Mechanotransduction through membrane tension: It's all about propagation?
Curr Opin Cell Biol. 2023 Dec 14;86:102294. doi: 10.1016/j.ceb.2023.102294. Online ahead of print.ABSTRACTOver the past 25 years, membrane tension has emerged as a primary mechanical factor influencing cell behavior. Although supporting evidences are accumulating, the integration of this parameter in the lifecycle of cells, organs, and tissues is complex. The plasma membrane is envisioned as a bilayer continuum acting as a 2D fluid. However, it possesses almost infinite combinations of proteins, lipids, and glycans that establish interactions with the extracellular or intracellular environments. This results in a tridimens...
Source: Current Opinion in Cell Biology - December 15, 2023 Category: Cytology Authors: Andrea Ghisleni Nils C Gauthier Source Type: research
Mechanotransduction through membrane tension: It's all about propagation?
Curr Opin Cell Biol. 2023 Dec 14;86:102294. doi: 10.1016/j.ceb.2023.102294. Online ahead of print.ABSTRACTOver the past 25 years, membrane tension has emerged as a primary mechanical factor influencing cell behavior. Although supporting evidences are accumulating, the integration of this parameter in the lifecycle of cells, organs, and tissues is complex. The plasma membrane is envisioned as a bilayer continuum acting as a 2D fluid. However, it possesses almost infinite combinations of proteins, lipids, and glycans that establish interactions with the extracellular or intracellular environments. This results in a tridimens...
Source: Current Opinion in Cell Biology - December 15, 2023 Category: Cytology Authors: Andrea Ghisleni Nils C Gauthier Source Type: research
Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis
Curr Opin Cell Biol. 2023 Dec 13;86:102301. doi: 10.1016/j.ceb.2023.102301. Online ahead of print.ABSTRACTKinesin-1, composed of kinesin heavy chain and kinesin light chain, is a founding member of kinesin superfamily and transports various neuronal cargos. Kinesin-1 is one of the most abundant ATPases in the cell and thus need to be tightly regulated to avoid wastage of energy. It has been well established that kinesin-1 is regulated by the autoinhibition mechanism. This review focuses on the recent researches that have contributed to the understanding of mechanisms for the autoinhibition of kinesin-1 and its unlocking. R...
Source: Current Opinion in Cell Biology - December 14, 2023 Category: Cytology Authors: Kyoko Chiba Shinsuke Niwa Source Type: research
Organelle morphology and positioning orchestrate physiological and disease-associated processes
Curr Opin Cell Biol. 2023 Dec 13;86:102293. doi: 10.1016/j.ceb.2023.102293. Online ahead of print.ABSTRACTIn cells, organelles are distributed nonrandomly to regulate cells' physiological and disease-associated processes. Based on their morphology, position within the cell, and contacts with other organelles, they exert different biological functions. Endo-lysosomes are critical cell metabolism and nutrient-sensing regulators modulating cell growth and cellular adaptation in response to nutrient availability. Their spatial distribution is intimately linked to their function. In this review, we will discuss the role of endo...
Source: Current Opinion in Cell Biology - December 14, 2023 Category: Cytology Authors: Katerina Jerabkova-Roda Rituraj Marwaha Tamal Das Jacky G Goetz Source Type: research
Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis
Curr Opin Cell Biol. 2023 Dec 13;86:102301. doi: 10.1016/j.ceb.2023.102301. Online ahead of print.ABSTRACTKinesin-1, composed of kinesin heavy chain and kinesin light chain, is a founding member of kinesin superfamily and transports various neuronal cargos. Kinesin-1 is one of the most abundant ATPases in the cell and thus need to be tightly regulated to avoid wastage of energy. It has been well established that kinesin-1 is regulated by the autoinhibition mechanism. This review focuses on the recent researches that have contributed to the understanding of mechanisms for the autoinhibition of kinesin-1 and its unlocking. R...
Source: Current Opinion in Cell Biology - December 14, 2023 Category: Cytology Authors: Kyoko Chiba Shinsuke Niwa Source Type: research
Organelle morphology and positioning orchestrate physiological and disease-associated processes
Curr Opin Cell Biol. 2023 Dec 13;86:102293. doi: 10.1016/j.ceb.2023.102293. Online ahead of print.ABSTRACTIn cells, organelles are distributed nonrandomly to regulate cells' physiological and disease-associated processes. Based on their morphology, position within the cell, and contacts with other organelles, they exert different biological functions. Endo-lysosomes are critical cell metabolism and nutrient-sensing regulators modulating cell growth and cellular adaptation in response to nutrient availability. Their spatial distribution is intimately linked to their function. In this review, we will discuss the role of endo...
Source: Current Opinion in Cell Biology - December 14, 2023 Category: Cytology Authors: Katerina Jerabkova-Roda Rituraj Marwaha Tamal Das Jacky G Goetz Source Type: research
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Curr Opin Cell Biol. 2023 Dec 6;86:102292. doi: 10.1016/j.ceb.2023.102292. Online ahead of print.ABSTRACTThe unique architecture of the liver allows for spatial compartmentalization of its functions, also known as liver zonation. In contrast to organelles and cells, this compartment is devoid of a surrounding membrane, rendering traditional biochemical tools ineffective for studying liver zonation. Recent advancements in tissue imaging and single-cell technologies have provided new insights into the complexity of tissue organization, rich cellular composition, and the gradients that shape zonation. Hepatocyte gene expressi...
Source: Current Opinion in Cell Biology - December 8, 2023 Category: Cytology Authors: Natalie Porat-Shliom Source Type: research
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Curr Opin Cell Biol. 2023 Dec 6;86:102292. doi: 10.1016/j.ceb.2023.102292. Online ahead of print.ABSTRACTThe unique architecture of the liver allows for spatial compartmentalization of its functions, also known as liver zonation. In contrast to organelles and cells, this compartment is devoid of a surrounding membrane, rendering traditional biochemical tools ineffective for studying liver zonation. Recent advancements in tissue imaging and single-cell technologies have provided new insights into the complexity of tissue organization, rich cellular composition, and the gradients that shape zonation. Hepatocyte gene expressi...
Source: Current Opinion in Cell Biology - December 8, 2023 Category: Cytology Authors: Natalie Porat-Shliom Source Type: research
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Curr Opin Cell Biol. 2023 Dec 6;86:102292. doi: 10.1016/j.ceb.2023.102292. Online ahead of print.ABSTRACTThe unique architecture of the liver allows for spatial compartmentalization of its functions, also known as liver zonation. In contrast to organelles and cells, this compartment is devoid of a surrounding membrane, rendering traditional biochemical tools ineffective for studying liver zonation. Recent advancements in tissue imaging and single-cell technologies have provided new insights into the complexity of tissue organization, rich cellular composition, and the gradients that shape zonation. Hepatocyte gene expressi...
Source: Current Opinion in Cell Biology - December 8, 2023 Category: Cytology Authors: Natalie Porat-Shliom Source Type: research
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Curr Opin Cell Biol. 2023 Dec 6;86:102292. doi: 10.1016/j.ceb.2023.102292. Online ahead of print.ABSTRACTThe unique architecture of the liver allows for spatial compartmentalization of its functions, also known as liver zonation. In contrast to organelles and cells, this compartment is devoid of a surrounding membrane, rendering traditional biochemical tools ineffective for studying liver zonation. Recent advancements in tissue imaging and single-cell technologies have provided new insights into the complexity of tissue organization, rich cellular composition, and the gradients that shape zonation. Hepatocyte gene expressi...
Source: Current Opinion in Cell Biology - December 8, 2023 Category: Cytology Authors: Natalie Porat-Shliom Source Type: research
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Curr Opin Cell Biol. 2023 Dec 6;86:102292. doi: 10.1016/j.ceb.2023.102292. Online ahead of print.ABSTRACTThe unique architecture of the liver allows for spatial compartmentalization of its functions, also known as liver zonation. In contrast to organelles and cells, this compartment is devoid of a surrounding membrane, rendering traditional biochemical tools ineffective for studying liver zonation. Recent advancements in tissue imaging and single-cell technologies have provided new insights into the complexity of tissue organization, rich cellular composition, and the gradients that shape zonation. Hepatocyte gene expressi...
Source: Current Opinion in Cell Biology - December 8, 2023 Category: Cytology Authors: Natalie Porat-Shliom Source Type: research
Cell cycle control by cell-matrix interactions
Curr Opin Cell Biol. 2023 Dec 5;86:102288. doi: 10.1016/j.ceb.2023.102288. Online ahead of print.ABSTRACTCell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression and accurate cell division. However, how cell adhesion to the wide range of ECM proteins found in human tissues influences the cell cycle is not fully understood. The composition and physical properties of the ECM can have profound effects on cell proliferation but can also promote cell cycle exit and quiescence. Furthermore, during tumor development and progression, changes in the ECM can drive both cancer cell proliferation a...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Michael J Jones Matthew C Jones Source Type: research
AAA ATPase protein-protein interactions as therapeutic targets in cancer
Curr Opin Cell Biol. 2023 Dec 5;86:102291. doi: 10.1016/j.ceb.2023.102291. Online ahead of print.ABSTRACTAAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein-protein interactions. Some of these interactions are potential therapeutic targets because of their role in cancers which rely on increased AAA ATPase activities for maintenance of genomic stability. Two well-characterized members of this family are p97/VCP and RUVBL ATPases where there is a growing understanding of their structure and function, as well as an emerging landsc...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Dhiraj Mannar Sana Ahmed Sriram Subramaniam Source Type: research
The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow
Curr Opin Cell Biol. 2023 Dec 5;86:102285. doi: 10.1016/j.ceb.2023.102285. Online ahead of print.ABSTRACTThe language of biology at the scale of the cell is constituted of alphabets represented by biomolecules. These are stitched together in a variety of ways to create meaning. We argue that the phrases of this language are nanoscale molecular assemblies or nano-hubs for the purpose of information flow. At the cell surface information is sensed and processed via membrane receptors, often configured as multimers. These nano-assemblies serve as receiver nano-hubs, which are flexibly configured with additional nano-hubs that ...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Maria F Garcia-Parajo Satyajit Mayor Source Type: research
Cell cycle control by cell-matrix interactions
Curr Opin Cell Biol. 2023 Dec 5;86:102288. doi: 10.1016/j.ceb.2023.102288. Online ahead of print.ABSTRACTCell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression and accurate cell division. However, how cell adhesion to the wide range of ECM proteins found in human tissues influences the cell cycle is not fully understood. The composition and physical properties of the ECM can have profound effects on cell proliferation but can also promote cell cycle exit and quiescence. Furthermore, during tumor development and progression, changes in the ECM can drive both cancer cell proliferation a...
Source: Current Opinion in Cell Biology - December 6, 2023 Category: Cytology Authors: Michael J Jones Matthew C Jones Source Type: research
