Novel nanoparticle CS-C60-Fe3O4 magnetically induces tissue-specific aggregation and enhances thermal ablation of hepatocellular carcinoma
In this study, we used an innovative method of emulsification and cross-linking to produce CS-C60-Fe3O4 (Chitosan-C60-Fe3O4) nanoparticles, which have the advantages of uniform particle size and high bioavailability, as a kind of novel nano-pharmaceutical. The CS-C60-Fe3O4 nanoparticles were prepared by the cross-linking reaction from chitosan –acetic acid solution, Fe3O4 nanoparticles by Fe2SO4·7H2O and FeCl3·6H2O, and C60. The average particle size of CS-C60-Fe3O4 was 194.3 nm. Because CS-C60-Fe3O4 is magnetic, it can achieve specific and tissue aggregation in HCC tumor tissues. Moreover, compared with normal solub...
Source: Cancer Nanotechnology - January 23, 2024 Category: Cancer & Oncology Source Type: research
Designing nanostructured lipid carriers modified with folate-conjugated chitosan for targeted delivery of osthole to HT-29 colon cancer cells: investigation of anticancer, antioxidant, and antibacterial activities
AbstractThe present study proposed to design nanostructured lipid carriers (NLC) coated with chitosan (CS) conjugated folate (FA) for the targeted delivery of Osthole (OST) to the HT-29 colon cancer cell line and improve its anticancer capability. To assess the physicochemical characteristics of OST-loaded NLC decorated with CS-conjugated FA (OST-NCF-NPS), several techniques, including DLS, SEM, and FTIR, were applied. After determining the encapsulation efficiency of OST in CSFA-modified NLC-NPs, an MTT test was conducted to evaluate the cytotoxic effects of this nano platform on the HT-29 cancer cell line in comparison t...
Source: Cancer Nanotechnology - January 23, 2024 Category: Cancer & Oncology Source Type: research
Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor
ConclusionsThrough the synergistic effects of PDA ’s photothermal therapy and DEM’s chemotherapy, this system demonstrated excellent inhibition and killing effects on tumor cells. Furthermore, we established its excellent biological safety profile. This study demonstrated the potential of this nanomaterial for clinical application in tumor ther apy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 13, 2024 Category: Cancer & Oncology Source Type: research
Anticancer platinum-drug delivered by mesenchymal stromal cells improves its activity on glioblastoma
ConclusionsThe major conclusions are that cell mediated drug delivery systems could provide a potential approach to facilitate the GBM therapy by intra-tumoral administration of cells loaded with Pt-8AQ, being MSCs able to integrate it into the tumor mass and exert high therapeutic efficacy in situ. The increased efficacy of Pt-8AQ delivered by MSCs even suggests to deeper investigate a possible direct use of MSCs secretome both in situ and/or by systemic administration, being secretome able to pass the blood –brain tumor. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 10, 2024 Category: Cancer & Oncology Source Type: research
SiO2 –alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase
ConclusionsSAMNs, especially with alginate lyase, offer an effective strategy for ovarian cancer treatment, optimizing melittin delivery while minimizing adverse effects of alginate. This approach enhances the therapeutic potential of melittin in combating ovarian cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2024 Category: Cancer & Oncology Source Type: research
Novel nanotherapeutics for cancer immunotherapy by albumin nanoparticles functionalized with PD-1 and PD-L1 aptamers
ConclusionThe results suggest that the bispecific PD1-NP-PDL1 is a promising nanotherapeutic to improve the efficacy of PD-1/PD-L1 blockade, and may have application potential in colon cancer treatment. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2024 Category: Cancer & Oncology Source Type: research
Synthesis and characterization of silver nanoparticles loaded with carboplatin as a potential antimicrobial and cancer therapy
AbstractIn recent studies with silver nanoparticles, it has been reported that the use of nanoparticles in carrier drug systems increases tumor suppression and reduces drug-related side effects. At the same time, the combination of traditional medicine with nanotechnology provides the opportunity to develop new antimicrobial agents. The aim of this study was to determine the anticancer, antimicrobial activities and pro-apoptotic effects of silver nanoparticles (AgNPs), and carboplatin-loaded silver nanoparticles (AgNPs-Car). Characterization studies of the synthesized nanoparticles were carried out by DLS, EDX-STEM, and FT...
Source: Cancer Nanotechnology - January 6, 2024 Category: Cancer & Oncology Source Type: research
Mesothelin-targeted MRI for assessing migration, invasion, and prognosis in malignant pleural mesothelioma
ConclusionOur comprehensive research succeeded in confirming the regulatory mechanisms by which MSLN influences migration and invasion. Moreover, we introduced a promising method for monitoring MSLN expression that may help in facilitating the early detection, histological subtype identification, and assessment of migration, invasion, and prognosis in MPM. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 5, 2024 Category: Cancer & Oncology Source Type: research
Publisher Correction: Green adeptness in synthesis of non-toxic copper and cobalt oxide nanocomposites with multifaceted bioactivities
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 30, 2023 Category: Cancer & Oncology Source Type: research
CD44-specific short peptide A6 boosts cellular uptake and anticancer efficacy of PEGylated liposomal doxorubicin in vitro and in vivo
This study aimed to evaluate the targeting ability and antitumor efficiency of A6, a specific short peptide (KPSSPPEE) when incorporated into PEGylated liposomal doxorubicin (PLD). The results revealed significantly enhanced cellular uptake. The cytotoxicity of the formulations was determined by 3 h and 6 h incubation of formulations with cells, followed by 48 h incubation to evaluate the targeted ability of the formulations and the results indicated the higher cytotoxicity of A6-PLD (IC50 of 7.52 µg/mL after 6 h incubation) in the CD44 overexpressing C26 cell line compared to non-targ eted PLD (IC50 of 15.02 µg/m...
Source: Cancer Nanotechnology - November 23, 2023 Category: Cancer & Oncology Source Type: research
Enhanced cancer immunotherapy through synergistic ferroptosis and immune checkpoint blockade using cell membrane-coated nanoparticles
ConclusionsOur study suggest the potential of PD-1@RSL3 NPs as an effective therapeutic approach for breast cancer by promoting tumor cell ferroptosis and inducing antitumor immunity. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 13, 2023 Category: Cancer & Oncology Source Type: research
Application of tumor microparticles in tumor prevention and treatment
AbstractTumor microparticles (T-MPs) are vesicles released from tumor cells when they receive apoptotic or stimuli signals. T-MPs, which contain some proteins, lipids and nucleic acids from tumor cells, contribute to the exchange of material, energy and information between cells. T-MPs contain both tumor antigens and innate immunostimulatory signals, making T-MPs as a new form of tumor vaccine. Meanwhile, T-MPs can be used as natural carriers to transport ‘‘cargoes’’, such as chemotherapy drugs, oncolytic viruses, nucleic acids, and metal nanoparticles to treat tumors. In addition, T-MPs enhance the effect of chemo...
Source: Cancer Nanotechnology - November 1, 2023 Category: Cancer & Oncology Source Type: research
Induction of ferroptosis by artesunate nanoparticles is an effective therapeutic strategy for hepatocellular carcinoma
AbstractArtesunate (ART) has great value in the field of tumor therapy. Interestingly, in this study, we found that ART could obviously induce ferroptosis in hepatocellular carcinoma (HCC) cells, but its low water solubility and bioavailability limited its application potential. Hence, we synthesized ART-loaded mesoporous silica nanoparticles (MSNs) conjugated with folic acid (FA) (MSN-ART-FA) with tumor-targeting performance and assessed their characteristics. We evaluated the ability of MSN-ART and MSN-ART-FA to induce ferroptosis of hepatoma cells via testing levels of reactive oxygen species (ROS), Fe2+, malondialdehyd...
Source: Cancer Nanotechnology - October 21, 2023 Category: Cancer & Oncology Source Type: research
Utilizing two-dimensional monolayer and three-dimensional spheroids to enhance radiotherapeutic potential by combining gold nanoparticles and docetaxel
ConclusionsCombining GNPs and DTX leads to a synergistic radiosensitization effect in spheroids, which can better mimic the tumour microenvironment. Testing treatment modalities with spheroids and RT may allow a quicker translation to the clinic. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 19, 2023 Category: Cancer & Oncology Source Type: research
Green adeptness in synthesis of non-toxic copper and cobalt oxide nanocomposites with multifaceted bioactivities
ConclusionsThis study concludes that in future as synthesized SM-CuONC and SM-Co3O4NC can be used in pharmaceutical, health care system for betterment and welfare of human life as both bio-nanocomposites exhibits better antimicrobial, anticancer, antioxidant and mosquito larvicidal potential. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 16, 2023 Category: Cancer & Oncology Source Type: research
