Post-translational modifications: Regulators of neurodegenerative proteinopathies
Ageing Res Rev. 2021 Mar 25:101336. doi: 10.1016/j.arr.2021.101336. Online ahead of print.ABSTRACTOne of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation of aggregated and/or non-functional protein in the cellular milieu. Post-translational modifications (PTMs) are an essential regulator of non-functional protein aggregation in the pathogenesis of NDDs. Any alteration in the post-translational mechanism and the protein quality control system, for instance, molecular chaperone, ubiquitin-proteasome system, autophagy-lysosomal degradation pathway, enhances the accumulation of misfolded prot...
Source: Ageing Research Reviews - March 29, 2021 Category: Genetics & Stem Cells Authors: Rohan Gupta Mehar Sahu Devesh Srivastava Swati Tiwari Rashmi K Ambasta Pravir Kumar Source Type: research

Post-translational modifications: Regulators of neurodegenerative proteinopathies
Ageing Res Rev. 2021 Mar 25:101336. doi: 10.1016/j.arr.2021.101336. Online ahead of print.ABSTRACTOne of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation of aggregated and/or non-functional protein in the cellular milieu. Post-translational modifications (PTMs) are an essential regulator of non-functional protein aggregation in the pathogenesis of NDDs. Any alteration in the post-translational mechanism and the protein quality control system, for instance, molecular chaperone, ubiquitin-proteasome system, autophagy-lysosomal degradation pathway, enhances the accumulation of misfolded prot...
Source: Ageing Research Reviews - March 29, 2021 Category: Genetics & Stem Cells Authors: Rohan Gupta Mehar Sahu Devesh Srivastava Swati Tiwari Rashmi K Ambasta Pravir Kumar Source Type: research

Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease
Ageing Res Rev. 2021 Mar 24:101333. doi: 10.1016/j.arr.2021.101333. Online ahead of print.ABSTRACTThe responses of central nervous system (CNS) cells such as neurons and glia in neurodegenerative diseases (NDs) suggest that regulation of neuronal and glial functions could be a strategy for ND prevention and/or treatment. However, attempts to develop such therapeutics for NDs have been hindered by the challenge of blood-brain barrier (BBB) permeability and continued constitutive neuronal loss. These limitations indicate the need for additional perspectives for the prevention/treatment of NDs. In particular, the disruption o...
Source: Ageing Research Reviews - March 28, 2021 Category: Genetics & Stem Cells Authors: Min-Tae Jeon Kyu-Sung Kim Eun Seon Kim Suji Lee Jieun Kim Hyang-Sook Hoe Do-Geun Kim Source Type: research

Attenuation of 7-ketocholesterol- and 7 β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: potential for the prevention of age-related diseases
Ageing Res Rev. 2021 Mar 24:101324. doi: 10.1016/j.arr.2021.101324. Online ahead of print.ABSTRACTAge-related diseases for which there are no effective treatments include cardiovascular diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as cataract and age-related macular degeneration; and, more recently, Severe Acute Respiratory Syndrome (SARS-CoV-2). These diseases are associated with plasma and/or tissue increases in cholesterol derivatives mainly formed by auto-oxidation: 7-ketocholesterol, also known as 7-oxo-cholesterol, and 7β-hydroxycholesterol. The formation of these oxystero...
Source: Ageing Research Reviews - March 28, 2021 Category: Genetics & Stem Cells Authors: T Nury A Yammine I Ghzaiel K Sassi A Zarrouk F Brahmi M Samadi S Rup-Jacques D Vervandier-Fasseur J P Pais de Barros V Bergas S Ghosh M Majeed A Pande A Atanasov S Hammami M Hammami J Mackrill B Nasser P Andreoletti M Cherkaoui-Malki A Vejux G Lizard Source Type: research

Ageing of the gut microbiome: potential influences on immune senescence and inflammageing
Ageing Res Rev. 2021 Mar 23:101323. doi: 10.1016/j.arr.2021.101323. Online ahead of print.ABSTRACTAdvancing age is accompanied by changes in the gut microbiota characterised by a loss of beneficial commensal microbes that is driven by intrinsic and extrinsic factors such as diet, medications, sedentary behaviour and chronic health conditions. Concurrently, ageing is accompanied by an impaired ability to mount a robust immune response, termed immunesenescence, and age-associated inflammation, termed inflammaging. The microbiome has been proposed to impact the immune system and is a potential determinant of healthy aging. In...
Source: Ageing Research Reviews - March 27, 2021 Category: Genetics & Stem Cells Authors: Jessica Conway Niharika A Duggal Source Type: research

Ageing of the gut microbiome: potential influences on immune senescence and inflammageing
Ageing Res Rev. 2021 Mar 23:101323. doi: 10.1016/j.arr.2021.101323. Online ahead of print.ABSTRACTAdvancing age is accompanied by changes in the gut microbiota characterised by a loss of beneficial commensal microbes that is driven by intrinsic and extrinsic factors such as diet, medications, sedentary behaviour and chronic health conditions. Concurrently, ageing is accompanied by an impaired ability to mount a robust immune response, termed immunesenescence, and age-associated inflammation, termed inflammaging. The microbiome has been proposed to impact the immune system and is a potential determinant of healthy aging. In...
Source: Ageing Research Reviews - March 27, 2021 Category: Genetics & Stem Cells Authors: Jessica Conway Niharika A Duggal Source Type: research

Altered Endocytosis in Cellular Senescence
Ageing Res Rev. 2021 Mar 19:101332. doi: 10.1016/j.arr.2021.101332. Online ahead of print.ABSTRACTCellular senescence occurs in response to diverse stresses (e.g., telomere shortening, DNA damage, oxidative stress, oncogene activation). A growing body of evidence indicates that alterations in multiple components of endocytic pathways contribute to cellular senescence. Clathrin-mediated endocytosis (CME) and caveolae-mediated endocytosis (CavME) represent major types of endocytosis that are implicated in senescence. More recent research has also identified a chromatin modifier and tumor suppressor that contributes to the in...
Source: Ageing Research Reviews - March 23, 2021 Category: Genetics & Stem Cells Authors: Eun-Young Shin Nak-Kyun Soung Martin Alexander Schwartz Eung-Gook Kim Source Type: research

Altered Endocytosis in Cellular Senescence
Ageing Res Rev. 2021 Mar 19:101332. doi: 10.1016/j.arr.2021.101332. Online ahead of print.ABSTRACTCellular senescence occurs in response to diverse stresses (e.g., telomere shortening, DNA damage, oxidative stress, oncogene activation). A growing body of evidence indicates that alterations in multiple components of endocytic pathways contribute to cellular senescence. Clathrin-mediated endocytosis (CME) and caveolae-mediated endocytosis (CavME) represent major types of endocytosis that are implicated in senescence. More recent research has also identified a chromatin modifier and tumor suppressor that contributes to the in...
Source: Ageing Research Reviews - March 23, 2021 Category: Genetics & Stem Cells Authors: Eun-Young Shin Nak-Kyun Soung Martin Alexander Schwartz Eung-Gook Kim Source Type: research

Altered Endocytosis in Cellular Senescence
Ageing Res Rev. 2021 Mar 19:101332. doi: 10.1016/j.arr.2021.101332. Online ahead of print.ABSTRACTCellular senescence occurs in response to diverse stresses (e.g., telomere shortening, DNA damage, oxidative stress, oncogene activation). A growing body of evidence indicates that alterations in multiple components of endocytic pathways contribute to cellular senescence. Clathrin-mediated endocytosis (CME) and caveolae-mediated endocytosis (CavME) represent major types of endocytosis that are implicated in senescence. More recent research has also identified a chromatin modifier and tumor suppressor that contributes to the in...
Source: Ageing Research Reviews - March 23, 2021 Category: Genetics & Stem Cells Authors: Eun-Young Shin Nak-Kyun Soung Martin Alexander Schwartz Eung-Gook Kim Source Type: research

Altered Endocytosis in Cellular Senescence
Ageing Res Rev. 2021 Mar 19:101332. doi: 10.1016/j.arr.2021.101332. Online ahead of print.ABSTRACTCellular senescence occurs in response to diverse stresses (e.g., telomere shortening, DNA damage, oxidative stress, oncogene activation). A growing body of evidence indicates that alterations in multiple components of endocytic pathways contribute to cellular senescence. Clathrin-mediated endocytosis (CME) and caveolae-mediated endocytosis (CavME) represent major types of endocytosis that are implicated in senescence. More recent research has also identified a chromatin modifier and tumor suppressor that contributes to the in...
Source: Ageing Research Reviews - March 23, 2021 Category: Genetics & Stem Cells Authors: Eun-Young Shin Nak-Kyun Soung Martin Alexander Schwartz Eung-Gook Kim Source Type: research

Fluorescence Microscopy Methods for Examining Telomeres During Cell Aging
Ageing Res Rev. 2021 Mar 17:101320. doi: 10.1016/j.arr.2021.101320. Online ahead of print.ABSTRACTTelomeres are protective structures, composed of nucleic acids and a complex protein mixture, located at the end of the chromosomes. They play an important role in preventing genomic instability and ensuring cell health. Defects in telomere integrity result in cell dysfunction and the development of diseases, including neurodegenerative disorders, cancer and premature aging syndromes, among others. Loss of telomere integrity during normal cell aging also initiates DNA damage signals that culminate in the senescence phenotype. ...
Source: Ageing Research Reviews - March 21, 2021 Category: Genetics & Stem Cells Authors: Nancy Adam Tara L Beattie Karl Riabowol Source Type: research

Fluorescence Microscopy Methods for Examining Telomeres During Cell Aging
Ageing Res Rev. 2021 Mar 17:101320. doi: 10.1016/j.arr.2021.101320. Online ahead of print.ABSTRACTTelomeres are protective structures, composed of nucleic acids and a complex protein mixture, located at the end of the chromosomes. They play an important role in preventing genomic instability and ensuring cell health. Defects in telomere integrity result in cell dysfunction and the development of diseases, including neurodegenerative disorders, cancer and premature aging syndromes, among others. Loss of telomere integrity during normal cell aging also initiates DNA damage signals that culminate in the senescence phenotype. ...
Source: Ageing Research Reviews - March 21, 2021 Category: Genetics & Stem Cells Authors: Nancy Adam Tara L Beattie Karl Riabowol Source Type: research

The impact of exercise, sleep, and diet on neurocognitive recovery from mild traumatic brain injury in older adults: A narrative review
Ageing Res Rev. 2021 Mar 15:101322. doi: 10.1016/j.arr.2021.101322. Online ahead of print.ABSTRACTMild traumatic brain injury (mTBI) accounts for a large majority of traumatic brain injuries sustained globally each year. Older adults, who are already susceptible to age-related declines to neurocognitive health, appear to be at an increased risk of both sustaining an mTBI and experiencing slower or impaired recovery. There is also growing evidence that mTBI is a potential risk factor for accelerated cognitive decline and neurodegeneration. Lifestyle-based interventions are gaining prominence as a cost-effective means of mai...
Source: Ageing Research Reviews - March 19, 2021 Category: Genetics & Stem Cells Authors: Shaun J Markovic Melinda Fitzgerald Jeremiah J Peiffer Brendan R Scott Stephanie R Rainey-Smith Hamid R Sohrabi Belinda M Brown Source Type: research

The impact of exercise, sleep, and diet on neurocognitive recovery from mild traumatic brain injury in older adults: A narrative review
Ageing Res Rev. 2021 Mar 15:101322. doi: 10.1016/j.arr.2021.101322. Online ahead of print.ABSTRACTMild traumatic brain injury (mTBI) accounts for a large majority of traumatic brain injuries sustained globally each year. Older adults, who are already susceptible to age-related declines to neurocognitive health, appear to be at an increased risk of both sustaining an mTBI and experiencing slower or impaired recovery. There is also growing evidence that mTBI is a potential risk factor for accelerated cognitive decline and neurodegeneration. Lifestyle-based interventions are gaining prominence as a cost-effective means of mai...
Source: Ageing Research Reviews - March 19, 2021 Category: Genetics & Stem Cells Authors: Shaun J Markovic Melinda Fitzgerald Jeremiah J Peiffer Brendan R Scott Stephanie R Rainey-Smith Hamid R Sohrabi Belinda M Brown Source Type: research

The emerging role of exosomes in Alzheimer's disease
Ageing Res Rev. 2021 Mar 13:101321. doi: 10.1016/j.arr.2021.101321. Online ahead of print.ABSTRACTAlzheimer's disease (AD), manifested by memory loss and a decline in cognitive functions, is the most prevalent neurodegenerative disease accounting for 60-80% of dementia cases. But, to-date, there is no effective treatment available to slow or stop the progression of AD. Exosomes are small extracellular vesicles that carry constituents, such as functional messenger RNAs, non-coding RNAs, proteins, lipids, DNA, and other bioactive substances of their source cells. In the brain, exosomes are likely to be sourced by almost all ...
Source: Ageing Research Reviews - March 17, 2021 Category: Genetics & Stem Cells Authors: Tongmei Zhang Sehui Ma Junkai Lv Xinyuan Wang Henok Kessete Afewerky Hao Li Youming Lu Source Type: research

The emerging role of exosomes in Alzheimer's disease
Ageing Res Rev. 2021 Mar 13:101321. doi: 10.1016/j.arr.2021.101321. Online ahead of print.ABSTRACTAlzheimer's disease (AD), manifested by memory loss and a decline in cognitive functions, is the most prevalent neurodegenerative disease accounting for 60-80% of dementia cases. But, to-date, there is no effective treatment available to slow or stop the progression of AD. Exosomes are small extracellular vesicles that carry constituents, such as functional messenger RNAs, non-coding RNAs, proteins, lipids, DNA, and other bioactive substances of their source cells. In the brain, exosomes are likely to be sourced by almost all ...
Source: Ageing Research Reviews - March 17, 2021 Category: Genetics & Stem Cells Authors: Tongmei Zhang Sehui Ma Junkai Lv Xinyuan Wang Henok Kessete Afewerky Hao Li Youming Lu Source Type: research

The emerging role of exosomes in Alzheimer's disease
Ageing Res Rev. 2021 Mar 13:101321. doi: 10.1016/j.arr.2021.101321. Online ahead of print.ABSTRACTAlzheimer's disease (AD), manifested by memory loss and a decline in cognitive functions, is the most prevalent neurodegenerative disease accounting for 60-80% of dementia cases. But, to-date, there is no effective treatment available to slow or stop the progression of AD. Exosomes are small extracellular vesicles that carry constituents, such as functional messenger RNAs, non-coding RNAs, proteins, lipids, DNA, and other bioactive substances of their source cells. In the brain, exosomes are likely to be sourced by almost all ...
Source: Ageing Research Reviews - March 17, 2021 Category: Genetics & Stem Cells Authors: Tongmei Zhang Sehui Ma Junkai Lv Xinyuan Wang Henok Kessete Afewerky Hao Li Youming Lu Source Type: research

Inflammatory pathways in Alzheimer's disease mediated by gut microbiota
Ageing Res Rev. 2021 Mar 9;68:101317. doi: 10.1016/j.arr.2021.101317. Online ahead of print.ABSTRACTIn the past decade, numerous studies have demonstrated the close relationship between gut microbiota and the occurrence and development of Alzheimer's disease (AD). However, the specific mechanism is still unclear. Both the neuroinflammation and systemic inflammation serve as the key hubs to accelerate the process of AD by promoting pathology and damaging neuron. What's more, the gut microbiota is also crucial for the regulation of inflammation. Therefore, this review focused on the role of gut microbiota in AD through infla...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Xiao-Hang Qian Xiao-Xuan Song Xiao-Li Liu Sheng-di Chen Hui-Dong Tang Source Type: research

Therapy for Alzheimer's disease: Missing Targets and Functional Markers?
Ageing Res Rev. 2021 Mar 9:101318. doi: 10.1016/j.arr.2021.101318. Online ahead of print.ABSTRACTThe development of the next generation therapy for Alzheimer's disease (AD) presents a huge challenge given the number of promising treatment candidates that failed in trials, despite recent advancements in understanding of genetic, pathophysiologic and clinical characteristics of the disease. This review reflects some of the most current concepts and controversies in developing disease-modifying and new symptomatic treatments. It elaborates on recent changes in the AD research strategy for broadening drug targets, and potentia...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Milan Stoiljkovic Tamas L Horvath Mih ály Hajós Source Type: research

From DNA damage to mutations: all roads lead to aging
Ageing Res Rev. 2021 Mar 9:101316. doi: 10.1016/j.arr.2021.101316. Online ahead of print.ABSTRACTDamage to the repository of genetic information in cells has plagued life since its very beginning 3-4 billion years ago. Initially, in the absence of an ozone layer, especially damage from solar UV radiation must have been frequent, with other sources, most notably endogenous sources related to cell metabolism, gaining in importance over time. To cope with this high frequency of damage to the increasingly long DNA molecules that came to encode the growing complexity of cellular functions in cells, DNA repair evolved as one of ...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Jan Vijg Source Type: research

Inflammatory pathways in Alzheimer's disease mediated by gut microbiota
Ageing Res Rev. 2021 Mar 9:101317. doi: 10.1016/j.arr.2021.101317. Online ahead of print.ABSTRACTIn the past decade, numerous studies have demonstrated the close relationship between intestinal flora and the occurrence and development of Alzheimer's disease (AD). However, the specific mechanism is still unclear. Both the neuroinflammation and systemic inflammation serve as the key hubs to accelerate the process of AD by promoting pathology and damaging neuron. What's more, the gut microbiota is also crucial for the regulation of inflammation. Therefore, this review focused on the role of gut microbiota in AD through inflam...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Xiao-Hang Qian Xiao-Xuan Song Xiao-Li Liu Sheng-di Chen Hui-Dong Tang Source Type: research

Therapy for Alzheimer's disease: Missing Targets and Functional Markers?
Ageing Res Rev. 2021 Mar 9:101318. doi: 10.1016/j.arr.2021.101318. Online ahead of print.ABSTRACTThe development of the next generation therapy for Alzheimer's disease (AD) presents a huge challenge given the number of promising treatment candidates that failed in trials, despite recent advancements in understanding of genetic, pathophysiologic and clinical characteristics of the disease. This review reflects some of the most current concepts and controversies in developing disease-modifying and new symptomatic treatments. It elaborates on recent changes in the AD research strategy for broadening drug targets, and potentia...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Milan Stoiljkovic Tamas L Horvath Mih ály Hajós Source Type: research

From DNA damage to mutations: all roads lead to aging
Ageing Res Rev. 2021 Mar 9:101316. doi: 10.1016/j.arr.2021.101316. Online ahead of print.ABSTRACTDamage to the repository of genetic information in cells has plagued life since its very beginning 3-4 billion years ago. Initially, in the absence of an ozone layer, especially damage from solar UV radiation must have been frequent, with other sources, most notably endogenous sources related to cell metabolism, gaining in importance over time. To cope with this high frequency of damage to the increasingly long DNA molecules that came to encode the growing complexity of cellular functions in cells, DNA repair evolved as one of ...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Jan Vijg Source Type: research

Inflammatory pathways in Alzheimer's disease mediated by gut microbiota
Ageing Res Rev. 2021 Mar 9:101317. doi: 10.1016/j.arr.2021.101317. Online ahead of print.ABSTRACTIn the past decade, numerous studies have demonstrated the close relationship between intestinal flora and the occurrence and development of Alzheimer's disease (AD). However, the specific mechanism is still unclear. Both the neuroinflammation and systemic inflammation serve as the key hubs to accelerate the process of AD by promoting pathology and damaging neuron. What's more, the gut microbiota is also crucial for the regulation of inflammation. Therefore, this review focused on the role of gut microbiota in AD through inflam...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Xiao-Hang Qian Xiao-Xuan Song Xiao-Li Liu Sheng-di Chen Hui-Dong Tang Source Type: research

Therapy for Alzheimer's disease: Missing Targets and Functional Markers?
Ageing Res Rev. 2021 Mar 9:101318. doi: 10.1016/j.arr.2021.101318. Online ahead of print.ABSTRACTThe development of the next generation therapy for Alzheimer's disease (AD) presents a huge challenge given the number of promising treatment candidates that failed in trials, despite recent advancements in understanding of genetic, pathophysiologic and clinical characteristics of the disease. This review reflects some of the most current concepts and controversies in developing disease-modifying and new symptomatic treatments. It elaborates on recent changes in the AD research strategy for broadening drug targets, and potentia...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Milan Stoiljkovic Tamas L Horvath Mih ály Hajós Source Type: research

From DNA damage to mutations: all roads lead to aging
Ageing Res Rev. 2021 Mar 9:101316. doi: 10.1016/j.arr.2021.101316. Online ahead of print.ABSTRACTDamage to the repository of genetic information in cells has plagued life since its very beginning 3-4 billion years ago. Initially, in the absence of an ozone layer, especially damage from solar UV radiation must have been frequent, with other sources, most notably endogenous sources related to cell metabolism, gaining in importance over time. To cope with this high frequency of damage to the increasingly long DNA molecules that came to encode the growing complexity of cellular functions in cells, DNA repair evolved as one of ...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Jan Vijg Source Type: research

Inflammatory pathways in Alzheimer's disease mediated by gut microbiota
Ageing Res Rev. 2021 Mar 9:101317. doi: 10.1016/j.arr.2021.101317. Online ahead of print.ABSTRACTIn the past decade, numerous studies have demonstrated the close relationship between intestinal flora and the occurrence and development of Alzheimer's disease (AD). However, the specific mechanism is still unclear. Both the neuroinflammation and systemic inflammation serve as the key hubs to accelerate the process of AD by promoting pathology and damaging neuron. What's more, the gut microbiota is also crucial for the regulation of inflammation. Therefore, this review focused on the role of gut microbiota in AD through inflam...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Xiao-Hang Qian Xiao-Xuan Song Xiao-Li Liu Sheng-di Chen Hui-Dong Tang Source Type: research

Therapy for Alzheimer's disease: Missing Targets and Functional Markers?
Ageing Res Rev. 2021 Mar 9:101318. doi: 10.1016/j.arr.2021.101318. Online ahead of print.ABSTRACTThe development of the next generation therapy for Alzheimer's disease (AD) presents a huge challenge given the number of promising treatment candidates that failed in trials, despite recent advancements in understanding of genetic, pathophysiologic and clinical characteristics of the disease. This review reflects some of the most current concepts and controversies in developing disease-modifying and new symptomatic treatments. It elaborates on recent changes in the AD research strategy for broadening drug targets, and potentia...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Milan Stoiljkovic Tamas L Horvath Mih ály Hajós Source Type: research

From DNA damage to mutations: all roads lead to aging
Ageing Res Rev. 2021 Mar 9:101316. doi: 10.1016/j.arr.2021.101316. Online ahead of print.ABSTRACTDamage to the repository of genetic information in cells has plagued life since its very beginning 3-4 billion years ago. Initially, in the absence of an ozone layer, especially damage from solar UV radiation must have been frequent, with other sources, most notably endogenous sources related to cell metabolism, gaining in importance over time. To cope with this high frequency of damage to the increasingly long DNA molecules that came to encode the growing complexity of cellular functions in cells, DNA repair evolved as one of ...
Source: Ageing Research Reviews - March 12, 2021 Category: Genetics & Stem Cells Authors: Jan Vijg Source Type: research

Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis
Ageing Res Rev. 2021 Mar 5;67:101315. doi: 10.1016/j.arr.2021.101315. Online ahead of print.ABSTRACTMechanical loading is essential for chondrocyte health. Chondrocytes can sense and respond to various extracellular mechanical signals through an integrated set of mechanisms. Recently, it has been found that mitochondria, acting as critical mechanotransducers, are at the intersection between extracellular mechanical signals and chondrocyte biology. Much attention has been focused on identifying how mechanical loading-induced mitochondrial dysfunction contributes to the pathogenesis of osteoarthritis. In contrast, little is ...
Source: Ageing Research Reviews - March 8, 2021 Category: Genetics & Stem Cells Authors: Weizhou Jiang Huan Liu Rongxue Wan Yanjiao Wu Zhanjun Shi Wenhua Huang Source Type: research

DNA methylation-based age clocks: from age prediction to age reversion
Ageing Res Rev. 2021 Mar 5:101314. doi: 10.1016/j.arr.2021.101314. Online ahead of print.ABSTRACTAging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the ...
Source: Ageing Research Reviews - March 8, 2021 Category: Genetics & Stem Cells Authors: Rezvan Noroozi Soudeh Ghafouri-Fard Aleksandra Pisarek Joanna Rudnicka Magdalena Sp ólnicka Wojciech Branicki Mohammad Taheri Ewelina Po śpiech Source Type: research

Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis
Ageing Res Rev. 2021 Mar 5:101315. doi: 10.1016/j.arr.2021.101315. Online ahead of print.ABSTRACTMechanical loading is essential for chondrocyte health. Chondrocytes can sense and respond to various extracellular mechanical signals through an integrated set of mechanisms. Recently, it has been found that mitochondria, acting as critical mechanotransducers, are at the intersection between extracellular mechanical signals and chondrocyte biology. Much attention has been focused on identifying how mechanical loading-induced mitochondrial dysfunction contributes to the pathogenesis of osteoarthritis. In contrast, little is kno...
Source: Ageing Research Reviews - March 8, 2021 Category: Genetics & Stem Cells Authors: Weizhou Jiang Huan Liu Rongxue Wan Yanjiao Wu Zhanjun Shi Wenhua Huang Source Type: research

DNA methylation-based age clocks: from age prediction to age reversion
Ageing Res Rev. 2021 Mar 5:101314. doi: 10.1016/j.arr.2021.101314. Online ahead of print.ABSTRACTAging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the ...
Source: Ageing Research Reviews - March 8, 2021 Category: Genetics & Stem Cells Authors: Rezvan Noroozi Soudeh Ghafouri-Fard Aleksandra Pisarek Joanna Rudnicka Magdalena Sp ólnicka Wojciech Branicki Mohammad Taheri Ewelina Po śpiech Source Type: research

Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis
Ageing Res Rev. 2021 Mar 5:101315. doi: 10.1016/j.arr.2021.101315. Online ahead of print.ABSTRACTMechanical loading is essential for chondrocyte health. Chondrocytes can sense and respond to various extracellular mechanical signals through an integrated set of mechanisms. Recently, it has been found that mitochondria, acting as critical mechanotransducers, are at the intersection between extracellular mechanical signals and chondrocyte biology. Much attention has been focused on identifying how mechanical loading-induced mitochondrial dysfunction contributes to the pathogenesis of osteoarthritis. In contrast, little is kno...
Source: Ageing Research Reviews - March 8, 2021 Category: Genetics & Stem Cells Authors: Weizhou Jiang Huan Liu Rongxue Wan Yanjiao Wu Zhanjun Shi Wenhua Huang Source Type: research

DNA methylation-based age clocks: from age prediction to age reversion
Ageing Res Rev. 2021 Mar 5:101314. doi: 10.1016/j.arr.2021.101314. Online ahead of print.ABSTRACTAging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the ...
Source: Ageing Research Reviews - March 8, 2021 Category: Genetics & Stem Cells Authors: Rezvan Noroozi Soudeh Ghafouri-Fard Aleksandra Pisarek Joanna Rudnicka Magdalena Sp ólnicka Wojciech Branicki Mohammad Taheri Ewelina Po śpiech Source Type: research

Role of the DNAJ/HSP40 family in the pathogenesis of insulin resistance and type 2 diabetes
Ageing Res Rev. 2021 Mar 3:101313. doi: 10.1016/j.arr.2021.101313. Online ahead of print.ABSTRACTInsulin resistance (IR) underpins a wide range of metabolic disorders including type 2 diabetes (T2D), metabolic syndrome and cardiovascular diseases. IR is characterized by a marked reduction in the magnitude and/or delayed onset of insulin to stimulate glucose disposal. This condition is due to defects in one or several intracellular intermediates of the insulin signaling cascade, ranging from insulin receptor substrate (IRS) inactivation to reduced glucose phosphorylation and oxidation. Genetic predisposition, as well as oth...
Source: Ageing Research Reviews - March 6, 2021 Category: Genetics & Stem Cells Authors: Abdoulaye Diane Hanan Abunada Namat Khattab Abu Saleh Md Moin Alexandra E Butler Mohammed Dehbi Source Type: research

Epigenetic enzymes: A role in aging and prospects for pharmacological targeting
Ageing Res Rev. 2021 Feb 28;67:101312. doi: 10.1016/j.arr.2021.101312. Online ahead of print.ABSTRACTThe development of interventions aimed at improving healthspan is one of the priority tasks for the academic and public health authorities. It is also the main objective of a novel branch in biogerontological research, geroscience. According to the geroscience concept, targeting aging is an effective way to combat age-related disorders. Since aging is an exceptionally complex process, system-oriented integrated approaches seem most appropriate for such an interventional strategy. Given the high plasticity and adaptability o...
Source: Ageing Research Reviews - March 3, 2021 Category: Genetics & Stem Cells Authors: Elena G Pasyukova Alexander V Symonenko Olga Y Rybina Alexander M Vaiserman Source Type: research

Epigenetic Enzymes: A Role in Aging and Prospects for Pharmacological Targeting
Ageing Res Rev. 2021 Feb 28:101312. doi: 10.1016/j.arr.2021.101312. Online ahead of print.ABSTRACTThe development of interventions aimed at improving healthspan is one of the priority tasks for the academic and public health authorities. It is also the main objective of a novel branch in biogerontological research, geroscience. According to the geroscience concept, targeting aging is an effective way to combat age-related disorders. Since aging is an exceptionally complex process, system-oriented integrated approaches seem most appropriate for such an interventional strategy. Given the high plasticity and adaptability of t...
Source: Ageing Research Reviews - March 3, 2021 Category: Genetics & Stem Cells Authors: Elena G Pasyukova Alexander V Symonenko Olga Y Rybina Alexander M Vaiserman Source Type: research

Epigenetic Enzymes: A Role in Aging and Prospects for Pharmacological Targeting
Ageing Res Rev. 2021 Feb 28:101312. doi: 10.1016/j.arr.2021.101312. Online ahead of print.ABSTRACTThe development of interventions aimed at improving healthspan is one of the priority tasks for the academic and public health authorities. It is also the main objective of a novel branch in biogerontological research, geroscience. According to the geroscience concept, targeting aging is an effective way to combat age-related disorders. Since aging is an exceptionally complex process, system-oriented integrated approaches seem most appropriate for such an interventional strategy. Given the high plasticity and adaptability of t...
Source: Ageing Research Reviews - March 3, 2021 Category: Genetics & Stem Cells Authors: Elena G Pasyukova Alexander V Symonenko Olga Y Rybina Alexander M Vaiserman Source Type: research

Association of HIV Infection and Cognitive Impairment in Older Adults: A Meta-analysis
CONCLUSIONS/IMPLICATIONS: Our meta-analysis provides empirical evidence that HIV infection is associated with an increased risk of cognitive impairment among older adults, especially in cognitive domains of executive function, processing speed, verbal, recall, and motor/psychomotor.PMID:33640473 | DOI:10.1016/j.arr.2021.101310 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - February 28, 2021 Category: Genetics & Stem Cells Authors: Luojia Deng Xuezhixing Zhang Yanxiao Gao DeAnne Turner Frank Qian Hui Lu Sten H Vermund Yue Zhang Han-Zhu Qian Source Type: research

Association of HIV Infection and Cognitive Impairment in Older Adults: A Meta-analysis
CONCLUSIONS/IMPLICATIONS: Our meta-analysis provides empirical evidence that HIV infection is associated with an increased risk of cognitive impairment among older adults, especially in cognitive domains of executive function, processing speed, verbal, recall, and motor/psychomotor.PMID:33640473 | DOI:10.1016/j.arr.2021.101310 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - February 28, 2021 Category: Genetics & Stem Cells Authors: Luojia Deng Xuezhixing Zhang Yanxiao Gao DeAnne Turner Frank Qian Hui Lu Sten H Vermund Yue Zhang Han-Zhu Qian Source Type: research

Association of HIV Infection and Cognitive Impairment in Older Adults: A Meta-analysis
CONCLUSIONS/IMPLICATIONS: Our meta-analysis provides empirical evidence that HIV infection is associated with an increased risk of cognitive impairment among older adults, especially in cognitive domains of executive function, processing speed, verbal, recall, and motor/psychomotor.PMID:33640473 | DOI:10.1016/j.arr.2021.101310 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - February 28, 2021 Category: Genetics & Stem Cells Authors: Luojia Deng Xuezhixing Zhang Yanxiao Gao DeAnne Turner Frank Qian Hui Lu Sten H Vermund Yue Zhang Han-Zhu Qian Source Type: research

Region-specific vulnerability in neurodegeneration: lessons from normal ageing
Ageing Res Rev. 2021 Feb 24:101311. doi: 10.1016/j.arr.2021.101311. Online ahead of print.ABSTRACTA number of age-associated neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS), possess a shared characteristic of region-specific neurodegeneration. However, the mechanisms which determine why particular regions within the nervous system are selectively vulnerable to neurodegeneration, whilst others remain relatively unaffected throughout disease progression, remain elusive. Here, we review how regional susceptibility to the ubiquitous physiological ...
Source: Ageing Research Reviews - February 27, 2021 Category: Genetics & Stem Cells Authors: Virenkumar A Pandya Rickie Patani Source Type: research

Region-specific vulnerability in neurodegeneration: lessons from normal ageing
Ageing Res Rev. 2021 Feb 24:101311. doi: 10.1016/j.arr.2021.101311. Online ahead of print.ABSTRACTA number of age-associated neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS), possess a shared characteristic of region-specific neurodegeneration. However, the mechanisms which determine why particular regions within the nervous system are selectively vulnerable to neurodegeneration, whilst others remain relatively unaffected throughout disease progression, remain elusive. Here, we review how regional susceptibility to the ubiquitous physiological ...
Source: Ageing Research Reviews - February 27, 2021 Category: Genetics & Stem Cells Authors: Virenkumar A Pandya Rickie Patani Source Type: research

Sestrin2 and mitochondrial quality control: potential impact in myogenic differentiation
Ageing Res Rev. 2021 Feb 21:101309. doi: 10.1016/j.arr.2021.101309. Online ahead of print.ABSTRACTMitochondria are highly dynamic organelles capable of adapting their network, morphology, and function, playing a role in oxidative phosphorylation and many cellular processes in most cell types. Skeletal muscle is a very plastic tissue, subjected to many morphological changes following diverse stimuli, such as during myogenic differentiation and regenerative myogenesis. For some time now, mitochondria have been reported to be involved in myogenesis by promoting a bioenergetic remodeling and assisting myoblasts in surviving th...
Source: Ageing Research Reviews - February 24, 2021 Category: Genetics & Stem Cells Authors: Luiz F Piochi Ivo F Machado Carlos M Palmeira Anabela P Rolo Source Type: research

Sestrin2 and mitochondrial quality control: potential impact in myogenic differentiation
Ageing Res Rev. 2021 Feb 21:101309. doi: 10.1016/j.arr.2021.101309. Online ahead of print.ABSTRACTMitochondria are highly dynamic organelles capable of adapting their network, morphology, and function, playing a role in oxidative phosphorylation and many cellular processes in most cell types. Skeletal muscle is a very plastic tissue, subjected to many morphological changes following diverse stimuli, such as during myogenic differentiation and regenerative myogenesis. For some time now, mitochondria have been reported to be involved in myogenesis by promoting a bioenergetic remodeling and assisting myoblasts in surviving th...
Source: Ageing Research Reviews - February 24, 2021 Category: Genetics & Stem Cells Authors: Luiz F Piochi Ivo F Machado Carlos M Palmeira Anabela P Rolo Source Type: research

Sestrin2 and mitochondrial quality control: potential impact in myogenic differentiation
Ageing Res Rev. 2021 Feb 21:101309. doi: 10.1016/j.arr.2021.101309. Online ahead of print.ABSTRACTMitochondria are highly dynamic organelles capable of adapting their network, morphology, and function, playing a role in oxidative phosphorylation and many cellular processes in most cell types. Skeletal muscle is a very plastic tissue, subjected to many morphological changes following diverse stimuli, such as during myogenic differentiation and regenerative myogenesis. For some time now, mitochondria have been reported to be involved in myogenesis by promoting a bioenergetic remodeling and assisting myoblasts in surviving th...
Source: Ageing Research Reviews - February 24, 2021 Category: Genetics & Stem Cells Authors: Luiz F Piochi Ivo F Machado Carlos M Palmeira Anabela P Rolo Source Type: research

Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy
Ageing Res Rev. 2021 Feb 20:101307. doi: 10.1016/j.arr.2021.101307. Online ahead of print.ABSTRACTThe entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex (EC) is a pivotal component of this memory system since it serves as the interface between the neocortex and the hippocampus. EC is heavily affected by the proteinopathies of Alzheimer's disease (AD). These appear in a stereotypical spatiotemporal manner and include increased levels of intracellular amyloid-beta Aβ (iAβ...
Source: Ageing Research Reviews - February 23, 2021 Category: Genetics & Stem Cells Authors: Asgeir Kobro-Flatmoen Maria Jose Lagartos-Donate Yahyah Aman Paul Edison Menno P Witter Evandro F Fang Source Type: research

COVID-19 mortality as a fingerprint of biological age
Ageing Res Rev. 2021 Feb 20;67:101308. doi: 10.1016/j.arr.2021.101308. Online ahead of print.ABSTRACTCorona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID...
Source: Ageing Research Reviews - February 23, 2021 Category: Genetics & Stem Cells Authors: M Cristina Polidori Helmut Sies Luigi Ferrucci Thomas Benzing Source Type: research

Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy
Ageing Res Rev. 2021 Feb 20:101307. doi: 10.1016/j.arr.2021.101307. Online ahead of print.ABSTRACTThe entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex (EC) is a pivotal component of this memory system since it serves as the interface between the neocortex and the hippocampus. EC is heavily affected by the proteinopathies of Alzheimer's disease (AD). These appear in a stereotypical spatiotemporal manner and include increased levels of intracellular amyloid-beta Aβ (iAβ...
Source: Ageing Research Reviews - February 23, 2021 Category: Genetics & Stem Cells Authors: Asgeir Kobro-Flatmoen Maria Jose Lagartos-Donate Yahyah Aman Paul Edison Menno P Witter Evandro F Fang Source Type: research