Profiling lung adenocarcinoma by liquid biopsy: can one size fit all?
ConclusionWith further optimisation, this hotspot panel could allow molecular diagnostics laboratories to build curated primer banks for ‘off-the-shelf’ monitoring of ctDNA by droplet-based digital PCR or similar techniques, in a time- and cost-effective manner. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 22, 2016 Category: Cancer & Oncology Source Type: research
Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy
AbstractRadiotherapy has been, and will continue to be, a critical modality to treat cancer. Since the discovery of radiation-induced cytotoxicity in the late 19th century, both external and internal radiation sources have provided tremendous benefits to extend the life of cancer patients. Despite the dramatic improvement of radiation techniques, however, one challenge persists to limit the anti-tumor efficacy of radiotherapy, which is to maximize the deposited dose in tumor while sparing the rest of the healthy vital organs. Nanomedicine has stepped into the spotlight of cancer diagnosis and therapy during the past decade...
Source: Cancer Nanotechnology - November 16, 2016 Category: Cancer & Oncology Source Type: research
Gold nanoparticles for cancer radiotherapy: a review
AbstractRadiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can adversely affect healthy tissue outside the tumour volume, especially in the case of photon radiation (gamma and X-rays). Improved radiotherapy outcomes can be achieved by employing ion beams due to the characteristic energy deposition curve which culminates in a localised, high radiation dose (in form of a Bragg peak). In addition to ion radiotherapy, novel sensitisers, such as nanoparticles, have shown to locally ...
Source: Cancer Nanotechnology - November 3, 2016 Category: Cancer & Oncology Source Type: research
Optical fibre sensors: their role in in vivo dosimetry for prostate cancer radiotherapy
We present the various sensor designs along with the main advantages and disadvantages associated with this technology. Optical fibres are ideally placed for applications in radiotherapy dosimetry; due to their small size they are lightweight and immune to electromagnetic interferences. The small dimensions of optical fibres allows it to be easily guided within existing brachytherapy equipment; for example, within the seed implantation needle for direct tumour dose analysis, in the urinary catheter to monitor urethral dose, or within the biopsy needle holder of the transrectal ultrasound probe to monitor rectal wall dose. ...
Source: Cancer Nanotechnology - October 17, 2016 Category: Cancer & Oncology Source Type: research
Trends in targeted prostate brachytherapy: from multiparametric MRI to nanomolecular radiosensitizers
Abstract
The treatment of localized prostate cancer is expected to become a significant problem in the next decade as an increasingly aging population becomes prone to developing the disease. Recent research into the biological nature of prostate cancer has shown that large localized doses of radiation to the cancer offer excellent long-term disease control. Brachytherapy, a form of localized radiation therapy, has been shown to be one of the most effective methods for delivering high radiation doses to the cancer; however, recent evidence suggests that increasing the localized radiation dose without bo...
Source: Cancer Nanotechnology - July 3, 2016 Category: Cancer & Oncology Source Type: research
Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields
Abstract
Poor biodistribution and accumulation of chemotherapeutics in tumors due to limitations on diffusive transport and high intra-tumoral pressures (Jain RK, Nat Med. 7(9):987–989, 2001) have prompted the investigation of adjunctive therapies to improve treatment outcomes. Hyperthermia has been widely applied in attempts to meet this need, but it is limited in its ability to reach tumors in deeply located body regions. High-intensity radiofrequency (RF) electric fields have the potential to overcome such barriers enhancing delivery and extravasation of chemotherapeutics. However, due to factors, ...
Source: Cancer Nanotechnology - June 29, 2016 Category: Cancer & Oncology Source Type: research
Gazelles, unicorns, and dragons battle cancer through the Nanotechnology Startup Challenge
Abstract
On March 4th, 2016, Springer’s Cancer Nanotechnology office promoted the launch of the Nanotechnology Startup Challenge in Cancer (NSC
2
). This innovation-development model is a partnership among our company, the Center for Advancing Innovation (CAI), MedImmune, the global biologics arm of AstraZeneca, and multiple institutes at the National Institutes of Health (NIH). NSC
2
“crowdsources” talent from around the world to launch startup...
Source: Cancer Nanotechnology - June 8, 2016 Category: Cancer & Oncology Source Type: research
Nanotechnology and cancer: improving real-time monitoring and staging of bladder cancer with multimodal mesoporous silica nanoparticles
Conclusions
These findings may present new options for therapeutic intervention. Ultimately, the combination of real-time and repeated MRI evaluation of the tumors enhanced by nanoparticle contrast may have the potential for translation into human clinical studies for tumor staging, therapeutic monitoring, and drug delivery. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 26, 2016 Category: Cancer & Oncology Source Type: research
Cancer Nanotechnology Startup Challenge: a new way to realize the fruits of innovation
Abstract
A significant new innovation-development model is being launched in the field of cancer and nanotechnology. A significant new innovation-development model is being launched in the field of cancer and nanotechnology. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 4, 2016 Category: Cancer & Oncology Source Type: research
Bio-conjugation of antioxidant peptide on surface-modified gold nanoparticles: a novel approach to enhance the radical scavenging property in cancer cell
Conclusions
The effects of GNPs-Pep-A on ROS reduction and regulation of antioxidant genes confirmed that Vitis vinifera L. polyphenol-coated GNPs synergistically improve the radical scavenging properties and enhanced the apoptosis of cancer cell. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 9, 2016 Category: Cancer & Oncology Source Type: research
AGuIX nanoparticles as a promising platform for image-guided radiation therapy
Abstract
AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as a radiosensitizer. We used MRI to quantify the uptake of AGuIX in pancreatic cancer cells, and TEM for intracellular localization. We measured the radiosensitization of a pancreatic cancer cell line in a low-energy (220 kVp) beam, a standard 6 MV beam (STD) and a flattening filter free 6 MV beam (FFF). We demonstrated that the presence of nanoparticles significantly decreases cell survival when combined with an X-ray beam with a large...
Source: Cancer Nanotechnology - September 2, 2015 Category: Cancer & Oncology Source Type: research
Erratum to: Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - July 29, 2015 Category: Cancer & Oncology Source Type: research
