Zinc oxide nanoparticle regulates the ferroptosis, proliferation, invasion and steaminess of cervical cancer by miR-506-3p/CD164 signaling
ConclusionsIn brief, we concluded that ZON regulated the ferroptosis, proliferation, invasion, and steaminess of cervical cancer by miR-506-3p/CD164 signaling. Our finding provides new insights into the mechanism by which ZON regulates ferroptosis and steaminess of cervical cancer by a miR-506-3p/CD164 axis. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 22, 2022 Category: Cancer & Oncology Source Type: research
A novel pH- and glutathione-responsive drug delivery system based on in situ growth of MOF199 on mesoporous organic silica nanoparticles targeting the hepatocellular carcinoma niche
ConclusionsThe in vitro and in vivo anti-tumor results indicated that these nanocomposites could be an efficient nanomedicine for targeting HCC therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 16, 2022 Category: Cancer & Oncology Source Type: research
Biosynthesized silver nanoparticles and miR34a mimics mediated activation of death receptor in MCF-7 human breast cancer cell lines
In this study, green-derived silver nanoparticles were synthesized by using leaf extract ofLitchi chinensis. Characterization of biosynthesized silver nanoparticles was performed by using UV –Vis spectroscopy, FTIR, XRD, EDS, and SEM analysis. The clinical application of green-drive nanoparticles was investigated by using MCF-7 cancer cell lines. MCF-7 breast cancer cell lines were analyzed against three different treatments. (i) Silver nanoparticles (AgNPs), (ii) miR34a mimics and (i ii) Co-delivery of AgNPs and miR34a mimics. Cell viability was determined by MTT assay and, extraction of mRNA and cDNA synthesis were per...
Source: Cancer Nanotechnology - October 11, 2022 Category: Cancer & Oncology Source Type: research
Fabrication of manganese-coordinated polyphenol carbon dots for photothermal therapy and immune activation
ConclusionThe present work offers a versatile strategy to integrate functional metal into CDs via metal –polyphenol coordination for photothermal/immune therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 11, 2022 Category: Cancer & Oncology Source Type: research
AuNPs and 2D functional nanomaterial-assisted SPR development for the cancer detection: a critical review
AbstractCancer ranks as a leading cause of death and a huge obstacle to rising life expectancy. If cancers are spotted early there's a high chance of survival. The conventional methods relying on the phenotypic features of the tumor are not powerful to the early screening of cancer. Cancer biomarkers are capable of indicating specific cancer states. Current biochemical assay suffers from time and reagents consuming and discontinuous monitoring. Surface plasmon resonance (SPR) technology, a refractive index-based optical biosensor, has significant promise in biomarker detection because of its outstanding features of label...
Source: Cancer Nanotechnology - October 6, 2022 Category: Cancer & Oncology Source Type: research
Development of highly efficient niosomal systems for co-delivery of drugs and genes to treat breast cancer in vitro and in vivo
In conclusion, we successfully designed a nanoscale niosomal system to carry drugs and genes to the tumor site to treat cancer cells and provided remarkable data for the scientific society. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 29, 2022 Category: Cancer & Oncology Source Type: research
Ginsenoside compound K-loaded gold nanoparticles synthesized from Curtobacterium proimmune K3 exerts anti-gastric cancer effect via promoting PI3K/Akt-mediated apoptosis
ConclusionOur findings provide data for understanding the molecular mechanisms of nanoparticles; thus, providing insight into the development of alternative medications based on gold nanoparticles of ginseng-derived CK. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 13, 2022 Category: Cancer & Oncology Source Type: research
Using green biosynthesized kaempferol-coated sliver nanoparticles to inhibit cancer cells growth: an in vitro study using hepatocellular carcinoma (HepG2)
AbstractThe ongoing loss of human life owing to various forms of cancer necessitates the development of a more effective/honorable therapeutic approach. Moreover, finding a novel green-synthesized anti-cancer therapy is vital because of the induced drug resistance against the commonly used drugs. Collecting the advantage of the nanometer size of nanoparticles with the biosafety of plant-based substances might potentiate the anticancer effect with minimal toxic effect. In the current study, we aimed to green-synthesize using kaempferol (flavonoid) as a coating the silver nanoparticles (AgNPs) and investigated their anti-can...
Source: Cancer Nanotechnology - August 30, 2022 Category: Cancer & Oncology Source Type: research
Improve the cytotoxic effects of megavoltage radiation treatment by Fe3O4@Cus –PEG nanoparticles as a novel radiosensitizer in colorectal cancer cells
ConclusionsOur study suggests that Fe3O4@Cus –PEG nanoparticles are the promising nano radio-sensitizing agents for the treatment of cancer cells to enhance the efficacy of radiation therapy through increasing the reactive oxygen species generation, nitric oxide production, and inducing apoptosis.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 19, 2022 Category: Cancer & Oncology Source Type: research
Collagen-induced assembly of adenosine monophosphate-modified gold nanoparticles for photothermal cancer therapy
ConclusionsA collagen-induced self-assembled gold photosensitizer for efficient PTT has been synthesized based on a biomolecule, AMP modification method. The synthesized AAu NPs with high PTT efficacy, superior biosafety and fast excretion from the body is an effective therapeutic agent in photothermal cancer therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 6, 2022 Category: Cancer & Oncology Source Type: research
Retro-inversion follicle-stimulating hormone peptide-modified nanoparticles for delivery of PDK2 shRNA against chemoresistant ovarian cancer by switching glycolysis to oxidative phosphorylation
ConclusionsOur findings showed the link between metabolic reprogramming and chemoresistance in ovarian cancer and provided an effective targeting strategy for switching metabolic pathways in cancer therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 25, 2022 Category: Cancer & Oncology Source Type: research
Frankincense essential oil nanoemulsion specifically induces lung cancer apoptosis and inhibits survival pathways
ConclusionsThese results point out to the potentials of frankincense essential oil (rich in α-pinene) and its PG-nanoemulsion as a promising adjuvant from plant-source to potentiate the activity of the systematic anti-lung cancer drugs. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 11, 2022 Category: Cancer & Oncology Source Type: research
Nanomicelles co-loaded with doxorubicin and salvianolic acid A for breast cancer chemotherapy
ConclusionsAll the findings substantiated that CPMSD would be a promising multifunctional nanosystem of DOX for breast cancer chemotherapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 4, 2022 Category: Cancer & Oncology Source Type: research
Antiproliferation effects of nanophytosome-loaded phenolic compounds from fruit of Juniperus polycarpos against breast cancer in mice model: synthesis, characterization and therapeutic effects
ConclusionOur results indicated that nanophytosome-loaded HPF might be a potential anticancer agent for the breast cancer treatment. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 1, 2022 Category: Cancer & Oncology Source Type: research
Small tumour microparticle enhances drug delivery efficiency and therapeutic antitumour efficacy
ConclusionsThe present data demonstrate that the SMPs had a higher cumulative concentration in tumour tissue, and the tumour suppressive effect was also significantly better than that of LMPs. It provides important process parameters for the drug-loaded vesicle delivery system. Future works will aim to expand production scale and improve the separation and purification process of the microparticles. Although the research and application of drug-loaded vesicles derived from tumour cells is still in its infancy, it has broad prospects for tumour therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 28, 2022 Category: Cancer & Oncology Source Type: research
