Lamins: The backbone of the nucleocytoskeleton interface
Curr Opin Cell Biol. 2024 Feb;86:102313. doi: 10.1016/j.ceb.2023.102313. Epub 2024 Jan 22.ABSTRACTThe nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and consists of lamin filaments and associated proteins. Lamins are type V intermediate filament proteins essential for maintaining the integrity and mechanical properties of the nucleus. In human cells, 'B-type' lamins (lamin B1 and lamin B2) are ubiquitously expressed, while 'A-type' lamins (lamin A, lamin C, and minor isoforms) are expressed in a tissue- and development-specific manner. Lamins homopolymerize to form filaments that localize pr...
Source: Current Opinion in Cell Biology - January 23, 2024 Category: Cytology Authors: Joan M Sobo Nicholas S Alagna Sean X Sun Katherine L Wilson Karen L Reddy Source Type: research
Membrane fusion and fission during eukaryogenesis
Curr Opin Cell Biol. 2024 Feb;86:102321. doi: 10.1016/j.ceb.2023.102321. Epub 2024 Jan 14.ABSTRACTAll eukaryotes can be traced back to a single shared ancestral lineage that emerged from interactions between different prokaryotic cells. Current models of eukaryogenesis describe various selective forces and evolutionary mechanisms that contributed to the formation of eukaryotic cells. Central to this process were significant changes in cellular structure, resulting in the configuration of a new cell type characterized by internal membrane compartments. Additionally, eukaryogenesis results in a life cycle that relies on cell...
Source: Current Opinion in Cell Biology - January 14, 2024 Category: Cytology Authors: H éctor Romero Pablo S Aguilar Martin Gra ña Mauricio Langleib Virginia Gudi ño Benjamin Podbilewicz Source Type: research
Decoding the cell nucleus
Curr Opin Cell Biol. 2024 Feb;86:102319. doi: 10.1016/j.ceb.2023.102319. Epub 2024 Jan 13.NO ABSTRACTPMID:38219526 | DOI:10.1016/j.ceb.2023.102319 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - January 14, 2024 Category: Cytology Authors: Hiroshi Kimura Melike Lakadamyali Source Type: research
Scaling the cellular frontier: Mechanobiology, tissue dynamics and function
Curr Opin Cell Biol. 2024 Feb;86:102318. doi: 10.1016/j.ceb.2023.102318. Epub 2024 Jan 11.NO ABSTRACTPMID:38215514 | DOI:10.1016/j.ceb.2023.102318 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - January 12, 2024 Category: Cytology Authors: JoAnn Trejo Giorgio Scita Source Type: research
Local cellular interactions: From signaling to mechanics across development, evolution, and disease
Curr Opin Cell Biol. 2024 Feb;86:102312. doi: 10.1016/j.ceb.2023.102312. Epub 2024 Jan 12.NO ABSTRACTPMID:38215515 | DOI:10.1016/j.ceb.2023.102312 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - January 12, 2024 Category: Cytology Authors: Anna Bigas David Sprinzak Source Type: research
Cellular stress management by caspases
Curr Opin Cell Biol. 2024 Feb;86:102314. doi: 10.1016/j.ceb.2023.102314. Epub 2024 Jan 11.ABSTRACTCellular stress plays a pivotal role in the onset of numerous human diseases. Consequently, the removal of dysfunctional cells, which undergo excessive stress-induced damage via various cell death pathways, including apoptosis, is essential for maintaining organ integrity and function. The evolutionarily conserved family of cysteine-aspartic-proteases, known as caspases, has been a key player in orchestrating apoptosis. However, recent research has unveiled the capability of these enzymes to govern fundamental cellular process...
Source: Current Opinion in Cell Biology - January 12, 2024 Category: Cytology Authors: Luis Alberto Baena-Lopez Li Wang Franz Wendler Source Type: research
Recent developments in membrane traffic and lipid dynamics
Curr Opin Cell Biol. 2024 Feb;86:102320. doi: 10.1016/j.ceb.2023.102320. Epub 2024 Jan 11.NO ABSTRACTPMID:38215517 | DOI:10.1016/j.ceb.2023.102320 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - January 12, 2024 Category: Cytology Authors: Aur élien Roux Karin Reinisch Source Type: research
Staying away from the breaking point: Probing the limits of epithelial cell elimination
Curr Opin Cell Biol. 2024 Feb;86:102316. doi: 10.1016/j.ceb.2023.102316. Epub 2024 Jan 9.ABSTRACTEpithelial tissues are dramatically remodelled during embryogenesis and tissue homeostasis and yet need to maintain their sealing properties to sustain their barrier functions at any time. Part of these remodellings involve the elimination of a large proportion of cells through apoptosis. Cell extrusion, the remodelling steps leading to seamless dying cell expulsion, helps to maintain tissue cohesion. However, there is an intrinsic limit in the system that can only accommodate a certain proportion/rate of cell elimination as we...
Source: Current Opinion in Cell Biology - January 10, 2024 Category: Cytology Authors: Romain Levayer Source Type: research
Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome
Curr Opin Cell Biol. 2024 Feb;86:102302. doi: 10.1016/j.ceb.2023.102302. Epub 2024 Jan 9.ABSTRACTNotch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch ligand 1 (JAG1), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain how pathology develops in the hepatic and cardiovascular systems and, together with recent elucidation of mechanisms modulating l...
Source: Current Opinion in Cell Biology - January 9, 2024 Category: Cytology Authors: Jan Ma šek Emma R Andersson Source Type: research
Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells
Curr Opin Cell Biol. 2024 Feb;86:102306. doi: 10.1016/j.ceb.2023.102306. Epub 2024 Jan 9.ABSTRACTDuring embryogenesis, the mammalian kidney arises because of reciprocal interactions between the ureteric bud (UB) and the metanephric mesenchyme (MM), driving UB branching and nephron induction. These morphogenetic processes involve a series of cellular rearrangements that are tightly controlled by gene regulatory networks and signaling cascades. Here, we discuss how kidney developmental studies have informed the definition of procedures to obtain kidney organoids from human pluripotent stem cells (hPSCs). Moreover, bioenginee...
Source: Current Opinion in Cell Biology - January 9, 2024 Category: Cytology Authors: Anisha Pahuja Iphig énie Goux Corredera Daniel Moya-Rull Elena Garreta Nuria Montserrat Source Type: research
Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome
Curr Opin Cell Biol. 2024 Jan 8;86:102302. doi: 10.1016/j.ceb.2023.102302. Online ahead of print.ABSTRACTNotch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch ligand 1 (JAG1), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain how pathology develops in the hepatic and cardiovascular systems and, together with recent elucidation of mechanisms modu...
Source: Current Opinion in Cell Biology - January 9, 2024 Category: Cytology Authors: Jan Ma šek Emma R Andersson Source Type: research
Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells
Curr Opin Cell Biol. 2024 Jan 8;86:102306. doi: 10.1016/j.ceb.2023.102306. Online ahead of print.ABSTRACTDuring embryogenesis, the mammalian kidney arises because of reciprocal interactions between the ureteric bud (UB) and the metanephric mesenchyme (MM), driving UB branching and nephron induction. These morphogenetic processes involve a series of cellular rearrangements that are tightly controlled by gene regulatory networks and signaling cascades. Here, we discuss how kidney developmental studies have informed the definition of procedures to obtain kidney organoids from human pluripotent stem cells (hPSCs). Moreover, bi...
Source: Current Opinion in Cell Biology - January 9, 2024 Category: Cytology Authors: Anisha Pahuja Iphig énie Goux Corredera Daniel Moya-Rull Elena Garreta Nuria Montserrat Source Type: research
Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems
Curr Opin Cell Biol. 2024 Jan 5;86:102309. doi: 10.1016/j.ceb.2023.102309. Online ahead of print.ABSTRACTThe interactions between cells and their surrounding extracellular matrix (ECM) are dynamic and play critical roles in cell migration during development, health, and diseases. Recent advances have highlighted the complexity and diversity of ECM compositions, or "matrisomes", of tissues resulting in ECMs of different physical, mechanical, and biochemical properties. Investigating the effects of these properties on cell-ECM interactions in the context of cell migration have led to a better understanding of the principles ...
Source: Current Opinion in Cell Biology - January 6, 2024 Category: Cytology Authors: Dharma Pally Alexandra Naba Source Type: research
Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems
Curr Opin Cell Biol. 2024 Jan 5;86:102309. doi: 10.1016/j.ceb.2023.102309. Online ahead of print.ABSTRACTThe interactions between cells and their surrounding extracellular matrix (ECM) are dynamic and play critical roles in cell migration during development, health, and diseases. Recent advances have highlighted the complexity and diversity of ECM compositions, or "matrisomes", of tissues resulting in ECMs of different physical, mechanical, and biochemical properties. Investigating the effects of these properties on cell-ECM interactions in the context of cell migration have led to a better understanding of the principles ...
Source: Current Opinion in Cell Biology - January 6, 2024 Category: Cytology Authors: Dharma Pally Alexandra Naba Source Type: research
Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems
Curr Opin Cell Biol. 2024 Jan 5;86:102309. doi: 10.1016/j.ceb.2023.102309. Online ahead of print.ABSTRACTThe interactions between cells and their surrounding extracellular matrix (ECM) are dynamic and play critical roles in cell migration during development, health, and diseases. Recent advances have highlighted the complexity and diversity of ECM compositions, or "matrisomes", of tissues resulting in ECMs of different physical, mechanical, and biochemical properties. Investigating the effects of these properties on cell-ECM interactions in the context of cell migration have led to a better understanding of the principles ...
Source: Current Opinion in Cell Biology - January 6, 2024 Category: Cytology Authors: Dharma Pally Alexandra Naba Source Type: research
