Facile synthesis of degradable DOX/ICG co-loaded metal –organic frameworks for targeted drug release and thermoablation
ConclusionsThis work provides a new strategy for co-delivery of different therapeutics for combined cancer therapy with high cancer cell specificity and low nanotoxicity. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 6, 2022 Category: Cancer & Oncology Source Type: research
Synergistic co-administration of docetaxel and curcumin to chemoresistant cancer cells using PEGylated and RIPL peptide-conjugated nanostructured lipid carriers
ConclusionsCo-administration of DTX/CUR (1:3 w/w) using P/R-NLCs induced a synergistic effect against chemoresistant cancer cells.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 3, 2022 Category: Cancer & Oncology Source Type: research
Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogramming
ConclusionsIt could be concluded that DDMPlusAF exerted a selective cancer radiosensitizing efficacy with targeted properties for TPF and metabolic reprogramming in BCCs therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 28, 2022 Category: Cancer & Oncology Source Type: research
Dynamics of intracellular clusters of nanoparticles
ConclusionsWe show the steady cluster density is in good agreement with experimental data on gold nanoparticle distribution inside endosomes. We find that for clusters containing between 1 and 20 nanoparticles, the exact cluster density provides a better description of the existing experimental data than the well-known approximate asymptotic power-law distribution\(x^{-3/2}\) (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 24, 2022 Category: Cancer & Oncology Source Type: research
Histopathology, pharmacokinetics and estimation of interleukin-6 levels of Moringa oleifera leaves extract-functionalized selenium nanoparticles against rats induced hepatocellular carcinoma
ConclusionsIn conclusion, MO/asc.-Se-NPs can be used as a potential agent for prevention and treatment of HCC after further preclinical studies. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 21, 2022 Category: Cancer & Oncology Source Type: research
Nanocluster-mediated photothermia improves eradication efficiency and antibiotic sensitivity of Helicobacter pylori
ConclusionsBased on this novel NCs-based photothermal approach, we were able to demonstrate in vitro a significant inhibition of bothH. pylori growth and molecular toxicity, and its improvement in antibiotic sensitivity alone with the eradication ofH. pylori biofilms previously believed to be tolerant to conventional antibiotics. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 16, 2022 Category: Cancer & Oncology Source Type: research
Folic acid-conjugated magnetic triblock copolymer nanoparticles for dual targeted delivery of 5-fluorouracil to colon cancer cells
ConclusionsThe results suggested that 5-FU-NPs-FA could be considered as promising sustained drug delivery platform for in vitro and in vivo conditions, which may provide selective treatment of tumor cancer cells.Graphical Abstarct (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 16, 2022 Category: Cancer & Oncology Source Type: research
New anti-tumor strategy based on acid-triggered self-destructive and near-infrared laser light responses of nano-biocatalysts integrating starvation –chemo–photothermal therapies
ConclusionsOur findings inform the development and applications of multi-modal methods in tumor therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 12, 2022 Category: Cancer & Oncology Source Type: research
Delivery of CXCL9/10/11 plasmid DNAs promotes the tumor-infiltration of T cells and synergizes with PD1 antibody for treating lung cancer
ConclusionsDelivery of CXCL9/10/11 plasmids by nanoparticles promoted T cell infiltration in tumors and synergizes with the activity of anti-PD1 antibody. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 25, 2022 Category: Cancer & Oncology Source Type: research
Hyaluronan self-agglomerating nanoparticles for non-small cell lung cancer targeting
ConclusionWe developed irinotecan-loaded ISHNs, which comprised irinotecan hydrochloride as a water-soluble anticancer agent, HA as a targeting moiety, FeCl3 as a binder for self-agglomeration, and GA as a stabilizer; HA is a binding material for CD44 in NSCLC cells. Owing to their ease of manufacture, excellent stability, non-cell toxicity and CD44-targeting ability, ISHNs are potential nanocarriers for passive and active tumor targeting. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 9, 2022 Category: Cancer & Oncology Source Type: research
Delivery of cisplatin and resiquimod in nanomicelles for the chemoimmunotherapy of ovarian cancer
ConclusionPLG-g-mPEG-loaded CDDP and resiquimod effectively achieves the targeted delivery of chemotherapy and immunotherapy, with a strong synergistic anti-cancer effect. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 7, 2022 Category: Cancer & Oncology Source Type: research
Early stage evaluation of colon cancer using tungsten disulfide quantum dots and bacteriophage nano-biocomposite as an efficient electrochemical platform
ConclusionsAs an interesting part of this study, some concentrations of the c-Met protein in colon cancer serum samples which could not be determined by Elisa, were easily analyzed by the developed bioassay system. The developed bioassay system has great potential to application in biomedical laboratories.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 5, 2022 Category: Cancer & Oncology Source Type: research
Co-axial electrospraying of injectable multi-cancer drugs nanocapsules with polymer shells for targeting aggressive breast cancers
ConclusionNanonized multi-cancer drugs were encapsulated in a PCL shell. The drug doses ratio and the polymer-to-drug ratio were controlled by engineered process parameters. The studies showed the importance of making nanocapsules containing nanocrystals of multiple drugs, which will pave the way of making multiple drug combinations in a controlled manner and capsules can be designed for sustained release of the drugs after accumulation into the TME. TME-directed therapy can be a norm in future cancer treatment strategies. These injectable nanocapsules will allow cancer site-specific precision and controlled delivery to cu...
Source: Cancer Nanotechnology - February 22, 2022 Category: Cancer & Oncology Source Type: research
Construction of pH-responsive nanocarriers in combination with ferroptosis and chemotherapy for treatment of hepatocellular carcinoma
ConclusionTaken together, these findings indicated that nanocarriers had an effective inhibitory effect on HCC cells. This safe and multifunctional treatment model was a valuable option for the treatment of HCC, as well as other cancers.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 29, 2022 Category: Cancer & Oncology Source Type: research
The inhibitory role of si-UBB delivered by degradable dendrimers-based lipid nanoparticles in ovarian cancer
Conclusions5A2SC8 complex was a safe and efficient gene delivery vehicle and ubiquitin B was a potential target for the ovarian cancer targeted therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 29, 2022 Category: Cancer & Oncology Source Type: research
