Biographies of Contributors
Cells Tissues Organs 2023;212:5 –7 (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - February 13, 2023 Category: Cytology Source Type: research
Biographies of Contributors
Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - February 13, 2023 Category: Cytology Source Type: research
Coupled Mutual Inhibition and Mutual Activation Motifs as Tools for Cell-Fate Control
Multistability is central to biological systems. It plays a crucial role in adaptation, evolvability, and differentiation. The presence of positive feedback loops can enable multistability. The simplest of such feedback loops are (a) a mutual inhibition (MI) loop, (b) a mutual activation (MA) loop, and (c) self-activation. While it is established that all three motifs can give rise to bistability, the characteristic differences in the bistability exhibited by each of these motifs is relatively less understood. Here, we use dynamical simulations across a large ensemble of parameter sets and initial conditions to study the b...
Source: Cells Tissues Organs - February 9, 2023 Category: Cytology Source Type: research
Coupled mutual inhibition and mutual activation motifs as tools for cell-fate control
Multistability is central to biological systems as it plays a crucial role in adaptation, evolvability, and differentiation. The presence of positive feedback loops can enable multistability. The simplest of such feedback loops are a) a mutual inhibition loop (MI), b) a mutual activation loop (MA), and c) self-activation, all three of them known to give rise to bistability. However, the characteristic differences in the bistability exhibited by these motifs are relatively less understood. Here, we use dynamical simulations across a large ensemble of parameter sets and initial conditions to study the bistability characteris...
Source: Cells Tissues Organs - February 9, 2023 Category: Cytology Source Type: research
Different effects of sugars and methods to preserve post-thaw functional properties of cryopreserved caprine spermatogonial stem cells
The present study aimed to identify the effects of sugar and methods [slow freezing (SF) vs fast freezing (FF)] on post-thaw in-vitro functional characteristics of cryopreserved caprine SSCs (cSSCs) and the cells obtained from cryopreserved testis tissue of pre-pubertal Barbari bucks. For this, in experiment-1, cSSCs were isolated and cryopreserved by either SF or FF method with different nonpermeable [sugars; trehalose (140 mM; 140T or 400 mM; 400T), and sucrose (140 mM; 140S or 400 mM; 400S)] or/and permeable [5% ethylene glycol (EG) and DMSO] cryoprotectants. After one-wk of cryopreservation, the cSSCs were thawed and c...
Source: Cells Tissues Organs - February 2, 2023 Category: Cytology Source Type: research
Give them vasculature and immune cells – how to fill the gap of organoids
Valid and relevant models are critical for research to have biological relevance or proceed in the right path. As well-established 2D cell cultures lack niches and cues and rodent models differ in species, 3D organoids emerged as a powerful platform for research. Cultured in vitro from stem cells, organoids are heterogeneous in cells and closely resemble the in vivo settings. Organoids also re capitulate the unique human features if cultured from a human source and are subject to genetic modification. However, one type of organoid possesses only a limited selection of cells. In particular, the absence of vasculatu...
Source: Cells Tissues Organs - January 30, 2023 Category: Cytology Source Type: research
Glycoconjugate-specific developmental changes in the horse vomeronasal organ
In conclusion, these results suggest that there are increase in the level of N-acetylglucosamine (labeled by WGA, DSL, LEL) and galactose (labeled by RCA120) in horse VSE during postnatal development, implying that they may influence the function of VNO in adult horses. (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - January 4, 2023 Category: Cytology Source Type: research
Adoptive Immunotherapy: A Human Pluripotent Stem Cell Perspective
The past decade has witnessed significant advances in cancer immunotherapy, particularly through the adoptive transfer of engineered T cells in treating advanced leukemias and lymphomas. Despite these excitements, challenges remain with scale, cost, and ensuring quality control of engineered immune cells, including chimeric antigen receptor (CAR) T, natural killer (NK) cells, and macrophages. The advent of human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), has transformed immunotherapy by providing a scalable, off-the-shelf source of any desired im...
Source: Cells Tissues Organs - January 4, 2023 Category: Cytology Source Type: research
Using optogenetics to investigate the shared mechanisms of apical-basal polarity and mitosis
The initiation of apical-basal (AB) polarity and the process of mitotic cell division are both characterised by the generation of specialised plasma membrane and cortical domains. These are generated using shared mechanisms, such as asymmetric protein accumulation, Rho GTPase signalling, cytoskeletal reorganisation, vesicle trafficking and asymmetric phosphoinositide distribution. In epithelial tissue, the coordination of AB polarity and mitosis in space and time is important both during initial epithelial development and to maintain tissue integrity and ensure appropriate cell differentiation at later stages. Whilst signi...
Source: Cells Tissues Organs - January 4, 2023 Category: Cytology Source Type: research
Contents Vol. 211, 2022
Cells Tissues Organs 2022;211:I –VI (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - January 4, 2023 Category: Cytology Source Type: research
Acknowledgement to Referees
Cells Tissues Organs 2022;211:755 (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - January 4, 2023 Category: Cytology Source Type: research
