The evaluation of DLCO changes in patients with relatively higher lung shunt fractions receiving TARE
ConclusionOur study showed that a significant reduction in DLCO after TARE may occur in patients with relatively higher lung shunt fractions. Further studies with larger sample sizes are needed to better investigate the changes in DLCO in patients with high lung shunt fractions. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
Dosimetry and efficacy of a tau PET tracer [18F]MK-6240 in Japanese healthy elderly and patients with Alzheimer ’s disease
ConclusionThe findings supported safety and efficacy of [18F]MK-6240 as a tau PET tracer for Japanese populations. Even though the number of subjects was limited, the radiation dosimetry profiles, pharmacokinetics, and biodistribution of [18F]MK-6240 were consistent with those for non-Japanese populations.Trial registrationJapan Pharmaceutical Information Center ID, JapicCTI-194972. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
PET-guided attention for prediction of microvascular invasion in preoperative hepatocellular carcinoma on PET/CT
ConclusionThe model exploits the particularities of the molecular metabolic function of PET and the anatomical structure of CT and can strongly improve the accuracy of clinical diagnosis of MVI. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
Evaluation of standardized uptake value on 131I-6 β-iodomethyl-19-norcholesterol scintigraphy for diagnosis of primary aldosteronism and correspondence with adrenal venous sampling
ConclusionIn this study, SUV on NP-59 SPECT helped in the diagnosis of PA and was consistent with the results of AVS in nearly all cases. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
Comparison of 1-h with 3-h planar 99mTc-pyrophosphate scintigraphy in patients with suspected transthyretin cardiac amyloidosis using SPECT as a reference standard
ConclusionsIn the assessment of ATTR-CA using PYP imaging, visual scores on 3-h anterior planar images for identifying positive PYP SPECT had lower sensitivity and higher specificity in comparison with those on 1-h anterior planar images. The diagnostic value of the visual scores on 1-h and 3-h anterior planar images was not improved by adding the H/CL ratio. Blood pool activity of PYP was not significantly associated with renal dysfunction. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
Glucose metabolic heterogeneity correlates with pathological features and improves survival stratification of resectable lung adenocarcinoma
ConclusionThe glycolytic heterogeneity portrayed by entropy is associated with aggressive histopathological characteristics. The proposed entropy-based models may provide more sophisticated survival stratification in addition to histopathology and may enable personalized treatment strategies for resectable lung cancer. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
Reproducibility assessment of uptake on dedicated breast PET for noise discrimination
ConclusionsOur results demonstrated that reproducibility assessment helped reduce false-positive findings caused by noise on dbPET without lowering the sensitivity for malignancy. While subjective visual assessment was also efficient in increasing PPV, it occasionally missed malignant uptake. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
Acknowledgements to Reviewers
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
PET-guided attention for prediction of microvascular invasion in preoperative hepatocellular carcinoma on PET/CT
ConclusionThe model exploits the particularities of the molecular metabolic function of PET and the anatomical structure of CT and can strongly improve the accuracy of clinical diagnosis of MVI. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 1, 2023 Category: Nuclear Medicine Source Type: research
Acknowledgements to Reviewers
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 25, 2023 Category: Nuclear Medicine Source Type: research
Effect of scan-time shortening on the 11C-PHNO binding potential to dopamine D3 receptor in humans and test –retest reliability
ConclusionThe scan-time shortening causes bias and decreasing test –retest reliability of11C-PHNO BPND. However, in the whole-body PET system, 90-min scan duration was sufficient for estimating the11C-PHNO BPND in the D3R-rich striatum and SN with small bias and at the test –retest reliability comparable to those derived from 120-min scans using the brain-dedicated PET systems. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 19, 2023 Category: Nuclear Medicine Source Type: research
18F-FP-CIT dopamine transporter PET findings in the striatum and retina of type 1 diabetic rats
ConclusionsDA neuron loss in the striatum and retina of T1DM rat model can be non-invasively detected with PET imaging using18F-FP-CIT targeting DAT.18F-FP-CIT PET imaging may be a useful tool used in clinic for DR and diabetic brain injury diagnosis in future. The expression level of DAT in striatum and retina may act as a new biomarker for DR and diabetic brain injury diagnosis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 6, 2023 Category: Nuclear Medicine Source Type: research
A review of harmonization strategies for quantitative PET
AbstractPET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are variable depending on technical, biological, and physical factors. The variability may have a significant impact on a study outcome. Appropriate scanner calibration and quality control, standardization of imaging protocols, and any necessary harmonization strategies are essential to make use of PET as a biomarker with low bias and variability. This review summarizes benefi...
Source: Annals of Nuclear Medicine - January 6, 2023 Category: Nuclear Medicine Source Type: research
18F-FP-CIT dopamine transporter PET findings in the striatum and retina of type 1 diabetic rats
ConclusionsDA neuron loss in the striatum and retina of T1DM rat model can be non-invasively detected with PET imaging using18F-FP-CIT targeting DAT.18F-FP-CIT PET imaging may be a useful tool used in clinic for DR and diabetic brain injury diagnosis in future. The expression level of DAT in striatum and retina may act as a new biomarker for DR and diabetic brain injury diagnosis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 6, 2023 Category: Nuclear Medicine Source Type: research
