Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications

ConclusionsDye-doped silica nanoparticles have found success in the immunodiagnostics domain and have also shown promise as bioimaging agents in human clinical trials. Their use in cancer delivery has been restricted to murine models, as has been the case for the vast majority of nanomaterials intended for cancer therapy. This is hampered by the need for more human-like disease models and the lack of standardisation towards assessing nanoparticle toxicity. However, developments in the manipulation of the protein corona have improved the understanding of fundamental bio –nano interactions, and will undoubtedly assist in the translation of silica nanoparticles for disease treatment to the clinic.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research