Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells
ConclusionQD –MUA–FA–DOX nanoconjugates can thus be considered as a potential drug delivery system for the effective treatment of adenocarcinomic human alveolar basal epithelial cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 8, 2021 Category: Cancer & Oncology Source Type: research
Investigating the effect of outer layer of magnetic particles on cervical cancer cells HeLa by magnetic fluid hyperthermia
ConclusionThe preliminary analysis of this study shows significant cell death due to hyperthermia, wherein MFWI revealed higher cytotoxicity compared to MFWL. Additional analysis into the role of the outer stabilizing layer on nanoparticle ’s surface, concentration of nanoparticles, and hyperthermic duration is desirable to utilize MFH as a futuristic anti-cancer therapeutic tool. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 8, 2021 Category: Cancer & Oncology Source Type: research
Quantum dots as targeted doxorubicin drug delivery nanosystems
ConclusionQD –MUA–FA–DOX nanoconjugates can thus be considered as a potential drug delivery system for the effective treatment of adenocarcinomic human alveolar basal epithelial cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 8, 2021 Category: Cancer & Oncology Source Type: research
Targeting BMI-1 with PLGA –PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells
AbstractDespite advances in glioblastoma (GBM) treatments, current approaches have failed to improve the overall survival of patients. The oncogene BMI-1, a core member of the polycomb group proteins, is a potential novel therapeutic target for GBM. To enhance the efficacy and reduce the toxicity, PTC209, a BMI-1 inhibitor, was loaded into a PLGA –PEG nanoparticle conjugated with CD133 antibody (Nano-PTC209) and its effect on the behavior of human GBM stem-like cells (GSCs) and the human glioblastoma cell line (U87MG) was assessed. Nano-PTC209 has a diameter of ~ 75 nm with efficient drug loading and controlled releas...
Source: Cancer Nanotechnology - February 6, 2021 Category: Cancer & Oncology Source Type: research
Non-invasive transdermal delivery of chemotherapeutic molecules in vivo using superparamagnetic iron oxide nanoparticles
ConclusionCorrectly formulated superparamagnetic iron oxide nanoparticles can facilitate the chemotherapeutic effectiveness of cytotoxic drugs on skin tumors by both increasing their transdermal penetration and ameliorating host –tumor interactions. This enhancement of skin penetration occurs without the need for conjugation or encapsulation of the co-administered drugs, and so will likely be applicable to other drugs, also. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 6, 2021 Category: Cancer & Oncology Source Type: research
Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization
ConclusionThese biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 5, 2021 Category: Cancer & Oncology Source Type: research
Excretable, ultrasmall hexagonal NaGdF 4 :Yb50% nanoparticles for bimodal imaging and radiosensitization
ConclusionThese biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 5, 2021 Category: Cancer & Oncology Source Type: research
Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro
ConclusionOur data confirmed that Gemini curcumin has the potential to suppress cell proliferation and inhibit metastasis in 3D spheroid HT-29 cells in vitro. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2021 Category: Cancer & Oncology Source Type: research
Experimental conditions influence the formation and composition of the corona around gold nanoparticles
ConclusionThe current study showed that the pre-processing conditions modulate PC composition and can be used to enhance identification of NMTPs. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2021 Category: Cancer & Oncology Source Type: research
Graphene oxide nanofilm and chicken embryo extract decrease the invasiveness of HepG2 liver cancer cells
ConclusionsStudies have shown that both the GO surface structure on which the cells are grown as well as the presence of a multi-component natural cocktail of regulatory proteins, can modify the expression of integrins, increase adhesion and, as a consequence, proliferation and the cell cycle —entering the resting phase. For the first time, it has been documented that hepatic cancer cells of the HepG2 line under the influence of stimuli derived from mimic ECM (graphene oxide) in interaction with a unique protein complex derived from chicken liver embryo decreased of the invasiveness of cancer cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 6, 2021 Category: Cancer & Oncology Source Type: research
Nanomedicine-mediated induction of immunogenic cell death and prevention of PD-L1 overexpression for enhanced hepatocellular carcinoma therapy
ConclusionTaken together, NPDOX/siPD-L1 showed significant anti-tumor effects on HCC by the induction of ICD and inhibition of PD-L1 overexpression. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 14, 2020 Category: Cancer & Oncology Source Type: research
Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro
ConclusionsThis study highlights the opportunity to exploit pluronic-based nanomicelles for the delivery of compounds that regulate epigenetic processes, thus inhibiting cancer development and progression. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 25, 2020 Category: Cancer & Oncology Source Type: research
Synthesis and analysis of silver –copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells
ConclusionThe data suggest that the AgCu-NP alloy imposes preferential toxicity in breast cancer MCF-7 cells and thus could be exploited as a new candidate for further anticancer investigation (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 25, 2020 Category: Cancer & Oncology Source Type: research
Nanotechnology approaches to addressing HER2-positive breast cancer
AbstractBreast cancer is a major cause of cancer-associated deaths in the United States. It was estimated that 12% of women in the U.S. will develop invasive breast cancer in their lifetime. The human epidermal growth factor receptor (HER2/neu) is a growth-promoting protein that is overexpressed in 15 –20% of breast cancers (HER2-positive breast cancer). HER2-positive breast cancer generally grows and spreads more quickly than other breast cancers, but it can be targeted therapeutically. Targeting drugs have been developed with a specific design to stop the growth and even the spread of cancer. These drugs include trastu...
Source: Cancer Nanotechnology - October 17, 2020 Category: Cancer & Oncology Source Type: research
Algae-meditated route to cuprous oxide (Cu 2 O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer
ConclusionsOur results confirm the beneficial cytotoxic effects of green-synthesized CM-Cu2O NPs on BC cell lines. This nanoparticle decreased angiogenesis and induces apoptosis, so we conclude that CM-Cu2O NPs can be used as a supplemental drug in cancer treatments. Significantly, elevated circulating lncRNAs were demonstrated to be BC specific and could differentiate BC cell lines from the normal cell lines. It was demonstrated that lncRNAs used in this study and their expression profiles can be created as biomarkers for early diagnosis and prognosis of BC. Further studies utilizing patients would give recognizable ident...
Source: Cancer Nanotechnology - October 14, 2020 Category: Cancer & Oncology Source Type: research
