From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity
Ageing Res Rev. 2023 Dec 23;93:102175. doi: 10.1016/j.arr.2023.102175. Online ahead of print.ABSTRACTIntrinsic capacity is the sum of an individual's physical and mental capacities, which helps determine functional ability. Intrinsic capacity decline is an important predictor of adverse health outcomes and can identify individuals at higher risk of functional decline. Aging is characterized by a decrease in physiological reserves and functional abilities. Chronic inflammation, a mechanism of aging, is associated with decreased intrinsic capacity, which may mirror the broader relationship between aging and functional abilit...
Source: Ageing Research Reviews - December 25, 2023 Category: Genetics & Stem Cells Authors: Xiaxia Li Lina Ma Source Type: research
From biological aging to functional decline: A narrative review of insights into chronic inflammation and intrinsic capacity
Ageing Res Rev. 2023 Dec 23:102175. doi: 10.1016/j.arr.2023.102175. Online ahead of print.ABSTRACTIntrinsic capacity is the sum of an individual's physical and mental capacities, which helps determine functional ability. Intrinsic capacity decline is an important predictor of adverse health outcomes and can identify individuals at higher risk of functional decline. Aging is characterized by a decrease in physiological reserves and functional abilities. Chronic inflammation, a mechanism of aging, is associated with decreased intrinsic capacity, which may mirror the broader relationship between aging and functional ability. ...
Source: Ageing Research Reviews - December 25, 2023 Category: Genetics & Stem Cells Authors: Xiaxia Li Lina Ma Source Type: research
From biological aging to functional decline: A narrative review of insights into chronic inflammation and intrinsic capacity
Ageing Res Rev. 2023 Dec 23:102175. doi: 10.1016/j.arr.2023.102175. Online ahead of print.ABSTRACTIntrinsic capacity is the sum of an individual's physical and mental capacities, which helps determine functional ability. Intrinsic capacity decline is an important predictor of adverse health outcomes and can identify individuals at higher risk of functional decline. Aging is characterized by a decrease in physiological reserves and functional abilities. Chronic inflammation, a mechanism of aging, is associated with decreased intrinsic capacity, which may mirror the broader relationship between aging and functional ability. ...
Source: Ageing Research Reviews - December 25, 2023 Category: Genetics & Stem Cells Authors: Xiaxia Li Lina Ma Source Type: research
Bridging Neurotrophic Factors and Bioactive Peptides to Alzheimer's Disease
Ageing Res Rev. 2023 Dec 22:102177. doi: 10.1016/j.arr.2023.102177. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder. As the demographic shifting towards an aging population, AD has emerged as a prominent public health concern. The pathogenesis of AD is complex, and there are no effective treatment methods for AD until now. In recent years, neurotrophic factors and bioactive peptides including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), irisin, melatonin, have been discovered to exert neuroprotective functions for AD. Bioactive peptides can be divided into t...
Source: Ageing Research Reviews - December 24, 2023 Category: Genetics & Stem Cells Authors: Minhui Wei Tong Wu Ning Chen Source Type: research
Bridging Neurotrophic Factors and Bioactive Peptides to Alzheimer's Disease
Ageing Res Rev. 2023 Dec 22:102177. doi: 10.1016/j.arr.2023.102177. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder. As the demographic shifting towards an aging population, AD has emerged as a prominent public health concern. The pathogenesis of AD is complex, and there are no effective treatment methods for AD until now. In recent years, neurotrophic factors and bioactive peptides including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), irisin, melatonin, have been discovered to exert neuroprotective functions for AD. Bioactive peptides can be divided into t...
Source: Ageing Research Reviews - December 24, 2023 Category: Genetics & Stem Cells Authors: Minhui Wei Tong Wu Ning Chen Source Type: research
ADP-ribosylation: an emerging direction for disease treatment
Ageing Res Rev. 2023 Dec 21:102176. doi: 10.1016/j.arr.2023.102176. Online ahead of print.ABSTRACTADP-ribosylation (ADPr) is a dynamically reversible post-translational modification (PTM) driven primarily by ADP-ribosyltransferases (ADPRTs or ARTs), which have ADP-ribosyl transfer activity. ADPr modification is involved in signaling pathways, DNA damage repair, metabolism, immunity, and inflammation. In recent years, several studies have revealed that new targets or treatments for tumors, cardiovascular diseases, neuromuscular diseases and infectious diseases can be explored by regulating ADPr. Here, we review the recent r...
Source: Ageing Research Reviews - December 23, 2023 Category: Genetics & Stem Cells Authors: Yu-Ting Liu Yan Che Hong-Liang Qiu Hong-Xia Xia Yi-Zhou Feng Jiang-Yang Deng Yuan Yuan Qi-Zhu Tang Source Type: research
Does Gut Brain Axis has an impact on Parkinson's Disease (PD)?
Ageing Res Rev. 2023 Dec 21:102171. doi: 10.1016/j.arr.2023.102171. Online ahead of print.ABSTRACTParkinson's Disease (PD) is becoming a growing global concern by being the second most prevalent disease next to Alzheimer's Disease (AD). Henceforth new exploration is needed in search of new aspects towards the disease mechanism and origin. Evidence from recent studies has clearly stated the role of Gut Microbiota (GM) in the maintenance of the brain and as a root cause of various diseases and disorders including other neurological conditions. In the case of PD, with an unknown etiology, the GM is said to have a larger impac...
Source: Ageing Research Reviews - December 23, 2023 Category: Genetics & Stem Cells Authors: Ajay Elangovan None Bhawna Laxmi Kirola Mahalaxmi Iyer Priyanka Jeeth Sakshi Maharaj Nikki Kumari Vikas Lakhanpal Tanja Maria Sheldrick-Michel K R S Sambasiva Rao Ssang-Goo Cho Mukesh Kumar Yadav Abilash Valsala Gopalakrishnan Saraboji Kadhirvel Nachimuth Source Type: research
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases
Ageing Res Rev. 2023 Dec 20:102174. doi: 10.1016/j.arr.2023.102174. Online ahead of print.ABSTRACTNeurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, present challenges in healthcare because of their complicated etiologies and absence of healing remedies. Lately, the emerging role of post-translational modifications (PTMs), in the context of cell cycle regulators, has garnered big interest as a potential avenue for therapeutic intervention. The review explores the problematic panorama of PTMs on cell cycle regulators and their implications in neurodegenerative diseases. W...
Source: Ageing Research Reviews - December 22, 2023 Category: Genetics & Stem Cells Authors: Neetu Rani Mehar Sahu Rashmi K Ambasta Pravir Kumar Source Type: research
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases
Ageing Res Rev. 2023 Dec 20:102174. doi: 10.1016/j.arr.2023.102174. Online ahead of print.ABSTRACTNeurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, present challenges in healthcare because of their complicated etiologies and absence of healing remedies. Lately, the emerging role of post-translational modifications (PTMs), in the context of cell cycle regulators, has garnered big interest as a potential avenue for therapeutic intervention. The review explores the problematic panorama of PTMs on cell cycle regulators and their implications in neurodegenerative diseases. W...
Source: Ageing Research Reviews - December 22, 2023 Category: Genetics & Stem Cells Authors: Neetu Rani Mehar Sahu Rashmi K Ambasta Pravir Kumar Source Type: research
Machine learning in Alzheimer's disease drug discovery and target identification
Ageing Res Rev. 2023 Dec 15:102172. doi: 10.1016/j.arr.2023.102172. Online ahead of print.ABSTRACTAlzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a substantial threat to the elderly population, with no known curative or disease-slowing drugs in existence. Among the vital and time-consuming stages in the drug discovery process, disease modeling and target identification hold particular significance. Disease modeling allows for a deeper comprehension of disease progression mechanisms and potential therapeutic avenues. On the other hand, target identification serves as the foundational ste...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Chaofan Geng ZhiBin Wang Yi Tang Source Type: research
Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village
Ageing Res Rev. 2023 Dec 15;93:102173. doi: 10.1016/j.arr.2023.102173. Online ahead of print.ABSTRACTThe recently announced revision of the Alzheimer's disease (AD) diagnostic ATN classification adds to an already existing disregard for clinical assessment the rejection of image-based in vivo assessment of the brain's condition. The revision suggests that the diagnosis of AD should be based solely on the presence of cerebral amyloid-beta and tau, indicated by the "A" and "T". The "N", which stands for neurodegeneration - detected by imaging - should no longer be given importance, except that A+ ± T + = AD with amyloid PET...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Poul F H øilund-Carlsen Abass Alavi Jorge R Barrio Rudolph J Castellani Tommaso Costa Karl Herrup Kasper P Kepp Rachael L Neve George Perry Mona-Elisabeth Revheim Nikolaos K Robakis Stefano L Sensi Bryce Vissel Source Type: research
Machine learning in Alzheimer's disease drug discovery and target identification
Ageing Res Rev. 2023 Dec 15:102172. doi: 10.1016/j.arr.2023.102172. Online ahead of print.ABSTRACTAlzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a substantial threat to the elderly population, with no known curative or disease-slowing drugs in existence. Among the vital and time-consuming stages in the drug discovery process, disease modeling and target identification hold particular significance. Disease modeling allows for a deeper comprehension of disease progression mechanisms and potential therapeutic avenues. On the other hand, target identification serves as the foundational ste...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Chaofan Geng ZhiBin Wang Yi Tang Source Type: research
Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village
Ageing Res Rev. 2023 Dec 15;93:102173. doi: 10.1016/j.arr.2023.102173. Online ahead of print.ABSTRACTThe recently announced revision of the Alzheimer's disease (AD) diagnostic ATN classification adds to an already existing disregard for clinical assessment the rejection of image-based in vivo assessment of the brain's condition. The revision suggests that the diagnosis of AD should be based solely on the presence of cerebral amyloid-beta and tau, indicated by the "A" and "T". The "N", which stands for neurodegeneration - detected by imaging - should no longer be given importance, except that A+ ± T + = AD with amyloid PET...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Poul F H øilund-Carlsen Abass Alavi Jorge R Barrio Rudolph J Castellani Tommaso Costa Karl Herrup Kasper P Kepp Rachael L Neve George Perry Mona-Elisabeth Revheim Nikolaos K Robakis Stefano L Sensi Bryce Vissel Source Type: research
Machine learning in Alzheimer's disease drug discovery and target identification
Ageing Res Rev. 2023 Dec 15:102172. doi: 10.1016/j.arr.2023.102172. Online ahead of print.ABSTRACTAlzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a substantial threat to the elderly population, with no known curative or disease-slowing drugs in existence. Among the vital and time-consuming stages in the drug discovery process, disease modeling and target identification hold particular significance. Disease modeling allows for a deeper comprehension of disease progression mechanisms and potential therapeutic avenues. On the other hand, target identification serves as the foundational ste...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Chaofan Geng ZhiBin Wang Yi Tang Source Type: research
Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village
Ageing Res Rev. 2023 Dec 15:102173. doi: 10.1016/j.arr.2023.102173. Online ahead of print.ABSTRACTThe recently announced revision of the Alzheimer's disease (AD) diagnostic ATN classification adds to an already existing disregard for clinical assessment the rejection of image-based in vivo assessment of the brain's condition. The revision suggests that the diagnosis of AD should be based solely on the presence of cerebral amyloid-beta and tau, indicated by the "A" and "T". The "N", which stands for neurodegeneration - detected by imaging - should no longer be given importance, except that A+ ± T+ = AD with amyloid PET bei...
Source: Ageing Research Reviews - December 17, 2023 Category: Genetics & Stem Cells Authors: Poul F H øilund-Carlsen Abass Alavi Jorge R Barrio Rudolph J Castellani Tommaso Costa Karl Herrup Kasper P Kepp Rachael L Neve George Perry Mona-Elisabeth Revheim Nikolaos K Robakis Stefano L Sensi Bryce Vissel Source Type: research
