Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline
Ageing Res Rev. 2023 Nov 17;92:102125. doi: 10.1016/j.arr.2023.102125. Online ahead of print.ABSTRACTThe therapeutic potential of natural stilbenes, with a particular focus on pterostilbene (PTE), has emerged as a promising avenue of research targeting age-associated conditions encompassing cardiovascular diseases (CVD), diabetes mellitus (DM), and cognitive decline. This comprehensive investigation delves into the intricate mechanisms through which PTE, a polyphenolic compound abundant in grapes and blueberries, exerts its advantageous effects as an anti-aging agent. Central to its action is the modulation of hallmark agi...
Source: Ageing Research Reviews - November 18, 2023 Category: Genetics & Stem Cells Authors: Bhaskar Jyoti Dutta Pratik Shankar Rakshe Niyogita Maurya Shivani Chib Sanjiv Singh Source Type: research

Effect of physical activity on risk of Alzheimer's disease: a systematic review and meta-analysis of twenty-nine prospective cohort studies
CONCLUSION: PA intervention reduces the incidence of AD, but merely in moderate to vigorous PA with follow-up of less than 15 years, thus conditionally recommending the popularization of PA as a modifiable lifestyle factor to prevent AD.PMID:37979700 | DOI:10.1016/j.arr.2023.102127 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 18, 2023 Category: Genetics & Stem Cells Authors: Xiaoqian Zhang Qu Li Wenqiang Cong Siyu Mu Rui Zhan Shanshan Zhong Mei Zhao Chuansheng Zhao Kexin Kang Zhike Zhou Source Type: research

Unlocking the Therapeutic Potential of Natural Stilbene: Exploring Pterostilbene as a Powerful Ally Against Aging and Cognitive Decline
Ageing Res Rev. 2023 Nov 16:102125. doi: 10.1016/j.arr.2023.102125. Online ahead of print.ABSTRACTThe therapeutic potential of natural stilbenes, with a particular focus on pterostilbene (PTE), has emerged as a promising avenue of research targeting age-associated conditions encompassing cardiovascular diseases (CVD), diabetes mellitus (DM), and cognitive decline. This comprehensive investigation delves into the intricate mechanisms through which PTE, a polyphenolic compound abundant in grapes and blueberries, exerts its advantageous effects as an anti-aging agent. Central to its action is the modulation of hallmark aging ...
Source: Ageing Research Reviews - November 18, 2023 Category: Genetics & Stem Cells Authors: Bhaskar Jyoti Dutta Pratik Shankar Rakshe Niyogita Maurya Shivani Chib Sanjiv Singh Source Type: research

Effect of physical activity on risk of Alzheimer's disease: a systematic review and meta-analysis of twenty-nine prospective cohort studies
CONCLUSION: PA intervention reduces the incidence of AD, but merely in moderate to vigorous PA with follow-up of less than 15 years, thus conditionally recommending the popularization of PA as a modifiable lifestyle factor to prevent AD.PMID:37979700 | DOI:10.1016/j.arr.2023.102127 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 18, 2023 Category: Genetics & Stem Cells Authors: Xiaoqian Zhang Qu Li Wenqiang Cong Siyu Mu Rui Zhan Shanshan Zhong Mei Zhao Chuansheng Zhao Kexin Kang Zhike Zhou Source Type: research

Global, regional, and national prevalence of hearing loss from 1990 to 2019: a trend and health inequality analyses based on the Global Burden of Disease Study 2019
Ageing Res Rev. 2023 Nov 14:102124. doi: 10.1016/j.arr.2023.102124. Online ahead of print.ABSTRACTAs a severe public health issue, hearing loss has caused an increasingly disease burden, especially in the elderly population. Hearing loss may inevitably induce asymmetric hearing, which makes it difficult for elderly individuals to locate sound sources, therefore resulting in increased postural instability and falling risk. To emphasize the public health emergence of hearing loss, we investigated the temporal trend of prevalence of hearing loss over the last 30 years and further predicted its changes in the next 20 years, de...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Chuan-Ya Jiang Ke Han Fan Yang Si-Yue Yin Lei Zhang Bing-Yu Liang Tai-Bao Wang Tao Jiang Yue-Rong Chen Tai-Yu Shi Yu-Chen Liu Shan-Wen Chen Bu-Sheng Tong Ye-Hai Liu Hai-Feng Pan Yan-Xun Han Source Type: research

Genomic and transcriptomic advances in amyotrophic lateral sclerosis
We report the most relevant genes implicated in ALS pathogenesis, discussing the use of different high-throughput sequencing techniques and the role of epigenomic modifications. Furthermore, we present transcriptomic studies discussing the most recent advances, from microarrays to bulk and single-cell RNA sequencing. Finally, we discuss the use of microRNAs as potential biomarkers and promising tools for molecular intervention. The integration of data from multiple omic approaches may provide new insights into pathogenic pathways in ALS by shedding light on diagnostic and prognostic biomarkers, helping to stratify patients...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Mafalda Rizzuti Luca Sali Valentina Melzi Simone Scarcella Gianluca Costamagna Linda Ottoboni Lorenzo Quetti Lorenzo Brambilla Dimitra Papadimitriou Federico Verde Antonia Ratti Nicola Ticozzi Giacomo Pietro Comi Stefania Corti Delia Gagliardi Source Type: research

Global, regional, and national prevalence of hearing loss from 1990 to 2019: a trend and health inequality analyses based on the Global Burden of Disease Study 2019
Ageing Res Rev. 2023 Nov 14:102124. doi: 10.1016/j.arr.2023.102124. Online ahead of print.ABSTRACTAs a severe public health issue, hearing loss has caused an increasingly disease burden, especially in the elderly population. Hearing loss may inevitably induce asymmetric hearing, which makes it difficult for elderly individuals to locate sound sources, therefore resulting in increased postural instability and falling risk. To emphasize the public health emergence of hearing loss, we investigated the temporal trend of prevalence of hearing loss over the last 30 years and further predicted its changes in the next 20 years, de...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Chuan-Ya Jiang Ke Han Fan Yang Si-Yue Yin Lei Zhang Bing-Yu Liang Tai-Bao Wang Tao Jiang Yue-Rong Chen Tai-Yu Shi Yu-Chen Liu Shan-Wen Chen Bu-Sheng Tong Ye-Hai Liu Hai-Feng Pan Yan-Xun Han Source Type: research

Genomic and transcriptomic advances in amyotrophic lateral sclerosis
We report the most relevant genes implicated in ALS pathogenesis, discussing the use of different high-throughput sequencing techniques and the role of epigenomic modifications. Furthermore, we present transcriptomic studies discussing the most recent advances, from microarrays to bulk and single-cell RNA sequencing. Finally, we discuss the use of microRNAs as potential biomarkers and promising tools for molecular intervention. The integration of data from multiple omic approaches may provide new insights into pathogenic pathways in ALS by shedding light on diagnostic and prognostic biomarkers, helping to stratify patients...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Mafalda Rizzuti Luca Sali Valentina Melzi Simone Scarcella Gianluca Costamagna Linda Ottoboni Lorenzo Quetti Lorenzo Brambilla Dimitra Papadimitriou Federico Verde Antonia Ratti Nicola Ticozzi Giacomo Pietro Comi Stefania Corti Delia Gagliardi Source Type: research

Factors affecting the GABAergic synapse function in Alzheimer's Disease: Focus on microRNAs
This study explored the types of GABA receptors associated with neurological dysfunction and various biological and environmental factors that cause GABAergic neuron dysfunction in AD, such as Aβ, p-tau, aging, sex, astrocytes, microglia, APOE, mental disorder, diet, physical activity, and sleep. Furthermore, we explored the role of microRNAs (miRNAs) in the regulation of GABAergic synapse function in neurological disorders and AD states. We also discuss the molecular mechanisms underlying GABAergic synapse dysfunction with a focus on miR-27b, miR-30a, miR-190a/b, miR-33, miR-51, miR-129-5p, miR-376-3p, miR-376c, miR-30b ...
Source: Ageing Research Reviews - November 15, 2023 Category: Genetics & Stem Cells Authors: Jazmin Rivera Bhupender Sharma Melissa M Torres Subodh Kumar Source Type: research

Factors affecting the GABAergic synapse function in Alzheimer's Disease: Focus on microRNAs
This study explored the types of GABA receptors associated with neurological dysfunction and various biological and environmental factors that cause GABAergic neuron dysfunction in AD, such as Aβ, p-tau, aging, sex, astrocytes, microglia, APOE, mental disorder, diet, physical activity, and sleep. Furthermore, we explored the role of microRNAs (miRNAs) in the regulation of GABAergic synapse function in neurological disorders and AD states. We also discuss the molecular mechanisms underlying GABAergic synapse dysfunction with a focus on miR-27b, miR-30a, miR-190a/b, miR-33, miR-51, miR-129-5p, miR-376-3p, miR-376c, miR-30b ...
Source: Ageing Research Reviews - November 15, 2023 Category: Genetics & Stem Cells Authors: Jazmin Rivera Bhupender Sharma Melissa M Torres Subodh Kumar Source Type: research

Pharmacological modulation of vascular ageing: a review from VascAgeNet
Ageing Res Rev. 2023 Nov 11:102122. doi: 10.1016/j.arr.2023.102122. Online ahead of print.ABSTRACTVascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current know...
Source: Ageing Research Reviews - November 13, 2023 Category: Genetics & Stem Cells Authors: Lynn Roth Soner Dogan Bilge Guvenc Tuna Tamas Aranyi Sonia Benitez Maria Borrell-Pages Perinur Bozaykut Guido R Y De Meyer Laurent Duca Nergiz Durmus Diogo Fonseca Emil Fraenkel Philippe Gillery Alessandro Giudici St éphane Jaisson Madeleine Johansson Jo Source Type: research

Pharmacological modulation of vascular ageing: a review from VascAgeNet
Ageing Res Rev. 2023 Nov 11:102122. doi: 10.1016/j.arr.2023.102122. Online ahead of print.ABSTRACTVascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current know...
Source: Ageing Research Reviews - November 13, 2023 Category: Genetics & Stem Cells Authors: Lynn Roth Soner Dogan Bilge Guvenc Tuna Tamas Aranyi Sonia Benitez Maria Borrell-Pages Perinur Bozaykut Guido R Y De Meyer Laurent Duca Nergiz Durmus Diogo Fonseca Emil Fraenkel Philippe Gillery Alessandro Giudici St éphane Jaisson Madeleine Johansson Jo Source Type: research

The Effectiveness of Dance Movement Interventions for Older Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Dementia: A Systematic Scoping Review and Meta-analysis
CONCLUSIONS: Dance is a non-pharmacological, effective, affordable, and engaging intervention that can be used as a complementary treatment for older adults with MCI, AD, and dementia.PMID:37944706 | DOI:10.1016/j.arr.2023.102120 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 9, 2023 Category: Genetics & Stem Cells Authors: Dan Tao Roger Awan-Scully Garrett I Ash Zhong Pei Yaodong Gu Yang Gao Alistair Cole Julien S Baker Source Type: research

Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network
Ageing Res Rev. 2023 Nov 8;92:102121. doi: 10.1016/j.arr.2023.102121. Online ahead of print.ABSTRACTAging is widespread worldwide and a significant risk factor for cardiovascular disease (CVD). Mechanisms underlying aging have attracted considerable attention in recent years. Remarkably, aging and CVD overlap in numerous ways, with deregulated nutrient sensing as a common mechanism and lifestyle as a communal modifier. Interestingly, lifestyle triggers or suppresses multiple nutrient-related signaling pathways. In this review, we first present the composition of the nutrient-sensing network (NSN) and its metabolic impact o...
Source: Ageing Research Reviews - November 9, 2023 Category: Genetics & Stem Cells Authors: Kaiying Yang Rongyao Hou Jie Zhao Xia Wang Jin Wei Xudong Pan Xiaoyan Zhu Source Type: research

The Effectiveness of Dance Movement Interventions for Older Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Dementia: A Systematic Scoping Review and Meta-analysis
CONCLUSIONS: Dance is a non-pharmacological, effective, affordable, and engaging intervention that can be used as a complementary treatment for older adults with MCI, AD, and dementia.PMID:37944706 | DOI:10.1016/j.arr.2023.102120 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 9, 2023 Category: Genetics & Stem Cells Authors: Dan Tao Roger Awan-Scully Garrett I Ash Zhong Pei Yaodong Gu Yang Gao Alistair Cole Julien S Baker Source Type: research