Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis

Curr Opin Cell Biol. 2023 Dec 13;86:102301. doi: 10.1016/j.ceb.2023.102301. Online ahead of print.ABSTRACTKinesin-1, composed of kinesin heavy chain and kinesin light chain, is a founding member of kinesin superfamily and transports various neuronal cargos. Kinesin-1 is one of the most abundant ATPases in the cell and thus need to be tightly regulated to avoid wastage of energy. It has been well established that kinesin-1 is regulated by the autoinhibition mechanism. This review focuses on the recent researches that have contributed to the understanding of mechanisms for the autoinhibition of kinesin-1 and its unlocking. Recent electron microscopic studies have shown an unanticipated structure of autoinhibited kinesin-1. Biochemical reconstitution have revealed detailed molecular mechanisms how the autoinhibition is unlocked. Importantly, misregulation of kinesin-1 is emerging as one of the major causes of amyotrophic lateral sclerosis.PMID:38096601 | DOI:10.1016/j.ceb.2023.102301
Source: Current Opinion in Cell Biology - Category: Cytology Authors: Source Type: research