A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Conclusions: Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration. Further investigation of the optimal treatment schedule for lenvatinib is warranted. Clinical Trial Registration: UMIN000022243.PMID:38629757 | DOI:10.1089/thy.2023.0553 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research
Using haematological indices to predict impaired liver function in DTC patients
CONCLUSION: Our results suggest that PC and ALC are independent predictors of hypo-related liver injury. Our study is the first to suggest that haematological indices can be used for predicting the development and progression of hypo-related liver disorders.PMID:38629813 | DOI:10.1967/s002449912700 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Yanli Zhou Hong Chai Source Type: research
Evaluation of hafnium oxide nanoparticles imaging characteristics as a contrast agent in X-ray computed tomography
AbstractThis research aimed to compare the quantitative imaging attributes of synthesized hafnium oxide nanoparticles (NPs) derived from UiO-66-NH2(Hf) and two gadolinium- and iodine-based clinical contrast agents (CAs) using cylindrical phantom. Aqueous solutions of the studied CAs, containing 2.5, 5, and 10 mg/mL of HfO2NPs, gadolinium, and iodine, were prepared. Constructed within a cylindrical phantom, 15 cc small tubes were filled with CAs. Maintaining constant mAs, the phantom underwent scanning at tube voltage variations from 80 to 140 kVp. The CT numbers were quantified in Hounsfield units (HU), and the contras...
Source: Radiological Physics and Technology - April 17, 2024 Category: Physics Source Type: research
Photophysicochemical and electrochemical properties of pyrene –BODIPY platforms
New J. Chem., 2024, Advance Article DOI: 10.1039/D4NJ00140K, Paperİpek Ömeroğlu, Baybars Köksoy, Dilek Öztürk, Lubna Salah, Saad Maksheed, Mahmut Durmuş The photochemical, photophysical, and electrochemical properties of novel BODIPY compounds substituted with iodine or pyrene groups at the 2-, 6-, or 8-positions (meso) were thoroughly investigated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 16, 2024 Category: Chemistry Authors: İpek Ömeroğlu Source Type: research
A Highly Sterically Encumbered Boron Lewis Acid Enabled by a Organotellurium-based Ligand
Chemistry. 2024 Apr 16:e202401231. doi: 10.1002/chem.202401231. Online ahead of print.ABSTRACTLewis acidic boron compounds are ubiquitous in chemistry due to their numerous applications, yet tuning and optimizing their properties towards different purposes is still a challenging field of research. In this work, the boron Lewis acid B[OTeF3(C6F5)2]3 was synthesized by reaction of the teflate derivative HOTeF3(C6F5)2 with BCl3 or BCl3·SMe2. This new compound presents a remarkably high thermal stability up to 300 °C, as well as one of the most sterically encumbered boron centres known in the literature. Theoretical and expe...
Source: Chemistry - April 16, 2024 Category: Chemistry Authors: Daniel Wegener Alberto P érez-Bitrián Niklas Limberg Anja Wiesner Kurt F Hoffmann Sebastian Hasenstab-Riedel Source Type: research
Knowledge, awareness, and risk practices related to bacterial contamination of antiseptics, disinfectants, and hand hygiene products among healthcare workers in sub-saharan Africa: a cross-sectional survey in three tertiary care hospitals (Benin, Burkina Faso, and DR Congo)
ConclusionsThe present findings can guide tailored training and IPC implementation at the healthcare facility and national levels, and sensitize stakeholders ’ and funders’ interest. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 16, 2024 Category: Infectious Diseases Source Type: research
Synthesis of Calix[4]arene-Based Porous Organic Cages and Their Gas Adsorption
Chemistry. 2024 Apr 15:e202400947. doi: 10.1002/chem.202400947. Online ahead of print.ABSTRACTTwo crystalline large-sized porous organic cages (POCs) based on conical calix[4]arene (C4A) were designed and synthesized. The four-jaw C4A unit tends to follow the face-directed self-assembly law with the planar triangular building blocks such as tris(4-aminophenyl)amine (TAPA) or 1,3,5-tris(4-aminophenyl)benzene (TAPB) to generate a predictable cage with a stoichiometry of [6+8]. The formation of the large cages is confirmed through their relative molecular mass measured using MALDI-TOF/TOF spectra. The protonated molecular ion...
Source: Chemistry - April 15, 2024 Category: Chemistry Authors: Qidi Kong Lei-Lei Liu Zhongyue Li Source Type: research
Association Between Iodine Status and Prevalence of Hypothyroidism, Autoimmune Thyroiditis, and Thyroid Nodule: a Cross-Sectional Study in Shandong Province, China
This study identified associations between different UIC levels and the prevalence of thyroid disorders, with low UIC (< 100 μg/L) posing a risk for TN, and the detection rate of TN and hypothyroidism was the lowest in UIC (200-299 μg/L) group. Therefore, the acceptable UIC range of 'adequate' iodine intake among adults can be widened from 100-199 µg/L to 100-299 µg/L.PMID:38619679 | DOI:10.1007/s12011-024-04179-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 15, 2024 Category: Biology Authors: Fangang Meng Peng Liu Yang Du Jinyin Yao Lijun Fan Chunpeng Lv Yi Chen Xianglan Chen Wen Jiang Wei Zhang Dianjun Sun Source Type: research
Association Between Iodine Status and Prevalence of Hypothyroidism, Autoimmune Thyroiditis, and Thyroid Nodule: a Cross-Sectional Study in Shandong Province, China
This study identified associations between different UIC levels and the prevalence of thyroid disorders, with low UIC (< 100 μg/L) posing a risk for TN, and the detection rate of TN and hypothyroidism was the lowest in UIC (200-299 μg/L) group. Therefore, the acceptable UIC range of 'adequate' iodine intake among adults can be widened from 100-199 µg/L to 100-299 µg/L.PMID:38619679 | DOI:10.1007/s12011-024-04179-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 15, 2024 Category: Biology Authors: Fangang Meng Peng Liu Yang Du Jinyin Yao Lijun Fan Chunpeng Lv Yi Chen Xianglan Chen Wen Jiang Wei Zhang Dianjun Sun Source Type: research
Association Between Iodine Status and Prevalence of Hypothyroidism, Autoimmune Thyroiditis, and Thyroid Nodule: a Cross-Sectional Study in Shandong Province, China
This study identified associations between different UIC levels and the prevalence of thyroid disorders, with low UIC (< 100 μg/L) posing a risk for TN, and the detection rate of TN and hypothyroidism was the lowest in UIC (200-299 μg/L) group. Therefore, the acceptable UIC range of 'adequate' iodine intake among adults can be widened from 100-199 µg/L to 100-299 µg/L.PMID:38619679 | DOI:10.1007/s12011-024-04179-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 15, 2024 Category: Biology Authors: Fangang Meng Peng Liu Yang Du Jinyin Yao Lijun Fan Chunpeng Lv Yi Chen Xianglan Chen Wen Jiang Wei Zhang Dianjun Sun Source Type: research
Endemic status of urogenital schistosomiasis and the efficacy of a single-dose praziquantel treatment in unmapped rural farming communities in Oyo East Local Government Area, Oyo State, Nigeria
ConclusionUrogenital schistosomiasis was hyperendemic in the Ajagba community, and hypoendemic in the Awosan community. The presence ofBulinus globosus supported the transmission of the schistosomiasis in the Ajagba community. Communities where schistosomiasis is still actively transmitted in Nigeria should be identified for effective intervention through the MDA programs. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 15, 2024 Category: Tropical Medicine Authors: Alexander B. Odaibo Source Type: research
Ventriculoperitoneal Shunt Surgery in Pediatrics: Does Preoperative Skin Antisepsis with Chlorhexidine/Alcohol Reduce Postoperative Shunt Infection Rate?
Conclusions Two steps of preoperative skin antisepsis, first using chlorhexidine/alcohol and then povidone-iodine scrub solution, may significantly reduce the infection rate in pediatric VP shunt surgeries. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - April 15, 2024 Category: Neurosurgery Authors: Ammar, Ahmed Shawky Elnoamany, Hossam Elkholy, Hany Tags: Original Article Source Type: research
The impact of delayed diagnosis and treatment due to COVID-19 on Australian thyroid cancer patients: a qualitative interview study
Conclusions
This study highlights an increased psychological burden in patients with thyroid cancer who experienced delayed diagnosis and/or treatment during COVID-19. The impacts experienced by patients during this time may be similar in the case of other unexpected delays and highlight the need for regular clinical review during delays to diagnosis or treatment. (Source: BMJ Open)
Source: BMJ Open - April 15, 2024 Category: General Medicine Authors: D'souza, B., Glover, A., Bavor, C., Brown, B., Dodd, R. H., Lee, J. C., Millar, J., Miller, J. A., Zalcberg, J. R., Serpell, J., Ioannou, L. J., Nickel, B. Tags: Open access, Surgery, COVID-19 Source Type: research
Paraaortic Extra-Adrenal Paraganglioma: Challenging Robotic Resection
CONCLUSIONS: Robotic-assisted resection can be safe and effective for retroperitoneal malignant paragangliomas. However, management extends beyond surgery and requires cascade genetic testing to address familial risks. Because of the high probability of cancer associated with SDHB mutation, lifelong patient surveillance is imperative.PMID:38615151 | DOI:10.1245/s10434-024-15267-z (Source: Ann Oncol)
Source: Ann Oncol - April 13, 2024 Category: Cancer & Oncology Authors: Andrei Nikiforchin Ekaterina Baron Jessica A Wernberg Rohit Sharma Source Type: research
