An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft
ConclusionsElectrostatic conjugation of the apMNKQ2 aptamer with PEI –IONPs impedes the accumulation of the latter in tumors, which appears to be necessary for PEI–IONPs to exert their antitumor activity.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 14, 2023 Category: Cancer & Oncology Source Type: research
Emerging applications of extracellular vesicles in tumor therapy
AbstractExtracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers.
Their physical, chemical and biological characteristics distinguish them as unique carriers with specific pharmacokinetic, circulating metabolic, and biodistribution patterns in the delivery of therapeutic cargoes. They are critical mediators in the pathology of many diseases, including inflammatory diseases, fibrosis, and cancer, but they are also essential mediators in immunomodulation, cancer treatment, infectious defense, and tissue repair. In this review, we emphasize recent advances in oncology therapy usin...
Source: Cancer Nanotechnology - June 14, 2023 Category: Cancer & Oncology Source Type: research
Nanoliposomal VEGF-R2 peptide vaccine acts as an effective therapeutic vaccine in a murine B16F10 model of melanoma
ConclusionOur findings suggest that the nanoliposomal formulation containing VEGFR-2 peptides could be a promising therapeutic vaccination approach capable of eliciting strong antigen-specific immunologic and anti-tumor responses. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 14, 2023 Category: Cancer & Oncology Source Type: research
Theranostic RGD@Fe3O4-Au/Gd NPs for the targeted radiotherapy and MR imaging of breast cancer
ConclusionOwing to an enhanced signal-to-noise ratio (SNR), as confirmed by the MRI of RGD receptor-expressing MDA-MB-231 cells, RGD@Fe3O4-Au/Gd NPs were found to confer higher radiosensitization and an overall better performance as a novel radiosensitizer for MRI-based breast cancer theranostics than Fe3O4-Au/Gd nanocomplex.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 14, 2023 Category: Cancer & Oncology Source Type: research
Nickel-gallate metal –organic framework as an efficient antimicrobial and anticancer agent: in vitro study
In this study, the Ni-gallate MOF nanostructures were characterized using scanning electron microscope (SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD), Fourier transform infra-red (FTIR), and Brunauer –Emmett–Teller (BET) method for surface area. The antibacterial and antifungal activity of gallic acid-based mesoporous framework nanostructure were tested, suggesting that Ni-gallate MOF has a dual anticancer and antimicrobial activity. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 9, 2023 Category: Cancer & Oncology Source Type: research
HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer
In conclusion, the developed Apt-cGO-DOX-Sili can be suggested as a simple and efficient drug delivery approach for breast chemotherapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - June 3, 2023 Category: Cancer & Oncology Source Type: research
Advances in blood –brain barrier-crossing nanomedicine for anti-glioma
AbstractGlioma is the most prevalent type of primary brain tumor, and glioblastoma multiforme (GBM) is the highest and most deadly type of primary central nervous system (CNS) tumor, affecting a significant number of patients each year, with a median overall survival of approximately 14.6 months after diagnosis. Despite intensive treatment, nearly all GBM patients experience recurrence, with a 5-year survival rate of about 5%. The protective BBB and high tumor heterogeneity prevent the effective delivery of drugs, resulting in the treatment failure of various drugs. The emergence o f nanometer-scale diagnosis and treatme...
Source: Cancer Nanotechnology - May 29, 2023 Category: Cancer & Oncology Source Type: research
ADAMTS9-AS1 inhibits tumor growth and drug resistance in clear cell renal cell carcinoma via recruiting HuR to enhance ADAMTS9 mRNA stability
AbstractThe lack of efficacious treatments for clear cell renal cell carcinoma (ccRCC) has led to a poor 5-year survival rate. Here, we found that the expression of ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) antisense RNA 1 (ADAMTS9-AS1) is commonly decreased in ccRCC tissues. Decreased ADAMTS9-AS1 is associated with advanced stages and poor prognosis in ccRCC patients. Additionally, we found that promoter hypermethylation contributes to the suppression of ADAMTS9-AS1 expression in ccRCC that contained relatively low levels of ADAMTS9-AS1. Further functional studies demonstrated that ADAMTS9-AS1 inh...
Source: Cancer Nanotechnology - May 20, 2023 Category: Cancer & Oncology Source Type: research
Early stage evaluation of cancer stem cells using platinum nanoparticles/CD133+ enhanced nanobiocomposite
ConclusionsAs a proof of concept, the designed nanobiocomposite was able to specifically detect CD133+ cells compared to whole HT-29 cells before magnetic activated cell sorting (MACS) process. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 20, 2023 Category: Cancer & Oncology Source Type: research
Targeting and sensitizing MDR cancer by an MMP2 and pH dual-responsive ZnO-based nanomedicine
In this study, we developed a novel dual-responsive hybrid ZnO NP (ZnO/DPPG/PEG-pp-PE) consisting of the ZnO NPs, phospholipid (DPPG), and enzyme-sensitive amphiphilic polymer (PEG-pp-PE), which could respond to both tumoral matrix metalloproteinase 2 (MMP2) and intracellular acidic pH, for tumor-targeted drug delivery and multidrug resistant (MDR) cancer treatment. The dual-responsive ZnO/DPPG/PEG-pp-PE could easily load the model drug, doxorubicin (DOX), and showed excellent physicochemical properties, stability, and MMP2 and pH dual sensitivity. The ZnO/DPPG/PEG-pp-PE/DOX showed the MMP2-dependent cellular uptake, enhan...
Source: Cancer Nanotechnology - May 20, 2023 Category: Cancer & Oncology Source Type: research
Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer
ConclusionThese results demonstrate that the fabrication of guidable MSC-based biohybrid microrobots is compatible with their biological and therapeutic functions. Thus, MSC-based biohybrid microrobots represent a novel way of delivering gene therapies to tumours as well as in the context of other diseases. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 19, 2023 Category: Cancer & Oncology Source Type: research
Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma
AbstractTumor hypoxia is an important factor for developing resistance to radiation therapy (RT) and presents a bleak prognosis in cancer patients undergoing treatment for RT resistant hepatocellular carcinoma. Here, we present the synthesis of liposome-coated Mn3O4 (MGN) nanoparticles (Lipo-MGN) and investigation of their therapeutic potential with RT utilizing a HepG2 cancer model. According to in vitro research, Lipo-MGN effectively produced oxygen in the presence of H2O2 and significantly reduced the expression of HIF-1 in human HepG2 cells that were under hypoxic conditions. Lipo-MGN reversed the radio-resistance brou...
Source: Cancer Nanotechnology - May 16, 2023 Category: Cancer & Oncology Source Type: research
Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections
AbstractThe accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO2 + QDs based on the combination of rare earth upconversion (UCNPs) and perovskite quantum dots (QDs) and design a new fluorescent probe MB-UCNP@SiO2 + QDs with molecular beacon (MB) as the carrier, that can be excited by near-infrared light, emitted ...
Source: Cancer Nanotechnology - May 12, 2023 Category: Cancer & Oncology Source Type: research
Inhibition of tumor immune escape by blocking PD-1/PD-L1 engagement with dual-targeting molecularly imprinted polymer layer
In this study, we present a different strategy, an aptamer modified molecularly imprinted polymer layer (APD –PD-L1–MIPL), to break PD-1/PD-L1 binding for the inhibition of tumor immune escape. The APD–PD-L1–MIPL is prepared by a MIP layer on the surface of CaCO3 nanospheres using the peptide segment of the PD-L1 protein as a template. The subsequent removal of CaCO3 nanospheres core formats the MIP layer, to ensure high specifically matching capacity and short equilibrium time. A PD-L1 antagonistic DNA aptamer, is modified into the MIP layer to enhance recognition capacity, resulting in dual-targeting functionalit...
Source: Cancer Nanotechnology - May 11, 2023 Category: Cancer & Oncology Source Type: research
Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcoma
ConclusionOverall, these findings suggested that using Man-NPs as an immunotherapeutic approach to treat osteosarcoma may be promising.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - May 9, 2023 Category: Cancer & Oncology Source Type: research
