Inhibition of ABCC9 by zinc oxide nanoparticles induces ferroptosis and inhibits progression, attenuates doxorubicin resistance in breast cancer
ConclusionsIn conclusion, we discovered that the inhibition of ABCC9 by zinc oxide nanoparticles induces ferroptosis and attenuates Dox resistance in BC. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 24, 2022 Category: Cancer & Oncology Source Type: research
Baicalin-loaded folic acid-modified albumin nanoparticles (FA-BSANPs/BA) induce autophagy in MCF-7 cells via ROS-mediated p38 MAPK and Akt/mTOR pathway
ConclusionsEncapsulation in folate albumin nanoparticles improved the antiproliferative activity of baicalin. FA-BSANPs/BA induced autophagy and apoptosis via ROS-mediated p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2022 Category: Cancer & Oncology Source Type: research
Non-homogeneous dispersion of graphene in polyacrylonitrile substrates induces a migrastatic response and epithelial-like differentiation in MCF7 breast cancer cells
ConclusionsThe present data demonstrate the capacity of these composite substrates to induce an epithelial-like differentiation in MCF7 breast cancer cells, resulting in a migrastatic effect without any chemical agent-mediated signaling. Future works will aim to thoroughly evaluate the mechanisms of how PAN/G10 substrates trigger these responses in cancer cells and their potential use as antimetastatics for the treatment of solid cancers.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 4, 2022 Category: Cancer & Oncology Source Type: research
Potential anti-tumor activity of 13.56 MHz alternating magnetic hyperthermia and chemotherapy on the induction of apoptosis in human colon cancer cell lines HT29 and HCT116 by up-regulation of Bax, cleaved caspase 3 & amp;9, and cleaved PARP proteins
ConclusionsThis study demonstrates that localized hyperthermia was able to significantly trigger the 5-Fu release and inhibit cell viability, which, due to the synchronization of hyperthermia and chemotherapy, exacerbated the damage of cancer cells.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 17, 2021 Category: Cancer & Oncology Source Type: research
Synergistic action of curcumin and cisplatin on spinel ferrite/hierarchical MCM-41 nanocomposite against MCF-7, HeLa and HCT 116 cancer cell line
ConclusionOur results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 27, 2021 Category: Cancer & Oncology Source Type: research
A combined miR-34a and arsenic trioxide nanodrug delivery system for synergistic inhibition of HCC progression after microwave ablation
ConclusionsDual-drug nanoparticles may improve the therapeutic efficacy of HCC treatment after insufficient ablation through Cyt-c and GSDME-N and decrease the expression levels of c-met. These nanoparticles are expected to provide new treatment methods for residual HCC after MWA, prolong the survival of patients and improve their quality of life. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 27, 2021 Category: Cancer & Oncology Source Type: research
Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer
ConclusionsThe presented results constitute a solid foundation for the implementation of a nano-sized drug delivery system containing folic acid for practical use in the treatment of drug-resistant cancer, as well as more effective therapy with fewer side effects.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 18, 2021 Category: Cancer & Oncology Source Type: research
Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): in vivo toxicity, biodistribution and cytotoxicity on DU-145 prostate cancer cells
ConclusionsThus, nanoLPG stands as a promising and biosafe lycopene delivery system for further development of nanotechnology-based health products.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 7, 2021 Category: Cancer & Oncology Source Type: research
Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
ConclusionsAlthough further in vitro and in vivo studies are necessary, our results suggested that β-CD-CL-Scu-cRGD could be an outstanding carrier to deliver Scu for potential therapeutic approaches into colon cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 7, 2021 Category: Cancer & Oncology Source Type: research
Cytotoxic, apoptotic, and genetic evaluations of Nigella sativa essential oil nanoemulsion against human hepatocellular carcinoma cell lines
ConclusionOverall, the study revealed the potentials ofN. sativa essential oil, after formulation in specially tailored nanoemulsion for application as potential adjuvant liver anticancer agent.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 4, 2021 Category: Cancer & Oncology Source Type: research
Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS-nBio
ConclusionOur multi-scale approach allows to study irradiation-induced physical and chemical effects on cells. We showed a potential increase in cell radiosensitization caused by relatively small concentrations of AuFeNPs. Our new methodology allows the individual adjustment of parameters in each simulation step and therefore can be used for other studies investigating the radiosensitizing effects of AuFeNPs or AuNPs in living cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 24, 2021 Category: Cancer & Oncology Source Type: research
A novel formulation of theranostic nanomedicine for targeting drug delivery to gastrointestinal tract cancer
ConclusionThis is one of its kind studies in which a novel targeted nanomedicines approach was formulated for therapeutic as well as prognostic purposes against GI tract cancer.Graphic Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 9, 2021 Category: Cancer & Oncology Source Type: research
Novel nanoformulation of disulfiram with bacterially synthesized copper oxide nanoparticles for augmenting anticancer activity: an in vitro study
ConclusionAll of the aforementioned findings verified that this novel nanocomplex was capable of improving the therapeutic index of the conventional DS –Cu complex. The potent selective anticancer activity of this promising nanomedicine merits further investigation, as a separate future study, using animal models as preliminary step before its clinical application.Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 6, 2021 Category: Cancer & Oncology Source Type: research
Antitumor efficiency of the natural alkaloid berberine complexed with C60 fullerene in Lewis lung carcinoma in vitro and in vivo
ConclusionsThis study indicates that complexation of natural alkaloid Ber with C60 may be a novel therapeutic strategy against lung carcinoma.Graphical abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 23, 2021 Category: Cancer & Oncology Source Type: research
Montmorillonite colloid plates with adsorbed cytochrome c: in vitro cytotoxic effect on colon cancer cell culture
ConclusionThe in vitro experiments with colon cancer cell culture disclose that cytC-MM composite particles have potential for application in anticancer therapy of superficial neoplasms of the skin and the alimentary system (mouth cavity, esophagus, stomach, jejunum and colon).Graphic abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 23, 2021 Category: Cancer & Oncology Source Type: research
