Celebrating 80 years anniversary of radioiodine for use in thyroid cancer and perspectives for theranostics
AbstractIn 1942, eighty years ago, Dr. Hertz first conducted radioiodine (RAI) diagnosis and therapy for thyroid disorders followed later by the successful treatment of thyroid cancer patients using RAI. In 2022, memorial 80 years later, alpha emitter astatine (211At), an analogue for iodine, was successfully administered to a patient with refractory thyroid cancer in Japan as a phase-1 clinical trial (first-in-human). Over the past two decades, the use of68 Ga labeled peptides for somatostatin receptor (SSTR)-targeted PET imaging followed by beta or alpha emitters labeled SSTR-analogues for peptide receptor radionucl...
Source: Annals of Nuclear Medicine - November 8, 2022 Category: Nuclear Medicine Source Type: research
Outcome of patients with differentiated thyroid cancer treated with empirical radioiodine therapy on the basis of Thyroglobulin Elevation Negative Iodine Scintigraphy (TENIS) syndrome without structural disease: a retrospective cohort study
ConclusionPatients with TENIS syndrome without structural disease can benefit from empirical RAI therapy in both PFS and Tg normalization. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - November 1, 2022 Category: Nuclear Medicine Source Type: research
Added prognostic value of molecular imaging parameters over proliferation index in typical lung carcinoid: an [18F]FDG PET/CT and SSTR imaging study
ConclusionVolumetric and semi-quantitative parameters measured using [18F]FDG PET/CT and SSTR imaging combined with Ki67 may provide a reference for prognosis evaluation of patients with TC, to better stratify risk groups with the goal of developing individualized therapeutic strategies. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 30, 2022 Category: Nuclear Medicine Source Type: research
Differentiation of lower limb vasculitis from physiological uptake on FDG PET/CT imaging
ConclusionsWhen PET/CT is used for the diagnosis and classification of vasculitis, the physiological uptake of lower limb vessels may mislead the diagnosis. PET/CT imaging features or delayed imaging improved diagnostic efficacy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 28, 2022 Category: Nuclear Medicine Source Type: research
Detection of apoptosis by [18F]ML-10 after cardiac ischemia –reperfusion injury in mice
ConclusionThe tracer [18F]ML-10 is suitable for detecting apoptosis after transient LAD ligation in mice. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 28, 2022 Category: Nuclear Medicine Source Type: research
Prognostic value of [18F]FDG-PET prior to [131I]MIBG treatment for pheochromocytoma and paraganglioma (PPGL)
ConclusionHigh MTV and high TLG were significantly associated with a poor prognosis after [131I]MIBG therapy for PPGLs. Other treatment strategies for such patients may need to be explored. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 27, 2022 Category: Nuclear Medicine Source Type: research
Consistency and prognostic value of preoperative staging and postoperative pathological staging using 18 F-FDG PET/MRI in patients with non-small cell lung cancer
ConclusionsIn NSCLC, pathologic staging was better at predicting recurrence, and preoperative PET/MRI staging was better at predicting survival. Preoperative staging by PET/MRI was superior to CT in diagnosing hilar and mediastinal lymph-node metastases, which contributed to the high concordance with pathologic staging. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 20, 2022 Category: Nuclear Medicine Source Type: research
Metabolic tumor volume predicts long-term survival after transplantation for unresectable colorectal liver metastases: 15 years of experience from the SECA study
ConclusionMTV of liver metastases is highly predictive of long-term OS, DFS and PRS after LT for unresectable CRLM and should be implemented in risk stratification prior to LT. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 14, 2022 Category: Nuclear Medicine Source Type: research
Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA)
ConclusionWe have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with99mTc and18F compared to SIA. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 13, 2022 Category: Nuclear Medicine Source Type: research
Correction to: [99mTc]-labeling and evaluation of a new linear peptide for imaging of glioblastoma as a αvβ3-positive tumor
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 12, 2022 Category: Nuclear Medicine Source Type: research
The effect of sodium iodide symporter protein on ablation success in patients with differentiated thyroid cancer
ConclusionsIn conclusion, we did not find any significant difference between successful and unsuccessful ablation groups in terms of NIS expression; however, we concluded that the intracellular (cytoplasmic) localization of NIS is one of the leading causes of ablation failure regardless of NIS expression in DTC patients. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 10, 2022 Category: Nuclear Medicine Source Type: research
Effect of radioactivity outside the field of view on image quality of dedicated breast positron emission tomography: preliminary phantom and clinical studies
ConclusionsFDG uptake in the myocardium affected dbPET images of the left breast, especially near the chest wall. Further, the effect of RI outside the FOV, such as in the myocardium, must be considered in the quantitative evaluation of breast cancer using dbPET. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 8, 2022 Category: Nuclear Medicine Source Type: research
Clinical impact of amyloid PET using 18F-florbetapir in patients with cognitive impairment and suspected Alzheimer ’s disease: a multicenter study
ConclusionAmyloid PET using18F-florbetapir PET had a substantial clinical impact on AD and non-AD diagnosis and on patient management by enhancing diagnostic confidence. In addition, the quantitative measures may improve the visual interpretation of amyloid positivity. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 4, 2022 Category: Nuclear Medicine Source Type: research
Chronic fluoxetine enhances extinction therapy for PTSD by evaluating brain glucose metabolism in rats: an [18F]FDG PET study
ConclusionsChronic fluoxetine enhanced the effects of extinction training in a rat model of PTSD. In vivo PET imaging may provide a promising approach for evaluation chronic fluoxetine treatment of PTSD. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 30, 2022 Category: Nuclear Medicine Source Type: research
Attenuation correction for phantom tests: an alternative to maximum-likelihood attenuation correction factor-based correction for clinical studies in time-of-flight PET
ConclusionsPAC is an attenuation correction method that can ensure the performance in phantom test, and is considered to be a reasonable alternative to clinically used ML-ACF-based attenuation correction. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 28, 2022 Category: Nuclear Medicine Source Type: research
