Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Curr Opin Cell Biol. 2024 Feb 23;87:102343. doi: 10.1016/j.ceb.2024.102343. Online ahead of print.NO ABSTRACTPMID:38401180 | DOI:10.1016/j.ceb.2024.102343 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Adele Marston Matthew J Tyska Source Type: research
Neurofilaments: Novel findings and future challenges
Curr Opin Cell Biol. 2024 Feb 23;87:102326. doi: 10.1016/j.ceb.2024.102326. Online ahead of print.ABSTRACTNeurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, pa...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Jessy V van Asperen Farah Kotaich Damien Caillol Pascale Bomont Source Type: research
GFAP-isoforms in the nervous system: Understanding the need for diversity
Curr Opin Cell Biol. 2024 Feb 23;87:102340. doi: 10.1016/j.ceb.2024.102340. Online ahead of print.ABSTRACTGlial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly propert...
Source: Current Opinion in Cell Biology - February 24, 2024 Category: Cytology Authors: Alexandra J E M de Reus Onur Basak Werner Dykstra Jessy V van Asperen Emma J van Bodegraven Elly M Hol Source Type: research
Cytoskeletal crosstalk: A focus on intermediate filaments
Curr Opin Cell Biol. 2024 Feb 14;87:102325. doi: 10.1016/j.ceb.2024.102325. Online ahead of print.ABSTRACTThe cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay...
Source: Current Opinion in Cell Biology - February 15, 2024 Category: Cytology Authors: Lucas Pradeau-Ph élut Sandrine Etienne-Manneville Source Type: research
Cytoskeletal crosstalk: A focus on intermediate filaments
Curr Opin Cell Biol. 2024 Feb 14;87:102325. doi: 10.1016/j.ceb.2024.102325. Online ahead of print.ABSTRACTThe cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay...
Source: Current Opinion in Cell Biology - February 15, 2024 Category: Cytology Authors: Lucas Pradeau-Ph élut Sandrine Etienne-Manneville Source Type: research
Cytoskeletal crosstalk: A focus on intermediate filaments
Curr Opin Cell Biol. 2024 Feb 14;87:102325. doi: 10.1016/j.ceb.2024.102325. Online ahead of print.ABSTRACTThe cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay...
Source: Current Opinion in Cell Biology - February 15, 2024 Category: Cytology Authors: Lucas Pradeau-Ph élut Sandrine Etienne-Manneville Source Type: research
Cytoskeletal crosstalk: A focus on intermediate filaments
Curr Opin Cell Biol. 2024 Feb 14;87:102325. doi: 10.1016/j.ceb.2024.102325. Online ahead of print.ABSTRACTThe cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay...
Source: Current Opinion in Cell Biology - February 15, 2024 Category: Cytology Authors: Lucas Pradeau-Ph élut Sandrine Etienne-Manneville Source Type: research
Cytoskeletal crosstalk: A focus on intermediate filaments
Curr Opin Cell Biol. 2024 Feb 14;87:102325. doi: 10.1016/j.ceb.2024.102325. Online ahead of print.ABSTRACTThe cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay...
Source: Current Opinion in Cell Biology - February 15, 2024 Category: Cytology Authors: Lucas Pradeau-Ph élut Sandrine Etienne-Manneville Source Type: research
Cytoskeletal crosstalk: A focus on intermediate filaments
Curr Opin Cell Biol. 2024 Feb 14;87:102325. doi: 10.1016/j.ceb.2024.102325. Online ahead of print.ABSTRACTThe cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay...
Source: Current Opinion in Cell Biology - February 15, 2024 Category: Cytology Authors: Lucas Pradeau-Ph élut Sandrine Etienne-Manneville Source Type: research
Cytoskeletal crosstalk: A focus on intermediate filaments
Curr Opin Cell Biol. 2024 Feb 14;87:102325. doi: 10.1016/j.ceb.2024.102325. Online ahead of print.ABSTRACTThe cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay...
Source: Current Opinion in Cell Biology - February 15, 2024 Category: Cytology Authors: Lucas Pradeau-Ph élut Sandrine Etienne-Manneville Source Type: research
Nuclear mechanotransduction on skin stem cell fate regulation
Curr Opin Cell Biol. 2024 Feb 9;87:102328. doi: 10.1016/j.ceb.2024.102328. Online ahead of print.ABSTRACTMammalian skin is a highly dynamic and regenerative organ that has long been recognized as a mechanically active composite of tissues withstanding daily compressive and tensile forces that arise from body movement. Importantly, cell- and tissue-scale mechanical signals are critical regulators of skin morphogenesis and homeostasis. These signals are sensed at the cellular periphery and transduced by mechanosensitive proteins within the plasma membrane to the cytoskeletal networks, and eventually into the nucleus to regul...
Source: Current Opinion in Cell Biology - February 10, 2024 Category: Cytology Authors: Leah C Biggs Yekaterina A Miroshnikova Source Type: research
Cell competition and the regulation of protein homeostasis
Curr Opin Cell Biol. 2024 Jan 31;87:102323. doi: 10.1016/j.ceb.2024.102323. Online ahead of print.ABSTRACTThe process of embryonic development involves remarkable cellular plasticity, which governs the coordination between cells necessary to build an organism. One role of this plasticity is to ensure that when aberrant cells are eliminated, growth adjustment occurs so that the size of the tissue is maintained. An important regulator of cellular plasticity that ensures cellular cooperation is a fitness-sensing mechanism termed cell competition. During cell competition, cells with defects that lower fitness but do not affect...
Source: Current Opinion in Cell Biology - February 1, 2024 Category: Cytology Authors: Shruthi Krishnan Pranab K Paul Tristan A Rodriguez Source Type: research
Mechanotransduction through protein stretching
Curr Opin Cell Biol. 2024 Jan 31;87:102327. doi: 10.1016/j.ceb.2024.102327. Online ahead of print.ABSTRACTCells sense and respond to subtle changes in their physicality, and via a myriad of different mechanosensitive processes, convert these physical cues into chemical and biochemical signals. This process, called mechanotransduction, is possible due to a highly sophisticated machinery within cells. One mechanism by which this can occur is via the stretching of mechanosensitive proteins. Stretching proteins that contain force-dependent regions results in altered geometry and dimensions of the connections, as well as differ...
Source: Current Opinion in Cell Biology - February 1, 2024 Category: Cytology Authors: Yanyu Guo Jie Yan Benjamin T Goult Source Type: research
Forced back into shape: Mechanics of epithelial wound repair
Curr Opin Cell Biol. 2024 Jan 29;87:102324. doi: 10.1016/j.ceb.2024.102324. Online ahead of print.ABSTRACTWound repair, the closing of a hole, is inherently a physical process that requires the change of shape of materials, in this case, cells and tissues. Not only is efficient and accurate wound repair critical for restoring barrier function and reducing infection, but it is also critical for restoring the complex three-dimensional architecture of an organ. This re-sculpting of tissues requires the complex coordination of cell behaviours in multiple dimensions, in space and time, to ensure that the repaired structure can ...
Source: Current Opinion in Cell Biology - January 30, 2024 Category: Cytology Authors: Shu En Lim Pablo Vicente-Munuera Yanlan Mao Source Type: research
All the small things: Nanoscale matrix alterations in aging tissues
Curr Opin Cell Biol. 2024 Jan 25;87:102322. doi: 10.1016/j.ceb.2024.102322. Online ahead of print.ABSTRACTCellular aging stems from multifaceted intra- and extracellular molecular changes that lead to the gradual deterioration of biological function. Altered extracellular matrix (ECM) properties that include biochemical, structural, and mechanical perturbations direct cellular- and tissue-level dysfunction. With recent advancements in high-resolution imaging modalities and nanomaterial strategies, the importance of nanoscale ECM features has come into focus. Here, we provide an updated window into micro- to nano-scale ECM ...
Source: Current Opinion in Cell Biology - January 26, 2024 Category: Cytology Authors: Avery Rui Sun Ranmadusha M Hengst Jennifer L Young Source Type: research
