Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis
This study is registered on PROSPERO (CRD42021250254).RESULTS: Nineteen cross-sectional studies that investigated 19.734 community-dwelling and institutionalized older adults free of disability and dementia were included. A high adherence to MeDi was cross-sectionally associated with better walking speed (SMD = 0.42; 95 % Confidence Interval (CI) = 0.12-0.72, P = 0.006; I² = 65 %, P = 0.06), knee muscle strength speed (SMD = 0.26; 95 % CI = 0.17-0.36, P
Source: Ageing Research Reviews - June 21, 2021 Category: Genetics & Stem Cells Authors: H élio José Coelho-Júnior Antonia Trichopoulou Francesco Panza Source Type: research

Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis
This study is registered on PROSPERO (CRD42021250254).RESULTS: Nineteen cross-sectional studies that investigated 19.734 community-dwelling and institutionalized older adults free of disability and dementia were included. A high adherence to MeDi was cross-sectionally associated with better walking speed (SMD = 0.42; 95 % Confidence Interval (CI) = 0.12-0.72, P = 0.006; I² = 65 %, P = 0.06), knee muscle strength speed (SMD = 0.26; 95 % CI = 0.17-0.36, P
Source: Ageing Research Reviews - June 21, 2021 Category: Genetics & Stem Cells Authors: H élio José Coelho-Júnior Antonia Trichopoulou Francesco Panza Source Type: research

Cross-Sectional and Longitudinal Associations Between Adherence to Mediterranean Diet with Physical Performance and Cognitive Function in Older Adults: A Systematic Review And Meta-Analysis
This study is registered on PROSPERO (CRD42021250254).RESULTS: Nineteen cross-sectional studies that investigated 19.734 community-dwelling and institutionalized older adults free of disability and dementia were included. A high adherence to MeDi was cross-sectionally associated with better walking speed (SMD = 0.42; 95% Confidence Interval (CI) = 0.12 to 0.72, P = 0.006; I² = 65%, P = 0.06), knee muscle strength speed (SMD = 0.26; 95% CI = 0.17 to 0.36, P
Source: Ageing Research Reviews - June 21, 2021 Category: Genetics & Stem Cells Authors: H élio José Coelho-Júnior Antonia Trichopoulou Francesco Panza Source Type: research

Cross-Sectional and Longitudinal Associations Between Adherence to Mediterranean Diet with Physical Performance and Cognitive Function in Older Adults: A Systematic Review And Meta-Analysis
This study is registered on PROSPERO (CRD42021250254).RESULTS: Nineteen cross-sectional studies that investigated 19.734 community-dwelling and institutionalized older adults free of disability and dementia were included. A high adherence to MeDi was cross-sectionally associated with better walking speed (SMD = 0.42; 95% Confidence Interval (CI) = 0.12 to 0.72, P = 0.006; I² = 65%, P = 0.06), knee muscle strength speed (SMD = 0.26; 95% CI = 0.17 to 0.36, P
Source: Ageing Research Reviews - June 21, 2021 Category: Genetics & Stem Cells Authors: H élio José Coelho-Júnior Antonia Trichopoulou Francesco Panza Source Type: research

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology
Ageing Res Rev. 2021 Jun 15;70:101393. doi: 10.1016/j.arr.2021.101393. Online ahead of print.ABSTRACTAgeing is a multifactorial biological process leading to a progressive decline of physiological functions. The process of ageing includes numerous changes in the cells and the interactions between cell-cell and cell-microenvironment remaining as a critical risk factor for the development of chronic degenerative diseases. Systemic inflammation, known as inflammageing, increases as a consequence of ageing contributing to age-related morbidities. But also, persistent and uncontrolled activation of fibrotic pathways, with exces...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Mois és Selman Annie Pardo Source Type: research

The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review
Ageing Res Rev. 2021 Jun 14:101394. doi: 10.1016/j.arr.2021.101394. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a common degenerative disease of the musculoskeletal system that develops with age. It is regarded as the main cause of chronic low back pain in the elderly. IDD has various causes, including ageing, mechanical overloading, and nutritional deficiency. Melatonin is a pleiotropic indole hormone secreted by the pineal gland and plays an important role in resisting various degenerative diseases. The serum levels of melatonin decline with age and are reported to be negatively correlated wit...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Zhangrong Cheng Qian Xiang Juntan Wang Yukun Zhang Source Type: research

Centenarians as models of healthy aging: Example of REST
This study goes from human to animal models and revealed that REST acts as an epigenetic regulator of neuronal homeostasis, to control aging and longevity. The aim of this view point is to summarize recent literature describing genetic and epigenetic factors, as well as molecular pathways associated with centenarians and the biology of aging. We will pay particular attention to the impact of REST in centenarians and longevity.PMID:34139339 | DOI:10.1016/j.arr.2021.101392 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Diego Marcos-P érez Ander Saenz-Anto ñanzas Ander Matheu Source Type: research

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology
Ageing Res Rev. 2021 Jun 15;70:101393. doi: 10.1016/j.arr.2021.101393. Online ahead of print.ABSTRACTAgeing is a multifactorial biological process leading to a progressive decline of physiological functions. The process of ageing includes numerous changes in the cells and the interactions between cell-cell and cell-microenvironment remaining as a critical risk factor for the development of chronic degenerative diseases. Systemic inflammation, known as inflammageing, increases as a consequence of ageing contributing to age-related morbidities. But also, persistent and uncontrolled activation of fibrotic pathways, with exces...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Mois és Selman Annie Pardo Source Type: research

The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review
Ageing Res Rev. 2021 Jun 14:101394. doi: 10.1016/j.arr.2021.101394. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a common degenerative disease of the musculoskeletal system that develops with age. It is regarded as the main cause of chronic low back pain in the elderly. IDD has various causes, including ageing, mechanical overloading, and nutritional deficiency. Melatonin is a pleiotropic indole hormone secreted by the pineal gland and plays an important role in resisting various degenerative diseases. The serum levels of melatonin decline with age and are reported to be negatively correlated wit...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Zhangrong Cheng Qian Xiang Juntan Wang Yukun Zhang Source Type: research

Centenarians as models of healthy aging: Example of REST
This study goes from human to animal models and revealed that REST acts as an epigenetic regulator of neuronal homeostasis, to control aging and longevity. The aim of this view point is to summarize recent literature describing genetic and epigenetic factors, as well as molecular pathways associated with centenarians and the biology of aging. We will pay particular attention to the impact of REST in centenarians and longevity.PMID:34139339 | DOI:10.1016/j.arr.2021.101392 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Diego Marcos-P érez Ander Saenz-Anto ñanzas Ander Matheu Source Type: research

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology
Ageing Res Rev. 2021 Jun 15;70:101393. doi: 10.1016/j.arr.2021.101393. Online ahead of print.ABSTRACTAgeing is a multifactorial biological process leading to a progressive decline of physiological functions. The process of ageing includes numerous changes in the cells and the interactions between cell-cell and cell-microenvironment remaining as a critical risk factor for the development of chronic degenerative diseases. Systemic inflammation, known as inflammageing, increases as a consequence of ageing contributing to age-related morbidities. But also, persistent and uncontrolled activation of fibrotic pathways, with exces...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Mois és Selman Annie Pardo Source Type: research

The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review
Ageing Res Rev. 2021 Jun 14:101394. doi: 10.1016/j.arr.2021.101394. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a common degenerative disease of the musculoskeletal system that develops with age. It is regarded as the main cause of chronic low back pain in the elderly. IDD has various causes, including ageing, mechanical overloading, and nutritional deficiency. Melatonin is a pleiotropic indole hormone secreted by the pineal gland and plays an important role in resisting various degenerative diseases. The serum levels of melatonin decline with age and are reported to be negatively correlated wit...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Zhangrong Cheng Qian Xiang Juntan Wang Yukun Zhang Source Type: research

Centenarians as models of healthy aging: Example of REST
This study goes from human to animal models and revealed that REST acts as an epigenetic regulator of neuronal homeostasis, to control aging and longevity. The aim of this view point is to summarize recent literature describing genetic and epigenetic factors, as well as molecular pathways associated with centenarians and the biology of aging. We will pay particular attention to the impact of REST in centenarians and longevity.PMID:34139339 | DOI:10.1016/j.arr.2021.101392 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Diego Marcos-P érez Ander Saenz-Anto ñanzas Ander Matheu Source Type: research

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology
Ageing Res Rev. 2021 Jun 14:101393. doi: 10.1016/j.arr.2021.101393. Online ahead of print.ABSTRACTAgeing is a multifactorial biological process leading to a progressive decline of physiological functions. The process of ageing includes numerous changes in the cells and the interactions between cell-cell and cell-microenvironment remaining as a critical risk factor for the development of chronic degenerative diseases. Systemic inflammation, known as inflammageing, increases as a consequence of ageing contributing to age-related morbidities. But also, persistent and uncontrolled activation of fibrotic pathways, with excessiv...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Mois és Selman Annie Pardo Source Type: research

The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review
Ageing Res Rev. 2021 Jun 14:101394. doi: 10.1016/j.arr.2021.101394. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is a common degenerative disease of the musculoskeletal system that develops with age. It is regarded as the main cause of chronic low back pain in the elderly. IDD has various causes, including ageing, mechanical overloading, and nutritional deficiency. Melatonin is a pleiotropic indole hormone secreted by the pineal gland and plays an important role in resisting various degenerative diseases. The serum levels of melatonin decline with age and are reported to be negatively correlated wit...
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Zhangrong Cheng Qian Xiang Juntan Wang Yukun Zhang Source Type: research

Centenarians as models of healthy aging: Example of REST
This study goes from human to animal models and revealed that REST acts as an epigenetic regulator of neuronal homeostasis, to control aging and longevity. The aim of this view point is to summarize recent literature describing genetic and epigenetic factors, as well as molecular pathways associated with centenarians and the biology of aging. We will pay particular attention to the impact of REST in centenarians and longevity.PMID:34139339 | DOI:10.1016/j.arr.2021.101392 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - June 17, 2021 Category: Genetics & Stem Cells Authors: Diego Marcos-P érez Ander Saenz-Anto ñanzas Ander Matheu Source Type: research

Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Ageing Res Rev. 2021 Jun 11;70:101391. doi: 10.1016/j.arr.2021.101391. Online ahead of print.ABSTRACTConformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with alpha-1 antitrypsin deficiency (AATD) are underdiagnosed. Enemy-aggregating proteins may reside in these underdiagnosed AATD patients for many years before a pathology for AATD fully develops. In this perspective review, we hypothesize that the AAT protein could exert a new and ...
Source: Ageing Research Reviews - June 13, 2021 Category: Genetics & Stem Cells Authors: Abdul-Hamid Emwas Mawadda Alghrably Manel Dhahri Abeer Sharfalddin Rawiah Alsiary Mariusz Jaremko Gavino Faa Marcello Campagna Terenzio Congiu Monica Piras Marco Piludu Giuseppina Pichiri Pierpaolo Coni Joanna Izabela Lachowicz Source Type: research

Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Ageing Res Rev. 2021 Jun 11;70:101391. doi: 10.1016/j.arr.2021.101391. Online ahead of print.ABSTRACTConformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with alpha-1 antitrypsin deficiency (AATD) are underdiagnosed. Enemy-aggregating proteins may reside in these underdiagnosed AATD patients for many years before a pathology for AATD fully develops. In this perspective review, we hypothesize that the AAT protein could exert a new and ...
Source: Ageing Research Reviews - June 13, 2021 Category: Genetics & Stem Cells Authors: Abdul-Hamid Emwas Mawadda Alghrably Manel Dhahri Abeer Sharfalddin Rawiah Alsiary Mariusz Jaremko Gavino Faa Marcello Campagna Terenzio Congiu Monica Piras Marco Piludu Giuseppina Pichiri Pierpaolo Coni Joanna Izabela Lachowicz Source Type: research

Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Ageing Res Rev. 2021 Jun 10:101391. doi: 10.1016/j.arr.2021.101391. Online ahead of print.ABSTRACTConformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with alpha-1 antitrypsin deficiency (AATD) are underdiagnosed. Enemy-aggregating proteins may reside in these underdiagnosed AATD patients for many years before a pathology for AATD fully develops. In this perspective review, we hypothesize that the AAT protein could exert a new and pre...
Source: Ageing Research Reviews - June 13, 2021 Category: Genetics & Stem Cells Authors: Abdul-Hamid Emwas Mawadda Alghrably Manel Dhahri Abeer Sharfalddin Rawiah Alsiary Mariusz Jaremko Gavino Faa Marcello Campagna Terenzio Congiu Monica Piras Marco Piludu Giuseppina Pichiri Pierpaolo Coni Joanna Izabela Lachowicz Source Type: research

Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Ageing Res Rev. 2021 Jun 10:101391. doi: 10.1016/j.arr.2021.101391. Online ahead of print.ABSTRACTConformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with alpha-1 antitrypsin deficiency (AATD) are underdiagnosed. Enemy-aggregating proteins may reside in these underdiagnosed AATD patients for many years before a pathology for AATD fully develops. In this perspective review, we hypothesize that the AAT protein could exert a new and pre...
Source: Ageing Research Reviews - June 13, 2021 Category: Genetics & Stem Cells Authors: Abdul-Hamid Emwas Mawadda Alghrably Manel Dhahri Abeer Sharfalddin Rawiah Alsiary Mariusz Jaremko Gavino Faa Marcello Campagna Terenzio Congiu Monica Piras Marco Piludu Giuseppina Pichiri Pierpaolo Coni Joanna Izabela Lachowicz Source Type: research

CircRNAs: Decrypting the novel targets of fibrosis and aging
Ageing Res Rev. 2021 Jun 9:101390. doi: 10.1016/j.arr.2021.101390. Online ahead of print.ABSTRACTFibrosis is a typical aging-related pathological process involving almost all organs. It is usually initiated by organic injury and leads to the gradual decline of organ function or even loss. Circular RNAs (circRNAs) are being hailed as a newly rediscovered class of covalently closed transcripts without a 5' cap or 3' tail which draw increasing attention. In particular, circRNAs have been identified to be involved in the multifaceted processes of fibrosis in various organs, including the heart, liver, lung, and kidney. As more...
Source: Ageing Research Reviews - June 12, 2021 Category: Genetics & Stem Cells Authors: Yang Yang Wangrui Lei Shuai Jiang Baoping Ding Changyu Wang Ying Chen Wenzhen Shi Zhen Wu Ye Tian Source Type: research

Age-related amyloidosis outside the brain: A state-of-the-art review
Ageing Res Rev. 2021 Jun 8:101388. doi: 10.1016/j.arr.2021.101388. Online ahead of print.ABSTRACTInside and outside the brain, accumulation of amyloid fibrils plays key roles in the pathogenesis of fatal age-related diseases such as Alzheimer's and Parkinson's diseases and wild-type transthyretin amyloidosis. Although the incidence of all amyloidoses increases with age, for some types of amyloidosis aging is known as the main direct risk factor, and these types are typically diseases of elderly people. More than 10 different precursor proteins are known to cause age-associated amyloidosis; these proteins include amyloid &b...
Source: Ageing Research Reviews - June 11, 2021 Category: Genetics & Stem Cells Authors: Masayoshi Tasaki Francesca Lavatelli Laura Obici Konen Obayashi Takeshi Miyamoto Giampaolo Merlini Giovanni Palladini Yukio Ando Mitsuharu Ueda Source Type: research

Age-related amyloidosis outside the brain: A state-of-the-art review
Ageing Res Rev. 2021 Jun 8:101388. doi: 10.1016/j.arr.2021.101388. Online ahead of print.ABSTRACTInside and outside the brain, accumulation of amyloid fibrils plays key roles in the pathogenesis of fatal age-related diseases such as Alzheimer's and Parkinson's diseases and wild-type transthyretin amyloidosis. Although the incidence of all amyloidoses increases with age, for some types of amyloidosis aging is known as the main direct risk factor, and these types are typically diseases of elderly people. More than 10 different precursor proteins are known to cause age-associated amyloidosis; these proteins include amyloid &b...
Source: Ageing Research Reviews - June 11, 2021 Category: Genetics & Stem Cells Authors: Masayoshi Tasaki Francesca Lavatelli Laura Obici Konen Obayashi Takeshi Miyamoto Giampaolo Merlini Giovanni Palladini Yukio Ando Mitsuharu Ueda Source Type: research

Novel insights into the relationship between cerebellum and dementia: a narrative review as a toolkit for clinicians
Ageing Res Rev. 2021 Jun 7:101389. doi: 10.1016/j.arr.2021.101389. Online ahead of print.ABSTRACTThe role of the cerebellum in neurodegenerative disorders that target cognitive functions has been a subject of increasing interest over the past years. However, a review focused on making clinicians more aware of the role of the cerebellum in dementia is still missing. This narrative review explores the possible factors explaining the involvement of the cerebellum in different kinds of dementia by providing more insights on how this structure can be relevant in clinical practice. It emerged that, despite overlapping in specifi...
Source: Ageing Research Reviews - June 10, 2021 Category: Genetics & Stem Cells Authors: Maria Devita Francesco Alberti Michela Fagnani Masina Fabio Enrica Ara Giuseppe Sergi Daniela Mapelli Alessandra Coin Source Type: research

Novel insights into the relationship between cerebellum and dementia: a narrative review as a toolkit for clinicians
Ageing Res Rev. 2021 Jun 7:101389. doi: 10.1016/j.arr.2021.101389. Online ahead of print.ABSTRACTThe role of the cerebellum in neurodegenerative disorders that target cognitive functions has been a subject of increasing interest over the past years. However, a review focused on making clinicians more aware of the role of the cerebellum in dementia is still missing. This narrative review explores the possible factors explaining the involvement of the cerebellum in different kinds of dementia by providing more insights on how this structure can be relevant in clinical practice. It emerged that, despite overlapping in specifi...
Source: Ageing Research Reviews - June 10, 2021 Category: Genetics & Stem Cells Authors: Maria Devita Francesco Alberti Michela Fagnani Masina Fabio Enrica Ara Giuseppe Sergi Daniela Mapelli Alessandra Coin Source Type: research

Gene targeting techniques for Huntington's disease
Ageing Res Rev. 2021 Jun 5;70:101385. doi: 10.1016/j.arr.2021.101385. Online ahead of print.ABSTRACTHuntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential, involved in a variety of crucial cellular functions such as vesicle transportation, cell division, transcription regulation, autophagy, and tissue maintenance. The mutant HTT (mHTT) proteins in the body interfere with HTT's normal cellular functions and cause additional detrimental effects. In this review, we discuss multiple approaches targetin...
Source: Ageing Research Reviews - June 7, 2021 Category: Genetics & Stem Cells Authors: Eric Fields Erik Vaughan Deepika Tripu Isabelle Lim Katherine Shrout Jessica Conway Nicole Salib Yubin Lee Akash Dhamsania Michael Jacobsen Ashley Woo Huijing Xue Kan Cao Source Type: research

Gene targeting techniques for Huntington's disease
Ageing Res Rev. 2021 Jun 4:101385. doi: 10.1016/j.arr.2021.101385. Online ahead of print.ABSTRACTHuntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential, involved in a variety of crucial cellular functions such as vesicle transportation, cell division, transcription regulation, autophagy, and tissue maintenance. The mutant HTT (mHTT) proteins in the body interfere with HTT's normal cellular functions and cause additional detrimental effects. In this review, we discuss multiple approaches targeting D...
Source: Ageing Research Reviews - June 7, 2021 Category: Genetics & Stem Cells Authors: Eric Fields Erik Vaughan Deepika Tripu Isabelle Lim Katherine Shrout Jessica Conway Nicole Salib Yubin Lee Akash Dhamsania Michael Jacobsen Ashley Woo Huijing Xue Kan Cao Source Type: research

Gene targeting techniques for Huntington's disease
Ageing Res Rev. 2021 Jun 4:101385. doi: 10.1016/j.arr.2021.101385. Online ahead of print.ABSTRACTHuntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential, involved in a variety of crucial cellular functions such as vesicle transportation, cell division, transcription regulation, autophagy, and tissue maintenance. The mutant HTT (mHTT) proteins in the body interfere with HTT's normal cellular functions and cause additional detrimental effects. In this review, we discuss multiple approaches targeting D...
Source: Ageing Research Reviews - June 7, 2021 Category: Genetics & Stem Cells Authors: Eric Fields Erik Vaughan Deepika Tripu Isabelle Lim Katherine Shrout Jessica Conway Nicole Salib Yubin Lee Akash Dhamsania Michael Jacobsen Ashley Woo Huijing Xue Kan Cao Source Type: research

Mitochondria: their relevance during oocyte ageing
Ageing Res Rev. 2021 Jun 3:101378. doi: 10.1016/j.arr.2021.101378. Online ahead of print.ABSTRACTThe oocyte is recognised as the largest cell in mammalian species and other multicellular organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and mitochondrial architecture is different in oocytes than in somatic cells, characterised by its rounder appearance and fragmented network. Although the number of mitochondria per oocyte is higher than in any other mammalian cell, their number and activity decrease with advancing age. Mitochondria integrate numerous processes essential for cellular function, ...
Source: Ageing Research Reviews - June 6, 2021 Category: Genetics & Stem Cells Authors: Jiska van der Reest Gustavo Nardini Cecchino Marcia C Haigis Pawe ł Kordowitzki Source Type: research

Mitochondria: their relevance during oocyte ageing
Ageing Res Rev. 2021 Jun 3:101378. doi: 10.1016/j.arr.2021.101378. Online ahead of print.ABSTRACTThe oocyte is recognised as the largest cell in mammalian species and other multicellular organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and mitochondrial architecture is different in oocytes than in somatic cells, characterised by its rounder appearance and fragmented network. Although the number of mitochondria per oocyte is higher than in any other mammalian cell, their number and activity decrease with advancing age. Mitochondria integrate numerous processes essential for cellular function, ...
Source: Ageing Research Reviews - June 6, 2021 Category: Genetics & Stem Cells Authors: Jiska van der Reest Gustavo Nardini Cecchino Marcia C Haigis Pawe ł Kordowitzki Source Type: research

Transcranial Direct Current Stimulation Decreased Cognition-Related Reaction Time in Older Adults: A Systematic Review and Meta-Analysis
CONCLUSIONS: These findings suggest that providing online tDCS may effectively improve the ageing-induced reaction time related to specific cognitive functions of elderly people.PMID:34089900 | DOI:10.1016/j.arr.2021.101377 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - June 5, 2021 Category: Genetics & Stem Cells Authors: Joon Ho Lee Tae Lee Lee Nyeonju Kang Source Type: research

The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging
Ageing Res Rev. 2021 Jun 2:101376. doi: 10.1016/j.arr.2021.101376. Online ahead of print.ABSTRACTAging can not only shorten a healthy lifespan, but can also lead to multi-organ dysfunction and failure. Anti-aging is a complex and worldwide conundrum for eliminating the various pathologies of senility. The past decade has seen great progress in the understanding of the aging-associated signaling pathways and their application for developing anti-aging approaches. Currently, some drugs can improve quality of life. The activation of mammalian target of rapamycin (mTOR) signaling is one of the core and detrimental mechanisms r...
Source: Ageing Research Reviews - June 5, 2021 Category: Genetics & Stem Cells Authors: Yan Zhang Jinjin Zhang Shixuan Wang Source Type: research

miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
Ageing Res Rev. 2021 May 31:101374. doi: 10.1016/j.arr.2021.101374. Online ahead of print.ABSTRACTThe first paper on "inflammaging" published in 2001 paved the way for a unifying theory on how and why aging turns out to be the main risk factor for the development of the most common age-related diseases (ARDs). The most exciting challenge on this topic was explaining how systemic inflammation steeps up with age and why it shows different rates among individuals of the same chronological age. The "epigenetic revolution" in the past twenty years conveyed that the assessment of the individual genetic make-u...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: Fabiola Olivieri Francesco Prattichizzo Angelica Giuliani Giulia Matacchione Maria Rita Rippo Jacopo Sabbatinelli Massimiliano Bonaf è Source Type: research

Interspecific interactions that affect ageing: age-distorters manipulate host ageing to their own evolutionary benefits
Ageing Res Rev. 2021 May 31:101375. doi: 10.1016/j.arr.2021.101375. Online ahead of print.ABSTRACTGenetic causes for ageing are traditionally investigated within a species. Yet, the lifecycles of many organisms intersect. Additional evolutionary and genetic causes of ageing, external to a focal species/organism, may thus be overlooked. Here, we introduce the phrase and concept of age-distorters and its evidence. Age-distorters carry ageing interfering genes, used to manipulate the biological age of other entities upon which the reproduction of age-distorters relies, e.g. age-distorters bias the reproduction/maintenance tra...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: J érôme Teulière Charles Bernard Eric Bapteste Source Type: research

miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
Ageing Res Rev. 2021 May 31:101374. doi: 10.1016/j.arr.2021.101374. Online ahead of print.ABSTRACTThe first paper on "inflammaging" published in 2001 paved the way for a unifying theory on how and why aging turns out to be the main risk factor for the development of the most common age-related diseases (ARDs). The most exciting challenge on this topic was explaining how systemic inflammation steeps up with age and why it shows different rates among individuals of the same chronological age. The "epigenetic revolution" in the past twenty years conveyed that the assessment of the individual genetic make-u...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: Fabiola Olivieri Francesco Prattichizzo Angelica Giuliani Giulia Matacchione Maria Rita Rippo Jacopo Sabbatinelli Massimiliano Bonaf è Source Type: research

Interspecific interactions that affect ageing: age-distorters manipulate host ageing to their own evolutionary benefits
Ageing Res Rev. 2021 May 31:101375. doi: 10.1016/j.arr.2021.101375. Online ahead of print.ABSTRACTGenetic causes for ageing are traditionally investigated within a species. Yet, the lifecycles of many organisms intersect. Additional evolutionary and genetic causes of ageing, external to a focal species/organism, may thus be overlooked. Here, we introduce the phrase and concept of age-distorters and its evidence. Age-distorters carry ageing interfering genes, used to manipulate the biological age of other entities upon which the reproduction of age-distorters relies, e.g. age-distorters bias the reproduction/maintenance tra...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: J érôme Teulière Charles Bernard Eric Bapteste Source Type: research

miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
Ageing Res Rev. 2021 May 31:101374. doi: 10.1016/j.arr.2021.101374. Online ahead of print.ABSTRACTThe first paper on "inflammaging" published in 2001 paved the way for a unifying theory on how and why aging turns out to be the main risk factor for the development of the most common age-related diseases (ARDs). The most exciting challenge on this topic was explaining how systemic inflammation steeps up with age and why it shows different rates among individuals of the same chronological age. The "epigenetic revolution" in the past twenty years conveyed that the assessment of the individual genetic make-u...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: Fabiola Olivieri Francesco Prattichizzo Angelica Giuliani Giulia Matacchione Maria Rita Rippo Jacopo Sabbatinelli Massimiliano Bonaf è Source Type: research

Interspecific interactions that affect ageing: age-distorters manipulate host ageing to their own evolutionary benefits
Ageing Res Rev. 2021 May 31:101375. doi: 10.1016/j.arr.2021.101375. Online ahead of print.ABSTRACTGenetic causes for ageing are traditionally investigated within a species. Yet, the lifecycles of many organisms intersect. Additional evolutionary and genetic causes of ageing, external to a focal species/organism, may thus be overlooked. Here, we introduce the phrase and concept of age-distorters and its evidence. Age-distorters carry ageing interfering genes, used to manipulate the biological age of other entities upon which the reproduction of age-distorters relies, e.g. age-distorters bias the reproduction/maintenance tra...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: J érôme Teulière Charles Bernard Eric Bapteste Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26;69:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is relevant in older people. Attention was given to the nursing homes in which frailer people are usually admitted. In this review, we discuss the approaches for daily problems found in nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anot...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26;69:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is relevant in older people. Attention was given to the nursing homes in which frailer people are usually admitted. In this review, we discuss the approaches for daily problems found in nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anot...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26;69:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is relevant in older people. Attention was given to the nursing homes in which frailer people are usually admitted. In this review, we discuss the approaches for daily problems found in nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anot...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is increasing in older people. Attention was given to the nursing homes in which frail people are usually admitted. In this work, we discuss the approaches for daily problems found in our nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anoth...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

The role of senescence in the pathogenesis of atrial fibrillation: a target process for health improvement and drug development
Ageing Res Rev. 2021 May 20:101363. doi: 10.1016/j.arr.2021.101363. Online ahead of print.ABSTRACTCellular senescence is a state of growth arrest that occurs after cells encounter various stresses. Senescence contributes to tumour suppression, embryonic development, and wound healing. It impacts on the pathology of various diseases by secreting inflammatory chemokines, immune modulators and other bioactive factors. These secretory biosignatures ultimately cause inflammation, tissue fibrosis, immunosenescence and many ageing-related diseases such as atrial fibrillation (AF). Because the molecular mechanisms underpinning AF ...
Source: Ageing Research Reviews - May 23, 2021 Category: Genetics & Stem Cells Authors: Guangran Guo Steven Watterson Shu-Dong Zhang Anthony Bjourson Victoria McGilligan Aaron Peace Taranjit Singh Rai Source Type: research

Cellular functions regulated by deubiquitinating enzymes in neurodegenerative diseases
Ageing Res Rev. 2021 May 20:101367. doi: 10.1016/j.arr.2021.101367. Online ahead of print.ABSTRACTNeurodegenerative diseases are one of the most common diseases in mankind. Although there are reports of several candidates that cause neurodegenerative diseases, the exact mechanism of pathogenesis is poorly understood. The ubiquitin-proteasome system (UPS) is an important posttranslational modification for protein degradation and control of homeostasis. Enzymes such as E1, E2, E3 ligases, and deubiquitinating enzymes (DUBs) participating in UPS, regulate disease-inducing proteins by controlling the degree of ubiquitination. ...
Source: Ageing Research Reviews - May 23, 2021 Category: Genetics & Stem Cells Authors: Hyeon-Ah Do Kwang-Hyun Baek Source Type: research

Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials
Ageing Res Rev. 2021 May 19:101368. doi: 10.1016/j.arr.2021.101368. Online ahead of print.ABSTRACTBACKGROUND: We aimed to summarize evidence on the safety, adherence and effectiveness of home-based resistance training (UHBRT) for improving health-related endpoints in community-dwelling older adults.METHODS: Randomized controlled trials of UHBRT in older adults (≥60yrs) were included after a systematic search (PubMed, CINAHL, PsycInfo, SPORTDiscus, Web of Science, MEDLINE, Cochrane Central Register of Controlled Trials) until 02/19/2021. Adverse events and adherence rates were assessed as indicators of feasibility. Other...
Source: Ageing Research Reviews - May 22, 2021 Category: Genetics & Stem Cells Authors: Asier Ma ñas Paola G ómez-Redondo Pedro L Valenzuela Javier S Morales Alejandro Luc ía Ignacio Ara Source Type: research