Formulation and optimization of folate-bovine serum albumin-coated ethoniosomes of pterostilbene as a targeted drug delivery system for lung cancer: In vitro and in vivo demonstrations
This study aimed to overcome the poor solubility of pterostilbene (PTS) by developing promising reconstituted proethoniosomes (PENs). The reconstituted PENs loaded with PTS were fabricated according to a 23 factorial design by Design-Expert ® software. The prepared ethoniosomes were assessed for entrapment efficiency (EE %) and % PTS released after 24 h (Q24h). According to the desirability criteria, the ethoniosomal formula (F4) was chosen as the optimized formulation with EE% of 93.19 ± 0.66 and Q24h of 75.10 ± 1.90%. The optimum ethoniosomal formulation was further coated with folic acid (FA) using bovine ...
Source: Cancer Nanotechnology - May 8, 2023 Category: Cancer & Oncology Source Type: research
Non-small cell lung cancer targeted nanoparticles with reduced side effects fabricated by flash nanoprecipitation
ConclusionThe facile design of FA-NPs by FNP and their achieved performance in vitro and in vivo evaluations offer new therapeutic opportunities for treatment of non-small cell lung cancer.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 5, 2023 Category: Cancer & Oncology Source Type: research
Investigation of hollow mesoporous NiFe2O4 nanospheres fabricated via a template-free solvothermal route as pH-responsive drug delivery system for potential anticancer application
AbstractA novel magnetic-targeted pH-responsive intelligent drug carrier based on hollow mesoporous structured NiFe2O4 nanospheres was designed and developed for potential anticancer treatment in the present study. The hollow mesoporous NiFe2O4 nanospheres were fabricated through a template-free solvothermal approach and the possible formation mechanism of this structure was proposed. The products were investigated comprehensively for their morphology, microstructure, composition and magnetic properties using a wide series of characterization methods. The NiFe2O4 nanospheres were demonstrated to possess a well-defined sphe...
Source: Cancer Nanotechnology - May 2, 2023 Category: Cancer & Oncology Source Type: research
Biological modeling of gadolinium-based nanoparticles radio-enhancement for kilovoltage photons: a Monte Carlo study
ConclusionsThe mechanism of radio-enhancement of GdNPs for kilovoltage photons was investigated using MC simulations. The prediction results of the established LEM-based biological model for GdNP radiosensitization showed good agreement with published experimental results, although the deviation of simulation parameters can lead to large disparity in the results. To our knowledge, this was the first LEM-based biological model for GdNP radiosensitization. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 2, 2023 Category: Cancer & Oncology Source Type: research
Development of an electrochemical biosensor for the detection of mammary gland carcinoma using molybdenum enhanced poly taurine nano-biofilms confirmed pathological findings
ConclusionsAccording to the obtained desirable coordination with pathological studies, the designed biosensor has excellent capability to use as a reliable diagnostic tool in clinical laboratories.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 27, 2023 Category: Cancer & Oncology Source Type: research
Magnetohyperthermia-synergistic glioma cancer therapy enabled by magnetic graphene oxide nanoheaters: promising nanostructure for in vitro and in vivo applications
AbstractIn the present study, a magnetohyperthermia (MH)-based therapy is introduced as an effective treatment for deep-seated tumors especially glioma, which combines the magnetothermal effect and the reactive oxygen species (ROS) induced with magnetic graphene oxide (GOMNPs) nanoheaters to overcome the issue of limited therapeutic efficacy in the current magnetothermal therapeutic strategy. Magnetic graphene oxide nanoheaters with a size of 34 nm and a surface charge of − 35 mV showed very little toxicity under in vitro and ex vivo circumstances based on MTT and hemolysis assay, respectively. The application of GOM...
Source: Cancer Nanotechnology - April 26, 2023 Category: Cancer & Oncology Source Type: research
Targeting nano-regulator based on metal –organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer
AbstractBone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows new hopes for bone metastatic PCa patients, while the efficacy is still unsatisfactory and limited by the unique immunosuppressive microenvironment in metastatic bone site. Here, we developed a bone-targeted nano-delivery system as a nano-regulator to enhance the immunotherapy of bone metastatic PCa. The nanosystem was assembled via coordination between phytic acid (PA) and Fe3+ to form nano-sized metal –organic framework (MOF), through which mitoxantrone (MTO) was enc...
Source: Cancer Nanotechnology - April 25, 2023 Category: Cancer & Oncology Source Type: research
Role of p53/circRNA0085439/Ku70 axis in DNA damage response in lung cells exposed to ZnO nanoparticles: Involvement of epigenetic regulation
ConclusionsThis study unraveled the epigenetic mechanisms underlying Nano-ZnO-induced DNA damage and EMT. The effect of Nano-ZnO-induced DNA damage through p53/circRNA_0085439/Ku70 pathway likely contribute to Nano-ZnO-induced cell cytotoxicity and apoptosis. Our findings will provide information to further elucidate the molecular mechanisms of Nano-ZnO-induced cytotoxicity and genotoxicity. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 24, 2023 Category: Cancer & Oncology Source Type: research
Two birds with one stone: triple negative breast cancer therapy by PtCo bimetallic nanozyme coated with gemcitabine-hyaluronic acid-polyethylene glycol
AbstractFor the treatment of triple-negative breast cancer (TNBC), without expression of estrogen, progesterone and HER2 receptors, specific treatment guideline is still under criticism, especially in tumor hypoxia. But assuming the molecular similarity of TNBC with breast cancer gene-1-related cancers, gemcitabine may be used in TNBC treatment on the nanozyme platform combined with photodynamic therapy (PDT). After designing the nanozyme with four components, platinum –cobalt: with catalase/peroxidase capabilities, hyaluronic acid: nanozyme targeting by interacting with CD44 receptor, poly[ethylene glycol]: water-solubl...
Source: Cancer Nanotechnology - April 24, 2023 Category: Cancer & Oncology Source Type: research
g-C3N4-based photoresponsive magnetic nanocatalyst drives type-I photodynamic therapy under visible light irradiation, boosting chemo/chemodynamic synergistic therapy of colon cancer
ConclusionBased on the results obtained, dual Fenton reactions were provided in a simple platform (CCFCA) where the cooperative combination of multiple approaches (chemotherapy, magnetic therapy, and PDT) enhanced CDT efficiency against colon cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 21, 2023 Category: Cancer & Oncology Source Type: research
Neutrophil membrane-derived nanoparticle loading TLR7 agonists augments radiotherapy efficacy and boosts abscopal effect via regulating tumor microenvironment
ConclusionIn summary, our findings suggested that neutrophil membrane-derived nanoparticle R837@PLGA@Neu with high uptake ability and low cytotoxicity showed strong tumor-targeting efficiency, and combination with RT had a promising effect in CT26-bearing mice via immune cell regulation. Our results provide a probable combination strategy for CRC treatment. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 21, 2023 Category: Cancer & Oncology Source Type: research
Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor
ConclusionCNSI-Fe induced the efficient apoptosis and ferroptosis of colonic tumor for cancer therapy. Our results would benefit the clinical applications of CNSI-Fe and stimulate great interest in the nanomedicine. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 19, 2023 Category: Cancer & Oncology Source Type: research
Effective combination of biocompatible zinc oxide nanocrystals and high-energy shock waves for the treatment of colorectal cancer
ConclusionOur work proposes the combination of the cytotoxic activity of ZnO NCs with the SW external stimulation to obtain a booster of the antitumor activity, which warrants further investigation in vivo on CRC as well as on other tumors.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 19, 2023 Category: Cancer & Oncology Source Type: research
Bacterial outer membrane vesicles as cationic dye carriers for optoacoustics-guided phototherapy of cancer
ConclusionsOur results demonstrate cationic dye-bound OMVs as promising novel nanoagents for tumor theranostics. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 17, 2023 Category: Cancer & Oncology Source Type: research
Aptamer modified Ti3C2 nanosheets application in smart targeted photothermal therapy for cancer
ConclusionThis study provides a new idea for the development of MXenes nanotherapeutic system with high active targeting performance.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 17, 2023 Category: Cancer & Oncology Source Type: research
