Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
AbstractTumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key chemotactic factor CCL2, which attracts monocytes to the vaccine injection site and enhances endocytosis of antigen. Monocytes subsequently enter the draining lymph node, and differentiate into monocyte-derived DCs (moDCs), which present tumor antigens to T lymphocytes and deliver a potent anti-tumor immune response. Mec...
Source: Cancer Nanotechnology - April 17, 2023 Category: Cancer & Oncology Source Type: research
Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer
ConclusionsTaken together, we believe this to be the first work providing evidence that AuNP radiosensitisation can be enhanced via metabolic modulation. This study reveals the dual action of both physical and biological pathways of AuNPs radiosensitisation, resulting in superior radiotherapeutic effects. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 8, 2023 Category: Cancer & Oncology Source Type: research
Hyaluronated nanoparticles deliver raloxifene to CD44-expressed colon cancer cells and regulate lncRNAs/miRNAs epigenetic cascade
ConclusionsWe may conclude that the RX NP effectively targets CRC cells in vitro via altering lncRNAs and miRNAs epigenetic cascade as well as cellular uptake through CD44-expressed CRC cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 7, 2023 Category: Cancer & Oncology Source Type: research
Photothermal therapy of papillary thyroid cancer tumor xenografts with targeted thyroid stimulating hormone receptor antibody functionalized multiwalled carbon nanotubes
AbstractMultiwalled carbon nanotubes (MWCNTs) are being widely investigated in multiple biomedical applications including, and not limited to, drug delivery, gene therapy, imaging, biosensing, and tissue engineering. Their large surface area and aspect ratio in addition to their unique structural, optical properties, and thermal conductivity also make them potent candidates for novel hyperthermia therapy. Here we introduce thyroid hormone stimulating receptor (TSHR) antibody –conjugate–MWCNT formulation as an enhanced tumor targeting and light-absorbing device for the photoablation of xenografted BCPAP papillary thyroi...
Source: Cancer Nanotechnology - April 5, 2023 Category: Cancer & Oncology Source Type: research
In vivo imaging of prostate tumor-targeted folic acid conjugated quantum dots
AbstractCancer is a major threat to human health; thus, early detection is imperative for successful management. Rapid diagnosis can be achieved by imaging primary (subcutaneous) tumors using fluorophores conjugated with tumor markers. Here, the application of biocompatible, quantum efficient, monodisperse, and photostable polymer-coated quantum dots (PQDs) is demonstrated for targeted prostate tumor imaging in living SCID mice. Briefly, PQDs (blue) are conjugated to folic acid (FA-PQDs) using DCC-NHS chemistry. Initially, in vitro targeted imaging via FA-PQDs is evaluated in LNCaP cells. The confocal microscopic evaluatio...
Source: Cancer Nanotechnology - March 30, 2023 Category: Cancer & Oncology Source Type: research
Anti-EGFR conjugated nanoparticles to deliver Alpelisib as targeted therapy for head and neck cancer
ConclusionsAnti-EGFR-conjugated polymeric nanoparticles are an effective delivery system to increase drug efficiency and bioavailability in head and neck cancer cells. This strategy can help reduce drug exposure in disease-free organs and decrease drug-associated unwanted side effects. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Development of glycan-targeted nanoparticles as a novel therapeutic opportunity for gastric cancer treatment
AbstractChemotherapy resistance remains a major cause of therapeutic failure in gastric cancer. The combination of genetic material such as interference RNAs (iRNAs) to silence cancer-associated genes with chemotherapeutics has become a novel approach for cancer treatment. However, finding the right target genes and developing non-toxic, highly selective nanocarrier systems remains a challenge. Here we developed a novel sialyl-Tn-targeted polylactic acid —didodecyldimethylammonium bromide nanoparticle (PLA-DDAB) nanoparticles (NPs) loaded with dsRNA targeting ST6GalNac-I and/or galectin-3 genes. Using single photon emiss...
Source: Cancer Nanotechnology - March 28, 2023 Category: Cancer & Oncology Source Type: research
Novel bispecific aptamer targeting PD-1 and nucleolin for cancer immunotherapy
ConclusionThe results suggest that bispecific agent combining ICB and tumor-homing functions has potential to improve the efficacy of ICB immunotherapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 28, 2023 Category: Cancer & Oncology Source Type: research
Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy
AbstractLung cancer is the leading cause of cancer mortality. As a heterogeneous disease, it has different subtypes and various treatment modalities. In addition to conventional surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy have also been applied in the clinics. However, drug resistance and systemic toxicity still cannot be avoided. Based on the unique properties of nanoparticles, it provides a new idea for lung cancer therapy, especially for targeted immunotherapy. When nanoparticles are used as carriers of drugs with special physical properties, the nanodrug delivery system ensures the accura...
Source: Cancer Nanotechnology - March 28, 2023 Category: Cancer & Oncology Source Type: research
Bufalin-loaded vitamin E succinate-grafted chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles inhibit intraperitoneal metastasis of ovarian cancer
ConclusionsOur studies show that BU@MMs are a potential multifunctional nano-drug delivery system that can effectively inhibit the intraperitoneal metastasis of ovarian cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 27, 2023 Category: Cancer & Oncology Source Type: research
In vitro and in vivo study on the anticancer effects of anethole-loaded bovine serum albumin nanoparticles surface decorated with chitosan and folic acid
AbstractAnethole (Ant) is a herbal compound with unique properties, which is limited in its clinical use due to its low solubility in aqueous solutions. Therefore, in this study, albumin nanocarrier modified with chitosan-folate was used to transfer Ant to cancer cells and its anticancer effects were evaluated. First, Ant was loaded on albumin nanoparticles by desolvation method and then the surface of nanoparticles was covered with chitosan bound to folate. After characterization, the amount of Ant loading in nanoparticles was measured by the absorption method and then its toxicity effects on breast cancer cell lines, col...
Source: Cancer Nanotechnology - March 27, 2023 Category: Cancer & Oncology Source Type: research
Doxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as specific vehicles to fight estrogen-dependent breast cancer
AbstractThe presented research concerns the preparation of polymer nanoparticles (PNPs) for the delivery of doxorubicin. Several block and statistical copolymers, composed of ketoester derivative,N-isopropylacrylamide, and cholesterol, were synthesized. In the nanoprecipitation process, doxorubicin (DOX) molecules were kept in spatial polymeric systems. DOX-loaded PNPs show high efficacy against estrogen-dependent MCF-7 breast cancer cell lines despite low doses of DOX applied and good compatibility with normal cells. Research confirms the effect of PNPs on the degradation of the biological membrane, and the accumulation o...
Source: Cancer Nanotechnology - March 21, 2023 Category: Cancer & Oncology Source Type: research
Multi-sensitive functionalized niosomal nanocarriers for controllable gene delivery in vitro and in vivo
AbstractMicroRNAs, which can contribute to numerous cellular functions through post-transcriptional silencing, have become well-documented candidates for cancer treatment applications, particularly in chemo-resistant cancers. Herein, several formulations were examined to optimize the essential parameters, and the niosomal formulation consisting of cholesterol:tween-80:DOTAP:PEG with 9:69:15:7 ratio had the best physicochemical parameters including spherical shape, high entrapment efficiency, small diameter (81 ± 0.65 nm), and appropriate positive charge (23 ± 0.64 mV). Here, we aimed to design a system with in...
Source: Cancer Nanotechnology - March 19, 2023 Category: Cancer & Oncology Source Type: research
Inhibition of PD-L1 and tumor growth in triple-negative breast cancer using a magnetic nanovector with microRNA34a
ConclusionThis study is the first to modulate PD-L1 by delivering miRNA34a with magnetic nanoparticles, and the results suggest that miRNA34a can be delivered effectively using magnetic nanoparticles and has potential as a molecular imaging contrast agent. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 11, 2023 Category: Cancer & Oncology Source Type: research
Boosting immunogenic cell death via hollow MnO2-based multiple stimuli-responsive drug delivery systems for improved cancer immunotherapy
This study overcame the limitations of monotherapy and provided a multifunctional platform for tumor immunotherapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 11, 2023 Category: Cancer & Oncology Source Type: research
