Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Curr Opin Cell Biol. 2024 Feb 23;87:102343. doi: 10.1016/j.ceb.2024.102343. Online ahead of print.NO ABSTRACTPMID:38401180 | DOI:10.1016/j.ceb.2024.102343 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Adele Marston Matthew J Tyska Source Type: research
Neurofilaments: Novel findings and future challenges
Curr Opin Cell Biol. 2024 Feb 23;87:102326. doi: 10.1016/j.ceb.2024.102326. Online ahead of print.ABSTRACTNeurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, pa...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Jessy V van Asperen Farah Kotaich Damien Caillol Pascale Bomont Source Type: research
GFAP-isoforms in the nervous system: Understanding the need for diversity
Curr Opin Cell Biol. 2024 Feb 23;87:102340. doi: 10.1016/j.ceb.2024.102340. Online ahead of print.ABSTRACTGlial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly propert...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Alexandra J E M de Reus Onur Basak Werner Dykstra Jessy V van Asperen Emma J van Bodegraven Elly M Hol Source Type: research
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Curr Opin Cell Biol. 2024 Feb 23;87:102343. doi: 10.1016/j.ceb.2024.102343. Online ahead of print.NO ABSTRACTPMID:38401180 | DOI:10.1016/j.ceb.2024.102343 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Adele Marston Matthew J Tyska Source Type: research
Neurofilaments: Novel findings and future challenges
Curr Opin Cell Biol. 2024 Feb 23;87:102326. doi: 10.1016/j.ceb.2024.102326. Online ahead of print.ABSTRACTNeurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, pa...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Jessy V van Asperen Farah Kotaich Damien Caillol Pascale Bomont Source Type: research
GFAP-isoforms in the nervous system: Understanding the need for diversity
Curr Opin Cell Biol. 2024 Feb 23;87:102340. doi: 10.1016/j.ceb.2024.102340. Online ahead of print.ABSTRACTGlial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly propert...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Alexandra J E M de Reus Onur Basak Werner Dykstra Jessy V van Asperen Emma J van Bodegraven Elly M Hol Source Type: research
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Curr Opin Cell Biol. 2024 Feb 23;87:102343. doi: 10.1016/j.ceb.2024.102343. Online ahead of print.NO ABSTRACTPMID:38401180 | DOI:10.1016/j.ceb.2024.102343 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Adele Marston Matthew J Tyska Source Type: research
Neurofilaments: Novel findings and future challenges
Curr Opin Cell Biol. 2024 Feb 23;87:102326. doi: 10.1016/j.ceb.2024.102326. Online ahead of print.ABSTRACTNeurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, pa...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Jessy V van Asperen Farah Kotaich Damien Caillol Pascale Bomont Source Type: research
GFAP-isoforms in the nervous system: Understanding the need for diversity
Curr Opin Cell Biol. 2024 Feb 23;87:102340. doi: 10.1016/j.ceb.2024.102340. Online ahead of print.ABSTRACTGlial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly propert...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Alexandra J E M de Reus Onur Basak Werner Dykstra Jessy V van Asperen Emma J van Bodegraven Elly M Hol Source Type: research
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Curr Opin Cell Biol. 2024 Feb 23;87:102343. doi: 10.1016/j.ceb.2024.102343. Online ahead of print.NO ABSTRACTPMID:38401180 | DOI:10.1016/j.ceb.2024.102343 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Adele Marston Matthew J Tyska Source Type: research
Neurofilaments: Novel findings and future challenges
Curr Opin Cell Biol. 2024 Feb 23;87:102326. doi: 10.1016/j.ceb.2024.102326. Online ahead of print.ABSTRACTNeurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, pa...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Jessy V van Asperen Farah Kotaich Damien Caillol Pascale Bomont Source Type: research
GFAP-isoforms in the nervous system: Understanding the need for diversity
Curr Opin Cell Biol. 2024 Feb 23;87:102340. doi: 10.1016/j.ceb.2024.102340. Online ahead of print.ABSTRACTGlial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly propert...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Alexandra J E M de Reus Onur Basak Werner Dykstra Jessy V van Asperen Emma J van Bodegraven Elly M Hol Source Type: research
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Curr Opin Cell Biol. 2024 Feb 23;87:102343. doi: 10.1016/j.ceb.2024.102343. Online ahead of print.NO ABSTRACTPMID:38401180 | DOI:10.1016/j.ceb.2024.102343 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Adele Marston Matthew J Tyska Source Type: research
Neurofilaments: Novel findings and future challenges
Curr Opin Cell Biol. 2024 Feb 23;87:102326. doi: 10.1016/j.ceb.2024.102326. Online ahead of print.ABSTRACTNeurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, pa...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Jessy V van Asperen Farah Kotaich Damien Caillol Pascale Bomont Source Type: research
GFAP-isoforms in the nervous system: Understanding the need for diversity
Curr Opin Cell Biol. 2024 Feb 23;87:102340. doi: 10.1016/j.ceb.2024.102340. Online ahead of print.ABSTRACTGlial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly propert...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Alexandra J E M de Reus Onur Basak Werner Dykstra Jessy V van Asperen Emma J van Bodegraven Elly M Hol Source Type: research
