Brain imaging in Aging Special Issue of Ageing Research Reviews (123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies.
Brain imaging in Aging Special Issue of Ageing Research Reviews (123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies. Ageing Res Rev. 2016 Jan 30; Authors: Orimo S, Yogo M, Nakamura T, Suzuki M, Watanabe H Abstract Cardiac meta-iodobenzylguanidine (MIBG) uptake on (123)I-MIBG cardiac scintigraphy is reduced in patients with Lewy body disease such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure, and has been reported to be useful for differentiating PD from other parkinsonian syndromes, as well as DLB from Alzheimer disease (A...
Source: Ageing Research Reviews - January 30, 2016 Category: Genetics & Stem Cells Authors: Orimo S, Yogo M, Nakamura T, Suzuki M, Watanabe H Tags: Ageing Res Rev Source Type: research
Hypertension and Aging.
The objective of the present review is to highlight the multi-dimensional risks of hypertension among older adults and discuss potential strategies for treatment and future areas of research for improving overall care for older adults with hypertension. PMID: 26835847 [PubMed - as supplied by publisher] (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - January 30, 2016 Category: Genetics & Stem Cells Authors: Buford TW Tags: Ageing Res Rev Source Type: research
Opportunities and challenges in developing relevant animal models for Alzheimer's disease.
Abstract A major impediment to the development of safe and effective therapeutics in Alzheimer's disease (AD) lies in difficulties in translating research findings across species: therapies that work in rodents often do not translate to humans. A route to bridge the gap between promising rodent research and the human clinical condition consists in using non-human primates (NHPs), which are phylogenetically much closer to humans. In this article, we discuss the importance of investigating disease mechanisms from cell culture, through different animal models of disease. We highlight that developing a viable, validat...
Source: Ageing Research Reviews - January 29, 2016 Category: Genetics & Stem Cells Authors: De Felice FG, Munoz DP Tags: Ageing Res Rev Source Type: research
Amyloid imaging: Past, Present and Future Perspectives.
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by the gradual onset of dementia. The pathological hallmarks of the disease are Aβ amyloid plaques, and tau neurofibrillary tangles, along dendritic and synaptic loss and reactive gliosis. Functional and molecular neuroimaging techniques such as positron emission tomography (PET) using functional and molecular tracers, in conjuction with other Aβ and tau biomarkers in CSF, are proving valuable in the differential diagnosis of AD, as well as in establishing disease prognosis. With the advent of new therapeutic stra...
Source: Ageing Research Reviews - January 28, 2016 Category: Genetics & Stem Cells Authors: Villemagne VL Tags: Ageing Res Rev Source Type: research
Neuroimaging biomarkers in Alzheimer's disease and other dementias.
lat G Abstract In vivo imaging of β-amyloid (Aβ) has transformed the assessment of Aβ pathology and its changes over time, extending our insight into Aβ deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional or global Aβ burden in the brain. This knowledge is essential for therapeutic trial recruitment and for the evaluation of anti-Aβ treatments. Although cross sectional evaluation of Aβ burden does not strongly correlate with cognitive impairment, it does correlate with cognitive (especially memory) decline and with ...
Source: Ageing Research Reviews - January 28, 2016 Category: Genetics & Stem Cells Authors: Villemagne VL, Chételat G Tags: Ageing Res Rev Source Type: research
Brain atrophy in Alzheimer's Disease and aging.
Abstract Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used in clinical routine and research field, largely contributing to our understanding of the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). This review aims to provide a comprehensive overview of the main findings in AD and normal aging over the past twenty years, focusing on the patterns of gray and white matter changes assessed in vivo using MRI. Major progresses in the field concern the segmentation of the hippocampus with novel manual and automatic segmentation approaches, which m...
Source: Ageing Research Reviews - January 28, 2016 Category: Genetics & Stem Cells Authors: Pini L, Pievani M, Bocchetta M, Altomare D, Bosco P, Cavedo E, Galluzzi S, Marizzoni M, Frisoni GB Tags: Ageing Res Rev Source Type: research
MRI morphometry in Alzheimer's disease.
Abstract MRI based evaluation of brain atrophy is regarded as a valid method to stage the disease and to assess progression in Alzheimer's disease (AD). Volumetric software programs have made it possible to quantify gray matter in the human brain in an automated fashion. At present, voxel based morphometry (VBM) is easily applicable to the routine clinical procedure with a short execution time. The importance of the VBM approach is that it is not biased to one particular structure and is able to assess anatomical differences throughout the brain. Stand-alone VBM software running on Windows, Voxel-based Specific Re...
Source: Ageing Research Reviews - January 23, 2016 Category: Genetics & Stem Cells Authors: Matsuda H Tags: Ageing Res Rev Source Type: research
Molecular Imaging of Dopamine Transporters.
Abstract The dopamine transporter (DAT) is responsible for clearance of dopamine from the synaptic cleft after its release. Imaging DAT availability provides a measure of dopamine terminal function and a method for detecting the striatal dopamine terminal dysfunction present in idiopathic Parkinson's disease (PD) and atypical neurodegenerative parkinsonian disorders such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). DAT imaging with positron emission tomography (PET) or single photon emission computed tomography (SPECT) can be used to support or refute...
Source: Ageing Research Reviews - January 20, 2016 Category: Genetics & Stem Cells Authors: Brooks DJ Tags: Ageing Res Rev Source Type: research
Advances in the Development of Tau PET Radiotracers and Their Clinical Applications.
Abstract Alzheimer's disease and other neurodegenerative dementias belong to the family of tauopathies. These diseases are characterized by the deposition of insoluble tau aggregates possessing an enriched β-sheet structure. In vivo imaging of the tau deposits by positron emission tomography (PET) will facilitate the early and accurate diagnosis of these diseases, tracking of disease progression, assessment of disease severity, and prediction of disease prognosis. Furthermore, this technology is expected to play a vital role in the monitoring of treatment outcomes and in the selection of patients for the ther...
Source: Ageing Research Reviews - January 20, 2016 Category: Genetics & Stem Cells Authors: Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y Tags: Ageing Res Rev Source Type: research
Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI).
Abstract The formation of senile plaques followed by the deposition of amyloid-β is the earliest pathological change in Alzheimer's disease. Thus, the detection of senile plaques remains the most important early diagnostic indicator of Alzheimer's disease. Amyloid imaging is a noninvasive technique for visualizing senile plaques in the brains of Alzheimer's patients using positron emission tomography (PET) or magnetic resonance imaging (MRI). Fluorine-19 ((19)F) displays an intense nuclear magnetic resonance signal and is almost non-existent in the body, targets are detected with a higher signal-to-noise rati...
Source: Ageing Research Reviews - January 6, 2016 Category: Genetics & Stem Cells Authors: Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S Tags: Ageing Res Rev Source Type: research
Systematic review of the association between chronic social stress and telomere length: A life course perspective.
Abstract Our aim was to examine whether chronic social stress is associated with telomere length throughout the life course, following our protocol published in 2014. Structured searches were conducted in MEDLINE (PubMed interface), EMBASE (OVID interface), Cochrane Central (OVID interface) and grey from their start date onwards. Reference lists of retrieved citations were hand searched for relevant studies. Eighteen studies published until May 1, 2015 investigating the association between chronic social stress (as defined by poverty, exposure to violence, or family caregiving) and telomere length in healthy or di...
Source: Ageing Research Reviews - December 28, 2015 Category: Genetics & Stem Cells Authors: Oliveira BS, Zunzunegui MV, Quinlan J, Fahmi H, Tu MT, Guerra RO Tags: Ageing Res Rev Source Type: research
Molecular aging of the mammalian vestibular system.
Abstract Dizziness and imbalance frequently affect the elderly and contribute to falls and frailty. In many geriatric patients, clinical testing uncovers a dysfunction of the vestibular system, but no specific etiology can be identified. Neuropathological studies have demonstrated age-related degeneration of peripheral and central vestibular neurons, but the molecular mechanisms are poorly understood. In contrast, recent studies into age-related hearing loss strongly implicate mitochondrial dysfunction, oxidative stress and apoptotic cell death of cochlear hair cells. While some data suggest that analogous biologi...
Source: Ageing Research Reviews - December 28, 2015 Category: Genetics & Stem Cells Authors: Brosel S, Laub C, Averdam A, Bender A, Elstner M Tags: Ageing Res Rev Source Type: research
Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?
a C Abstract Aging process is often accompanied with a high incidence of cardiovascular diseases (CVD) due to the synergistic effects of age-related changes in heart morphology/function and prolonged exposure to injurious effects of CVD risk factors. Oxidative stress, considered a hallmark of aging, is also an important feature in pathologies that predispose to CVD development, like hypertension, diabetes and obesity. Approaches directed to prevent the occurrence of CVD during aging have been explored both in experimental models and in controlled clinical trials, in order to improve health span, reduce hospitaliza...
Source: Ageing Research Reviews - December 27, 2015 Category: Genetics & Stem Cells Authors: Silva-Palacios A, Königsberg M, Zazueta C Tags: Ageing Res Rev Source Type: research
Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin.
Abstract Alpha-synuclein aggregation is associated with Parkinson's disease and other neurodegenerative disorders termed synucleinopathies. The sequence of alpha-synuclein has a remarkable amount of lysines, which may be a target for modifications by several aldehydes found at increased concentration in parkinsonian brains. The involved aldehydes are the dopamine metabolite 3,4-dihydroxyphenylacetaldehyde, the lipid peroxidation products 4-hydroxynonenal, acrolein and malondialdehyde, and advanced glycation end-products. Moreover, both relative expression levels and enzymatic activity of aldehyde dehydrogenases, w...
Source: Ageing Research Reviews - December 9, 2015 Category: Genetics & Stem Cells Authors: Plotegher N, Bubacco L Tags: Ageing Res Rev Source Type: research
Skeletal muscle regeneration and impact of aging and nutrition.
Abstract After skeletal muscle injury a regeneration process takes place to repair muscle. Skeletal muscle recovery is a highly coordinated process involving cross-talk between immune and muscle cells. It is well known that the physiological activities of both immune cells and muscle stem cells decline with advancing age, thereby blunting the capacity of skeletal muscle to regenerate. The age-related reduction in muscle repair efficiency contributes to the development of sarcopenia, one of the most important factors of disability in elderly people. Preserving muscle regeneration capacity may slow the development o...
Source: Ageing Research Reviews - December 9, 2015 Category: Genetics & Stem Cells Authors: Domingues-Faria C, Vasson MP, Goncalves-Mendes N, Boirie Y, Walrand S Tags: Ageing Res Rev Source Type: research
Frailty Assessment Instruments: Identification and Systematic Characterization of the Uses and Contexts of Highly-Cited Instruments.
This study reviewed the frailty-related research literature by a) comprehensively cataloging the wide array of instruments that have been utilized to measure frailty, and b) systematically categorizing the different purposes and contexts of use for frailty instruments frequently cited in the research literature. We identified 67 frailty instruments total; of these, nine were highly-cited (≥200 citations). We randomly sampled and reviewed 545 English-language articles citing at least one highly-cited instrument. We estimated the total number of uses, and classified use into eight categories: risk assessment for adverse h...
Source: Ageing Research Reviews - December 7, 2015 Category: Genetics & Stem Cells Authors: Buta BJ, Walston JD, Godino JG, Park M, Kalyani RR, Xue QL, Bandeen-Roche K, Varadhan R Tags: Ageing Res Rev Source Type: research
Long noncoding RNAs in aging and age-related diseases.
Abstract Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-dependent intricate biological process characterised by the cumulative decline in the physiological functions and their coordination in an organism after the attainment of adulthood resulting in the imbalance of neurological, immunological and metabolic functions of the body. Various biological processes and mechanisms along with altered levels of mRNAs and proteins have been reported to be involved in the progression of aging. It is one of the major risk factors in the patho-physiology of various diseases and dis...
Source: Ageing Research Reviews - December 3, 2015 Category: Genetics & Stem Cells Authors: Kour S, Rath PC Tags: Ageing Res Rev Source Type: research
Ageing and the telomere connection: An intimate relationship with inflammation.
Abstract Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes, whose length is considered to be a determinant of biological ageing. Normal ageing itself is associated with telomere shortening. Here, critically short telomeres trigger senescence and eventually cell death. This shortening rate may be further increased by inflammation and oxidative stress and thus affect the ageing process. Apart from shortened or dysfunctional telomeres, cells undergoing senescence are also associated with hyperactivity of the transcription factor NF-κB and overexpression of inflammatory cytok...
Source: Ageing Research Reviews - November 23, 2015 Category: Genetics & Stem Cells Authors: Zhang J, Rane G, Dai X, Shanmugam MK, Arfuso F, Samy RP, Peng Lai MK, Kappei D, Kumar AP, Sethi G Tags: Ageing Res Rev Source Type: research
The Effect of Physical Activity on Cognitive Function in Patients with Dementia: A Meta-Analysis of Randomized Control Trials.
Abstract Non-pharmacological therapies, such as physical activity interventions, are an appealing alternative or add-on to current pharmacological treatment of cognitive symptoms in patients with dementia. In this meta-analysis, we investigated the effect of physical activity interventions on cognitive function in dementia patients, by synthesizing data from 802 patients included in 18 randomized control trials that applied a physical activity intervention with cognitive function as an outcome measure. Post-intervention standardized mean difference (SMD) scores were computed for each study, and combined into poole...
Source: Ageing Research Reviews - November 19, 2015 Category: Genetics & Stem Cells Authors: Groot C, Hooghiemstra AM, Raijmakers PG, Berckel BN, Scheltens P, Scherder EJ, Flieram WM, Ossenkoppele R Tags: Ageing Res Rev Source Type: research
Does Transcranial Direct Current Stimulation Enhance Cognitive and Motor Functions in the Ageing Brain? A Systematic Review and Meta-Analysis.
Abstract The use of transcranial direct current stimulation (tDCS) to enhance cognitive and motor functions has enjoyed a massive increase in popularity. Modifying neuroplasticity via non-invasive cortical stimulation has enormous potential to slow or even reverse declines in functions associated with ageing. The current meta-analysis evaluated the effects of tDCS on cognitive and motor performance in healthy older adults. Of the 81 studies identified, 25 qualified for inclusion. A random effects model meta-analysis revealed a significant overall standardized mean difference equal to 0.53 (SE = 0.09; medium hetero...
Source: Ageing Research Reviews - November 19, 2015 Category: Genetics & Stem Cells Authors: Summers JJ, Kang N, Cauraugh JH Tags: Ageing Res Rev Source Type: research
Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications.
en A Abstract Association of common aging signs (i.e. male pattern baldness, hair graying, and facial wrinkles) as well as other age-related appearance factors (i.e. arcus corneae, xanthelasmata, and earlobe crease) with increased risk of ischemic heart disease was initially described in anecdotal reports from clinicians observing trends in the physical appearance of patients with ischemic heart disease. Following these early observations numerous epidemiological studies have reported these associations. Since the prevalences of both visible aging signs and ischemic heart disease have a strong correlation with inc...
Source: Ageing Research Reviews - November 15, 2015 Category: Genetics & Stem Cells Authors: Christoffersen M, Tybjærg-Hansen A Tags: Ageing Res Rev Source Type: research
Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly.
Abstract The prevalence of Alzheimer's Disease (AD) is constantly growing worldwide in absence of any effective treatment. Methodology and technique advancements facilitated the early diagnosis of AD leading to a shift toward preclinical AD stages investigation in order to delay the disease onset in individuals at risk for AD. Recent evidence demonstrating the aging related multifactorial nature of AD supported the hypothesis that modifiable environmental factors can accelerate or delay the disease onset. In particular, healthy dietary habits, constant physical and cognitive activities are associated with reduced ...
Source: Ageing Research Reviews - November 14, 2015 Category: Genetics & Stem Cells Authors: Rolandi E, Frisoni GV, Cavedo E Tags: Ageing Res Rev Source Type: research
Is the Mediterranean diet a feasible approach to preserving cognitive function and reducing risk of dementia for older adults in Western countries? New insights and future directions.
Abstract The rise in the ageing population has resulted in increased incident rates of cognitive impairment and dementia. The subsequent financial and societal burden placed on an already strained public health care system is of increasing concern. Evidence from recent studies has revealed modification of lifestyle and dietary behaviours is, at present, the best means of prevention. Some of the most important findings, in relation to the Mediterranean diet (MedDiet) and the contemporary Western diet, and potential molecular mechanisms underlying the effects of these two diets on age-related cognitive function, are...
Source: Ageing Research Reviews - November 2, 2015 Category: Genetics & Stem Cells Authors: Knight A, Bryan J, Murphy K Tags: Ageing Res Rev Source Type: research
The zebrafish as a gerontology model in nervous system aging, disease, and repair.
Abstract Considering the increasing number of elderly in the world's population today, developing effective treatments for age-related pathologies is one of the biggest challenges in modern medical research. Age-related neurodegeneration, in particular, significantly impacts important sensory, motor, and cognitive functions, seriously constraining life quality of many patients. Although our understanding of the causal mechanisms of aging has greatly improved in recent years, animal model systems still have much to tell us about this complex process. Zebrafish (Danio rerio) have gained enormous popularity for this ...
Source: Ageing Research Reviews - October 29, 2015 Category: Genetics & Stem Cells Authors: Van Houcke J, Groef L, Dekeyster E, Moons L Tags: Ageing Res Rev Source Type: research
Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient.
Abstract Compared to younger patients, traumatic injury in older patients is associated with increased mortality and a range of adverse outcomes such as higher rates of infectious episodes, longer length of hospital stay and poor functional outcome at follow up. Data emerging from human and murine-based studies suggest age-related changes in immune function, collectively termed immunesenescence, and the chronic sub-clinical systemic inflammatory state of older adults, termed inflammaging, may contribute to these poor outcomes. Here, we review the findings of these studies, whose results demonstrate that the geriat...
Source: Ageing Research Reviews - October 17, 2015 Category: Genetics & Stem Cells Authors: Hazeldine J, Lord JM, Hampson P Tags: Ageing Res Rev Source Type: research
Emerging Role of P2X7 Receptors in CNS Health and Disease.
Abstract Purinergic signalling in the brain is becoming an important focus in the study of CNS health and disease. Various purinergic receptors are found to be present in different brain cells in varying extent, which get activated upon binding of ATP or its analogues. Conventionally, ATP was considered only as a major metabolic fuel of the cell but its recognition as a neurotransmitter in early 1970s, brought meaningful insights in neuron glia crosstalk, participating in various physiological functions in the brain. P2X7R, a member of ligand gated purinergic receptor (P2X) family, is gaining attention in the fiel...
Source: Ageing Research Reviews - October 15, 2015 Category: Genetics & Stem Cells Authors: Tewari M, Seth P Tags: Ageing Res Rev Source Type: research
Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery.
Abstract Progeria, also known as HGPS, is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children. This syndrome is typically caused by mutations in codon 608 (p.G608G) of the LMNA, leading to the production of a mutated form of lamin A precursor called progerin. In HGPS, progerin accumulates in cells causing progressive molecular defects, including nuclear shape abnormalities, chromatin disorganization, damage to DNA and delays in cell proliferation. Here we report how, over the past five years, pluripotent stem cells have provided new insights into the study of HGPS and how ...
Source: Ageing Research Reviews - October 13, 2015 Category: Genetics & Stem Cells Authors: Cicero AL, Nissan X Tags: Ageing Res Rev Source Type: research
Successful aging: Advancing the science of physical independence in older adults.
Mutchie HL, Perri MG, Ranka S, Rashidi P, Sandesara B, Scarpace PJ, Sibille KT, Solberg LM, Someya S, Uphold C, Wohlgemuth S, Wu SS, Pahor M Abstract The concept of 'successful aging' has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. The doma...
Source: Ageing Research Reviews - October 10, 2015 Category: Genetics & Stem Cells Authors: Anton SD, Woods AJ, Ashizawa T, Barb D, Buford TW, Carter CS, Clark DJ, Cohen RA, Corbett DB, Cruz-Almeida Y, Dotson V, Ebner N, Efron PA, Fillingim RB, Foster TC, Gundermann DM, Joseph AM, Karabetian C, Leeuwenburgh C, Manini TM, Marsiske M, Mankowski RT Tags: Ageing Res Rev Source Type: research
Air Pollution modifies the association between successful and pathological aging throughout the frailty condition.
ari M Abstract The rapid growth in the number of older adults has many implications for public health, including the need to better understand the risks posed by environmental exposures. Aging leads to a decline and deterioration of functional properties at the cellular, tissue and organ level. This loss of functional properties yields to a loss of homeostasis and decreased adaptability to internal and external stress. Frailty is a geriatric syndrome characterized by weakness, weight loss, and low activity that is associated with adverse health outcomes. Frailty manifests as an age-related, biological vulnerabilit...
Source: Ageing Research Reviews - October 10, 2015 Category: Genetics & Stem Cells Authors: Fougère B, Vellas B, Billet S, Martin PJ, Gallucci M, Cesari M Tags: Ageing Res Rev Source Type: research
Controversies looming over Alzheimer's research: Do we have consensus over the path to follow?
Abstract Alzheimer's disease (AD) represents a personal tragedy of enormous magnitude, which imposes a daunting worldwide challenge for health-care providers and society as well. In last five decades, global research in clinics and laboratories has illuminated many features of this sinister and eventually fatal disease. Notwithstanding this development, the Alzheimer's research apparently has come across a phase of disappointment and a little reservation about the direction to follow. Persistently distressing controversies and a significant number of missing facts shed further uncertainty about the path forward. A...
Source: Ageing Research Reviews - September 12, 2015 Category: Genetics & Stem Cells Authors: Amtul Z Tags: Ageing Res Rev Source Type: research
Exercise training for managing behavioral and psychological symptoms in people with dementia: a systematic review and meta-analysis.
In conclusion, exercise reduces depression levels in PWD. Future studies should examine whether exercise reduces the use (and doses) of antipsychotics and other drugs often used to manage BPSD. PMID: 26369357 [PubMed - as supplied by publisher] (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - September 11, 2015 Category: Genetics & Stem Cells Authors: Barreto PS, Demougeot L, Pillard F, Lapeyre-Mestre M, Rolland Y Tags: Ageing Res Rev Source Type: research
RPE Necroptosis in Response to Oxidative Stress and in AMD.
Abstract Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. The underlying mechanism of non-neovascular AMD (dry AMD), also named geographic atrophy (GA) remains unclear and the mechanism of retinal pigment epithelial (RPE) cell death in AMD is controversial. We review the history and recent progress in understanding the mechanism of RPE cell death induced by oxidative stress, in AMD mouse models, and in AMD patients. Due to the limitation of toolsets to distinguish between apoptosis and necroptosis (or necrosis), most previous research concludes that apoptosis is...
Source: Ageing Research Reviews - September 11, 2015 Category: Genetics & Stem Cells Authors: Hanus J, Anderson C, Wang S Tags: Ageing Res Rev Source Type: research
microRNAs: modulators of the underlying pathophysiology of sarcopenia?
Abstract Skeletal muscle homeostasis depends on an intricate balance between muscle hypertrophy, atrophy and regeneration. As we age, maintenance of muscle homeostasis is perturbed, resulting in a loss of muscle mass and function, termed sarcopenia. Individuals with sarcopenia exhibit impaired balance, increased falls (leading to subsequent injury) and an overall decline in quality of life. The mechanisms mediating sarcopenia are still not fully understood but clarity in our understanding of the precise pathophysiological changes occurring during skeletal muscle ageing has improved dramatically. Advances in transc...
Source: Ageing Research Reviews - September 2, 2015 Category: Genetics & Stem Cells Authors: Brown DM, Goljanek-Whysall K Tags: Ageing Res Rev Source Type: research
Quality control systems in aging.
PMID: 26099809 [PubMed - in process] (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - June 26, 2015 Category: Genetics & Stem Cells Authors: Osiewacz HD Tags: Ageing Res Rev Source Type: research
Aging: A deficiency state involving declining angiogenic factors.
Abstract This essay begins by proposing that muscle weakness of old age from sarcopenia is due in large part to reduced capillary density in the muscles, as documented in 9 reports of aged persons and animals. Capillary density (CD) is determined by local levels of various angiogenic factors, which also decline in muscles with aging, as reported in 7 studies of old persons and animals. There are also numerous reports of reduced CD in the aged brain and other studies showing reduced CD in the kidney and heart of aged animals. Thus a waning angiogenesis throughout the body may be a natural occurrence in later years ...
Source: Ageing Research Reviews - June 17, 2015 Category: Genetics & Stem Cells Authors: Ambrose C Tags: Ageing Res Rev Source Type: research
Sarcopenia - The search for emerging biomarkers.
Abstract Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically affects the life quality of elder people. In view of increasing life expectancy, sarcopenia renders a heavy burden on the health care system. However, although there is a consensus that sarcopenia is a multifactorial syndrome, its etiology, underlying mechanisms, and even definition remain poorly delineated, thus, preventing development of a precise treatment strategy. The main aim of our review is to critically analyze potential sarcopenia biomarkers in light of the molecular mechanisms of their involvement in sarcopeni...
Source: Ageing Research Reviews - May 8, 2015 Category: Genetics & Stem Cells Authors: Kalinkovich A, Livshits G Tags: Ageing Res Rev Source Type: research
Social relationships and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies.
Abstract It is unclear to what extent poor social relationships are related to the development of dementia. A comprehensive systematic literature search identified 19 longitudinal cohort studies investigating the association between various social relationship factors and incident dementia in the general population. Relative risks (RRs) with 95% confidence intervals (CIs) were pooled using random-effects meta-analysis. Low social participation (RR: 1.41 (95% CI: 1.13-1.75)), less frequent social contact (RR: 1.57 (95% CI: 1.32-1.85)), and more loneliness (RR: 1.58 (95% CI: 1.19-2.09)) were statistically significan...
Source: Ageing Research Reviews - May 5, 2015 Category: Genetics & Stem Cells Authors: Kuiper JS, Zuidersma M, Oude Voshaar RC, Zuidema SU, van den Heuvel ER, Stolk RP, Smidt N Tags: Ageing Res Rev Source Type: research
Effects of Physical Activity in Telomere Length: Systematic Review and Meta-Analysis.
llo R Abstract The aim of this systematic review is to assess the effects of exercise on telomeres length. We searched the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), Scopus, LILACS, SPORTDiscus and Web of Science from inception to August 2014. All articles that assessed the effects of exercise in telomere length were included in this review. The search strategy used the following combinations of terms: telomere AND "motor activity" OR exercise OR "physical activity". Two reviewers, working independently, screened all tit...
Source: Ageing Research Reviews - May 5, 2015 Category: Genetics & Stem Cells Authors: Mundstock E, Zatti H, Louzada FM, Oliveira SG, Guma FT, Parisi MM, Rueda AB, Machado DG, Stein RT, Jones MH, Sarria EE, Barbé-Tuana FM, Mattiello R Tags: Ageing Res Rev Source Type: research
Folates and aging: Role in mild cognitive impairment, dementia and depression.
In conclusion, folate deficiency seems to be an important contributor for the onset and progression of neuropsychiatric diseases in the geriatric population but additional studies are needed in order to increase the knowledge of this promising, but still largely unexplored, area of research. PMID: 25939915 [PubMed - as supplied by publisher] (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - May 2, 2015 Category: Genetics & Stem Cells Authors: Araújo JR, Martel F, Borges N, Araújo JM, Keating E Tags: Ageing Res Rev Source Type: research
Genetics and molecular biology of brain calcification.
Abstract Brain calcification is a common neuroimaging finding in patients with neurological, metabolic, or developmental disorders, mitochondrial diseases, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. Patients with brain calcification may exhibit movement disorders, seizures, cognitive impairment, and a variety of other neurologic and psychiatric symptoms. Brain calcification may also present as a single, isolated neuroimaging finding. When no specific cause is evident, a genetic etiology should be considered. The aim of the review is to highlight clinical disorders...
Source: Ageing Research Reviews - April 20, 2015 Category: Genetics & Stem Cells Authors: Deng H, Zheng W, Jankovic J Tags: Ageing Res Rev Source Type: research
FROM CELLULAR SENESCENCE TO ALZHEIMER's DISEASE: THE ROLE OF TELOMERE SHORTENING.
Abstract The old age population is increasing worldwide as well as age related diseases, including neurodegenerative disorders such as Alzheimer's disease (AD), which negatively impacts on the health care systems. Aging represents per se a risk factor for AD. Thus, the study and identification of pathways within the biology of aging represent an important end point for the development of novel and effective disease-modifying drugs to treat, delay, or prevent AD. Cellular senescence and telomere shortening represent suitable and promising targets. Several studies show that cellular senescence is tightly interconnec...
Source: Ageing Research Reviews - April 17, 2015 Category: Genetics & Stem Cells Authors: Boccardi V, Pelini L, Ercolani S, Ruggiero C, Mecocci P Tags: Ageing Res Rev Source Type: research
Programmed cell death in aging.
Abstract Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is increasingly implicated in aging and aging-related disease. During aging the cell turnover rate declines for several highly-mitotic tissues. Aging-associated disruptions in systemic and inter-cell signaling combined with cell-autonomous damage and mitochondrial malfunction result in increased PCD in some cell types, and decreased PCD in other cell types. Increased PCD during aging is implicated in immune system decline, skeletal muscle was...
Source: Ageing Research Reviews - April 8, 2015 Category: Genetics & Stem Cells Authors: Tower J Tags: Ageing Res Rev Source Type: research
Modifications to the frailty phenotype criteria: Systematic review of the current literature and investigation of 262 frailty phenotypes in the Survey of Health, Ageing, and Retirement in Europe.
Abstract We conducted a systematic review to determine variability in how the criteria of the frailty phenotype (grip strength, weight loss, exhaustion, walking speed, physical activity) were assessed. We then evaluated the impact on estimating prevalence and mortality of modifying the criteria, using the Survey of Health, Ageing, & Retirement in Europe (SHARE). Five databases were searched for original research articles published after 2000, which evaluated frailty using the phenotypic criteria. Among the 264 included studies, 24 studies provided enough information to demonstrate that all criteria were assess...
Source: Ageing Research Reviews - April 3, 2015 Category: Genetics & Stem Cells Authors: Theou O, Cann L, Blodgett J, Wallace LM, Brothers TD, Rockwood K Tags: Ageing Res Rev Source Type: research
Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing.
Abstract Human ageing is associated with a gradual decline in the physiological functions of the body at multiple levels and it is a key risk factor for many diseases, including cancer. Ageing process is intimately related to widespread cellular senescence, characterised by an irreversible loss of proliferative capacity and altered functioning associated with telomere attrition, accumulation of DNA damage and compromised mitochondrial and metabolic function. Tumour and senescent cells may be generated in response to the same stimuli, where either cellular senescence or transformation would constitute two opposite ...
Source: Ageing Research Reviews - April 3, 2015 Category: Genetics & Stem Cells Authors: Badiola I, Santaolalla F, Garcia-Gallastegui P, Rey AS, Unda F, Ibarretxe G Tags: Ageing Res Rev Source Type: research
Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment.
ski G Abstract Floaters and flashes are most commonly symptoms of age-related degenerative changes in the vitreous body and posterior vitreous detachment. The etiology and pathogenesis of floaters' formation is still not well understood. Patients with acute-onset floaters, flashes and defects in their visual field, represent a medical emergency with the need for same day referral to an ophthalmologist. Indirect ophthalmoscopy with scleral indentation is needed in order to find possible retinal break(s), on-time treatment and prevention of retinal detachment. The molecular and genetic pathogenesis, as well as the e...
Source: Ageing Research Reviews - April 1, 2015 Category: Genetics & Stem Cells Authors: Lumi X, Hawlina M, Glavač D, Facskó A, Moe MC, Kaarniranta K, Petrovski G Tags: Ageing Res Rev Source Type: research
DAMPs activating innate immune responses in sepsis.
Abstract Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the host to microbial infection and is the leading cause of death in intensive care units. The pathogenesis of sepsis is highly complex. It is principally attributable to dysregulation of the innate immune system. Damage-associated molecular patterns (DAMPs) are actively secreted by innate immune cells and/or released passively by injured or damaged cells in response to infection or injury. In the present review, we highlight emerging evidence that supports the notion that extracellular DAMPs act as crucial proinflammator...
Source: Ageing Research Reviews - March 25, 2015 Category: Genetics & Stem Cells Authors: Kang JW, Kim SJ, Cho HI, Lee SM Tags: Ageing Res Rev Source Type: research
Muscle and bone, two interconnected tissues.
Abstract As bones are levers for skeletal muscle to exert forces, both are complementary and essential for locomotion and individual autonomy. In the past decades, the idea of a bone-muscle unit has emerged. Numerous studies have confirmed this hypothesis from in utero to aging works. Space flight, bed rest as well as osteoporosis and sarcopenia experimentations have allowed to accumulate considerable evidence. Mechanical loading is a key mechanism linking both tissues with a central promoting role of physical activity. Moreover, the skeletal muscle secretome accounts various molecules that affect bone including i...
Source: Ageing Research Reviews - March 21, 2015 Category: Genetics & Stem Cells Authors: Tagliaferri C, Wittrant Y, Davicco MJ, Walrand S, Coxam V Tags: Ageing Res Rev Source Type: research
siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery.
Abstract As the population ages, brain pathologies such as neurodegenerative diseases and brain cancer increase their incidence, being the need to find successful treatments of upmost importance. Drug delivery to the central nervous system (CNS) is required in order to reach diseases causes and treat them. However, biological barriers, mainly blood-brain barrier (BBB), are the key obstacles that prevent the effectiveness of possible treatments due to their ability to strongly limit the perfusion of compounds into the brain. Over the past decades, new approaches towards overcoming BBB and its efflux transporters ha...
Source: Ageing Research Reviews - March 18, 2015 Category: Genetics & Stem Cells Authors: Gomes MJ, Martins S, Sarmento B Tags: Ageing Res Rev Source Type: research
Energy metabolism and the brain: A bidirectional relationship.
PMID: 25728594 [PubMed - in process] (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 1, 2015 Category: Genetics & Stem Cells Authors: Kapogiannis D Tags: Ageing Res Rev Source Type: research
Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: a ticking time bomb in ageing.
Abstract Ageing has pronounced effects on the immune system, including on innate immune cells. Whilst most studies suggest that total numbers of different innate immune cell populations do not change dramatically during ageing, many of their functions such as phagocytosis, antigen presentation and inflammatory molecule secretion decline. In contrast, many endogenous damage-associated molecular patterns (DAMPs) accumulate during ageing. These include reactive oxygen species (ROS) released from damaged mitochondria, extracellular nucleotides like ATP, high mobility group box (HMGB) 1 protein, oxidized low density li...
Source: Ageing Research Reviews - February 25, 2015 Category: Genetics & Stem Cells Authors: Kapetanovic R, Bokil NJ, Sweet MJ Tags: Ageing Res Rev Source Type: research