An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft

ConclusionsElectrostatic conjugation of the apMNKQ2 aptamer with PEI –IONPs impedes the accumulation of the latter in tumors, which appears to be necessary for PEI–IONPs to exert their antitumor activity.Graphical Abstract

http://link.springer.com/10.1186/s12645-023-00204-8

Source: Cancer Nanotechnology - June 14, 2023 Category: Cancer & Oncology Source Type: research