Lipid Profile Evolution in Graves ’ Disease Treated with Titration
Regimen of Anti-Thyroid Drugs Versus Block and Replace Regimen
In this study were
included 149 medically treated GD patients, aged+>+18 years. Pregnant women
and patients treated with radioactive iodine therapy or partial/total
thyroidectomy were excluded. Patients were divided into 2 subgroups: titration
(A) and block and replace (B) therapy, according to the ATD regimen used.
Thyroid and metabolic profile was measured at baseline and at least one visit
during medical treatment. The whole group included 122 (81.87%) females (F) and
27 (18.12%) males (M), ratio F:M=4.5:1. As expected, at the time of diagnosis,
...
Source: Hormone and Metabolic Research - April 2, 2024 Category: Endocrinology Authors: Stancu, Ana-Maria Pop, Oana Purice, Mariana Badiu, Corin Tags: Original Article: Endocrine Care Source Type: research
Development and Preclinical Evaluation of [211At]PSAt-3-Ga: An Inhibitor for Targeted {alpha}-Therapy of Prostate Cancer
Conclusion: The reported findings support the use of iodine-based and 68Ga-labeled variants as a convenient strategy for developing astatinated compounds and confirm [211At]PSAt-3 as a promising radiopharmaceutical for targeted α-therapy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - April 1, 2024 Category: Nuclear Medicine Authors: El Fakiri, M., Ayada, N., Muller, M., Hvass, L., Gamzov, T. H., Clausen, A. S., Geis, N. M., Steinacker, N., Hansson, E., Lindegren, S., Aneheim, E., Jensen, H., Eder, A.-C., Jensen, A. I., Poulie, C. B. M., Kjaer, A., Eder, M., Herth, M. M. Tags: Basic Science Investigations Source Type: research
The Accomplishments and Legacy of Saul Hertz, MD
This article is a comprehensive review of the accomplishments of Saul Hertz. Extensive use of primary-source verification has clarified several issues, including the question of whether Hertz alone conceived and asked the pivotal question: "Could iodine be made radioactive artificially?"; on what date RAI was first used to treat hyperthyroidism; and why 2 articles on the first use of RAI for treatment of hyperthyroidism, from 2 different sets of authors from the same department of the same institution, appeared adjacent to each other in the same issue of the Journal of the American Medical Association in 1946. Our review a...
Source: Journal of Nuclear Medicine - April 1, 2024 Category: Nuclear Medicine Authors: Greenspan, B. S., Hofman, M. S., Buscombe, J. Tags: Special Contributions Source Type: research
Assessment of post-thrombectomy brain hemorrhage in acute ischemic stroke with dual-energy CT: how reliable is it in clinical practice?
ConclusionDual-energy CT scan after endovascular recanalization in ischemic stroke identifies early hemorrhagic infarction with excellent specificity and good overall diagnostic accuracy, representing a reliable diagnostic tool in everyday clinical practice. (Source: La Radiologia Medica)
Source: La Radiologia Medica - April 1, 2024 Category: Radiology Source Type: research
Modeling the Complexity of Drug-Drug Interactions: A Physiologically-based Pharmacokinetic Study of Lenvatinib with Schisantherin A/Schisandrin A
CONCLUSION: Our study developed the first PBPK and DDI models for lenvatinib as a victim drug. STA and SIA slightly increased lenvatinib exposure in simulations, providing clinically valuable information on the safety of concurrent use. Given the minimal pharmacokinetic changes, STA/SIA are unlikely to interact with lenvatinib through pharmacokinetic alterations synergistically but rather may enhance efficacy through inherent anti-cancer efficacy of STA/ SIA.PMID:38556066 | DOI:10.1016/j.ejps.2024.106757 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - March 31, 2024 Category: Drugs & Pharmacology Authors: Aole Zheng Dongsheng Yang Chunyang Pan Qingfeng He Xiao Zhu Xiaoqiang Xiang Peiying Ji Source Type: research
Modeling the Complexity of Drug-Drug Interactions: A Physiologically-based Pharmacokinetic Study of Lenvatinib with Schisantherin A/Schisandrin A
CONCLUSION: Our study developed the first PBPK and DDI models for lenvatinib as a victim drug. STA and SIA slightly increased lenvatinib exposure in simulations, providing clinically valuable information on the safety of concurrent use. Given the minimal pharmacokinetic changes, STA/SIA are unlikely to interact with lenvatinib through pharmacokinetic alterations synergistically but rather may enhance efficacy through inherent anti-cancer efficacy of STA/ SIA.PMID:38556066 | DOI:10.1016/j.ejps.2024.106757 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - March 31, 2024 Category: Drugs & Pharmacology Authors: Aole Zheng Dongsheng Yang Chunyang Pan Qingfeng He Xiao Zhu Xiaoqiang Xiang Peiying Ji Source Type: research
Modeling the complexity of drug-drug interactions: A physiologically-based pharmacokinetic study of Lenvatinib with Schisantherin A/Schisandrin A
CONCLUSION: Our study developed the first PBPK and DDI models for lenvatinib as a victim drug. STA and SIA slightly increased lenvatinib exposure in simulations, providing clinically valuable information on the safety of concurrent use. Given the minimal pharmacokinetic changes, STA/SIA are unlikely to interact with lenvatinib through pharmacokinetic alterations synergistically but rather may enhance efficacy through inherent anti-cancer efficacy of STA/ SIA.PMID:38556066 | DOI:10.1016/j.ejps.2024.106757 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - March 31, 2024 Category: Drugs & Pharmacology Authors: Aole Zheng Dongsheng Yang Chunyang Pan Qingfeng He Xiao Zhu Xiaoqiang Xiang Peiying Ji Source Type: research
Cancers, Vol. 16, Pages 1382: Increased Pituitary Fluorine-18-Fluorodeoxyglucose Uptake in Patients with Differentiated Thyroid Cancer in Hypothyroidism versus under Recombinant Human Thyroid-Stimulating Hormone Stimulation
Conclusions: The present findings support the hypothesis that pituitary hypermetabolism on 18F-FDG PET/CT in patients with DTC undergoing THW is a common physiological response to hypothyroidism. Awareness of this physiological hypermetabolism is important to avoid potential pitfalls in image interpretation. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Xinyi Shi Ilaria Giordani Marie Nicod Lalonde Gerasimos P. Sykiotis Tags: Article Source Type: research
Advances in Radioligand Theranostics in Oncology
AbstractTheranostics with radioligands (radiotheranostics) has played a pivotal role in oncology. Radiotheranostics explores the molecular targets expressed on tumor cells to target them for imaging and therapy. In this way, radiotheranostics entails non-invasive demonstration of the in vivo expression of a molecular target of interest through imaging followed by the administration of therapeutic radioligand targeting the tumor-expressed molecular target. Therefore, radiotheranostics ensures that only patients with a high likelihood of response are treated with a particular radiotheranostic agent, ensuring the delivery of ...
Source: Molecular Diagnosis and Therapy - March 31, 2024 Category: Molecular Biology Source Type: research
A case of a peritoneal dialysis patient with left pleuroperitoneal communication caused by a pericardial defect after coronary artery bypass surgery
AbstractA 74-year-old woman with reduced kidney and cardiac function and a history of coronary artery bypass surgery involving the gastroepiploic artery to the right coronary artery and posterior descending artery #4 presented with dyspnea on exertion. Shortly after the induction of peritoneal dialysis (PD), an increase in the left pleural effusion was observed, and a diagnosis of left pleuroperitoneal communication was made by puncture drainage. The pleuroperitoneal communication hole was not detected under thoracoscopic observation; however, a 10 mm-sized hole in the pericardium was found, confirming leakage of ICG-loa...
Source: CEN Case Reports - March 31, 2024 Category: Urology & Nephrology Source Type: research
Plasmapheresis in thyrotoxicosis: a single-center case series
Discussion/conclusionThe standard management of thyrotoxicosis and thyroid storm was usually codified by the concomitant use of antithyroid medication, iodine, beta-blockers, and corticosteroids. This medical preparation can be effective in most cases. However, drug toxicity or ineffectiveness can limit the use of such therapeutics. Our paper supports the efficiency and safety of therapeutic plasma exchange in the preoperative management of thyrotoxicosis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 30, 2024 Category: General Medicine Source Type: research
Potassium Iodide Use and Patient Outcomes for Thyroid Storm: An Observational Study
CONCLUSION: Our findings suggest that KI may reduce in-hospital mortality among patients hospitalized for thyroid storm with Graves' disease.PMID:38546426 | DOI:10.1210/clinem/dgae187 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 28, 2024 Category: Endocrinology Authors: Yuichiro Matsuo Atsushi Miyawaki Hideaki Watanabe Hiroki Matsui Kiyohide Fushimi Hideo Yasunaga Source Type: research
Potassium Iodide Use and Patient Outcomes for Thyroid Storm: An Observational Study
CONCLUSION: Our findings suggest that KI may reduce in-hospital mortality among patients hospitalized for thyroid storm with Graves' disease.PMID:38546426 | DOI:10.1210/clinem/dgae187 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 28, 2024 Category: Endocrinology Authors: Yuichiro Matsuo Atsushi Miyawaki Hideaki Watanabe Hiroki Matsui Kiyohide Fushimi Hideo Yasunaga Source Type: research
Iodine –mediated Oxidative Triple Functionalization of Indolines with Azoles and Diazonium Salts
We report herein an innovative synthetic strategy for the generation of polysubstituted indoles from indolines, aryldia-zonium salts, and azoles. The methodology encompasses an electrophilic substitution reaction affording C5-indoline in-termediates, which... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - March 27, 2024 Category: Chemistry Authors: Yifeng Liu Source Type: research
