Cadherin-linked morphogen gradient actualizes robust tissue patterning

Curr Opin Cell Biol. 2023 Nov 6;85:102275. doi: 10.1016/j.ceb.2023.102275. Online ahead of print.ABSTRACTMorphogen gradients govern tissue patterning. These gradients provide positional information, instructing cells to adopt distinct fates. Over the past few decades, extensive studies have revealed the detailed mechanisms by which morphogens generate tissue patterns. However, the communication between morphogen-receiving cells is still poorly understood. Here, I describe how cadherin-mediated cell competition ensures robust morphogen-gradient formation. In normal zebrafish embryos, unfit cells with abnormal Wnt signaling activity spontaneously appear and produce a noisy morphogen gradient. These unfit cells communicate with neighboring cells through cadherins and are subsequently killed by cell competition. This process of killing unfit cells corrects noisy gradients to support reproducible patterning. I also discuss the significance of cell-competition-mediated morphogen-gradient correction from the perspectives of evolution and disease biology.PMID:37944424 | DOI:10.1016/j.ceb.2023.102275

Source: Current Opinion in Cell Biology - November 9, 2023 Category: Cytology Authors: Tohru Ishitani Source Type: research