Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate the Pancreatic Changes of Chemically Induced Hypothyroidism by Carbimazole in Male Rats
In conclusion, many of the significant structural and func tional pancreatic alterations detected in HT rats were ameliorated after the injection of BM-MSCs. These data demonstrate the ability of BM-MSCs to repair pancreatic disturbances. Further studies on humans are necessary to determine the potential clinical applications of BM-MSCs.Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 31, 2019 Category: Cytology Source Type: research
Naringin (4 ′,5,7-Trihydroxyflavanone 7-Rhamnoglucoside) Attenuates β-Cell Dysfunction in Diabetic Rats through Upregulation of PDX-1
Conclusions: Naringin was found to be an effective antidiabetic agent which increasedInsulin gene expression and insulin secretion by upregulating the PDX-1 gene and protein expression.Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 20, 2019 Category: Cytology Source Type: research
Current Advancements in the Development and Characterization of Full-Thickness Adult Neuroretina Organotypic Culture Systems
Retinal degenerative diseases such as macular degeneration, glaucoma, and diabetic retinopathy constitute the leading cause of blindness in the industrialized world. There is a continuous demand in investigative ophthalmic research for the development of new treatment modalities for retinal therapy. Unfortunately, efforts to identify novel neuroprotective and neuroregenerative agents have often been hindered by an experimental model gap that exists between high-throughput methods via dissociated cells and preclinical animal models. Even though dissociated cell culture is rapid and high-throughput, it is limited in its abil...
Source: Cells Tissues Organs - March 15, 2019 Category: Cytology Source Type: research
Comparison between Operative and Non-Operative Treatment of the Medial Collateral Ligament: Histological and Ultrastructural Findings during Early Healing in the Epiligament Tissue in a Rat Knee Model
The medial collateral ligament of the knee joint is one of the most commonly injured ligaments of the knee. Recent data have shown that the thin layer of connective tissue covering the ligament, known as the epiligament, is essential for its nutrition and normal function, as well as its healing after injury. The aim of the present study was to investigate and compare the changes in the epiligament of the medial collateral ligament which occurred during operative and non-operative treatment throughout the first month after injury. We used 27 male Wistar rats randomly allocated to three groups. In the 9 rats belonging to the...
Source: Cells Tissues Organs - March 15, 2019 Category: Cytology Source Type: research
Myocardial Telocyte-Like Cells: A Review Including New Evidence
Telocytes (TCs) are a controversial cell type characterized by the presence of a particular kind of prolongations, known as telopodes, which are long, thin, and moniliform. A number of attempts has been made to establish the molecular phenotype of cardiac TCs (i.e., expression of c-kit, CD34, vimentin, PDGRF α, PDGRFβ, etc.). We designed an immunohistochemical study involving cardiac tissue samples obtained from 10 cadavers with the aim of determining whether there are TC-like interstitial cells that populate the interstitial space other than the mural microvascular cells. We applied the markers for C D31, CD34, PDGRFα,...
Source: Cells Tissues Organs - March 15, 2019 Category: Cytology Source Type: research
Author Index Vol. 205, 2018
Cells Tissues Organs 2018;205:396 (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 7, 2019 Category: Cytology Source Type: research
Contents Vol. 205, 218
Cells Tissues Organs 2018;205:I –IV (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 7, 2019 Category: Cytology Source Type: research
Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Human induced pluripotent stem cell (hiPSC)-derived cardio myocytes (hiPSC-CMs) hold great promise for cardiovascular disease modeling and regenerative medicine. However, these cells are both structurally and functionally immature, primarily due to their differentiation into cardiomyocytes occurring under static culture which only reproduces biomolecula r cues and ignores the dynamic hemodynamic cues that shape early and late heart development during cardiogenesis. To evaluate the effects of hemodynamic stimuli on hiPSC-CM maturation, we used the biomimetic cardiac tissue model to reproduce the hemodynamics and press...
Source: Cells Tissues Organs - March 7, 2019 Category: Cytology Source Type: research
Ameliorative Effect of Cardamom Aqueous Extract on Doxorubicin-Induced Cardiotoxicity in Rats
This study was conducted to evaluate the potential cardioprotective effect of cardamom (CAR) against myocardial injuries induced by doxorubicin (DOX) in rats through investigation of histological alterations and the associated oxidative stress, apoptosis, inflammation, and angiogenesis. This study included 30 adult male albino rats that were randomized to 3 groups (n = 10/group): group I (control), group II (DOX) rats injected with DOX (2.5 mg/kg body weight [BW] i.p.) every other day for 2 weeks, and group III (CAR+DOX) received CAR extract (200 mg/kg BW) orally for 3 weeks, and 1 week later (starting from the 2nd week) t...
Source: Cells Tissues Organs - February 4, 2019 Category: Cytology Source Type: research
A New Beginning for < b > < i > Cells Tissues Organs < /i > < /b >
Cells Tissues Organs 2018;205:1 –2 (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - January 31, 2019 Category: Cytology Source Type: research
The Effect of the Prethanol Extract of < b > < i > Trifolium pratense < /i > < /b > Leaves on Interleukin-1 β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes
Conclusion: These results suggested that 40% PeTP has a chondroprotective effect on inflammation and may be a potential preventative agent for OA progression.Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - January 31, 2019 Category: Cytology Source Type: research
The Effect of Adenosine on Extracellular Matrix Production in Porcine Intervertebral Disc Cells
The objectives of this study were to investigate the effects of exogenous adenosine on the production of extracellular matrix (ECM; i.e., collagen type II and aggrecan) and ATP of IVD cells and explore the underlying mechanism of action. It was found that adenosine treatment significantly upregulated aggrecan and type II collagen gene expression and the ATP level in IVD cells. Dipyridamole, an adenosine transport blocker, completely suppressed the effects of adenosine on the ATP production and ECM gene expression of the IVD cells, whereas antagonists of adenosine receptors did not significantly affect adenosine-treated IVD...
Source: Cells Tissues Organs - January 31, 2019 Category: Cytology Source Type: research
Two Web Resources Linking Major Human Embryology Collections Worldwide
Human embryology is a core subject for medicine and current research. While animal models of development now have significant online resources available, the vast majority of human embryonic material is locked up in historic collections. When accessed today, these collections are still contributing to our understanding of human development. This paper describes two online resources for studying human development that are unlocking these invaluable collections and providing related human developmental resources. The first of these is the online Embryology website (http://tiny.cc/Embryo) that links the human developmental ti...
Source: Cells Tissues Organs - January 28, 2019 Category: Cytology Source Type: research
Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities
In this study, a range of different mi crobes and an osteoblast-like cell line (human fetal osteoblast, hFOB) were used to assess the combined effect of: (1) green tea extract (GTE), rich in the polyphenol epigallocatechin gallate (EGCG), and (2) whey protein isolate (WPI), rich in bLG. It was shown that approximately 20–48% of the EGC G in GTE reacted with WPI. GTE inhibited the growth of Gram-positive bacteria, an effect which was potentiated by the addition of WPI. GTE alone also significantly inhibited the growth of hFOB cells after 1, 4, and 7 days of culture. Alternatively, WPI significantly promoted hFOB cell grow...
Source: Cells Tissues Organs - January 28, 2019 Category: Cytology Source Type: research
Melanocytes, Organogenesis, and Angiogenesis: Evidence for More than a Pigment-Producing Capability of Melanocytes
Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - January 17, 2019 Category: Cytology Source Type: research
