Vascular Dementia: From Pathobiology to Emerging Perspectives
Ageing Res Rev. 2024 Mar 19:102278. doi: 10.1016/j.arr.2024.102278. Online ahead of print.ABSTRACTVascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial number of risk factors for VaD, the pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, a biogerontological imperative exists to highlight the modifiable lifestyle factors which can mitigate against the risk of developing VaD. This review will critically ex...
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Amy Elizabeth Morgan Mark Tom ás Mc Auley Source Type: research
Intermittent fasting and longevity: from animal models to implication for humans
Ageing Res Rev. 2024 Mar 16:102274. doi: 10.1016/j.arr.2024.102274. Online ahead of print.ABSTRACTIn recent years, intermittent fasting (IF) and its numerous modifications have been increasingly suggested as a promising therapy for age-related problems and a non-pharmacological strategy to extend lifespan. Despite the great variability in feeding schedules that we describe in the current work, underlying physiological processes are the same and include a periodic switch from glucose metabolism (generated by glycogenolysis) to fatty acids and fatty acid-derived ketones. Many of the beneficial effects of IF appear to be medi...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Olha Strilbytska Svitlana Klishch Kenneth B Storey Alexander Koliada Oleh Lushchak Source Type: research
Worldwide cohort studies to support healthy ageing research: data availabilities and gaps
CONCLUSIONS: The comprehensive summary of data availability enables timely evidence to contribute to the United Nations Decades of Healthy Ageing goals of promoting healthy ageing for all. Highlighted gaps guide strategies for increased data collection in regions with limited cohort studies. Comprehensive data, encompassing intrinsic capacity and various sociodemographic, social, and environmental factors, is crucial for advancing our understanding of healthy ageing and its underlying pathways.PMID:38499160 | DOI:10.1016/j.arr.2024.102277 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Saman Khalatbari-Soltani Yafei Si Marielle Dominguez Tabitha Scott Fiona M Blyth Source Type: research
Amyloid-Induced Neurodegeneration: A Comprehensive Review through Aggregomics Perception of Proteins in Health and Pathology
Ageing Res Rev. 2024 Mar 16:102276. doi: 10.1016/j.arr.2024.102276. Online ahead of print.ABSTRACTAmyloidosis of protein caused by fibrillation and aggregation are some of the most exciting new edges not only in protein sciences but also in molecular medicines. The present review discusses recent advancements in the field of neurodegenerative diseases and therapeutic applications with ongoing clinical trials, featuring new areas of protein misfolding resulting in aggregation. The endogenous accretion of protein fibrils having fibrillar morphology symbolizes the beginning of neuro-disorders. Prognostic amyloidosis is promin...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Sania Bashir Ayesha Aiman Mohammad Shahid Anis Ahmad Chaudhary Neha Sami Seemi Farhat Basir Imtaiyaz Hassan Asimul Islam Source Type: research
Intermittent fasting and longevity: from animal models to implication for humans
Ageing Res Rev. 2024 Mar 16:102274. doi: 10.1016/j.arr.2024.102274. Online ahead of print.ABSTRACTIn recent years, intermittent fasting (IF) and its numerous modifications have been increasingly suggested as a promising therapy for age-related problems and a non-pharmacological strategy to extend lifespan. Despite the great variability in feeding schedules that we describe in the current work, underlying physiological processes are the same and include a periodic switch from glucose metabolism (generated by glycogenolysis) to fatty acids and fatty acid-derived ketones. Many of the beneficial effects of IF appear to be medi...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Olha Strilbytska Svitlana Klishch Kenneth B Storey Alexander Koliada Oleh Lushchak Source Type: research
Worldwide cohort studies to support healthy ageing research: data availabilities and gaps
CONCLUSIONS: The comprehensive summary of data availability enables timely evidence to contribute to the United Nations Decades of Healthy Ageing goals of promoting healthy ageing for all. Highlighted gaps guide strategies for increased data collection in regions with limited cohort studies. Comprehensive data, encompassing intrinsic capacity and various sociodemographic, social, and environmental factors, is crucial for advancing our understanding of healthy ageing and its underlying pathways.PMID:38499160 | DOI:10.1016/j.arr.2024.102277 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Saman Khalatbari-Soltani Yafei Si Marielle Dominguez Tabitha Scott Fiona M Blyth Source Type: research
Amyloid-Induced Neurodegeneration: A Comprehensive Review through Aggregomics Perception of Proteins in Health and Pathology
Ageing Res Rev. 2024 Mar 16:102276. doi: 10.1016/j.arr.2024.102276. Online ahead of print.ABSTRACTAmyloidosis of protein caused by fibrillation and aggregation are some of the most exciting new edges not only in protein sciences but also in molecular medicines. The present review discusses recent advancements in the field of neurodegenerative diseases and therapeutic applications with ongoing clinical trials, featuring new areas of protein misfolding resulting in aggregation. The endogenous accretion of protein fibrils having fibrillar morphology symbolizes the beginning of neuro-disorders. Prognostic amyloidosis is promin...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Sania Bashir Ayesha Aiman Mohammad Shahid Anis Ahmad Chaudhary Neha Sami Seemi Farhat Basir Imtaiyaz Hassan Asimul Islam Source Type: research
Intermittent fasting and longevity: from animal models to implication for humans
Ageing Res Rev. 2024 Mar 16:102274. doi: 10.1016/j.arr.2024.102274. Online ahead of print.ABSTRACTIn recent years, intermittent fasting (IF) and its numerous modifications have been increasingly suggested as a promising therapy for age-related problems and a non-pharmacological strategy to extend lifespan. Despite the great variability in feeding schedules that we describe in the current work, underlying physiological processes are the same and include a periodic switch from glucose metabolism (generated by glycogenolysis) to fatty acids and fatty acid-derived ketones. Many of the beneficial effects of IF appear to be medi...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Olha Strilbytska Svitlana Klishch Kenneth B Storey Alexander Koliada Oleh Lushchak Source Type: research
Worldwide cohort studies to support healthy ageing research: data availabilities and gaps
CONCLUSIONS: The comprehensive summary of data availability enables timely evidence to contribute to the United Nations Decades of Healthy Ageing goals of promoting healthy ageing for all. Highlighted gaps guide strategies for increased data collection in regions with limited cohort studies. Comprehensive data, encompassing intrinsic capacity and various sociodemographic, social, and environmental factors, is crucial for advancing our understanding of healthy ageing and its underlying pathways.PMID:38499160 | DOI:10.1016/j.arr.2024.102277 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Saman Khalatbari-Soltani Yafei Si Marielle Dominguez Tabitha Scott Fiona M Blyth Source Type: research
Amyloid-Induced Neurodegeneration: A Comprehensive Review through Aggregomics Perception of Proteins in Health and Pathology
Ageing Res Rev. 2024 Mar 16:102276. doi: 10.1016/j.arr.2024.102276. Online ahead of print.ABSTRACTAmyloidosis of protein caused by fibrillation and aggregation are some of the most exciting new edges not only in protein sciences but also in molecular medicines. The present review discusses recent advancements in the field of neurodegenerative diseases and therapeutic applications with ongoing clinical trials, featuring new areas of protein misfolding resulting in aggregation. The endogenous accretion of protein fibrils having fibrillar morphology symbolizes the beginning of neuro-disorders. Prognostic amyloidosis is promin...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Sania Bashir Ayesha Aiman Mohammad Shahid Anis Ahmad Chaudhary Neha Sami Seemi Farhat Basir Imtaiyaz Hassan Asimul Islam Source Type: research
Senolytic therapeutics: An emerging treatment modality for osteoarthritis
Ageing Res Rev. 2024 Mar 15:102275. doi: 10.1016/j.arr.2024.102275. Online ahead of print.ABSTRACTOsteoarthritis (OA), a chronic joint disease affecting millions of people aged over 65 years, is the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized by lingering pain and increasing deterioration of articular cartilage. Aging and accumulation of senescent cells (SCs) in the joints are frequently associated with OA. Apoptosis resistance; irreversible cell cycle arrest; increased p16INK4a expression, secretion of senescence-associated secretory phenotype factors, senescence-associated ...
Source: Ageing Research Reviews - March 17, 2024 Category: Genetics & Stem Cells Authors: Md Meraj Ansari Mrinmoy Ghosh Dong-Sun Lee Young-Ok Son Source Type: research
Senolytic therapeutics: An emerging treatment modality for osteoarthritis
Ageing Res Rev. 2024 Mar 15:102275. doi: 10.1016/j.arr.2024.102275. Online ahead of print.ABSTRACTOsteoarthritis (OA), a chronic joint disease affecting millions of people aged over 65 years, is the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized by lingering pain and increasing deterioration of articular cartilage. Aging and accumulation of senescent cells (SCs) in the joints are frequently associated with OA. Apoptosis resistance; irreversible cell cycle arrest; increased p16INK4a expression, secretion of senescence-associated secretory phenotype factors, senescence-associated ...
Source: Ageing Research Reviews - March 17, 2024 Category: Genetics & Stem Cells Authors: Md Meraj Ansari Mrinmoy Ghosh Dong-Sun Lee Young-Ok Son Source Type: research
Sonic Hedgehog Signalling Pathway Contributes in Age-Related Disorders and Alzheimer's Disease
Ageing Res Rev. 2024 Mar 14:102271. doi: 10.1016/j.arr.2024.102271. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD by affecting Sonic hedgehog (Shh) signalling. In addition to being essential for cell differentiation and proliferation, Shh signalling is involved in tissue repair and the prevention of neurodegeneration. Neurogenesis is dependent on Shh signalling; inhibition of this pathway ...
Source: Ageing Research Reviews - March 16, 2024 Category: Genetics & Stem Cells Authors: Arun Parashar Dhruv Jha Vineet Mehta Bonney Chauhan Pappu Ghosh Prashanta Kumar Deb Mohit Jaiswal Santosh Kumar Prajapati Source Type: research
Improving Geriatric Outcomes through Nutritional and Immunonutritional Strategies: focus on Surgical Setting by a Comprehensive Evidence Review
This study reviews current literature on the impact of nutrition and immunonutrition on surgical outcomes in geriatrics, highlighting the potential benefits in terms of reduced complications, enhanced wound healing, and shortened hospital stays. Recognizing and addressing the specific nutritional needs of older persons undergoing surgery is essential for promoting successful surgical outcomes and improving overall quality of life in this vulnerable population.PMID:38492809 | DOI:10.1016/j.arr.2024.102272 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 16, 2024 Category: Genetics & Stem Cells Authors: Virginia Boccardi Luigi Marano Source Type: research
Understanding the Intricacies of Cellular Senescence in Atherosclerosis: Mechanisms and Therapeutic Implications
Ageing Res Rev. 2024 Mar 14:102273. doi: 10.1016/j.arr.2024.102273. Online ahead of print.ABSTRACTCardiovascular disease is currently the largest cause of mortality and disability globally, surpassing communicable diseases, and atherosclerosis is the main contributor to this epidemic. Aging is intimately linked to atherosclerosis development and progression, however, the mechanism of aging in atherosclerosis is not well known. To emphasize the significant research on the involvement of senescent cells in atherosclerosis, we begin by outlining compelling evidence that indicates various types of senescent cells and SASP fact...
Source: Ageing Research Reviews - March 16, 2024 Category: Genetics & Stem Cells Authors: Ilyas Ali Hongliang Zhang Syed Aqib Ali Zaidi Guangqian Zhou Source Type: research
