Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment
In this study, doxorubicin-loaded O-carboxymethyl chitosan/perfluorohexane nanodroplets (O-CS-DOX NDs) were synthesized and functionally tested as an effective drug delivery system in vitro and in vivo. O-CS-DOX NDs with small size (159.6 nm) and good doxorubicin encapsuling ability showed pH- and ultrasound-dependent drug release profile and satisfying ultrasound imaging performance. With high biocompatibility and biosafety, these nanodroplets could accumulate in the tumor sites and exhibit high efficiency in inhibiting tumor grow th with ultrasound irradiation. These stable, safe and smart O-CS-DOX NDs showed promising...
Source: Cancer Nanotechnology - March 11, 2023 Category: Cancer & Oncology Source Type: research
Doxorubicin-loaded liposomes surface engineered with the matrix metalloproteinase-2 cleavable polyethylene glycol conjugate for cancer therapy
ConclusionAltogether, the MMP-2-cleavable CLs have great potency to improve tumor-targeted drug delivery and cellular/tumor-vasculature uptake which merits further investigation. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 7, 2023 Category: Cancer & Oncology Source Type: research
Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma
AbstractFerroptosis represents an innovative strategy to overcome the resistance of traditional cancer therapeutic through lethal lipid peroxidation leading to immunogenic cell death. However, the inefficiency of ferroptosis inducers and mild immunogenicity restrict the further clinical applications. Herein, engineering exosome-mimic M1 nanovesicles (MNV) were prepared by serial extrusion of M1 macrophage and served as an efficient vehicle for docosahexaenoic acid (DHA) delivery. MNV loaded with DHA (MNV@DHA) could promote more DHA accumulation in tumor cells, depletion glutathione and reduction of lipid antioxidant glutat...
Source: Cancer Nanotechnology - March 7, 2023 Category: Cancer & Oncology Source Type: research
Coupling magnetic levitation of graphene oxide –protein complexes with blood levels of glucose for early detection of pancreatic adenocarcinoma
ConclusionIf confirmed by further studies on larger cohorts, a multiplexed Maglev-based nanotechnology-enabled blood test could be employed as a screening tool for PDAC in populations with hyperglycemia. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 1, 2023 Category: Cancer & Oncology Source Type: research
Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts
This article provides an overview of various radionuclides used in diagnostic, therapeutic, and theranostic applications, radionuclide production through different techniques, conventional radionuclide delivery systems, and advancements in the delivery systems for nanomaterials. The review also provides insights into fundamental concepts necessary to improve currently available radionuclide agents and formulate new nano-radiopharmaceuticals. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 27, 2023 Category: Cancer & Oncology Source Type: research
Targeted therapy for HCC using dumbbell-like nanoparticles conjugated to monoclonal antibodies against VEGF and cancer stem cell receptors in mice
ConclusionDumbbell-like nanoparticles conjugated to anti-CD90 and Avastin is a novel therapeutic tool for HCC to target cancer stem cells and endothelial cells in the niche of the tumor. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 25, 2023 Category: Cancer & Oncology Source Type: research
Carboxylated graphene quantum dots-mediated photothermal therapy enhances drug-membrane permeability, ROS production, and the immune system recruitment on 3D glioblastoma models
AbstractGraphene quantum dots (GQDs) are biocompatible nanoparticles employed in biomedical field, thanks to their size and photophysical properties. GQDs have shown the capability to cross biological barriers, including the blood –brain barrier, which makes them promising agents for brain diseases therapy. It has been shown that surface-functionalized GQDs enhance membrane fluidity and intracellular uptake, exerting a synergistic effect with antitumor drugs at subtherapeutic doses. Here, we tested GQDs effects in combinat ion with chemotherapeutic agents doxorubicin and temozolomide, on a complex 3D spheroid model of g...
Source: Cancer Nanotechnology - February 24, 2023 Category: Cancer & Oncology Source Type: research
Functional targeted therapy for glioma based on platelet membrane-coated nanogels
AbstractGlioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood –brain barrier (BBB) hinders the efficient uptake of therapeutics into the brain. Vasculogenic mimicry (VM) formed by invasive glioma cells negatively affects the treatment of glioma. Herein, we developed a targeted biomimetic drug delivery system comprising a doxorubicin-loaded platelet membrane- coated nanogel (DOX@PNGs). The nanogels provide great redox/pH dual responsiveness, while the platelet membrane (PLTM) promotes stability and circulation time. In vitro cellular uptake and in vivo imaging experiments demo...
Source: Cancer Nanotechnology - February 24, 2023 Category: Cancer & Oncology Source Type: research
Targeted magnetochemotherapy modified by 5-Fu-loaded thermally on/off switching nanoheaters for the eradication of CT26 murine colon cancer by inducing apoptotic and autophagic cell death
In this study, we evaluated the efficacy of our new tumor-selective nanoplatforms at induction of apoptosis and autophagy, which was tested using active 5-fluorouracil (5-Fu)-based targeting of tumor cells in a BALB/c murine model of CRC combined with magnetic thermal therapy. Nanoparticles were synthesized and characterized by zeta sizer, transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The cytotoxicity and tissue uptake of 5-Fu-loaded folic acid (Fa)-modified magnetic nanoparticles (5-Fu/MNPs-Fa) was assessed using MTT, ICP-OES, and HPLC. The rate of apoptosis and autophagy, as two major in...
Source: Cancer Nanotechnology - February 23, 2023 Category: Cancer & Oncology Source Type: research
Optimized synthesis characterization and protective activity of quercetin and quercetin –chitosan nanoformula against cardiotoxicity that was induced in male Wister rats via anticancer agent: doxorubicin
AbstractThe study ’s goal was to look into the protective properties of quercetin (QU) in natural form and QU nanoparticles-loaded chitosan nanoparticles (QU-CHSNPs) against cardiotoxicity. The ionotropic gelation approach was adopted to form QU-CHSNPs. The characterizations were performed using advanced techniques . In vitro, the release profile of QU was studied. Cardiotoxicity was induced by doxorubicin (DOX) and protected via concurrent administration of QU and QU-CHSNPs. The heart's preventive effects of QU and QU-CHSNPs were manifested by a decrease in elevated serum activities of cardiac enzymes, as wel l as an im...
Source: Cancer Nanotechnology - February 13, 2023 Category: Cancer & Oncology Source Type: research
Preparation and characterization of the myricetin-loaded solid lipid nanoparticles decorated with folic acid-bound chitosan and evaluation of its antitumor and anti-angiogenic activities in vitro and in vivo in mice bearing tumor models
This study aimed to formulate myricetin in the form of solid lipid nanoparticles (SLN), decorated with chitosan (CS) and active-targeted with folic acid (FA). After characterization, the in vitro release, cytotoxicity, antioxidant, and ability of the formulation to induce apoptosis using flow cytometry, fluorescent microscopy, and real-time qPCR were examined. Then in vivo anti-angiogenesis on chick chorioallantoic membrane (CAM) and antitumor activities on mice bearing tumor models were investigated. The present study showed that the size of 310 nm and zeta potential of + 30 mV were acceptable for oral administrati...
Source: Cancer Nanotechnology - February 6, 2023 Category: Cancer & Oncology Source Type: research
Low-dose pleiotropic radiosensitive nanoformulations for three-pronged radiochemotherapy of hypoxic brain glioblastoma under BOLD/DWI monitoring
ConclusionsThis work provides a promising alternative for hypoxia-specific GBM-targeted comprehensive therapy, noninvasive monitoring, and precise prognosis.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 4, 2023 Category: Cancer & Oncology Source Type: research
Polyethylenimine-CO2 adduct templated CaCO3 nanoparticles as anticancer drug carrier
ConclusionsA new and effective vaterite drug carrier for anticancer therapy has been developed using PEI-CO2 adduct as both a CO2 source and vaterite template for CaCO3 mineralization. This delivery system illustrates an application of CO2 generation materials in drug delivery and has the potential for further development. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 4, 2023 Category: Cancer & Oncology Source Type: research
Pristine/folate-functionalized graphene oxide as two intrinsically radioiodinated nano-theranostics: self/dual in vivo targeting comparative study
ConclusionsIn conclusion, ICGO can be used as a selective tumor targeting agent for cancer theranosis with aid of I-131 that has a maximum beta and gamma energies of 606.3 and 364.5 keV, respectively. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 2, 2023 Category: Cancer & Oncology Source Type: research
Curcumin-loaded nanocomplexes alleviate the progression of fluke-related cholangiocarcinoma in hamsters
ConclusionCNCs (10 mg cur/kg bw) attenuate the progression of fluke-related CCA in hamsters partly via a NF-κB and FOXM1-mediated pathway. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 24, 2023 Category: Cancer & Oncology Source Type: research
