A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum

CONCLUSIONS: The multimodal meta-analysis demonstrated that patients with AD exhibited convergent functional and structural alterations in the PCC/precuneus and PHG, as well as cortical thinning in the primary sensory and motor areas. Furthermore, patients with preclinical AD showed reduced functional activity in the precuneus. AD and preclinical AD showed genetic modulations/neurotransmitter deficits of brain functional and structural impairments. These findings may provide new insights into the pathophysiology of the AD spectrum.PMID:38395200 | DOI:10.1016/j.arr.2024.102240

Source: Ageing Research Reviews - February 23, 2024 Category: Genetics & Stem Cells Authors: Xinyue Tang Zixuan Guo Guanmao Chen Shilin Sun Shu Xiao Pan Chen Guixian Tang Li Huang Ying Wang Source Type: research