Effect of physical activity on risk of Alzheimer's disease: a systematic review and meta-analysis of twenty-nine prospective cohort studies
CONCLUSION: PA intervention reduces the incidence of AD, but merely in moderate to vigorous PA with follow-up of less than 15 years, thus conditionally recommending the popularization of PA as a modifiable lifestyle factor to prevent AD.PMID:37979700 | DOI:10.1016/j.arr.2023.102127 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - November 18, 2023 Category: Genetics & Stem Cells Authors: Xiaoqian Zhang Qu Li Wenqiang Cong Siyu Mu Rui Zhan Shanshan Zhong Mei Zhao Chuansheng Zhao Kexin Kang Zhike Zhou Source Type: research
Global, regional, and national prevalence of hearing loss from 1990 to 2019: a trend and health inequality analyses based on the Global Burden of Disease Study 2019
Ageing Res Rev. 2023 Nov 14:102124. doi: 10.1016/j.arr.2023.102124. Online ahead of print.ABSTRACTAs a severe public health issue, hearing loss has caused an increasingly disease burden, especially in the elderly population. Hearing loss may inevitably induce asymmetric hearing, which makes it difficult for elderly individuals to locate sound sources, therefore resulting in increased postural instability and falling risk. To emphasize the public health emergence of hearing loss, we investigated the temporal trend of prevalence of hearing loss over the last 30 years and further predicted its changes in the next 20 years, de...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Chuan-Ya Jiang Ke Han Fan Yang Si-Yue Yin Lei Zhang Bing-Yu Liang Tai-Bao Wang Tao Jiang Yue-Rong Chen Tai-Yu Shi Yu-Chen Liu Shan-Wen Chen Bu-Sheng Tong Ye-Hai Liu Hai-Feng Pan Yan-Xun Han Source Type: research
Genomic and transcriptomic advances in amyotrophic lateral sclerosis
We report the most relevant genes implicated in ALS pathogenesis, discussing the use of different high-throughput sequencing techniques and the role of epigenomic modifications. Furthermore, we present transcriptomic studies discussing the most recent advances, from microarrays to bulk and single-cell RNA sequencing. Finally, we discuss the use of microRNAs as potential biomarkers and promising tools for molecular intervention. The integration of data from multiple omic approaches may provide new insights into pathogenic pathways in ALS by shedding light on diagnostic and prognostic biomarkers, helping to stratify patients...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Mafalda Rizzuti Luca Sali Valentina Melzi Simone Scarcella Gianluca Costamagna Linda Ottoboni Lorenzo Quetti Lorenzo Brambilla Dimitra Papadimitriou Federico Verde Antonia Ratti Nicola Ticozzi Giacomo Pietro Comi Stefania Corti Delia Gagliardi Source Type: research
Global, regional, and national prevalence of hearing loss from 1990 to 2019: a trend and health inequality analyses based on the Global Burden of Disease Study 2019
Ageing Res Rev. 2023 Nov 14:102124. doi: 10.1016/j.arr.2023.102124. Online ahead of print.ABSTRACTAs a severe public health issue, hearing loss has caused an increasingly disease burden, especially in the elderly population. Hearing loss may inevitably induce asymmetric hearing, which makes it difficult for elderly individuals to locate sound sources, therefore resulting in increased postural instability and falling risk. To emphasize the public health emergence of hearing loss, we investigated the temporal trend of prevalence of hearing loss over the last 30 years and further predicted its changes in the next 20 years, de...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Chuan-Ya Jiang Ke Han Fan Yang Si-Yue Yin Lei Zhang Bing-Yu Liang Tai-Bao Wang Tao Jiang Yue-Rong Chen Tai-Yu Shi Yu-Chen Liu Shan-Wen Chen Bu-Sheng Tong Ye-Hai Liu Hai-Feng Pan Yan-Xun Han Source Type: research
Genomic and transcriptomic advances in amyotrophic lateral sclerosis
We report the most relevant genes implicated in ALS pathogenesis, discussing the use of different high-throughput sequencing techniques and the role of epigenomic modifications. Furthermore, we present transcriptomic studies discussing the most recent advances, from microarrays to bulk and single-cell RNA sequencing. Finally, we discuss the use of microRNAs as potential biomarkers and promising tools for molecular intervention. The integration of data from multiple omic approaches may provide new insights into pathogenic pathways in ALS by shedding light on diagnostic and prognostic biomarkers, helping to stratify patients...
Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Mafalda Rizzuti Luca Sali Valentina Melzi Simone Scarcella Gianluca Costamagna Linda Ottoboni Lorenzo Quetti Lorenzo Brambilla Dimitra Papadimitriou Federico Verde Antonia Ratti Nicola Ticozzi Giacomo Pietro Comi Stefania Corti Delia Gagliardi Source Type: research
