Preparation and characterization of cetuximab-loaded egg serum albumin nanoparticles and their uses as a drug delivery system against Caco-2 colon cancer cells
AbstractTo avoid the harmful side effects of cetuximab and improve its therapeutic efficacy, egg serum albumin (ESA) was used as a targeting drug carrier moiety for cancer therapy against Caco-2 colon cancer cells. The simple improved desolvation method was used to synthesize ESA nanoparticles (ESA-NPs) and cetuximab-loaded albumin nanoparticles (CET-ANPs) with glutaraldehyde as a crosslinking agent. The ESA-NPs and CET-ANPs were spherically shaped, and their sizes and surface potentials were 100 and − 24 nm and 170 and − 20 nm, respectively, as determined using transmission electron microscopy (TEM) and a Z...
Source: Cancer Nanotechnology - January 16, 2023 Category: Cancer & Oncology Source Type: research
Novel delivery system with a dual –trigger release of savory essential oil by mesoporous silica nanospheres and its possible targets in leukemia cancer cells: in vitro study
ConclusionsThese results suggest potential impacts for nanoformulations composed of SA with a sustained release pattern controlled by dual –trigger release of pH/GSH that enhanced anticancer cells. This approach may offer a new route for using EOs as new targets for cancers and open the door for deep preclinical investigations. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 13, 2023 Category: Cancer & Oncology Source Type: research
A simple self-assembling system of melittin for hepatoma treatment
ConclusionOur research provides a promising strategy for the development of natural self-assembled biological peptides for clinical application, particularly for transforming toxic peptides into safe therapeutic systems.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 10, 2023 Category: Cancer & Oncology Source Type: research
SN38-loaded nanomedicine mediates chemo-radiotherapy against CD44-expressing cancer growth
ConclusionsTherefore, this SN38-loaded and HA-incorporated nanoparticle combined with radiotherapy may be a promising therapeutic artifice for CRC in the future. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 3, 2023 Category: Cancer & Oncology Source Type: research
The human immune cell simulated anti-breast cancer nanorobot: the efficient, traceable, and dirigible anticancer bio-bot
ConclusionThe hisABC-NB ’s traceability, dirigibility, and selective cytotoxicity were approved, which are the three main required factors for an efficient anticancer compound. Therefore, it has the potential to be used as an intelligent safe anticancer agent for human breast cancer treatment. However, several in vitro a nd in vivo studies are required to clarify its selectivity, stability, and safety. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 13, 2022 Category: Cancer & Oncology Source Type: research
Ultrasmall Fe3O4 and Gd2O3 hybrid nanoparticles for T1-weighted MR imaging of cancer
AbstractGadolinium-based contrast agents (GdCAs) have been the most frequently usedT1-weighted magnetic resonance imaging (MRI) contrast agents for decades. However, they have serious disadvantages such as low longitudinal relaxivity value (r1) and high dose associated-nephrotoxicity that restrict their wide applications. These emphasize the need for an ideal stable and biocompatibleT1-weighted CA with high contrast enhancement performance. Here, we propose a wet-chemical synthesis technique to form a nanocomposite consisting of ultrasmall iron oxide nanoparticles (US-IO) and Gd2O3 hybrid nanoparticles stabilized with dext...
Source: Cancer Nanotechnology - December 9, 2022 Category: Cancer & Oncology Source Type: research
Cisplatin-loaded metal –phenolic network with photothermal-triggered ROS generation for chemo-photothermal therapy of cancer
AbstractDeveloping multifunctional composites has received widespread attention for cancer treatment. Herein, a metal –phenolic network (MPN)-based composite loading with chemotherapy agents (TAFP) exhibits high anti-tumor therapeutic efficacy via photothermal therapy (PTT), chemo-dynamic therapy (CDT), and chemotherapy. The nanocomposite was formed by mixing the chemotherapeutic drugs (cisplatin, DDP) into the t annic acid (TA) and Fe3+ network (TAFe) to integrate the synergistic effect of PTT, CDT, and chemotherapy. Due to the acidic tumor microenvironment, the active substances could be released with the degradation o...
Source: Cancer Nanotechnology - December 5, 2022 Category: Cancer & Oncology Source Type: research
Correction: Nanoparticles for MRI-guided radiation therapy: a review
(Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - December 5, 2022 Category: Cancer & Oncology Source Type: research
Tyrosine kinase inhibitor-loaded biomimetic nanoparticles as a treatment for osteosarcoma
In this study, we demonstrate enhanced targeting ability and maintain potent ponatinib nano-therapeutic activity, while also reducing toxicity. In in vitro two- and three-dimensional models, we demonstrate that ponatinib-loaded biomimetic NPs maintain the efficacy of the free drug, while in vivo we show that they can improve tumor targeting, slow tumor growth, and reduce evidence of systemic toxicities. Though there is limited Pon encapsulation within NPs, this platform may improve current therapeutic approaches and reduce dosage-related side effects to achieve better clinical outcomes in OS patients.Graphical Abstract (So...
Source: Cancer Nanotechnology - December 2, 2022 Category: Cancer & Oncology Source Type: research
Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells
ConclusionThus, our data suggest the CNPs intrinsic nanozyme activity of phosphatase may crosstalk with drug resistance, which can be reversed upon modulations. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - November 28, 2022 Category: Cancer & Oncology Source Type: research
Nanoparticles for MRI-guided radiation therapy: a review
AbstractThe development of nanoparticle agents for MRI-guided radiotherapy is growing at an increasing pace, with clinical trials now underway and many pre-clinical evaluation studies ongoing. Gadolinium and iron-oxide-based nanoparticles remain the most clinically advanced nanoparticles to date, although several promising candidates are currently under varying stages of development. Goals of current and future generation nanoparticle-based contrast agents for MRI-guided radiotherapy include achieving positive signal contrast on T1-weighted MRI scans, local radiation enhancement at clinically relevant concentrations and, w...
Source: Cancer Nanotechnology - November 12, 2022 Category: Cancer & Oncology Source Type: research
Development of doped ZnO-based biomimicking and tumor-targeted nanotheranostics to improve pancreatic cancer treatment
AbstractDespite different nanomaterials were developed so far against cancer, their potential drawbacks are still scarcely considered. The off-target delivery of a therapeutic compound, as well as the non-specific uptake of these nanomaterials by healthy tissues or organs, and their potential immunogenicity are some of the major issues that still have to be faced prior to a successful clinical translation. This work aims to develop an innovative theranostic, biocompatible, and drug-loaded nanoconstruct based on Gadolinium-doped Zinc Oxide (ZnO-Gd) nanocrystals (NCs), focusing on one of the most lethal diseases, i.e., pancr...
Source: Cancer Nanotechnology - November 5, 2022 Category: Cancer & Oncology Source Type: research
Fabrication and application of cisplatin-loaded mesoporous magnetic nanobiocomposite: a novel approach to smart cervical cancer chemotherapy
AbstractThere are significant challenges in developing drug carriers for therapeutic perspective. We have investigated a novel nanocarrier system, based on combining functionalized magnetic nanocomposite with Metal –Organic Frameworks (MOFs). Magnetic nanoparticles modified using biocompatible copolymers may be suitable for delivering hydrophobic drugs, such as cisplatin. Furthermore, compared to polymeric nanocarriers, nanocomposite constructed from zeolitic imidazolate framework-8 (ZIF-8) have demonstrated better drug loading capacity, as well as excellent pH-triggered drug release. Cisplatin-encapsulated Fe3O4@SiO2-ZI...
Source: Cancer Nanotechnology - November 2, 2022 Category: Cancer & Oncology Source Type: research
Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity
ConclusionsBecause of the absence of toxic chemical surfactants, the eco-friendly synthesis method of Au NPs modified by natural phytochemicals avoided tedious separation and modification processes. On the other hand, Au@ginsenoside Rh2 NPs also improved water solubility and bioavailability of the hydrophobic drug ginsenoside Rh2. It broadened minds for preparation and application of traditional Chinese medicines (TCMs) modified metal nanoparticles and deserved further study. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 29, 2022 Category: Cancer & Oncology Source Type: research
Resveratrol-loaded gold nanoparticles enhance caspase-mediated apoptosis in PANC-1 pancreatic cells via mitochondrial intrinsic apoptotic pathway
ConclusionsThe results demonstrate that RVT@PVP-GNPs enhance the anti-tumor efficacy of free RVT by activating the intrinsic apoptotic pathway and could be considered as potential anti-tumor drug candidates against pancreatic cancer cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - October 28, 2022 Category: Cancer & Oncology Source Type: research
