The neuroprotective effects of Ferulic acid in toxin-induced models of Parkinson's disease: a review
Ageing Res Rev. 2024 Apr 9:102299. doi: 10.1016/j.arr.2024.102299. Online ahead of print.ABSTRACTParkinson's disease is predominantly caused by dopaminergic neuron loss in the substantia nigra pars compacta and the accumulation of alpha-synuclein protein. Though the general consensus is that several factors, such as aging, environmental factors, mitochondrial dysfunction, accumulations of neurotoxic alpha-synuclein, malfunctions of the lysosomal and proteasomal protein degradation systems, oxidative stress, and neuroinflammation, are involved in the neurodegeneration process of Parkinson's disease, the precise mechanism by...
Source: Ageing Research Reviews - April 11, 2024 Category: Genetics & Stem Cells Authors: Samira Hassani Abolghasem Esmaeili Source Type: research
Innovative Approaches to Alzheimer's Therapy: Harnessing the Power of Heterocycles, Oxidative Stress Management, and Nanomaterial Drug Delivery System
Ageing Res Rev. 2024 Apr 9:102298. doi: 10.1016/j.arr.2024.102298. Online ahead of print.ABSTRACTAlzheimer's disease (AD) presents a complex pathology involving amyloidogenic proteolysis, neuroinflammation, mitochondrial dysfunction, and cholinergic deficits. Oxidative stress exacerbates AD progression through pathways like macromolecular peroxidation, mitochondrial dysfunction, and metal ion redox potential alteration linked to amyloid-beta (Aβ). Despite limited approved medications, heterocyclic compounds have emerged as promising candidates in AD drug discovery. This review highlights recent advancements in synthetic h...
Source: Ageing Research Reviews - April 11, 2024 Category: Genetics & Stem Cells Authors: Mohammad Umar Yasir Rehman Subiya Ambreen Sayed Md Mumtaz Mohd Shaququzzaman Mohammad Mumtaz Alam Ruhi Ali Source Type: research
Effects of home-based and telerehabilitation exercise on mental and physical health, and disease cost in people with Alzheimer's disease: a meta-analysis
CONCLUSION: There is a low evidence on the effects of home-based physical activity or exercise on global cognitive function, neuropsychiatric symptoms and ADL.PMID:38599523 | DOI:10.1016/j.arr.2024.102284 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 10, 2024 Category: Genetics & Stem Cells Authors: Auwal Abdullahi Thomson Wai-Lung Wong Shamay Sheung-Mei Ng Source Type: research
NETosis in tumour microenvironment of liver: from primary to metastatic hepatic carcinoma
In conclusion, NETosis is important in the TME of liver. NETs have been shown to contribute to the progression and metastasis of liver cancer. The interaction between NETosis and immune cells in the TME, as well as related therapies, are important areas of research.PMID:38599524 | DOI:10.1016/j.arr.2024.102297 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 10, 2024 Category: Genetics & Stem Cells Authors: Yi Yang Siyue Yu Chao Lv Yu Tian Source Type: research
Effects of home-based and telerehabilitation exercise on mental and physical health, and disease cost in people with Alzheimer's disease: a meta-analysis
CONCLUSION: There is a low evidence on the effects of home-based physical activity or exercise on global cognitive function, neuropsychiatric symptoms and ADL.PMID:38599523 | DOI:10.1016/j.arr.2024.102284 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 10, 2024 Category: Genetics & Stem Cells Authors: Auwal Abdullahi Thomson Wai-Lung Wong Shamay Sheung-Mei Ng Source Type: research
NETosis in tumour microenvironment of liver: from primary to metastatic hepatic carcinoma
In conclusion, NETosis is important in the TME of liver. NETs have been shown to contribute to the progression and metastasis of liver cancer. The interaction between NETosis and immune cells in the TME, as well as related therapies, are important areas of research.PMID:38599524 | DOI:10.1016/j.arr.2024.102297 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 10, 2024 Category: Genetics & Stem Cells Authors: Yi Yang Siyue Yu Chao Lv Yu Tian Source Type: research
A systematic review of lifespan studies in rodents using stem cell transplantations
Ageing Res Rev. 2024 Apr 6:102295. doi: 10.1016/j.arr.2024.102295. Online ahead of print.ABSTRACTOrganismal aging involves the progressive decline in organ function and increased susceptibility to age-associated diseases. Regardless of its origin, cellular aging is consequently reflected at the level of organ and associated systems dysfunction. Aging of stem cell populations within the body and their decreased ability to self-renew, differentiate, and regenerate damaged tissues, is a key contributor to organismal decline. Based on this, supplementing young stem cells may delay tissue aging, improve frailty and extend healt...
Source: Ageing Research Reviews - April 8, 2024 Category: Genetics & Stem Cells Authors: Oliver G Frost Pranav Ramkilawan Abdelhadi Rebbaa Alexandra Stolzing Source Type: research
Tissue fibroblasts are versatile immune regulators: an evaluation of their impact on the aging process
Ageing Res Rev. 2024 Apr 6:102296. doi: 10.1016/j.arr.2024.102296. Online ahead of print.ABSTRACTFibroblasts are abundant stromal cells which not only control the integrity of extracellular matrix (ECM) but also act as immune regulators. It is known that the structural cells within tissues can establish an organ-specific immunity expressing many immune-related genes and closely interact with immune cells. In fact, fibroblasts can modify their immune properties to display both pro-inflammatory and immunosuppressive activities in a context-dependent manner. After acute insults, fibroblasts promote tissue inflammation althoug...
Source: Ageing Research Reviews - April 8, 2024 Category: Genetics & Stem Cells Authors: Antero Salminen Kai Kaarniranta Anu Kauppinen Source Type: research
A systematic review of lifespan studies in rodents using stem cell transplantations
Ageing Res Rev. 2024 Apr 6:102295. doi: 10.1016/j.arr.2024.102295. Online ahead of print.ABSTRACTOrganismal aging involves the progressive decline in organ function and increased susceptibility to age-associated diseases. Regardless of its origin, cellular aging is consequently reflected at the level of organ and associated systems dysfunction. Aging of stem cell populations within the body and their decreased ability to self-renew, differentiate, and regenerate damaged tissues, is a key contributor to organismal decline. Based on this, supplementing young stem cells may delay tissue aging, improve frailty and extend healt...
Source: Ageing Research Reviews - April 8, 2024 Category: Genetics & Stem Cells Authors: Oliver G Frost Pranav Ramkilawan Abdelhadi Rebbaa Alexandra Stolzing Source Type: research
Tissue fibroblasts are versatile immune regulators: an evaluation of their impact on the aging process
Ageing Res Rev. 2024 Apr 6:102296. doi: 10.1016/j.arr.2024.102296. Online ahead of print.ABSTRACTFibroblasts are abundant stromal cells which not only control the integrity of extracellular matrix (ECM) but also act as immune regulators. It is known that the structural cells within tissues can establish an organ-specific immunity expressing many immune-related genes and closely interact with immune cells. In fact, fibroblasts can modify their immune properties to display both pro-inflammatory and immunosuppressive activities in a context-dependent manner. After acute insults, fibroblasts promote tissue inflammation althoug...
Source: Ageing Research Reviews - April 8, 2024 Category: Genetics & Stem Cells Authors: Antero Salminen Kai Kaarniranta Anu Kauppinen Source Type: research
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
Ageing Res Rev. 2024 Apr 5;97:102294. doi: 10.1016/j.arr.2024.102294. Online ahead of print.ABSTRACTCellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also re...
Source: Ageing Research Reviews - April 7, 2024 Category: Genetics & Stem Cells Authors: Qing Zeng Yongzhen Gong Neng Zhu Yaning Shi Chanjuan Zhang Li Qin Source Type: research
Lipids and Lipid Metabolism in Cellular Senescence: Emerging Targets for Age-Related Diseases
Ageing Res Rev. 2024 Apr 5:102294. doi: 10.1016/j.arr.2024.102294. Online ahead of print.ABSTRACTCellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also regul...
Source: Ageing Research Reviews - April 7, 2024 Category: Genetics & Stem Cells Authors: Qing Zeng YongZhen Gong Neng Zhu YaNing Shi ChanJuan Zhang Li Qin Source Type: research
Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs
Ageing Res Rev. 2024 Apr 4;96:102289. doi: 10.1016/j.arr.2024.102289. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases; however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of populations. The term dementia is defined as loss of memory which further takes several other categories of memories like working memory, spatial memory, fear memory, and long-term, and short-term memory into consideration. In this review, these memories have critically been elaborated based on context, duration, events, appearance, intensity, etc. ...
Source: Ageing Research Reviews - April 6, 2024 Category: Genetics & Stem Cells Authors: Ansab Akhtar Siddharth Singh Ravinder Kaushik Rajendra Awasthi Tapan Behl Source Type: research
The Impact of Maternal Age on Aneuploidy in Oocytes: Reproductive Consequences, Molecular Mechanisms, and Future Directions
Ageing Res Rev. 2024 Apr 4:102292. doi: 10.1016/j.arr.2024.102292. Online ahead of print.ABSTRACTAge-related aneuploidy in human oocytes is a major factor contributing to decreased fertility and adverse reproductive outcomes. As females age, their oocytes are more prone to meiotic chromosome segregation errors, leading primarily to aneuploidy. Elevated aneuploidy rates have also been observed in oocytes from very young, prepubertal conceptions. A key barrier to developing effective treatments for age-related oocyte aneuploidy is our incomplete understanding of the molecular mechanisms involved. The challenge is becoming in...
Source: Ageing Research Reviews - April 6, 2024 Category: Genetics & Stem Cells Authors: Weiwei Huang Xinyuan Li Hongbo Yang Hefeng Huang Source Type: research
Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs
Ageing Res Rev. 2024 Apr 4:102289. doi: 10.1016/j.arr.2024.102289. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases; however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of populations. The term dementia is defined as loss of memory which further takes several other categories of memories like working memory, spatial memory, fear memory, and long-term, and short-term memory into consideration. In this review, these memories have critically been elaborated based on context, duration, events, appearance, intensity, etc. The...
Source: Ageing Research Reviews - April 6, 2024 Category: Genetics & Stem Cells Authors: Ansab Akhtar Siddharth Singh Ravinder Kaushik Rajendra Awasthi Tapan Behl Source Type: research
