Disturbed endothelial cell signaling in tumor progression and therapy resistance
Curr Opin Cell Biol. 2023 Nov 28;86:102287. doi: 10.1016/j.ceb.2023.102287. Online ahead of print.ABSTRACTGrowth of new blood vessels is considered requisite to cancer progression. Recent findings revealed that in addition to inducing angiogenesis, tumor-derived factors alter endothelial cell gene transcription within the tumor mass but also systemically throughout the body. This subsequently contributes to immunosuppression, altered metabolism, therapy resistance and metastasis. Clinical studies demonstrated that targeting the endothelium can increase the success rate of immunotherapy. Single-cell technologies revealed re...
Source: Current Opinion in Cell Biology - November 29, 2023 Category: Cytology Authors: Andreas Fischer Elisenda Alsina-Sanchis Source Type: research
The keratin-desmosome scaffold of internal epithelia in health and disease - The plot is thickening
Curr Opin Cell Biol. 2023 Nov 23;86:102282. doi: 10.1016/j.ceb.2023.102282. Online ahead of print.ABSTRACTKeratin (K) intermediate filaments are attached to desmosomes and constitute the orchestrators of epithelial cell and tissue architecture. While their relevance in the epidermis is well recognized, our review focuses on their emerging importance in internal epithelia. The significance of keratin-desmosome scaffolds (KDSs) in the intestine is highlighted by transgenic mouse models and individuals with inflammatory bowel disease who display profound KDS alterations. In lung, high K8 expression defines a transitional cell...
Source: Current Opinion in Cell Biology - November 24, 2023 Category: Cytology Authors: Diana M Toivola Lauri Polari Tobias Schwerd Nicolas Schlegel Pavel Strnad Source Type: research
The keratin-desmosome scaffold of internal epithelia in health and disease - The plot is thickening
Curr Opin Cell Biol. 2023 Nov 23;86:102282. doi: 10.1016/j.ceb.2023.102282. Online ahead of print.ABSTRACTKeratin (K) intermediate filaments are attached to desmosomes and constitute the orchestrators of epithelial cell and tissue architecture. While their relevance in the epidermis is well recognized, our review focuses on their emerging importance in internal epithelia. The significance of keratin-desmosome scaffolds (KDSs) in the intestine is highlighted by transgenic mouse models and individuals with inflammatory bowel disease who display profound KDS alterations. In lung, high K8 expression defines a transitional cell...
Source: Current Opinion in Cell Biology - November 24, 2023 Category: Cytology Authors: Diana M Toivola Lauri Polari Tobias Schwerd Nicolas Schlegel Pavel Strnad Source Type: research
The keratin-desmosome scaffold of internal epithelia in health and disease - The plot is thickening
Curr Opin Cell Biol. 2023 Nov 23;86:102282. doi: 10.1016/j.ceb.2023.102282. Online ahead of print.ABSTRACTKeratin (K) intermediate filaments are attached to desmosomes and constitute the orchestrators of epithelial cell and tissue architecture. While their relevance in the epidermis is well recognized, our review focuses on their emerging importance in internal epithelia. The significance of keratin-desmosome scaffolds (KDSs) in the intestine is highlighted by transgenic mouse models and individuals with inflammatory bowel disease who display profound KDS alterations. In lung, high K8 expression defines a transitional cell...
Source: Current Opinion in Cell Biology - November 24, 2023 Category: Cytology Authors: Diana M Toivola Lauri Polari Tobias Schwerd Nicolas Schlegel Pavel Strnad Source Type: research
The keratin-desmosome scaffold of internal epithelia in health and disease - The plot is thickening
Curr Opin Cell Biol. 2023 Nov 23;86:102282. doi: 10.1016/j.ceb.2023.102282. Online ahead of print.ABSTRACTKeratin (K) intermediate filaments are attached to desmosomes and constitute the orchestrators of epithelial cell and tissue architecture. While their relevance in the epidermis is well recognized, our review focuses on their emerging importance in internal epithelia. The significance of keratin-desmosome scaffolds (KDSs) in the intestine is highlighted by transgenic mouse models and individuals with inflammatory bowel disease who display profound KDS alterations. In lung, high K8 expression defines a transitional cell...
Source: Current Opinion in Cell Biology - November 24, 2023 Category: Cytology Authors: Diana M Toivola Lauri Polari Tobias Schwerd Nicolas Schlegel Pavel Strnad Source Type: research
Stress-protecting harbors for hematopoietic stem cells
Curr Opin Cell Biol. 2023 Nov 22;86:102284. doi: 10.1016/j.ceb.2023.102284. Online ahead of print.ABSTRACTHematopoietic stem cells (HSCs) rely on specialized microenvironments known as niches to maintain their self-renewal and multilineage potential to generate diverse types of blood cells continuously. Over the last two decades, substantial advancements have been made in unraveling the niche cell components and HSC localizations under homeostatic and stressed circumstances. Advances in imaging, combined with the discovery of phenotypic surface markers combinations and single cell sequencing, have greatly facilitated the s...
Source: Current Opinion in Cell Biology - November 23, 2023 Category: Cytology Authors: Zhe Yang Ruochen Dong Xinjian Mao Xi C He Linheng Li Source Type: research
Stress-protecting harbors for hematopoietic stem cells
Curr Opin Cell Biol. 2023 Nov 22;86:102284. doi: 10.1016/j.ceb.2023.102284. Online ahead of print.ABSTRACTHematopoietic stem cells (HSCs) rely on specialized microenvironments known as niches to maintain their self-renewal and multilineage potential to generate diverse types of blood cells continuously. Over the last two decades, substantial advancements have been made in unraveling the niche cell components and HSC localizations under homeostatic and stressed circumstances. Advances in imaging, combined with the discovery of phenotypic surface markers combinations and single cell sequencing, have greatly facilitated the s...
Source: Current Opinion in Cell Biology - November 23, 2023 Category: Cytology Authors: Zhe Yang Ruochen Dong Xinjian Mao Xi C He Linheng Li Source Type: research
The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation
Curr Opin Cell Biol. 2023 Nov 20;86:102283. doi: 10.1016/j.ceb.2023.102283. Online ahead of print.ABSTRACTIntermediate filaments are critical for cell and tissue homeostasis and for stress responses. Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect cellular organelles, participate in signaling and protect cells and tissues against stress. Here we have focused on their involvement in redox signaling and oxidative stress, which arises in numerous pathophysiological situations. We pay special attention to type III intermediate filaments, mainly vimentin, because it provides a physical...
Source: Current Opinion in Cell Biology - November 21, 2023 Category: Cytology Authors: Dolores P érez-Sala Roy A Quinlan Source Type: research
The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation
Curr Opin Cell Biol. 2023 Nov 20;86:102283. doi: 10.1016/j.ceb.2023.102283. Online ahead of print.ABSTRACTIntermediate filaments are critical for cell and tissue homeostasis and for stress responses. Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect cellular organelles, participate in signaling and protect cells and tissues against stress. Here we have focused on their involvement in redox signaling and oxidative stress, which arises in numerous pathophysiological situations. We pay special attention to type III intermediate filaments, mainly vimentin, because it provides a physical...
Source: Current Opinion in Cell Biology - November 21, 2023 Category: Cytology Authors: Dolores P érez-Sala Roy A Quinlan Source Type: research
Drivers of heterogeneity in the glioblastoma immune microenvironment
We describe recent insights into how each of these factors affects key aspects ranging from TIME composition to therapy response, with an emphasis on the cross-talk between tumor and immune cells. Deciphering these local interactions is fundamental to understanding therapy resistance and identifying novel immunomodulatory strategies.PMID:37984008 | DOI:10.1016/j.ceb.2023.102279 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - November 20, 2023 Category: Cytology Authors: Alina Brosque Dinorah Friedmann-Morvinski Source Type: research
Transmit and protect: The mechanical functions of intermediate filaments
Curr Opin Cell Biol. 2023 Nov 18;85:102281. doi: 10.1016/j.ceb.2023.102281. Online ahead of print.ABSTRACTNew aspects of the unique mechanical properties of intermediate filaments (IFs) continue to emerge from studies that illuminate the structure and mechanical response of single filaments, the interaction of intermediate filaments with each other or with other cytoskeletal elements, and the viscoelasticity of the networks that these intermediate filaments form. The relation of purified IF network mechanics to the role of IFs in cells and tissues is a particularly active area, with several new demonstrations of the unique...
Source: Current Opinion in Cell Biology - November 20, 2023 Category: Cytology Authors: Katarzyna Pogoda Paul A Janmey Source Type: research
Drivers of heterogeneity in the glioblastoma immune microenvironment
We describe recent insights into how each of these factors affects key aspects ranging from TIME composition to therapy response, with an emphasis on the cross-talk between tumor and immune cells. Deciphering these local interactions is fundamental to understanding therapy resistance and identifying novel immunomodulatory strategies.PMID:37984008 | DOI:10.1016/j.ceb.2023.102279 (Source: Current Opinion in Cell Biology)
Source: Current Opinion in Cell Biology - November 20, 2023 Category: Cytology Authors: Alina Brosque Dinorah Friedmann-Morvinski Source Type: research
Transmit and protect: The mechanical functions of intermediate filaments
Curr Opin Cell Biol. 2023 Nov 18;85:102281. doi: 10.1016/j.ceb.2023.102281. Online ahead of print.ABSTRACTNew aspects of the unique mechanical properties of intermediate filaments (IFs) continue to emerge from studies that illuminate the structure and mechanical response of single filaments, the interaction of intermediate filaments with each other or with other cytoskeletal elements, and the viscoelasticity of the networks that these intermediate filaments form. The relation of purified IF network mechanics to the role of IFs in cells and tissues is a particularly active area, with several new demonstrations of the unique...
Source: Current Opinion in Cell Biology - November 20, 2023 Category: Cytology Authors: Katarzyna Pogoda Paul A Janmey Source Type: research
Cytoplasm mechanics and cellular organization
Curr Opin Cell Biol. 2023 Nov 16;85:102278. doi: 10.1016/j.ceb.2023.102278. Online ahead of print.ABSTRACTAs cells organize spatially or divide, they translocate many micron-scale organelles in their cytoplasm. These include endomembrane vesicles, nuclei, microtubule asters, mitotic spindles, or chromosomes. Organelle motion is powered by cytoskeleton forces but is opposed by viscoelastic forces imparted by the surrounding crowded cytoplasm medium. These resistive forces associated to cytoplasm physcial properties remain generally underappreciated, yet reach significant values to slow down organelle motion or even limit th...
Source: Current Opinion in Cell Biology - November 18, 2023 Category: Cytology Authors: Mar ía Isabel Arjona Javad Najafi Nicolas Minc Source Type: research
Cytoplasm mechanics and cellular organization
Curr Opin Cell Biol. 2023 Nov 16;85:102278. doi: 10.1016/j.ceb.2023.102278. Online ahead of print.ABSTRACTAs cells organize spatially or divide, they translocate many micron-scale organelles in their cytoplasm. These include endomembrane vesicles, nuclei, microtubule asters, mitotic spindles, or chromosomes. Organelle motion is powered by cytoskeleton forces but is opposed by viscoelastic forces imparted by the surrounding crowded cytoplasm medium. These resistive forces associated to cytoplasm physcial properties remain generally underappreciated, yet reach significant values to slow down organelle motion or even limit th...
Source: Current Opinion in Cell Biology - November 18, 2023 Category: Cytology Authors: Mar ía Isabel Arjona Javad Najafi Nicolas Minc Source Type: research
