Machine learning in Alzheimer's disease drug discovery and target identification
Ageing Res Rev. 2023 Dec 15:102172. doi: 10.1016/j.arr.2023.102172. Online ahead of print.ABSTRACTAlzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a substantial threat to the elderly population, with no known curative or disease-slowing drugs in existence. Among the vital and time-consuming stages in the drug discovery process, disease modeling and target identification hold particular significance. Disease modeling allows for a deeper comprehension of disease progression mechanisms and potential therapeutic avenues. On the other hand, target identification serves as the foundational ste...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Chaofan Geng ZhiBin Wang Yi Tang Source Type: research
Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village
Ageing Res Rev. 2023 Dec 15:102173. doi: 10.1016/j.arr.2023.102173. Online ahead of print.ABSTRACTThe recently announced revision of the Alzheimer's disease (AD) diagnostic ATN classification adds to an already existing disregard for clinical assessment the rejection of image-based in vivo assessment of the brain's condition. The revision suggests that the diagnosis of AD should be based solely on the presence of cerebral amyloid-beta and tau, indicated by the "A" and "T". The "N", which stands for neurodegeneration - detected by imaging - should no longer be given importance, except that A+ ± T+ = AD with amyloid PET bei...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Poul F H øilund-Carlsen Abass Alavi Jorge R Barrio Rudolph J Castellani Tommaso Costa Karl Herrup Kasper P Kepp Rachael L Neve George Perry Mona-Elisabeth Revheim Nikolaos K Robakis Stefano L Sensi Bryce Vissel Source Type: research
Machine learning in Alzheimer's disease drug discovery and target identification
Ageing Res Rev. 2023 Dec 15:102172. doi: 10.1016/j.arr.2023.102172. Online ahead of print.ABSTRACTAlzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a substantial threat to the elderly population, with no known curative or disease-slowing drugs in existence. Among the vital and time-consuming stages in the drug discovery process, disease modeling and target identification hold particular significance. Disease modeling allows for a deeper comprehension of disease progression mechanisms and potential therapeutic avenues. On the other hand, target identification serves as the foundational ste...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Chaofan Geng ZhiBin Wang Yi Tang Source Type: research
Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village
Ageing Res Rev. 2023 Dec 15:102173. doi: 10.1016/j.arr.2023.102173. Online ahead of print.ABSTRACTThe recently announced revision of the Alzheimer's disease (AD) diagnostic ATN classification adds to an already existing disregard for clinical assessment the rejection of image-based in vivo assessment of the brain's condition. The revision suggests that the diagnosis of AD should be based solely on the presence of cerebral amyloid-beta and tau, indicated by the "A" and "T". The "N", which stands for neurodegeneration - detected by imaging - should no longer be given importance, except that A+ ± T+ = AD with amyloid PET bei...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Poul F H øilund-Carlsen Abass Alavi Jorge R Barrio Rudolph J Castellani Tommaso Costa Karl Herrup Kasper P Kepp Rachael L Neve George Perry Mona-Elisabeth Revheim Nikolaos K Robakis Stefano L Sensi Bryce Vissel Source Type: research
Obesity paradox in older sarcopenic adults - a delay in aging: A systematic review and meta-analysis
Ageing Res Rev. 2023 Dec 14:102164. doi: 10.1016/j.arr.2023.102164. Online ahead of print.ABSTRACTThe prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older co...
Source: Ageing Research Reviews - December 16, 2023 Category: Genetics & Stem Cells Authors: Szimonetta Eitmann Peter Matrai Peter Hegyi Marta Balasko Balint Eross Kira Dorogi Erika Petervari Source Type: research
Clinical research on extreme longevity: The FACET experience
Ageing Res Rev. 2023 Dec 13;93:102170. doi: 10.1016/j.arr.2023.102170. Online ahead of print.ABSTRACTPeople with extreme longevity represent a unique model to study the biology of aging. Unfortunately, their inclusion in research projects is challenging with the consequent lack of evidence and the need to rely on small convenience samples. Given the growing global aging population, especially in the segment of the oldest old (i.e., aged 90 and older), research in this population has become crucial. Furthermore, by studying the characteristics of extremely longeval persons, it might be possible to 1) better understand the m...
Source: Ageing Research Reviews - December 15, 2023 Category: Genetics & Stem Cells Authors: Domenico Azzolino Gabriel Dias Rodrigues Valentina Maria Manzini Marco Proietti Beatrice Arosio Nicola Montano Matteo Cesari Source Type: research
Clinical research on extreme longevity: The FACET experience
Ageing Res Rev. 2023 Dec 13:102170. doi: 10.1016/j.arr.2023.102170. Online ahead of print.ABSTRACTPeople with extreme longevity represent a unique model to study the biology of aging. Unfortunately, their inclusion in research projects is challenging with the consequent lack of evidence and the need to rely on small convenience samples. Given the growing global aging population, especially in the segment of the oldest old (i.e., aged 90 and older), research in this population has become crucial. Furthermore, by studying the characteristics of extremely longeval persons, it might be possible to 1) better understand the mech...
Source: Ageing Research Reviews - December 15, 2023 Category: Genetics & Stem Cells Authors: Domenico Azzolino Gabriel Dias Rodrigues Valentina Maria Manzini Marco Proietti Beatrice Arosio Nicola Montano Matteo Cesari Source Type: research
Prevalence and Patterns of Multimorbidity in China during 2002-2022: A Systematic Review and Meta-Analysis
CONCLUSION: Multimorbidity was present nearly one in four Chinese adults, with hypertensive diseases and other comorbidities being the most-observed pattern; the prevalence increased rapidly with increased age. There is huge variation in the prevalence of multimorbidity across China. Coordinated, comprehensive strategies are urgently needed to control the ongoing impact of multimorbidity.PMID:38096988 | DOI:10.1016/j.arr.2023.102165 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - December 14, 2023 Category: Genetics & Stem Cells Authors: Yaoda Hu Zixing Wang Huijing He Li Pan Ji Tu Guangliang Shan Source Type: research
Prevalence and Patterns of Multimorbidity in China during 2002-2022: A Systematic Review and Meta-Analysis
CONCLUSION: Multimorbidity was present nearly one in four Chinese adults, with hypertensive diseases and other comorbidities being the most-observed pattern; the prevalence increased rapidly with increased age. There is huge variation in the prevalence of multimorbidity across China. Coordinated, comprehensive strategies are urgently needed to control the ongoing impact of multimorbidity.PMID:38096988 | DOI:10.1016/j.arr.2023.102165 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - December 14, 2023 Category: Genetics & Stem Cells Authors: Yaoda Hu Zixing Wang Huijing He Li Pan Ji Tu Guangliang Shan Source Type: research
Pentraxin 3: A promising Therapeutic Target for Cardiovascular Diseases
Ageing Res Rev. 2023 Dec 11:102163. doi: 10.1016/j.arr.2023.102163. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the primary global cause of death，and inflammation is a crucial factor in the development of CVDs. The acute phase inflammatory protein pentraxin 3 (PTX3) is a biomarker reflecting the immune response. Recent research indicates that PTX3 plays a critical role in CVDs and has been investigated as a possible biomarker for CVD in clinical settings. PTX3 is implicated in the progression of CVDs through mechanisms such as exacerbating vascular endothelial dysfunction, affecting angiogenesis, and re...
Source: Ageing Research Reviews - December 13, 2023 Category: Genetics & Stem Cells Authors: Xingyan Ye Zheng Wang Wangrui Lei Mingzhi Shen Jiayou Tang Xuezeng Xu Yang Yang Huan Zhang Source Type: research
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies
Ageing Res Rev. 2023 Dec 7:102162. doi: 10.1016/j.arr.2023.102162. Online ahead of print.ABSTRACTUnhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition, gradually increasing the risk for mild cognitive impairment (MCI) and the continuum comprising early dementia. Aging is the greatest risk factor for age-related dementias such as Alzheimer's disease, and the aging process is known to be influenced by life events that can positively or negatively affect age-related diseases. Remarkably, life experiences that make the brain vulnerable to dementia, such as seizure episodes, neurotoxin expo...
Source: Ageing Research Reviews - December 9, 2023 Category: Genetics & Stem Cells Authors: Michael F Almeida Karen L G Farizatto Renato S Almeida Ben A Bahr Source Type: research
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies
Ageing Res Rev. 2023 Dec 7:102162. doi: 10.1016/j.arr.2023.102162. Online ahead of print.ABSTRACTUnhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition, gradually increasing the risk for mild cognitive impairment (MCI) and the continuum comprising early dementia. Aging is the greatest risk factor for age-related dementias such as Alzheimer's disease, and the aging process is known to be influenced by life events that can positively or negatively affect age-related diseases. Remarkably, life experiences that make the brain vulnerable to dementia, such as seizure episodes, neurotoxin expo...
Source: Ageing Research Reviews - December 9, 2023 Category: Genetics & Stem Cells Authors: Michael F Almeida Karen L G Farizatto Renato S Almeida Ben A Bahr Source Type: research
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies
Ageing Res Rev. 2023 Dec 7:102162. doi: 10.1016/j.arr.2023.102162. Online ahead of print.ABSTRACTUnhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition, gradually increasing the risk for mild cognitive impairment (MCI) and the continuum comprising early dementia. Aging is the greatest risk factor for age-related dementias such as Alzheimer's disease, and the aging process is known to be influenced by life events that can positively or negatively affect age-related diseases. Remarkably, life experiences that make the brain vulnerable to dementia, such as seizure episodes, neurotoxin expo...
Source: Ageing Research Reviews - December 9, 2023 Category: Genetics & Stem Cells Authors: Michael F Almeida Karen L G Farizatto Renato S Almeida Ben A Bahr Source Type: research
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies
Ageing Res Rev. 2023 Dec 7:102162. doi: 10.1016/j.arr.2023.102162. Online ahead of print.ABSTRACTUnhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition, gradually increasing the risk for mild cognitive impairment (MCI) and the continuum comprising early dementia. Aging is the greatest risk factor for age-related dementias such as Alzheimer's disease, and the aging process is known to be influenced by life events that can positively or negatively affect age-related diseases. Remarkably, life experiences that make the brain vulnerable to dementia, such as seizure episodes, neurotoxin expo...
Source: Ageing Research Reviews - December 9, 2023 Category: Genetics & Stem Cells Authors: Michael F Almeida Karen L G Farizatto Renato S Almeida Ben A Bahr Source Type: research
Modulating the polarization phenotype of microglia - a valuable strategy for central nervous system diseases
Ageing Res Rev. 2023 Dec 6:102160. doi: 10.1016/j.arr.2023.102160. Online ahead of print.ABSTRACTCentral nervous system (CNS) diseases have become one of the leading causes of death in the global population. The pathogenesis of CNS diseases is complicated, so it is important to find the patterns of the disease to improve the treatment strategy. Microglia are considered to be a double-edged sword, playing both harmful and beneficial roles in CNS diseases. Therefore, it is crucial to understand the progression of the disease and the changes in the polar phenotype of microglia to provide guidance in the treatment of CNS disea...
Source: Ageing Research Reviews - December 8, 2023 Category: Genetics & Stem Cells Authors: Yu Long Lin Shen Jie Deng Qiao-Bo Ye Xiao-Qiu Li Yin Ma Yuan-Yuan Wu Yue Hu Xiao-Fang He Jing Wen Ai Shi Shuang Yu Dan Li Zhen Ye Chuan Zheng Nan Li Source Type: research
