Heavy Metal Pollution and Male Fertility: An Overview on Adverse Biological Effects and Socio-Economic Implications
Endocr Metab Immune Disord Drug Targets. 2022 Jun 27. doi: 10.2174/1871530322666220627141651. Online ahead of print.ABSTRACTTrace metals can be divided into two subgroups considering their pathophysiological effects: the first consists of microelements essential for life (arsenic, cobalt, chromium, copper, fluorine, iron, iodine, manganese, molybdenum, nickel, selenium, silicon, tin, vanadium and zinc), implicated in important metabolic processes; the second includes toxic microelements, such as cadmium (Cd), mercury (Hg), chromium (Cr), and lead (Pb) for living organisms, even at low concentrations. These metals contribut...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2022 Category: Drugs & Pharmacology Authors: Felice Crocetto Rossella Risolo Rita Colapietro Rosa Bellavita Biagio Barone Andrea Ballini Roberto Arrigoni Vincenzo Francesco Caputo Giovanni Luca Paolo Grieco Giunio Santini Stefano Brancorsini Source Type: research

Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice
by Lena Ar évalo, Gina Esther Merges, Simon Schneider, Franka Enow Oben, Isabelle Sophie Neumann, Hubert Schorle Protamines are unique sperm-specific proteins that package and protect paternal chromatin until fertilization. A subset of mammalian species expresses two protamines (PRM1 and PRM2), while in others PRM1 is sufficient for sperm chromatin packaging. Alterations of the species-specific ratio between PRM1 and PRM2 are associated with infertility. Unlike PRM1, PRM2 is generated as a precursor protein consisting of a highly conserved N-terminal domain, termed cleaved PRM2 (cP2), which is consecutively trimmed off d...
Source: PLoS Genetics - June 28, 2022 Category: Genetics & Stem Cells Authors: Lena Ar évalo Source Type: research

MicroRNA expression in male infertility
Reprod Fertil Dev. 2022 Jun 28. doi: 10.1071/RD21131. Online ahead of print.ABSTRACTMale infertility is a multifactorial disorder that involves different physiopathological mechanisms and multiple genes. In this sense, we analyse the role of miRNAs in this pathology. Gene expression analysis can provide relevant information to detect biomarkers, signalling pathways, pathologic mechanisms, and potential therapeutic targets for the disease. In this review, we describe four miRNA microarrays related to patients who present infertility diseases, including azoospermia, asthenozoospermia, and oligoasthenozoospermic. We selected ...
Source: Reproduction, Fertility, and Development - June 27, 2022 Category: Reproduction Medicine Authors: C F Burgos R Cikutovic M Alarc ón Source Type: research

Effects of N-Acetylcysteine Supplementation on Oxidative Stress and Expression of Apoptosis-Related Genes in Testicular Tissue of Rats Exposed to Lead
CONCLUSION: Lead exposure strongly motivated testicular cells towards apoptosis, caused an oxidant/antioxidant imbalance, and decreased sperm quality along with morphological changes in testis cells. NAC treatments was associated with protective effects on testicular tissue mainly by rebalancing of the antioxidants capacity, as well as downregulation of apoptosis-related genes.PMID:35761113 | DOI:10.1007/s12011-022-03325-0 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - June 27, 2022 Category: Biology Authors: Fahimeh Abedini Bajgiran Zeinab Khazaei Koohpar Ali Salehzadeh Source Type: research

Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency
CONCLUSION: COS might provide an opportunity for POI women with abnormal karyotypes to conceive a biological offspring.PMID:35755970 | PMC:PMC9199886 | DOI:10.1002/rmb2.12471 (Source: Reproductive Biology)
Source: Reproductive Biology - June 27, 2022 Category: Reproduction Medicine Authors: Leonti Grin Bunpei Ishizuka Asami Onimaru Masataka Furuya Kazuhiro Kawamura Source Type: research

Endometrial osseous metaplasia with secondary infertility
CMAJ. 2022 Jun 27;194(25):E868-E869. doi: 10.1503/cmaj.220183.NO ABSTRACTPMID:35760426 | DOI:10.1503/cmaj.220183 (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - June 27, 2022 Category: General Medicine Authors: Justin White Joanne Hickey Donna Gilmour Afshin Ansari Source Type: research

Long-read Oxford nanopore sequencing reveals a de novo case of complex chromosomal rearrangement involving chromosomes 2, 7, and 13
CONCLUSIONS: LRS is effective for analyzing the complex structural variations of the human genome and may be used to clarify the specific CCRs for effective genetic counseling and appropriate intervention.PMID:35758276 | DOI:10.1002/mgg3.2011 (Source: Molecular Medicine)
Source: Molecular Medicine - June 27, 2022 Category: Molecular Biology Authors: Lingling Xing Ying Shen Xiang Wei Yuan Luo Yan Yang Haipeng Liu Hongqian Liu Source Type: research

Killer Timing: The Temporal Uterine Natural Killer Cell Differentiation Pathway and Implications for Female Reproductive Health
Natural killer (NK) cells are the predominant maternal uterine immune cell component, and they densely populate uterine mucosa to promote key changes in the post-ovulatory endometrium and in early pregnancy. It is broadly accepted that (a) immature, inactive endometrial NK (eNK) cells in the pre-ovulatory endometrium become activated and transition into decidual NK (dNK) cells in the secretory stage, peri-implantation endometrium, and continue to mature into early pregnancy; and (b) that secretory-stage and early pregnancy dNK cells promote uterine vascular growth and mediate trophoblast invasion, but do not exert their ki...
Source: Frontiers in Endocrinology - June 27, 2022 Category: Endocrinology Source Type: research

Early Spontaneous Abortion in Fresh- and Frozen-Embryo Transfers: An Analysis of Over 35,000 Transfer Cycles
ConclusionsMaternal age, BMI, number of embryos transferred, and frozen-thawed transfer were independent risk factors for ESA in assisted reproductive technology treatment cycles. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 27, 2022 Category: Endocrinology Source Type: research

Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice
Conclusions Our findings support that CCDC34 is crucial to the formation of sperm flagella and that biallelic deleterious mutations in CCDC34/Ccdc34 cause male infertility with oligoasthenoteratozoospermia in humans and mice. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - June 27, 2022 Category: Genetics & Stem Cells Authors: Cong, J., Wang, X., Amiri-Yekta, A., Wang, L., Kherraf, Z.-E., Liu, C., Cazin, C., Tang, S., Hosseini, S. H., Tian, S., Daneshipour, A., Wang, J., Zhou, Y., Zeng, Y., Yang, S., He, X., Li, J., Cao, Y., Jin, L., Ray, P. F., Zhang, F. Tags: Gametes Source Type: research

The Urologist's Guide to Religion and Male Factor Fertility Treatment
Semen quality in the United States has been declining since at least the early twentieth century. A review published in the British Medical Journal evaluated semen parameters of 14,947 men across 61 papers published between 1938 and 1991, and found a clear decrease in both semen volume and mean sperm count1. Male factor infertility, however, is hardly a novel concern. There are innumerable references to male fertility which have ingratiated themselves into religions and cultures over millennia which continue to play a role in societal attitudes towards male factor infertility. (Source: Urology)
Source: Urology - June 27, 2022 Category: Urology & Nephrology Authors: Samuel R. Donnenfeld, Akanksha Mehta Source Type: research

Effects of COVID-19 vaccination status, vaccine type, and vaccination interval on IVF pregnancy outcomes in infertile couples
ConclusionsThe vaccination status of both partners in infertile couples, different types of vaccines, and time intervals have no effect on embryo quality and pregnancy rates in IVF. This is the first study to compare the vaccination status of both partners in infertile couples and the impact of different vaccine types on pregnancy rates and embryo quality in detail. Our findings provide evidence of vaccine safety for infertile couples wishing to undergo IVF treatment. This evidence is crucial for decision-making by clinicians and policymakers involved in IVF cycles. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - June 27, 2022 Category: Reproduction Medicine Source Type: research

Basal serum level of Δ4-androstenedione reflects the ovaries’ ability to respond to stimulation in IVF cycles: setting up a new reliable index of both ovarian reserve and response
ConclusionBaseline serum Δ4-A, presumably crucial for ensuring a regular follicular growth, is a reliable marker of ovarian response to stimulation. Since the ovarian capacity to respond to gonadotropins does not depend exclusively on the presence of follicles, we suggest a new index, the G-index, able to contemplate both the ovarian reserve and the Δ4-A level. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - June 27, 2022 Category: Reproduction Medicine Source Type: research

EE29 Annual Health Insurance Treatment Cost of Female Infertility Associated with Male Factors Based on Real-World Health Insurance Claims Data
Female infertility constitutes a significant and growing burden on patients, health care systems and the society. Our aim was to determine the annual costs of the health insurance system related to the female infertility associated with male factors in Hungary. (Source: Value in Health)
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: D P ónusz-Kovács, D Elmer, T Csákvári, L Kajos, R Pónusz, B Kovács, A Sebestyén, J Bódis, I Boncz Source Type: research

EE28 Annual Health Insurance Treatment Cost of Female Infertility of Other Origin Based on Real-World Health Insurance Claims Data
Female infertility is a global medical condition that could be caused by various disorders of the reproductive system. Female infertility constitutes a significant and growing burden on patients, health care systems and the society. Our aim was to determine the annual costs of the health insurance system related to the female infertility of other origin in Hungary. (Source: Value in Health)
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: D P ónusz-Kovács, D Elmer, T Csákvári, L Kajos, R Pónusz, B Kovács, A Sebestyén, J Bódis, I Boncz Source Type: research