Emodin-loaded polymer-lipid hybrid nanoparticles enhance the sensitivity of breast cancer to doxorubicin by inhibiting epithelial –mesenchymal transition
ConclusionE-PLNs inhibit EMT to enhance the sensitivity of breast cancer to DOX. The combination of E-PLNs and DOX can improve the efficacy of DOX in the treatment of breast cancer, which provides a new method to prevent or delay clinical drug resistance. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 11, 2021 Category: Cancer & Oncology Source Type: research
Nanoparticles derived from insect exoskeleton modulates NLRP3 inflammasome complex activation in cervical cancer cell line model
ConclusionIn contrast to gCSNP, the CSNP not only demonstrated inhibitory effect on the expression of genes coding for the NLRP3 inflammasome complex (signal 1 —priming), but also decreased relative expression of gene involved in the activation of NLRP3 inflammasome complex (signal 2—activation). Conjugation of gallic acid reversed the immunosuppressor mimicking action of CSNP in cervical cancer cell line. Future research can reveal the immunomodulator y mechanism of CSNP may have its translational significance as potential treatment strategies targeting immune evasion as an important hallmark of cancer.Graphical abstr...
Source: Cancer Nanotechnology - August 11, 2021 Category: Cancer & Oncology Source Type: research
Synthesis of gold nanorods and their performance in the field of cancer cell imaging and photothermal therapy
AbstractCancer is one of the most common incident in the world, with malignant tumors having a death rate of up to 19%. A new method of treating cancer cells effectively with minimal cytotoxicity is needed. In the field of biomedicine with unique shape-dependent optical properties, gold nanorods (GNRs) have attracted worldwide interest. These nanorods have two distinct plasmon bands. One is transverse plasmon band in the area of visible light, and the other is longitudinal band of plasmons in near infrared region. These specific characters provide promise for the design of new optically active reagents that simultaneously ...
Source: Cancer Nanotechnology - July 23, 2021 Category: Cancer & Oncology Source Type: research
Comparative effect of thermo/pH-responsive polymer-coated gold nanocages and hollow nanostars on chemo-photothermal therapy of breast cancer cells
ConclusionsThis work highlights the potential application of designed GNSs@Dox-Pol in a combinational chemo-PTT to treat breast cancer cells.Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 23, 2021 Category: Cancer & Oncology Source Type: research
Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment
ConclusionsFinally, the conclusions and perspectives on further advancing the graphene oxide-based multifunctional nanomaterials toward potential and versatile development for fundamental researches and nanomedicine are proposed.Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 12, 2021 Category: Cancer & Oncology Source Type: research
Ultrasound-activated nano-TiO2 loaded with temozolomide paves the way for resection of chemoresistant glioblastoma multiforme
ConclusionWe found this nanomedicine-based ultrasound modality highly efficient in GBM treatment and is of future clinical application value due to the employment of already FDA-approved techniques and nanomedicine. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 10, 2021 Category: Cancer & Oncology Source Type: research
Radiolabeling and PET –MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer
ConclusionOur results demonstrate that PET –MRI following a microdose injection of the agent will accurately reflect the innate biodistribution of the therapeutic. The tools developed in the present study lay the groundwork for the clinical testing of MN-anti-miR10b and other similar therapeutics in patients with cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 8, 2021 Category: Cancer & Oncology Source Type: research
Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles
ConclusionOwing to the results achieved from this study, the novel drug-loaded nanoparticles are compatible to be used for breast cancer treatment and could potentially be used for further in vivo studies. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 8, 2021 Category: Cancer & Oncology Source Type: research
Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect
ConclusionsOur study successfully declares that melittin-loaded niosome had more anti-cancer effects than free melittin. This project has demonstrated that niosomes are suitable vesicle carriers for melittin, compare to the free form. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 22, 2021 Category: Cancer & Oncology Source Type: research
Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood –brain barrier model
ConclusionTJ-modulating peptide-modified LPN could be a prospective platform for the delivery of chemotherapeutics across the BBB to the brain for the potential treatment of the BM of NSCLC. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 7, 2021 Category: Cancer & Oncology Source Type: research
Development of Fe3O4 core –TiO2 shell nanocomposites and nanoconjugates as a foundation for neuroblastoma radiosensitization
ConclusionsThe intracellular distribution pattern of different nanoconjugates used in this study was different for different nanoconjugate surface molecules. Cells exposed to DOPAC covered nanoconjugates showed the smallest nanoconjugate uptake, with the most prominent pattern of large intracellular aggregates. Interestingly, cells treated with this nanoconjugate also showed the most pronounced radiosensitization effect in combination with the external beam x-ray irradiation. Further studies are necessary to evaluate mechanistic basis for this increased radiosensitization effect. Preliminary studies with the nanoparticles ...
Source: Cancer Nanotechnology - May 14, 2021 Category: Cancer & Oncology Source Type: research
Development of Fe 3 O 4 core –TiO 2 shell nanocomposites and nanoconjugates as a foundation for neuroblastoma radiosensitization
ConclusionsThe intracellular distribution pattern of different nanoconjugates used in this study was different for different nanoconjugate surface molecules. Cells exposed to DOPAC covered nanoconjugates showed the smallest nanoconjugate uptake, with the most prominent pattern of large intracellular aggregates. Interestingly, cells treated with this nanoconjugate also showed the most pronounced radiosensitization effect in combination with the external beam x-ray irradiation. Further studies are necessary to evaluate mechanistic basis for this increased radiosensitization effect. Preliminary studies with the nanoparticles ...
Source: Cancer Nanotechnology - May 14, 2021 Category: Cancer & Oncology Source Type: research
Methylene blue associated with maghemite nanoparticles has antitumor activity in breast and ovarian carcinoma cell lines
ConclusionsTreatment with MAGCIT –MB induces the death of cancer cells but not normal cells. These results highlight the importance of the maghemite core for drug delivery and for increasing methylene blue activity, aiming at the treatment of breast and ovarian cancer.Graphic Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 11, 2021 Category: Cancer & Oncology Source Type: research
Ultrasensitive bioassaying of HER-2 protein for diagnosis of breast cancer using reduced graphene oxide/chitosan as nanobiocompatible platform
ConclusionsAs a proof of concept, the designed immunosensor was desirably applied for the quantification of HER-2 protein in breast cancer suffering patients. As a result, the designed ECL-based immunosensor has the capability of being used as a conventional test method in biomedical laboratories for early detection of HER-2 protein in biological fluids.Graphic Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 1, 2021 Category: Cancer & Oncology Source Type: research
Correction to: Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells
An amendment to this paper has been published and can be accessed via the original article. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 11, 2021 Category: Cancer & Oncology Source Type: research
