New index to assess the extent of bone disease in patients with prostate cancer using SPECT/CT
ConclusionsAlthough assessed in a small number of cases, the new index for assessing the extent of bone disease using SPECT/CT imaging was highly value than BSI and was significantly correlated with alkaline phosphatase. Therefore, this study suggests that BMVI could improve the low sensitivity of BSI in patients with low extent of disease grade. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 1, 2022 Category: Nuclear Medicine Source Type: research
Role of baseline 68Ga-PSMA PET/CT-derived whole-body volumetric parameters in predicting survival outcomes of metastatic castration-resistant prostate cancer patients receiving first-line treatment
ConclusionThe wbPSMA-TV may be a useful tool to reflect tumor burden and predict survival outcomes in patients with mCRPC. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 23, 2022 Category: Nuclear Medicine Source Type: research
Identification of patients with Graves ’ disease who benefit from high-dose radioactive iodine therapy
ConclusionAlthough the overall remission rate was not significantly different between the patients who received high- or low-dose I-131, treatment with high-dose RAI may improve the probability of remission in patients with a massive thyroid volume and/or high-TSAb Graves' disease. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 16, 2022 Category: Nuclear Medicine Source Type: research
PD1 blockade alters cell-cycle distribution and affects 3 ′-deoxy-3′-[18F]fluorothymidine uptake in a mouse CT26 tumor model
ConclusionPD1 blockade-induced alteration of the TME increased CT26 tumor cells in the G2/M phase, which have high thymidine kinase 1 activity. Therefore, [18F]FLT is taken up by tumor cells even if tumor proliferation is suppressed. This observation may be useful for evaluating the response to immunotherapy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 15, 2022 Category: Nuclear Medicine Source Type: research
Deep-learning prediction of amyloid deposition from early-phase amyloid positron emission tomography imaging
ConclusionThis study demonstrates the feasibility of an image-based deep-learning framework to predict delayed patterns of Amyloid PET uptake using only the early phase images. This AI-based image generation method has the potential to reduce scan time for amyloid PET and increase the patient throughput, without sacrificing diagnostic accuracy for amyloid positivity. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 1, 2022 Category: Nuclear Medicine Source Type: research
Recent topics of the clinical utility of PET/MRI in oncology and neuroscience
AbstractSince the inline positron emission tomography (PET)/magnetic resonance imaging (MRI) system appeared in clinical, more than a decade has passed. In this article, we have reviewed recently-published articles about PET/MRI. There have been articles about staging in rectal and breast cancers by PET/MRI using fluorodeoxyglucose (FDG) with higher diagnostic performance in oncology. Assessing possible metastatic bone lesions is considered a proper target by FDG PET/MRI. Other than FDG, PET/MRI with prostate specific membrane antigen (PSMA)-targeted tracers or fibroblast activation protein inhibitor have been reported. Es...
Source: Annals of Nuclear Medicine - July 27, 2022 Category: Nuclear Medicine Source Type: research
The safe handling of 211At compounds
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 27, 2022 Category: Nuclear Medicine Source Type: research
Response to the letter to the editor
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 26, 2022 Category: Nuclear Medicine Source Type: research
The feasibility of ultralow-activity 18F-FDG dynamic PET imaging in lung adenocarcinoma patients through total-body PET/CT scanner
ConclusionsThe 10 × reduction of injected18F-FDG could achieve comparable kinetic metrics and T/N ratios by total-body dynamic PET imaging in lung adenocarcinoma patients. Ultralow-activity total-body PET imaging is feasible for clinical practice in oncological patients without obesity, especially in dynamic PET scanning. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 20, 2022 Category: Nuclear Medicine Source Type: research
Brain PET motion correction using 3D face-shape model: the first clinical study
ConclusionOur motion correction method provided good accuracy for the volunteer data which suggested it is useable in clinical settings. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 19, 2022 Category: Nuclear Medicine Source Type: research
Pretreatment [18F]FDG PET/CT and MRI in the prognosis of nasopharyngeal carcinoma
ConclusionsThe present study highlights N-SUV max, NTR and MTV derived from [18F]FDG PET/CT, and skull-base bone invasion defined by HN-MRI, as promising metabolic and anatomic prognosis biomarkers for NPC. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 14, 2022 Category: Nuclear Medicine Source Type: research
Advances in positron emission tomography tracers related to vascular calcification
AbstractMicrocalcification, a type of vascular calcification, increases the instability of plaque and easily leads to acute clinical events. Positron emission tomography (PET) is a new examination technology with significant advantages in identifying vascular calcification, especially microcalcification. The use of the18F-NaF is undoubtedly the benchmark, and other PET tracers related to vascular calcification are also currently in development. Despite all this, a large number of studies are still needed to further clarify the specific mechanisms and characteristics. This review aimed at providing a summary of the applicat...
Source: Annals of Nuclear Medicine - July 14, 2022 Category: Nuclear Medicine Source Type: research
18F FDG-PET/CT analysis of spread through air spaces (STAS) in clinical stage I lung adenocarcinoma
ConclusionsSUVmax rather than MTV and TLG were shown to be valuable indices for the prediction of STAS in clinical stage I lung adenocarcinoma. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 12, 2022 Category: Nuclear Medicine Source Type: research
Radiological predictive factors on preoperative multimodality imaging are related to Oncotype DX recurrence score in estrogen-positive/human epidermal growth factor receptor 2-negative invasive breast cancer: a cross-sectional study
ConclusionsThe combination of perpendicular tumor growth orientation to Cooper ’s ligaments on MRI and a low SUVmax on PET/CT may predict a low ODXRS. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 11, 2022 Category: Nuclear Medicine Source Type: research
Automated semi-quantitative amyloid PET analysis technique without MR images for Alzheimer ’s disease
ConclusionsThis semi-quantitative analysis technique using18F-flutemetamol-PET calculated SUVr and CL automatically without anatomical images. Moreover, it objectively and homogeneously interpreted positive or negative A β burden in the brain as a supplemental tool for the visual reading of equivocal cases in routine clinical practice. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 11, 2022 Category: Nuclear Medicine Source Type: research
