Three-component N-alkenylation of azoles with alkynes and iodine(III) electrophile: synthesis of multisubstituted N-vinylazoles
Abstract A stereoselective N-alkenylation of azoles with alkynes and iodine(III) electrophile is reported. The reaction between various azoles and internal alkynes is mediated by benziodoxole triflate as the electrophile in a trans-fashion, affording azole-bearing vinylbenziodoxoles in moderate to good yields. The tolerable azole nuclei include pyrazole, indazole, 1,2,3-triazole, benzotriazole, and tetrazole. The iodanyl group in the product can be leveraged as a versatile synthetic handle, allowing for the preparation of hitherto inaccessible types of densely functionalized N-vinylazoles. Beilstein J. Org. Chem. 2024, 20...
Source: Beilstein Journal of Organic Chemistry - April 22, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: alkynes azoles cross-coupling hypervalent iodine Full Research Paper Source Type: research

Associations among environmental exposure to trace elements and biomarkers of early kidney damage in the pediatric population
Conclusions. Among the explored metals, exposure to Cu and iodine impairs renal function. In contrast, Se may manifest as a beneficial metal. Interactions of Mo-Se and Mo-Iodine seem to alter the expression of NGAL; Mo-Cu for CLU; Mo-Cu, Mo-Se, and Mo-iodine for Cys-C and a-1MG; and Mo-Cu and Mo-iodine for KIM-1; were noticed. Our study could suggest that trace element interactions were associated with early kidney damage biomarkers.PMID:38642266 | DOI:10.1007/s10534-024-00603-3 (Source: Biometals)
Source: Biometals - April 20, 2024 Category: Biochemistry Authors: Manolo Ortega-Romero Elodia Rojas-Lima Juan Carlos Rubio-Guti érrez Octavio Gamaliel Aztatzi-Aguilar Juana Narv áez-Morales Mariela Esparza-Garc ía Ángel Barrera-Hernández Miguel Ángel Mejia Pablo Mendez-Hern ández Mara Medeiros Olivier Christophe Source Type: research

Fast kV-switching and dual-layer flat-panel detector enabled cone-beam CT joint spectral imaging
Conclusions: A feasibility study of the joint spectral imaging for CBCT by utilizing both the FKS and DL-FPD was conducted, with the first tabletop CBCT system having such a capability being developed, which exhibits improved spectral imaging performance as expected.PMID:38640917 | DOI:10.1088/1361-6560/ad40f3 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 19, 2024 Category: Physics Authors: Hao Zhou Li Zhang Zhilei Wang Hewei Gao Source Type: research

Molecules, Vol. 29, Pages 1864: The Antioxidant, Anti-Inflammatory and Moisturizing Effects of Camellia oleifera Oil and Its Potential Applications
This study determined the physicochemical properties of CO oil extracted via direct pressing, identified its main components using GC-MS, and evaluated its antioxidant, moisturizing, and anti-inflammatory activities. The results revealed that CO oil’s acid, peroxide, iodine, and saponification values were 1.06 ± 0.031 mg/g, 0.24 ± 0.01 g/100 g, 65.14 ± 8.22 g/100 g, and 180.41 ± 5.60 mg/g, respectively. CO oil’s tocopherol, polyphenol, and squalene contents were 82.21 ± 9.07 mg/kg, 181.37 ± 3.76 mg/kg, and ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Lijun Zhou Yunlan Peng Zhou Xu Jingyi Chen Ningbo Zhang Tao Liang Tao Chen Yao Xiao Shiling Feng Chunbang Ding Tags: Article Source Type: research

Dual-energy CT quantitative parameters to evaluate occult peritoneal metastasis in advanced gastric cancer preoperatively
ConclusionThe lower quantitative NIC, IC ratio, andZeff on DECT was associated with peritoneal metastasis in advanced gastric cancer and was promising to identify patients with OPM noninvasively.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 18, 2024 Category: Radiology Source Type: research

A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Conclusions: Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration. Further investigation of the optimal treatment schedule for lenvatinib is warranted. Clinical Trial Registration: UMIN000022243.PMID:38629757 | DOI:10.1089/thy.2023.0553 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research

Using haematological indices to predict impaired liver function in DTC patients
CONCLUSION: Our results suggest that PC and ALC are independent predictors of hypo-related liver injury. Our study is the first to suggest that haematological indices can be used for predicting the development and progression of hypo-related liver disorders.PMID:38629813 | DOI:10.1967/s002449912700 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Yanli Zhou Hong Chai Source Type: research

A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Conclusions: Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration. Further investigation of the optimal treatment schedule for lenvatinib is warranted. Clinical Trial Registration: UMIN000022243.PMID:38629757 | DOI:10.1089/thy.2023.0553 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research

Using haematological indices to predict impaired liver function in DTC patients
CONCLUSION: Our results suggest that PC and ALC are independent predictors of hypo-related liver injury. Our study is the first to suggest that haematological indices can be used for predicting the development and progression of hypo-related liver disorders.PMID:38629813 | DOI:10.1967/s002449912700 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Yanli Zhou Hong Chai Source Type: research

A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Conclusions: Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration. Further investigation of the optimal treatment schedule for lenvatinib is warranted. Clinical Trial Registration: UMIN000022243.PMID:38629757 | DOI:10.1089/thy.2023.0553 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research

Using haematological indices to predict impaired liver function in DTC patients
CONCLUSION: Our results suggest that PC and ALC are independent predictors of hypo-related liver injury. Our study is the first to suggest that haematological indices can be used for predicting the development and progression of hypo-related liver disorders.PMID:38629813 | DOI:10.1967/s002449912700 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Yanli Zhou Hong Chai Source Type: research

Using haematological indices to predict impaired liver function in DTC patients
CONCLUSION: Our results suggest that PC and ALC are independent predictors of hypo-related liver injury. Our study is the first to suggest that haematological indices can be used for predicting the development and progression of hypo-related liver disorders.PMID:38629813 | DOI:10.1967/s002449912700 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Yanli Zhou Hong Chai Source Type: research