Autophagy prevents osteocyte cell death under hypoxic conditions.
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - August 19, 2021 Category: Cytology Source Type: research
In situ Tissue Regeneration in the Cornea from Bench to Bedside
Corneal blindness accounts for 5.1% of visual deficiency and is the fourth leading cause of blindness globally. An additional 1.5 –2 million people develop corneal blindness each year, including many children born with or who later develop corneal infections. Over 90% of corneal blind people globally live in low- and middle-income regions (LMIRs), where corneal ulcers are approximately 10-fold higher compared to high-income countries. While corneal transplantation is an effective option for patients in high-income countries, there is a considerable global shortage of corneal graft tissue and limited corneal transplant pr...
Source: Cells Tissues Organs - August 11, 2021 Category: Cytology Source Type: research
Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development
Microphysiological systems (MPS) or tissue chips/organs-on-chips are novelin vitro models that emulate human physiology at the most basic functional level. In this review, we discuss various hurdles to widespread adoption of MPS technology focusing on issues from multiple stakeholder sectors, e.g., academic MPS developers, commercial suppliers of platforms, the pharmaceutical and biotechnology industries, and regulatory organizations. Broad adoption of MPS technology has thus far been limited by a gap in translation between platform developers, end-users, regulatory agencies, and the pharmaceutical industry. In this brief ...
Source: Cells Tissues Organs - August 11, 2021 Category: Cytology Source Type: research
Engineered Aging Cardiac Tissue Chip Model for Studying Cardiovascular Disease
In conclusion, the described methodology provides a novel approach to generate stress-induced aging cardiac cell phenotypes and engineer cardiac tissue chip models to study the cardiovascular disease pathologies associated with aging.Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - August 6, 2021 Category: Cytology Source Type: research
Special Issue: Epithelial-Mesenchymal Transition 2020
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - July 29, 2021 Category: Cytology Source Type: research
Preface Special Issue Epithelial-Mesenchymal Transition 2020
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - July 29, 2021 Category: Cytology Source Type: research
The inhibitory effect of miR-345 on glioma progression is closely related to circRNA-hsa_circ_0073237 and HDGF
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - July 29, 2021 Category: Cytology Source Type: research
A Histopathological Evaluation of Ovarian Hyperstimulation Syndrome on Reproductive and Vital Organs and the Role of the VEGF-PKA Pathway in a Mouse Model
Ovarian hyperstimulation syndrome (OHSS) is one of the most common and iatrogenic complications of in vitro fertilization therapy, which is an exaggerated response to excess hormones resulting in the development of a large number of maturing follicles. Although the complications of and reasons for the condition are well known, the overall histopathological effects on systemic organs and the extent of the damage have not been fully elucidated. Besides, the mechanism that underlies the situation is not very well known. The aim of the present work was to analyse the histopathological effects of OHSS on reproductive (uterus an...
Source: Cells Tissues Organs - July 28, 2021 Category: Cytology Source Type: research
Pretreatment with Coenzyme Q10 Combined with Aescin Protects against Sepsis-Induced Acute Lung Injury
Sepsis-associated acute lung injury (ALI) is a critical condition characterized by severe inflammatory response and mitochondrial dysfunction. Coenzyme Q10 (CoQ10) and aescin (AES) are well-known for their anti-inflammatory activities. However, their effects on lipopolysaccharide (LPS)-induced lung injury have not been explored yet. Here, we asked whether combined pretreatment with CoQ10 and AES synergistically prevents LPS-induced lung injury. Fifty male rats were randomized into 5 groups: (1) control; (2) LPS-treated, rats received a single i.p. injection of LPS (8 mg/kg); (3) CoQ10-pretreated, (4) AES-pretreated, or (5)...
Source: Cells Tissues Organs - July 19, 2021 Category: Cytology Source Type: research
A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-Physiological Loads
In this report, we compared the early response of cartilage to physiological and supra-physiological mechanical loading to the response to IL-1 β exposure, a common but rudimentary in vitro model of cartilage osteoarthritis. Physiological loading rapidly upregulated gene expression of anabolic markers along the TGF-β1 pathway. Notably, TGF-β1 or serum was not included in the medium. Supra-physiological loading caused a mild catabolic res ponse while IL-1β exposure drove a rapid anabolic shift. This aligns well with recent findings suggesting that overloading is a more realistic and biomimetic model of cartilage degener...
Source: Cells Tissues Organs - July 14, 2021 Category: Cytology Source Type: research
Inaugural Young Investigator Issue for Cells Tissues Organs
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - July 13, 2021 Category: Cytology Source Type: research
Evaluation of the effects of human bone marrow mesenchymal stem cells conditioned medium on growth and maturation of mouse ovarian follicle after vitrification
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - July 13, 2021 Category: Cytology Source Type: research
Fabrication and Characterization of Silk Fibroin-Based Nanofibrous Scaffolds Supplemented with Gelatin for Corneal Tissue Engineering
Tissue engineering is a promising approach to overcome the severe worldwide shortage of healthy donor corneas. In this work, we have developed a silk-gelatin composite scaffold using electrospinning and permeation techniques to achieve the properties comparable to cornea analog. In particular, we present the fabrication and comparative evaluation of the novel gelatin sheets consisting of silk fibroin nanofibers, which are prepared using silk fibroin (SF) (in formic acid) and SF (in aqueous) electrospun scaffolds, for its suitability as corneal stromal analogs. All the fabricated samples were treated with ethanol vapor (T) ...
Source: Cells Tissues Organs - July 12, 2021 Category: Cytology Source Type: research
Bioartificial Organs: Ongoing Researches and Future Trends
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - July 8, 2021 Category: Cytology Source Type: research
Twenty years on for The Epithelial-Mesenchymal Transition International Association (TEMTIA): an interview with co-founders Erik Thompson and Donald Newgreen
(Source: Cells Tissues Organs)
Source: Cells Tissues Organs - July 8, 2021 Category: Cytology Source Type: research
