Cockle shell-derived aragonite calcium carbonate nanoparticle for targeting cancer and breast cancer stem cells
AbstractCockle shell-derived aragonite calcium carbonate nanoparticles (CACNP) have demonstrated prospect as nano-sized drug carriers for targeting cancer cells. CACNP is biocompatible, biodegradable and its biomaterial is readily available and is of low cost. In addition, CACNP is highly porous, has a large surface area which confer a high loading capacity. The pH-dependent release properties as well as its potential for surface functionalization with targeting agents make CACNP useful in passive and active targeting of cancer cells and cancer stem cells. In this article, we reviewed the current state of CACNP as nano-siz...
Source: Cancer Nanotechnology - October 6, 2020 Category: Cancer & Oncology Source Type: research
Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac
ConclusionsNovel nano-enhanced radiotherapy with gadolinium-containing nanoparticles is ideally suited for implementation on an MRI-linac, allowing a workflow with time-of-treatment imaging. Live irradiations using this treatment workflow, carried out for the first time at the Australian MRI-linac, confirm the safety and feasibility of performing MRI-guided radiotherapy with AGuIX® nanoparticles. Follow-up studies are needed to demonstrate on an MRI-linac the radiation enhancement effects previously shown with conventional radiotherapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 5, 2020 Category: Cancer & Oncology Source Type: research
Elucidating the fate of nanoparticles among key cell components of the tumor microenvironment for promoting cancer nanotechnology
AbstractSuccessful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on cancer cells, but FBs and CAFs also play a critical role: FBs suppress the tumor growth while CAFs promote it. It is not yet known how NPs interact with FBs and CAFs compared to cancer cells. Hence, our goal was to elucidate the extent of NP uptake, retention, and toxicity...
Source: Cancer Nanotechnology - August 17, 2020 Category: Cancer & Oncology Source Type: research
Cancer research, treatment, and COVID-19
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 5, 2020 Category: Cancer & Oncology Source Type: research
Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy
ConclusionsDoxorubicin-loaded HAuNS is a promising therapeutic agent for dual ablation/chemoembolization treatment of liver cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 30, 2020 Category: Cancer & Oncology Source Type: research
Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI
ConclusionThis study showed no significance difference in MRI contrast between Mag and Mag-Lnp pancreatic cancer PDX mouse models. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 13, 2020 Category: Cancer & Oncology Source Type: research
Preferential drug delivery to tumor cells than normal cells using a tunable niosome –chitosan double package nanodelivery system: a novel in vitro model
ConclusionBased on the observation of the DDS preferentially targeting tumor cells, there is a potential implication for the localized delivery of therapeutic drug doses to solid tumors or post-surgical solid tumors cavities containing residual tumor cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 29, 2020 Category: Cancer & Oncology Source Type: research
Reducing the effective dose of cisplatin using gold nanoparticles as carriers
AbstractNanotechnology is a frequent treatment for cancer. Nanomaterials are the vehicles which deliver drugs in smaller but equally effective quantities. The aim of this investigation is to synthesize gold nanoparticles, functionalize them for the transportation of cisplatin and release them to the cancer-affected area. They have the same cytotoxicity as conventional treatments but with the smallest effective quantity of cisplatin. We synthesized spherical gold nanoparticles using the Turkevich method. We functionalized them with polyethylene glycol and cisplatin, adapting the method used by Sun. Using electronic transmis...
Source: Cancer Nanotechnology - March 29, 2020 Category: Cancer & Oncology Source Type: research
A [60]fullerene nanoconjugate with gemcitabine: synthesis, biophysical properties and biological evaluation for treating pancreatic cancer
ConclusionIn this paper, we present a robust approach for synthesizing a highly water-soluble [60]fullerene nanoconjugate with gemcitabine. The performed biological assays on pancreatic cancer cell lines demonstrated cytotoxic effects of nanoC60GEM, which were enhanced by the generation of reactive oxygen species after blue LED irradiation of synthesized fullerene nanomaterial. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 17, 2020 Category: Cancer & Oncology Source Type: research
Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications
ConclusionsDye-doped silica nanoparticles have found success in the immunodiagnostics domain and have also shown promise as bioimaging agents in human clinical trials. Their use in cancer delivery has been restricted to murine models, as has been the case for the vast majority of nanomaterials intended for cancer therapy. This is hampered by the need for more human-like disease models and the lack of standardisation towards assessing nanoparticle toxicity. However, developments in the manipulation of the protein corona have improved the understanding of fundamental bio –nano interactions, and will undoubtedly assist in t...
Source: Cancer Nanotechnology - January 8, 2020 Category: Cancer & Oncology Source Type: research
Nanomedicine review: clinical developments in liposomal applications
ConclusionLiposomal formulations are less toxic than drugs alone and have better pharmacological parameters. Although they seem to be the first choice for drug delivery systems for various diseases, further research about dosage regimen regarding dose and time needs to be carried out. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 18, 2019 Category: Cancer & Oncology Source Type: research
A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays
ConclusionsBeyond identifying promising metal oxide NP radiosensitisers and radioprotectors, our broad comparisons reveal unexpected differences that suggest the surface chemistry of NP radiosensitisers is an important criterion for their success. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 18, 2019 Category: Cancer & Oncology Source Type: research
Science vs. technology in radiation therapy from X-rays to ions
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 30, 2019 Category: Cancer & Oncology Source Type: research
Effects and side effects of plasmonic photothermal therapy in brain tissue
ConclusionsOur results stress the conclusion that a personalized analysis of the local environment is needed to balance the effect and side effects prior to plasmonic photothermal therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 23, 2019 Category: Cancer & Oncology Source Type: research
Comparison of the effect of rhodium citrate-associated iron oxide nanoparticles on metastatic and non-metastatic breast cancer cells
ConclusionMRC act at the nucleus, inhibiting DNA synthesis and proliferation and inducing cell death. These effects were verified in both tumor lines, but MDA-MB-231 cells seem to be more responsive to the effects of NPs. In addition, NPs may also disrupt the metastatic activity of remaining cells, by reducing their migratory capacity. Our results suggest that MRC nanoparticles are a promising nanomaterial that can provide a convenient route for tumor targeting and treatment, mainly in metastatic cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - September 10, 2019 Category: Cancer & Oncology Source Type: research
