Circulating arginine metabolites in Alzheimer's disease and vascular dementia: A systematic review and meta-analysis
CONCLUSION: Alterations in ADMA, SDMA, and citrulline, biomarkers of NO synthesis, may be useful to investigate the pathophysiology of different forms of dementia and identify novel therapeutic strategies. (PROSPERO registration number: CRD42023439528).PMID:38007048 | DOI:10.1016/j.arr.2023.102139 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 25, 2023 Category: Genetics & Stem Cells Authors: Angelo Zinellu Sara Tommasi Stefania Sedda Arduino A Mangoni Source Type: research
An Umbrella Review on the Association between Factors of Oral Health and Cognitive Dysfunction
In conclusion, the diversity of oral and cognitive factors included in the review studies reflects the complexity of oral-cognitive links. Clarifying the factors helps to form evidence-based clinical advice for healthcare.PMID:38007045 | DOI:10.1016/j.arr.2023.102128 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 25, 2023 Category: Genetics & Stem Cells Authors: Chia-Shu Lin Ta-Chung Chen Merel Charlotte Verhoeff Frank Lobbezoo Mats Trulsson Jong-Ling Fuh Source Type: research
DNA damage response, a double-edged sword for vascular aging
Ageing Res Rev. 2023 Nov 23:102137. doi: 10.1016/j.arr.2023.102137. Online ahead of print.ABSTRACTVascular aging is a major risk factor for age-related cardiovascular diseases, which have high rates of morbidity and mortality. It is characterized by changes in the blood vessels, such as macroscopically increased vascular diameter and intima-medial thickness, chronic inflammation, vascular calcification, arterial stiffening, and atherosclerosis. DNA damage and the subsequent various DNA damage response (DDR) pathways are important causative factors of vascular aging. Deficient DDR, which may result in the accumulation of un...
Source: Ageing Research Reviews - November 25, 2023 Category: Genetics & Stem Cells Authors: Xiao Zhang Qing Zhao Tao Wang Qilin Long Yixin Sun Liqun Jiao Monika Gullerova Source Type: research
Universal masking during COVID-19 outbreaks in aged care settings: a systematic review and meta-analysis
Ageing Res Rev. 2023 Nov 23:102138. doi: 10.1016/j.arr.2023.102138. Online ahead of print.ABSTRACTAged care facilities (ACFs) are a high-risk COVID-19 transmission setting, and older residents are at greater risk of severe outcomes. This systematic review and meta-analysis assessed whether universal masking and COVID-19 vaccination reduce SARS-CoV-2 attack rates (ARs) in ACFs. Articles published between 1 December 2019 and 28 February 2022 were screened across five databases (Medline, Embase, PubMed, Scopus, Web of Science and Cumulative Index to Nursing and Allied Health Literature (CINAHL)). Risk of bias was assessed usi...
Source: Ageing Research Reviews - November 25, 2023 Category: Genetics & Stem Cells Authors: Rosalie Chen Shwetha G Kezhekkekara Mohana P Kunasekaran Chandini R MacIntyre Source Type: research
Circulating arginine metabolites in Alzheimer's disease and vascular dementia: a systematic review and meta-analysis
CONCLUSION: Alterations in ADMA, SDMA, and citrulline, biomarkers of NO synthesis, may be useful to investigate the pathophysiology of different forms of dementia and identify novel therapeutic strategies. (PROSPERO registration number: CRD42023439528).PMID:38007048 | DOI:10.1016/j.arr.2023.102139 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 25, 2023 Category: Genetics & Stem Cells Authors: Angelo Zinellu Sara Tommasi Stefania Sedda Arduino A Mangoni Source Type: research
Phytomolecules from conventional to nano form: next-generation approach for parkinson's disease
Ageing Res Rev. 2023 Nov 22:102136. doi: 10.1016/j.arr.2023.102136. Online ahead of print.ABSTRACTThe incidence of neurodegenerative diseases is increasing exponentially worldwide. Parkinson's disease (PD) is a neurodegenerative disease caused by factors like oxidative stress, gene mutation, mitochondrial dysfunction, neurotoxins, activation of microglial inflammatory mediators, deposition of Lewy's bodies, and α- synuclein proteins in the neurons leading to neuroinflammation and neurodegeneration in the substantia nigra. Hence the development of efficacious neuro-therapy is in demand which can prevent neurodegeneration a...
Source: Ageing Research Reviews - November 24, 2023 Category: Genetics & Stem Cells Authors: Sweta Priyadarshini Pradhan P Tejaswani Anindita Behera Pratap Kumar Sahu Source Type: research
Neural stem cells persist to generate new neurons in the hippocampus of adult and aged human brain - Fiction or accurate?
Ageing Res Rev. 2023 Nov 23;92:102133. doi: 10.1016/j.arr.2023.102133. Online ahead of print.ABSTRACTAdult neurogenesis, comprising the generation, differentiation and integration of new neurons in the mature brain, has emerged as a dynamic area of research over decades. The discovery of adult neurogenesis was a paradigm shift to comprehend mechanisms underlying brain plasticity, cognitive function, and neurological disorders. This review deliberates significant findings from articles published over four decades on adult neurogenesis, highlighting key milestones, methodological advances, and controversies that have shaped ...
Source: Ageing Research Reviews - November 24, 2023 Category: Genetics & Stem Cells Authors: Gabriele Zanirati Padmashri A Shetty Ashok K Shetty Source Type: research
Phytomolecules from conventional to nano form: next-generation approach for parkinson's disease
Ageing Res Rev. 2023 Nov 22:102136. doi: 10.1016/j.arr.2023.102136. Online ahead of print.ABSTRACTThe incidence of neurodegenerative diseases is increasing exponentially worldwide. Parkinson's disease (PD) is a neurodegenerative disease caused by factors like oxidative stress, gene mutation, mitochondrial dysfunction, neurotoxins, activation of microglial inflammatory mediators, deposition of Lewy's bodies, and α- synuclein proteins in the neurons leading to neuroinflammation and neurodegeneration in the substantia nigra. Hence the development of efficacious neuro-therapy is in demand which can prevent neurodegeneration a...
Source: Ageing Research Reviews - November 24, 2023 Category: Genetics & Stem Cells Authors: Sweta Priyadarshini Pradhan P Tejaswani Anindita Behera Pratap Kumar Sahu Source Type: research
Neural Stem Cells Persist to Generate New Neurons in the Hippocampus of Adult and Aged Human Brain - Fiction or Accurate?
Ageing Res Rev. 2023 Nov 22:102133. doi: 10.1016/j.arr.2023.102133. Online ahead of print.ABSTRACTAdult neurogenesis, comprising the generation, differentiation and integration of new neurons in the mature brain, has emerged as a dynamic area of research over decades. The discovery of adult neurogenesis was a paradigm shift to comprehend mechanisms underlying brain plasticity, cognitive function, and neurological disorders. This review deliberates significant findings from articles published over four decades on adult neurogenesis, highlighting key milestones, methodological advances, and controversies that have shaped our...
Source: Ageing Research Reviews - November 24, 2023 Category: Genetics & Stem Cells Authors: Gabriele Zanirati Padmashri A Shetty Ashok K Shetty Source Type: research
The effectiveness of nursing interventions for elderly dementia patients based on virtual reality technology: a systematic review and meta-analysis
CONCLUSIONS: The current results suggest that virtual reality-based nursing interventions have a positive effect on improving cognitive function, activities of daily living and improving quality of life in patients with dementia. Due to the limitations of the quantity and quality of the included literature, the above findings are yet to be validated by more high-quality studies.PMID:37995900 | DOI:10.1016/j.arr.2023.102135 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 23, 2023 Category: Genetics & Stem Cells Authors: Jun Wen Hong Yan Siyu Wang Jialan Xu Zitong Zhou Source Type: research
Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging
Ageing Res Rev. 2023 Nov 19;92:102132. doi: 10.1016/j.arr.2023.102132. Online ahead of print.ABSTRACTRepurposing drugs already approved in the clinic to be used off-label as geroprotectors, compounds that combat mechanisms of aging, are a promising way to rapidly reduce age-related disease incidence in society. Several recent studies have found that a class of drugs-nucleoside reverse transcriptase inhibitors (NRTIs)-originally developed as treatments for cancers and human immunodeficiency virus (HIV) infection, could be repurposed to slow the aging process. Interestingly, these studies propose complementary mechanisms tha...
Source: Ageing Research Reviews - November 20, 2023 Category: Genetics & Stem Cells Authors: Thomas Brochard Rebecca L McIntyre Riekelt H Houtkooper Andrei Seluanov Vera Gorbunova Georges E Janssens Source Type: research
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?
Ageing Res Rev. 2023 Nov 19;92:102131. doi: 10.1016/j.arr.2023.102131. Online ahead of print.ABSTRACTHere we propose that SGLT2 inhibitors (SGLT2i), a class of drugs primarily used to treat type 2 diabetes, could also be repositioned as anti-aging senomorphic drugs (agents that prevent the extrinsic harmful effects of senescent cells). As observed for metformin, another anti-diabetic drug with established anti-aging potential, increasing evidence suggests that SGLT2i can modulate some relevant pathways associated with the aging process, such as free radical production, cellular energy regulation through AMP-activated prote...
Source: Ageing Research Reviews - November 20, 2023 Category: Genetics & Stem Cells Authors: Lucia Scisciola Fabiola Olivieri Concetta Ambrosino Michelangela Barbieri Maria Rosaria Rizzo Giuseppe Paolisso Source Type: research
Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging
Ageing Res Rev. 2023 Nov 18:102132. doi: 10.1016/j.arr.2023.102132. Online ahead of print.ABSTRACTRepurposing drugs already approved in the clinic to be used off-label as geroprotectors, compounds that combat mechanisms of aging, are a promising way to rapidly reduce age-related disease incidence in society. Several recent studies have found that a class of drugs-nucleoside reverse transcriptase inhibitors (NRTIs)-originally developed as treatments for cancers and human immunodeficiency virus (HIV) infection, could be repurposed to slow the aging process. Interestingly, these studies propose complementary mechanisms that t...
Source: Ageing Research Reviews - November 20, 2023 Category: Genetics & Stem Cells Authors: Thomas Brochard Rebecca L McIntyre Riekelt H Houtkooper Andrei Seluanov Vera Gorbunova Georges E Janssens Source Type: research
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?
Ageing Res Rev. 2023 Nov 19;92:102131. doi: 10.1016/j.arr.2023.102131. Online ahead of print.ABSTRACTHere we propose that SGLT2 inhibitors (SGLT2i), a class of drugs primarily used to treat type 2 diabetes, could also be repositioned as anti-aging senomorphic drugs (agents that prevent the extrinsic harmful effects of senescent cells). As observed for metformin, another anti-diabetic drug with established anti-aging potential, increasing evidence suggests that SGLT2i can modulate some relevant pathways associated with the aging process, such as free radical production, cellular energy regulation through AMP-activated prote...
Source: Ageing Research Reviews - November 20, 2023 Category: Genetics & Stem Cells Authors: Lucia Scisciola Fabiola Olivieri Concetta Ambrosino Michelangela Barbieri Maria Rosaria Rizzo Giuseppe Paolisso Source Type: research
Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging
Ageing Res Rev. 2023 Nov 18:102132. doi: 10.1016/j.arr.2023.102132. Online ahead of print.ABSTRACTRepurposing drugs already approved in the clinic to be used off-label as geroprotectors, compounds that combat mechanisms of aging, are a promising way to rapidly reduce age-related disease incidence in society. Several recent studies have found that a class of drugs-nucleoside reverse transcriptase inhibitors (NRTIs)-originally developed as treatments for cancers and human immunodeficiency virus (HIV) infection, could be repurposed to slow the aging process. Interestingly, these studies propose complementary mechanisms that t...
Source: Ageing Research Reviews - November 20, 2023 Category: Genetics & Stem Cells Authors: Thomas Brochard Rebecca L McIntyre Riekelt H Houtkooper Andrei Seluanov Vera Gorbunova Georges E Janssens Source Type: research
