Mechanisms of pain in aging and age-related conditions: Focus on caregivers
Ageing Res Rev. 2024 Feb 27;95:102249. doi: 10.1016/j.arr.2024.102249. Online ahead of print.ABSTRACTPain is a complex, subjective experience that can significantly impact quality of life, particularly in aging individuals, by adversely affecting physical and emotional well-being. Whereas acute pain usually serves a protective function, chronic pain is a persistent pathological condition that contributes to functional deficits, cognitive decline, and emotional disturbances in the elderly. Despite substantial progress that has been made in characterizing age-related changes in pain, complete mechanistic details of pain proc...
Source: Ageing Research Reviews - February 28, 2024 Category: Genetics & Stem Cells Authors: Peyton Presto Ujala Sehar Jonathan Kopel P Hemachandra Reddy Source Type: research
Blood-based Biomarkers of Cerebral Small Vessel Disease
Ageing Res Rev. 2024 Feb 26:102247. doi: 10.1016/j.arr.2024.102247. Online ahead of print.ABSTRACTAge-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and vascular cognitive impairment in aging populations. Owing to advances in neuroimaging, in vivo visualization of cerebral vasculature abnormities and detection of CSVD, including lacunes, microinfarcts, microbleeds and white matter lesions, is now possible, but remains a resource-,...
Source: Ageing Research Reviews - February 28, 2024 Category: Genetics & Stem Cells Authors: Liu-Yun Wu Yuek Ling Chai Irwin K Cheah Rachel S L Chia Saima Hilal Thiruma V Arumugam Christopher P Chen Mitchell K P Lai Source Type: research
Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia
Ageing Res Rev. 2024 Feb 26:102250. doi: 10.1016/j.arr.2024.102250. Online ahead of print.ABSTRACTDementia has been faced with significant public health challenges and economic burdens that urges the need to develop safe and effective interventions. In recent years, an increasing number of studies have focused on the relationship between dementia and liver and pancreatic metabolic disorders that result in diseases such as diabetes, obesity, hypertension and dyslipidemia. Previous reports have shown that there is a plausible correlation between pathologies caused by hepatopancreatic dysfunctions and dementia. Glucose, insul...
Source: Ageing Research Reviews - February 28, 2024 Category: Genetics & Stem Cells Authors: Francisco Irochima Pinheiro Irami Ara újo-Filho Am ália Cinthia Meneses do Rego Eduardo Pereira de Azevedo Ricardo Ney Cobucci Fausto Pierdona Guzen Source Type: research
Mechanisms of pain in aging and age-related conditions: Focus on caregivers
Ageing Res Rev. 2024 Feb 27;95:102249. doi: 10.1016/j.arr.2024.102249. Online ahead of print.ABSTRACTPain is a complex, subjective experience that can significantly impact quality of life, particularly in aging individuals, by adversely affecting physical and emotional well-being. Whereas acute pain usually serves a protective function, chronic pain is a persistent pathological condition that contributes to functional deficits, cognitive decline, and emotional disturbances in the elderly. Despite substantial progress that has been made in characterizing age-related changes in pain, complete mechanistic details of pain proc...
Source: Ageing Research Reviews - February 28, 2024 Category: Genetics & Stem Cells Authors: Peyton Presto Ujala Sehar Jonathan Kopel P Hemachandra Reddy Source Type: research
The effect of Ferroptosis -related Mitochondrial Dysfunction in the Development of Temporal Lobe Epilepsy
Ageing Res Rev. 2024 Feb 24:102248. doi: 10.1016/j.arr.2024.102248. Online ahead of print.ABSTRACTTemporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an important neuronal death mechanism in TLE, which is primarily influenced by lipid accumulation and oxidative stress. In previous studies of ferroptosis, more attention has been focused on the impact of changes in the levels of proteins related to the redox equilibrium and signal...
Source: Ageing Research Reviews - February 26, 2024 Category: Genetics & Stem Cells Authors: Yang Su Ningrui Cao Dingkun Zhang Minjin Wang Source Type: research
The effect of Ferroptosis -related Mitochondrial Dysfunction in the Development of Temporal Lobe Epilepsy
Ageing Res Rev. 2024 Feb 24:102248. doi: 10.1016/j.arr.2024.102248. Online ahead of print.ABSTRACTTemporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an important neuronal death mechanism in TLE, which is primarily influenced by lipid accumulation and oxidative stress. In previous studies of ferroptosis, more attention has been focused on the impact of changes in the levels of proteins related to the redox equilibrium and signal...
Source: Ageing Research Reviews - February 26, 2024 Category: Genetics & Stem Cells Authors: Yang Su Ningrui Cao Dingkun Zhang Minjin Wang Source Type: research
The effect of Ferroptosis -related Mitochondrial Dysfunction in the Development of Temporal Lobe Epilepsy
Ageing Res Rev. 2024 Feb 24:102248. doi: 10.1016/j.arr.2024.102248. Online ahead of print.ABSTRACTTemporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an important neuronal death mechanism in TLE, which is primarily influenced by lipid accumulation and oxidative stress. In previous studies of ferroptosis, more attention has been focused on the impact of changes in the levels of proteins related to the redox equilibrium and signal...
Source: Ageing Research Reviews - February 26, 2024 Category: Genetics & Stem Cells Authors: Yang Su Ningrui Cao Dingkun Zhang Minjin Wang Source Type: research
Multiomics insights into the female reproductive aging
Ageing Res Rev. 2024 Feb 22:102245. doi: 10.1016/j.arr.2024.102245. Online ahead of print.ABSTRACTThe human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities have facilitated the emergence of multiomics deep phenotyping. Through the application and refinement of various high-th...
Source: Ageing Research Reviews - February 24, 2024 Category: Genetics & Stem Cells Authors: Simin Wei Weicheng Tang Dan Chen Jiaqiang Xiong Liru Xue Yun Dai Yican Guo Chuqing Wu Jun Dai Meng Wu Shixuan Wang Source Type: research
Understanding age-related pathologic changes in TDP-43 functions and their consequence on RNA splicing and signalling in health and disease
Ageing Res Rev. 2024 Feb 22:102246. doi: 10.1016/j.arr.2024.102246. Online ahead of print.ABSTRACTTAR DNA binding protein-43 (TDP-43) is a key component in RNA splicing which plays a crucial role in the aging process. In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Limbic-predominant age-related TDP-43 Encephalopathy (LATE), TDP-43 can be mutated, mislocalised out of the nucleus of neurons and glial cells and form cytoplasmic inclusions. These TDP-43 alterations can lead to its RNA splicing dysregulation and contribute to mis-splicing of various types of RNA, suc...
Source: Ageing Research Reviews - February 24, 2024 Category: Genetics & Stem Cells Authors: Flora Cheng Tyler Chapman Selina Zhang Marco Morsch Roger Chung Albert Lee Stephanie L Rayner Source Type: research
Multiomics insights into the female reproductive aging
Ageing Res Rev. 2024 Feb 22:102245. doi: 10.1016/j.arr.2024.102245. Online ahead of print.ABSTRACTThe human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities have facilitated the emergence of multiomics deep phenotyping. Through the application and refinement of various high-th...
Source: Ageing Research Reviews - February 24, 2024 Category: Genetics & Stem Cells Authors: Simin Wei Weicheng Tang Dan Chen Jiaqiang Xiong Liru Xue Yun Dai Yican Guo Chuqing Wu Jun Dai Meng Wu Shixuan Wang Source Type: research
Understanding age-related pathologic changes in TDP-43 functions and their consequence on RNA splicing and signalling in health and disease
Ageing Res Rev. 2024 Feb 22:102246. doi: 10.1016/j.arr.2024.102246. Online ahead of print.ABSTRACTTAR DNA binding protein-43 (TDP-43) is a key component in RNA splicing which plays a crucial role in the aging process. In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Limbic-predominant age-related TDP-43 Encephalopathy (LATE), TDP-43 can be mutated, mislocalised out of the nucleus of neurons and glial cells and form cytoplasmic inclusions. These TDP-43 alterations can lead to its RNA splicing dysregulation and contribute to mis-splicing of various types of RNA, suc...
Source: Ageing Research Reviews - February 24, 2024 Category: Genetics & Stem Cells Authors: Flora Cheng Tyler Chapman Selina Zhang Marco Morsch Roger Chung Albert Lee Stephanie L Rayner Source Type: research
The measurement properties and feasibility of FRAIL scale in older adults: A systematic review and meta-analysis
Ageing Res Rev. 2024 Feb 21:102243. doi: 10.1016/j.arr.2024.102243. Online ahead of print.ABSTRACTFrailty is a prevalent condition amongst older adults, significantly affecting their quality of life. The FRAIL tool has been purposefully designed for clinical application by assisting healthcare professionals in identifying and managing frailty-related issues in older adults, making it a preferred choice for assessing frailty across diverse older populations. This review aimed to synthesize the measurement properties and feasibility of FRAIL. Guided by COSMIN guidelines, seven databases were searched from inception to 31 Mar...
Source: Ageing Research Reviews - February 23, 2024 Category: Genetics & Stem Cells Authors: N G Yu Xuan Ling Jie Cheng Yu Yi Quek Ruby Yu W U Xi Vivien Source Type: research
Vitamin D and ischemic stroke - association, mechanisms, and therapeutics
Ageing Res Rev. 2024 Feb 21:102244. doi: 10.1016/j.arr.2024.102244. Online ahead of print.ABSTRACTConfronting the rising tide of ischemic stroke and its associated mortality and morbidity with ageing, prevention and acute management of ischemic stroke is of paramount importance. Mounting observational studies have established a non-linear association of vitamin D status with cardiovascular diseases, including ischemic stroke. Paradoxically, current clinical trials fail to demonstrate the cardiovascular benefits of vitamin D supplementation. We aim to update recent clinical and experimental findings on the role of vitamin D...
Source: Ageing Research Reviews - February 23, 2024 Category: Genetics & Stem Cells Authors: Pan Cui Haiman Hou Bo Song Zongping Xia Yuming Xu Source Type: research
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum
CONCLUSIONS: The multimodal meta-analysis demonstrated that patients with AD exhibited convergent functional and structural alterations in the PCC/precuneus and PHG, as well as cortical thinning in the primary sensory and motor areas. Furthermore, patients with preclinical AD showed reduced functional activity in the precuneus. AD and preclinical AD showed genetic modulations/neurotransmitter deficits of brain functional and structural impairments. These findings may provide new insights into the pathophysiology of the AD spectrum.PMID:38395200 | DOI:10.1016/j.arr.2024.102240 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - February 23, 2024 Category: Genetics & Stem Cells Authors: Xinyue Tang Zixuan Guo Guanmao Chen Shilin Sun Shu Xiao Pan Chen Guixian Tang Li Huang Ying Wang Source Type: research
The measurement properties and feasibility of FRAIL scale in older adults: A systematic review and meta-analysis
Ageing Res Rev. 2024 Feb 21:102243. doi: 10.1016/j.arr.2024.102243. Online ahead of print.ABSTRACTFrailty is a prevalent condition amongst older adults, significantly affecting their quality of life. The FRAIL tool has been purposefully designed for clinical application by assisting healthcare professionals in identifying and managing frailty-related issues in older adults, making it a preferred choice for assessing frailty across diverse older populations. This review aimed to synthesize the measurement properties and feasibility of FRAIL. Guided by COSMIN guidelines, seven databases were searched from inception to 31 Mar...
Source: Ageing Research Reviews - February 23, 2024 Category: Genetics & Stem Cells Authors: N G Yu Xuan Ling Jie Cheng Yu Yi Quek Ruby Yu W U Xi Vivien Source Type: research
