient formation. In normal zebrafish embryos, unfit cells with abnormal Wnt signaling ...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Tohru Ishitani Source Type: research
Roles of ESCRT-III polymers in cell division across the tree of life
Curr Opin Cell Biol. 2023 Nov 7;85:102274. doi: 10.1016/j.ceb.2023.102274. Online ahead of print.ABSTRACTEvery cell becomes two through a carefully orchestrated process of division. Prior to division, contractile machinery must first be assembled at the cell midzone to ensure that the cut, when it is made, bisects the two separated copies of the genetic material. Second, this contractile machinery must be dynamically tethered to the limiting plasma membrane so as to bring the membrane with it as it constricts. Finally, the connecting membrane must be severed to generate two physically separate daughter cells. In several or...
Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Jeremy Graham Carlton Buzz Baum Source Type: research
Posttranslational modifications of keratins and their associated proteins as therapeutic targets in keratin diseases
Curr Opin Cell Biol. 2023 Nov 3;85:102264. doi: 10.1016/j.ceb.2023.102264. Online ahead of print.ABSTRACTThe keratin cytoskeleton protects epithelia against mechanical, nonmechanical, and physical stresses, and participates in multiple signaling pathways that regulate cell integrity and resilience. Keratin gene mutations cause multiple rare monoallelic epithelial diseases termed keratinopathies, including the skin diseases Epidermolysis Bullosa Simplex (EBS) and Pachyonychia Congenita (PC), with limited available therapies. The disease-related keratin mutations trigger posttranslational modifications (PTMs) in keratins and...
Source: Current Opinion in Cell Biology - November 5, 2023 Category: Cytology Authors: Pei Li Katrin Rietscher Henriette Jopp Thomas M Magin M Bishr Omary Source Type: research
