Recent topics in fibroblast activation protein inhibitor-PET/CT: clinical and pharmacological aspects
This article aimed to provide a comprehensive overview of the recently published articles investigating FAPI and discuss its clinical utility with an emphasis on its application in tumor diagnostics. Numerous radiopharmaceutical FAPIs, including18F- and68Ga-labeled compounds, have been developed, and they offer various advantages and applications. With the progress in the FAPI PET synthesis to enhance accumulation and retention in pathological lesions, future studies are expected to provide valuable data on its therapeutic efficacy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 20, 2023 Category: Nuclear Medicine Source Type: research
High efficacy of particle beam therapies against tumors under hypoxia and prediction of the early stage treatment effect using 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography
ConclusionsCarbon beam treatment shows a strong therapeutic effect against cells under hypoxia. Unlike normoxic tumors, it is desirable to perform18F-FLT positron emission tomography 2 –3 days after irradiation for early prediction of the treatment effect.Graphical Abstract (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 19, 2023 Category: Nuclear Medicine Source Type: research
Difference in arterial FDG accumulation in healthy study participants between digital PET/CT and standard PET/CT
ConclusionsArterial FDG accumulation was significantly higher with digital PET/CT compared to conventional PET/CT. With digital PET/CT, an arterial FDG accumulation equal to the liver may not to be considered as abnormal accumulation. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 18, 2023 Category: Nuclear Medicine Source Type: research
Correction: Practice recommendation for measuring washout rates in 123I-BMIPP fatty acid images
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 14, 2023 Category: Nuclear Medicine Source Type: research
Performance of deep learning models for response evaluation on whole-body bone scans in prostate cancer
ConclusionWith preprocessing of spatial and count normalization, our deep learning model achieved excellent performance in classifying the therapeutic response of bone scans in patients with prostate cancer. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 11, 2023 Category: Nuclear Medicine Source Type: research
Impact of irregular waveforms on data-driven respiratory gated PET/CT images processed using MotionFree algorithm
ConclusionsThe PET images using AMF with the DDG algorithm provided the precise waveform of respiratory motions and the improvement of quantitative accuracy in the four types of respiratory waveforms. The improvement rate was the most obvious in expiratory-paused waveforms, and the most subtle in those with a shifted baseline. Optimizing the width parameter in irregular waveform will benefit patients who breathe like the waveform with the shifted baseline. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 5, 2023 Category: Nuclear Medicine Source Type: research
18F-FES and 18F-FDG PET/CT imaging as a predictive biomarkers for metastatic breast cancer patients undergoing cyclin-dependent 4/6 kinase inhibitors with endocrine treatment
ConclusionsThis study shows that FDG and FES PET imaging may serve as valuable tools for patient selection in the context of CDK4/6 inhibitor therapy combined with endocrine treatment, and have the potential to function as prognostic biomarkers. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 3, 2023 Category: Nuclear Medicine Source Type: research
Enhancing PSMA PET/CT imaging of prostate cancer: investigating the impact of multiple time point evaluation, diuretic administration, cribriform pattern, and intraductal carcinoma
ConclusionsCribriform pattern correlates with higher Gleason 4 ratios and SUVs in PSMA PET. Intraductal carcinoma is associated with larger tumors but not higher Gleason 4 ratios and SUVs. Multiple late imaging times did not enhance tumor detection and may pose tolerability issues for some patients. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 3, 2023 Category: Nuclear Medicine Source Type: research
The OCDA-Net: a 3D convolutional neural network-based system for classification and staging of ovarian cancer patients using [18F]FDG PET/CT examinations
ConclusionsThe proposed 3D CNN-based models provide potential tools for recurrence/post-therapy surveillance in OC. The OCDAc-Net and the OCDAs-Net model provide a new prognostic analysis method that can utilize PET images without pathological findings for diagnostic classification and staging. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 28, 2023 Category: Nuclear Medicine Source Type: research
Convolutional neural network-based program to predict lymph node metastasis of non-small cell lung cancer using 18F-FDG PET
ConclusionThe CNN-based program could potentially assist radiologists in predicting lymph node metastasis by increasing diagnostic confidence and reducing reading time without affecting diagnostic accuracy, at least in the limited situations using MIP images. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 27, 2023 Category: Nuclear Medicine Source Type: research
From FDG and beyond: the evolving potential of nuclear medicine
This article reviews recently established evidence of FDG and non-FDG drugs and anticipates the future trajectory of nuclear medicine. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 25, 2023 Category: Nuclear Medicine Source Type: research
Inflammatory atherosclerotic plaque identification by SPECT/CT imaging of LFA-1 using [111In] In-DANBIRT in a novel dyslipidemic rat model
ConclusionOur results are highly encouraging as they demonstrated the potential of [111In] In-DANBIRT to detect early-stage atherosclerosis in rats that might otherwise go unnoticed by other methods, showcasing the high sensitivity of [111In] In-DANBIRT. Our future studies will aim to establish a viable T2D atherosclerosis model in rats with more advanced stages of the disease to further demonstrate the reliability of [111In] In-DANBIRT as a diagnostic tool for patients in all stages of atherosclerosis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 24, 2023 Category: Nuclear Medicine Source Type: research
Association of mismatch repair deficiency in endometrial cancer with 18F-FDG PET/CT and clinicopathological features and their prognostic value
ConclusionHigher SUVmax was associated with MMR deficiency in EC patients with endometrioid type, advanced stage, or deep myometrial invasion, which may be useful for predicting the MMR status and thus aiding in determination of immunotherapy for patients with EC. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 24, 2023 Category: Nuclear Medicine Source Type: research
Practice recommendation for measuring washout rates in 123I-BMIPP fatty acid images
AbstractThe purpose of this practice recommendation is to specifically identify the critical steps involved in performing and interpreting123I- β-methyl-iodophenyl-pentadecanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and measurement of washout rate (WR) from the heart. This document will cover backgrounds, patient preparation, testing procedure, visual image interpretation, quantitation methods using planar and SPE CT studies, and reporting of WR. The pitfall and some tips for the calculation of123I-BMIPP WR are also included. The targets of global and regional WR calculation include ischemic hear...
Source: Annals of Nuclear Medicine - September 11, 2023 Category: Nuclear Medicine Source Type: research
Deep learning study on the mechanism of edge artifacts in point spread function reconstruction for numerical brain images
ConclusionsUnlike DIP, PSF lacks high-frequency components around the Nyquist frequency, generating EA. PSF-RD mitigates EA while simultaneously suppressing the signal, diminishing spatial resolution. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 23, 2023 Category: Nuclear Medicine Source Type: research
