Based polymer nanoparticles from bee pollen attenuate non-small lung cancer through enhancement of apoptosis and cell cycle arrest in vivo
AbstractBee pollen extract (BPE)-based polymer nanoparticles (BPENP) were fabricated using bovine serum albumin (BSA) and targeted with folic acid and were further characterized. Mice groups are: Group 1 received saline, whereas Groups 2, 3, 4, 5, and 6 received a single dose of urethane, followed by weekly injections of butylated hydroxy-toluene (BHT). After the BHT injection, the mice in Groups 3, 4, 5, and 6 received BPE, Avastin, BPENP, and BPENP + Avastin, respectively. The number and size of tumors were decreased in Group 6 compared to those in the other groups. The ratios of early and late apoptotic cells in Gr...
Source: Cancer Nanotechnology - October 6, 2023 Category: Cancer & Oncology Source Type: research
Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
ConclusionsModification of mPEG × CD20 can confer PLD with CD20 specificity to enhance the internalization and the anti-cancer efficacy of PEG-NPs. This therapeutic strategy can conveniently be used to modify various PEG-NPs with anti-PEG BsAb to overcome the lack of EPR effect of hematologic malignancies and improve therape utic efficacy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 6, 2023 Category: Cancer & Oncology Source Type: research
Boosting nuclear-targeted photothermal-chemotherapy by NIR-responsive hybrid membrane camouflaged nanotherapeutics
ConclusionsTherefore, this spatiotemporal controllable biomimetic nanotherapeutics will provide a new insight and strategy for specific targeted therapy of tumors. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 3, 2023 Category: Cancer & Oncology Source Type: research
Dual enhancement in the radiosensitivity of prostate cancer through nanoparticles and chemotherapeutics
ConclusionsIncorporating DTX to work in unison with GNPs and RT can increase the efficacy of RT treatment. Our study suggests that the treatment strategy could improve tumor control through local dose enhancement. As the concentrations used in this study are clinically feasible, there is potential for this strategy to be translated into clinical settings. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 29, 2023 Category: Cancer & Oncology Source Type: research
Iron oxide polyaniline-coated nanoparticles modulate tumor microenvironment in breast cancer: an in vitro study on the reprogramming of tumor-associated macrophages
ConclusionsThese findings highlight the potential of Pani/y-Fe2O3 as a promising therapeutic approach in the context of breast cancer treatment by effectively reprogramming M2 macrophages into an anti-tumor M1 phenotype, Pani/y-Fe2O3 nanoparticles demonstrated the ability to elicit antitumor effects in both MCF-7 and MDA-MB-231 breast cancer cell lines. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 7, 2023 Category: Cancer & Oncology Source Type: research
ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation
AbstractProstate cancer (PCa) is one of the fatal illnesses among males globally. PCa-treatment does not include radiotherapy. Chemotherapy eventually causes drug resistance, disease recurrence, metastatic advancement, multi-organ failure, and death. Preclinical data on PCa-induced by carcinogens are truly scarce. Although some data on xenograft-PCa in animals are available, they mostly belonged to immuno-compromised animals. Here, we developed ΔPSap4#5 aptamer surface-functionalized abiraterone-loaded biodegradable nanoparticle (Apt-ABR-NP) to investigate its targeting ability to prostate-specific membrane antigen (PSMA)...
Source: Cancer Nanotechnology - September 4, 2023 Category: Cancer & Oncology Source Type: research
A ‘golden’ alternative for prevention of cisplatin nephrotoxicity in bladder cancer
AbstractCisplatin (CP) is the first-line standard of care for bladder cancer. However, a significant percentage of advanced bladder cancer patients are ineligible to receive standard CP treatment, due to the drug ’s toxicity, and in particular its nephrotoxicity. These patients currently face suboptimal therapeutic options with lower efficacy. To overcome this limitation, here we designed CP-conjugated gold nanoparticles (GNPs) with specific properties that prevent renal toxicity, and concurrently preserve the therapeutic efficacy of CP. Safety and efficacy of the particles were studied in bladder tumor-bearing mice, usi...
Source: Cancer Nanotechnology - September 1, 2023 Category: Cancer & Oncology Source Type: research
Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
ConclusionOur findings suggest that encapsulation of the virus in thiolated chitosan and CD44 targeting enhanced retention and sustained release of the virus in tumors as compared to pure NDV, with increased oncolytic effect both in vitro and in vivo. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 12, 2023 Category: Cancer & Oncology Source Type: research
Cabazitaxel-loaded human serum albumin nanoparticles combined with TGF β-1 siRNA lipid nanoparticles for the treatment of paclitaxel-resistant non-small cell lung cancer
ConclusionsThe antitumor effect of CTX-HSA-NPs on paclitaxel-resistant NSCLC was higher than that of CTX-Tween, and the toxicity was lower than that of CTX-Tween. TGF β-1 siRNA LNP can treat paclitaxel-resistant NSCLC by inhibiting the express ofTGF β-1 mRNA. The combined treatment of TGF β-1 siRNA LNP and CTX-HSA-NPs could effectively improve the antitumor efficacy of paclitaxel-resistant NSCLC. A combination therapy of chemotherapy and nucleic acid drugs could be an effective approach for treating paclitaxel-resistant NSCLC. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 29, 2023 Category: Cancer & Oncology Source Type: research
Investigating the anticancer and anti-angiogenic effects of graphene oxide nanoparticles containing 6-gingerol modified with chitosan and folate
ConclusionsThese results show the promising effect of Ging-GO-CS-FA on gastric cancer cells by inhibiting angiogenesis and increasing the level of oxidants. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 25, 2023 Category: Cancer & Oncology Source Type: research
Correction: Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 6, 2023 Category: Cancer & Oncology Source Type: research
Mesoporous silica nanoparticles boost aggressive cancer response to hydrophilic chlorin e6-mediated photodynamic therapy
ConclusionThe newly developed hydrophilic chlorin and even more its MSN conjugate show high activities in anticancer PDT. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 1, 2023 Category: Cancer & Oncology Source Type: research
Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation
AbstractThe in vivo anticancer potential of vincristine (VC) loaded, thiolated chitosan-based nanoformulation (NFs) with an outer hyaluronic acid (VC-loaded in TCs-HA) coating was studied in prostate cancer (PC) xenograft in the immunosuppressed rat model induced by PC3 cell lines. Our previous study has already reported the in vitro efficacy of the said NFs. The ADMET Predictor (TM) Cloud version 10.4.0.5, 64-bit, was used to simulate VC's physicochemical and pharmacokinetic parameters. The percentage of encapsulation efficiency of VC by direct and indirect methods was 81.5 and 90%, respectively. Plasma samples from healt...
Source: Cancer Nanotechnology - June 20, 2023 Category: Cancer & Oncology Source Type: research
Co-delivery of curcumin and si-STAT3 with a bioinspired tumor homing for polydopamine nanoparticles for synergistic osteosarcoma therapy
ConclusionThis study revealed that CPDA/siSTAT3@SCM NPs can target drug delivery by biomimetic multifunctional nanoparticles to treat OS through chemo-gene combined therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 20, 2023 Category: Cancer & Oncology Source Type: research
An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft
ConclusionsElectrostatic conjugation of the apMNKQ2 aptamer with PEI –IONPs impedes the accumulation of the latter in tumors, which appears to be necessary for PEI–IONPs to exert their antitumor activity.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 14, 2023 Category: Cancer & Oncology Source Type: research
