Unveiling the Interplay of AMPK/SIRT1/PGC-1 α axis in Brain Health: Promising Targets Against Aging and NDDs
Ageing Res Rev. 2024 Mar 13:102255. doi: 10.1016/j.arr.2024.102255. Online ahead of print.ABSTRACTThe escalating prevalence of neurodegenerative diseases (NDDs) within an aging global population presents a pressing challenge. The multifaceted pathophysiological mechanisms underlying these disorders, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, remain complex and elusive. Among these, the AMPK/SIRT1/PGC-1α pathway emerges as a pivotal network implicated in neuroprotection against these destructive processes. This review sheds light on the potential therapeutic implications of targeting this...
Source: Ageing Research Reviews - March 15, 2024 Category: Genetics & Stem Cells Authors: Pratik Shankar Rakshe Bhaskar Jyoti Dutta Shivani Chib Niyogita Maurya Sanjiv Singh Source Type: research
Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations
Ageing Res Rev. 2024 Mar 13:102268. doi: 10.1016/j.arr.2024.102268. Online ahead of print.ABSTRACTThe accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing phenotypes is unclear. Recent advances in DNA sequencing technologies have allowed the large-scale quantification of somatic mutations in ageing tissues. These studies have revealed a gradual accumulation of mutations in most normal tissues with age as well as a substantial clonal expansion drive...
Source: Ageing Research Reviews - March 15, 2024 Category: Genetics & Stem Cells Authors: Kasit Chatsirisupachai Jo ão Pedro de Magalhães Source Type: research
Unveiling the Interplay of AMPK/SIRT1/PGC-1 α axis in Brain Health: Promising Targets Against Aging and NDDs
Ageing Res Rev. 2024 Mar 13:102255. doi: 10.1016/j.arr.2024.102255. Online ahead of print.ABSTRACTThe escalating prevalence of neurodegenerative diseases (NDDs) within an aging global population presents a pressing challenge. The multifaceted pathophysiological mechanisms underlying these disorders, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, remain complex and elusive. Among these, the AMPK/SIRT1/PGC-1α pathway emerges as a pivotal network implicated in neuroprotection against these destructive processes. This review sheds light on the potential therapeutic implications of targeting this...
Source: Ageing Research Reviews - March 15, 2024 Category: Genetics & Stem Cells Authors: Pratik Shankar Rakshe Bhaskar Jyoti Dutta Shivani Chib Niyogita Maurya Sanjiv Singh Source Type: research
Somatostatin and the pathophysiology of Alzheimer's disease
Ageing Res Rev. 2024 Mar 12:102270. doi: 10.1016/j.arr.2024.102270. Online ahead of print.ABSTRACTAmong the central features of Alzheimer's disease (AD) progression are altered levels of the neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST-INs) with amyloid-β plaques, leading to cell death. In this theoretical review, I propose a molecular model for the pathogenesis of AD based on SST-IN hypofunction and hyperactivity. Namely, hypofunctional and hyperactive SST-INs struggle to control hyperactivity in mid-temporal regions in early stages, leading to axonal Aβ production through ex...
Source: Ageing Research Reviews - March 14, 2024 Category: Genetics & Stem Cells Authors: Victor N Almeida Source Type: research
Somatostatin and the pathophysiology of Alzheimer's disease
Ageing Res Rev. 2024 Mar 12:102270. doi: 10.1016/j.arr.2024.102270. Online ahead of print.ABSTRACTAmong the central features of Alzheimer's disease (AD) progression are altered levels of the neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST-INs) with amyloid-β plaques, leading to cell death. In this theoretical review, I propose a molecular model for the pathogenesis of AD based on SST-IN hypofunction and hyperactivity. Namely, hypofunctional and hyperactive SST-INs struggle to control hyperactivity in mid-temporal regions in early stages, leading to axonal Aβ production through ex...
Source: Ageing Research Reviews - March 14, 2024 Category: Genetics & Stem Cells Authors: Victor N Almeida Source Type: research
Agmatine as a Novel Intervention for Alzheimer's Disease: Pathological Insights and Cognitive Benefits
Ageing Res Rev. 2024 Mar 11:102269. doi: 10.1016/j.arr.2024.102269. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and a significant societal burden. Despite extensive research and efforts of the multidisciplinary scientific community, to date, there is no cure for this debilitating disease. Moreover, the existing pharmacotherapy for AD only provides symptomatic support and does not modify the course of the illness or halt the disease progression. This is a significant limitation as the underlying pathology of the disease con...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Raj A Katariya Shivkumar S Sammeta Mayur B Kale Nandkishor R Kotagale Milind J Umekar Brijesh G Taksande Source Type: research
The underlying roles and neurobiological mechanisms of Music-Based Intervention in Alzheimer's disease: A comprehensive review
Ageing Res Rev. 2024 Mar 11:102265. doi: 10.1016/j.arr.2024.102265. Online ahead of print.ABSTRACTNon-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically delineated. This review aims to holistically review how music-based intervention (MBI) ameliorates abnormal emotion, cognit...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Liyang Sun Qin Wang Jing Ai Source Type: research
The efficacy of dyadic interventions for community-dwelling people with dementia and their caregivers: a systematic review and meta-analysis
This article is an update of a review of dyadic interventions up to 2012 (Van't Leven et al., 2013). Twenty-two randomized controlled trials published between January 2012 and March 2023 met eligibility criteria, representing 3857 dyads. Results of a meta-analysis showed no overall intervention effect. Thirteen studies reported positive intervention effects, 9 studies reported no intervention effects. Intervention content and participant characteristics and knowledge of the disease varied widely between the studies reviewed. Effective interventions were those that matched activities for the person with dementia to their in...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Sanne C E Balvert Giovanna C Del Sordo Maarten V Milders Source Type: research
Agmatine as a Novel Intervention for Alzheimer's Disease: Pathological Insights and Cognitive Benefits
Ageing Res Rev. 2024 Mar 11:102269. doi: 10.1016/j.arr.2024.102269. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and a significant societal burden. Despite extensive research and efforts of the multidisciplinary scientific community, to date, there is no cure for this debilitating disease. Moreover, the existing pharmacotherapy for AD only provides symptomatic support and does not modify the course of the illness or halt the disease progression. This is a significant limitation as the underlying pathology of the disease con...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Raj A Katariya Shivkumar S Sammeta Mayur B Kale Nandkishor R Kotagale Milind J Umekar Brijesh G Taksande Source Type: research
The underlying roles and neurobiological mechanisms of Music-Based Intervention in Alzheimer's disease: A comprehensive review
Ageing Res Rev. 2024 Mar 11:102265. doi: 10.1016/j.arr.2024.102265. Online ahead of print.ABSTRACTNon-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically delineated. This review aims to holistically review how music-based intervention (MBI) ameliorates abnormal emotion, cognit...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Liyang Sun Qin Wang Jing Ai Source Type: research
The efficacy of dyadic interventions for community-dwelling people with dementia and their caregivers: a systematic review and meta-analysis
This article is an update of a review of dyadic interventions up to 2012 (Van't Leven et al., 2013). Twenty-two randomized controlled trials published between January 2012 and March 2023 met eligibility criteria, representing 3857 dyads. Results of a meta-analysis showed no overall intervention effect. Thirteen studies reported positive intervention effects, 9 studies reported no intervention effects. Intervention content and participant characteristics and knowledge of the disease varied widely between the studies reviewed. Effective interventions were those that matched activities for the person with dementia to their in...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Sanne C E Balvert Giovanna C Del Sordo Maarten V Milders Source Type: research
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia
Ageing Res Rev. 2024 Mar 8:102267. doi: 10.1016/j.arr.2024.102267. Online ahead of print.ABSTRACTSarcopenia is an age-associated loss of skeletal muscle mass, strength, and function, accompanied by severe adverse health outcomes, such as falls and fractures, functional decline, high health costs, and mortality. Hence, its prevention and treatment have become increasingly urgent. However, despite the wide prevalence and extensive research on sarcopenia, no FDA-approved disease-modifying drugs exist. This is probably due to a poor understanding of the mechanisms underlying its pathophysiology. Recent evidence demonstrate tha...
Source: Ageing Research Reviews - March 10, 2024 Category: Genetics & Stem Cells Authors: Gregory Livshits Alexander Kalinkovich Source Type: research
Estimated prevalence of frailty and prefrailty in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and proportional meta-analysis
CONCLUSION: Frailty represents a considerable health challenge among patients undergoing cardiac surgeries/procedures. Routine screening for frailty should be considered during perioperative care planning.PMID:38462047 | DOI:10.1016/j.arr.2024.102266 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 10, 2024 Category: Genetics & Stem Cells Authors: Cathy W Y Wong Polly W C Li Doris S F Yu Benjamin M H Ho Bernice Shinyi Chan Source Type: research
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia
Ageing Res Rev. 2024 Mar 8:102267. doi: 10.1016/j.arr.2024.102267. Online ahead of print.ABSTRACTSarcopenia is an age-associated loss of skeletal muscle mass, strength, and function, accompanied by severe adverse health outcomes, such as falls and fractures, functional decline, high health costs, and mortality. Hence, its prevention and treatment have become increasingly urgent. However, despite the wide prevalence and extensive research on sarcopenia, no FDA-approved disease-modifying drugs exist. This is probably due to a poor understanding of the mechanisms underlying its pathophysiology. Recent evidence demonstrate tha...
Source: Ageing Research Reviews - March 10, 2024 Category: Genetics & Stem Cells Authors: Gregory Livshits Alexander Kalinkovich Source Type: research
Estimated prevalence of frailty and prefrailty in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and proportional meta-analysis
CONCLUSION: Frailty represents a considerable health challenge among patients undergoing cardiac surgeries/procedures. Routine screening for frailty should be considered during perioperative care planning.PMID:38462047 | DOI:10.1016/j.arr.2024.102266 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 10, 2024 Category: Genetics & Stem Cells Authors: Cathy W Y Wong Polly W C Li Doris S F Yu Benjamin M H Ho Bernice Shinyi Chan Source Type: research
