Cytokine and chemokine profiles in women with endometriosis, polycystic ovary syndrome, and unexplained infertility
Cytokine. 2024 Mar 30;178:156588. doi: 10.1016/j.cyto.2024.156588. Online ahead of print.ABSTRACTNumerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and EMS is a benign disease characterized by the presence of ectopic endometrial tissue. UI refers to couples who are unable to conce...
Source: Cytokine - March 31, 2024 Category: Molecular Biology Authors: Alireza Omidvar-Mehrabadi Fateme Ebrahimi Mehdi Shahbazi Mousa Mohammadnia-Afrouzi Source Type: research
Cytokine and chemokine profiles in women with endometriosis, polycystic ovary syndrome, and unexplained infertility
Cytokine. 2024 Mar 30;178:156588. doi: 10.1016/j.cyto.2024.156588. Online ahead of print.ABSTRACTNumerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and EMS is a benign disease characterized by the presence of ectopic endometrial tissue. UI refers to couples who are unable to conce...
Source: Cytokine - March 31, 2024 Category: Molecular Biology Authors: Alireza Omidvar-Mehrabadi Fateme Ebrahimi Mehdi Shahbazi Mousa Mohammadnia-Afrouzi Source Type: research
Cytokine and chemokine profiles in women with endometriosis, polycystic ovary syndrome, and unexplained infertility
Cytokine. 2024 Mar 30;178:156588. doi: 10.1016/j.cyto.2024.156588. Online ahead of print.ABSTRACTNumerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and EMS is a benign disease characterized by the presence of ectopic endometrial tissue. UI refers to couples who are unable to conce...
Source: Cytokine - March 31, 2024 Category: Molecular Biology Authors: Alireza Omidvar-Mehrabadi Fateme Ebrahimi Mehdi Shahbazi Mousa Mohammadnia-Afrouzi Source Type: research
Cytokine and chemokine profiles in women with endometriosis, polycystic ovary syndrome, and unexplained infertility
Cytokine. 2024 Mar 30;178:156588. doi: 10.1016/j.cyto.2024.156588. Online ahead of print.ABSTRACTNumerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and EMS is a benign disease characterized by the presence of ectopic endometrial tissue. UI refers to couples who are unable to conce...
Source: Cytokine - March 31, 2024 Category: Molecular Biology Authors: Alireza Omidvar-Mehrabadi Fateme Ebrahimi Mehdi Shahbazi Mousa Mohammadnia-Afrouzi Source Type: research
GSE252198 Nanopore-based full-length transcriptome sequencing of yak (Bos grunniens) testis
Contributors : Xingdong Wang ; Shaoke Guo ; Jie Pei ; Xian GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Bos grunniens ; Bos grunniens x Bos taurusAlternative splicing (AS) is strictly regulated during cell differentiation and development. AS events are common in the testis, but the splicing regulation in spermatogenesis is still unclear. In this experiment, the third-generation ONT sequencing was used to sequence the full-length transcriptome of testicular tissue, and 40,038 new transcripts were obtained, and the proportion was almost close to the number of known transcripts identified....
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Bos grunniens Bos grunniens x Bos taurus Source Type: research
GSE226551 SRSF1-mediated alternative splicing is required for spermatogonial stem cell differentiation and mitotic-to-meiotic transition [LACE-seq]
Contributors : Wen-Long Lei ; Zongchang Du ; Ruibao SuSeries Type : OtherOrganism : Mus musculusAlternative splicing (AS) plays significant roles in fundamental biological activities. AS also are prevalent in the testis, but the regulations of alternative splicing in spermatogenesis is vague. Here, we report that Serine/arginine-rich splicing factor 1 (SRSF1), plays critical roles in alternative splicing and male reproduction. Male germ cell-specific deletion of Srsf1 led to complete infertility and abnormal spermatogenesis. We further demonstrated that Srsf1 is required for spermatogonial stem cell differentiation and ...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
GSE226550 SRSF1-mediated alternative splicing is required for spermatogonial stem cell differentiation and mitotic-to-meiotic transition [RNA-Seq]
Contributors : Wen-Long Lei ; Zongchang Du ; Ruibao SuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlternative splicing (AS) plays significant roles in fundamental biological activities. AS also are prevalent in the testis, but the regulations of alternative splicing in spermatogenesis is vague. Here, we report that Serine/arginine-rich splicing factor 1 (SRSF1), plays critical roles in alternative splicing and male reproduction. Male germ cell-specific deletion of Srsf1 led to complete infertility and abnormal spermatogenesis. We further demonstrated that Srsf1 is required for ...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE225277 Balanced spatiotemporal arrangements of Histone H3 and H4 post-translational modifications are necessary for meiotic prophase I chromosome organization
Contributors : Lava K Surarapu ; Aradhana mohanthy ; anjali kumari ; ajith kumar ; ranjiht kumar ; mohd Athar ; R K Gandham ; H Prasada RaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDynamic nuclear architecture and chromatin organizations are the key features of the mid- prophase I in mammalian meiosis. Where the chromatin undergoes major changes, including meiosis-specific spatiotemporal arrangements and remodelling, the establishment of chromatin loop –axis structure, pairing, and crossing over between homologous chromosomes, any deficiencies in these events may induce ...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE262471 Gene regulatory activity associated with PCOS reveals DENND1A-dependent testosterone production
We report the discovery of gene regulatory mechanisms that help explain genetic association with PCOS in the GATA4, FSHB and DENND1A loci. We based those findings using a combination of high throughput reporter assays, CRISPR-based epigenome editing, and genetic association analysis from PCOS case and control populations. In addition, we found that elevated endogenous DENND1A expression causes elevated testosterone levels, a hallmark PCOS phenotype. These results further highlight the potential for combining genetic variant analyses with experimental approaches to fine map genetic associations with disease risk. (Source: G...
Source: GEO: Gene Expression Omnibus - March 30, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
Effects of hysteroscopic septum incision versus expectant management on IVF outcomes in women with complete septate uterus: a retrospective study
This retrospective study aimed to assess the impact of hysteroscopic septum incision on in vitro fertilization (IVF) outcomes among infertile women diagnosed with a complete septate uterus and no history of re... (Source: BMC Women's Health)
Source: BMC Women's Health - March 30, 2024 Category: OBGYN Authors: Jiajia Zhang, Jia Kang, Xueling Song, Shuo Yang, Yan Yang, Jie Qiao and Caihong Ma Tags: Research Source Type: research
Individualized Weight Management and Its Impact on Pregnancy Outcomes in Overweight/Obese Infertile Women: A Retrospective Study
CONCLUSIONS: Individualized weight management enhances pregnancy outcomes in overweight/obese infertile women. Achieving a reduction in body weight by 10% or more, combined with effective control of visceral fat, proves important in improving pregnancy outcomes. Excess visceral fat emerges as an adverse factor impacting successful pregnancy.PMID:38551442 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Huimei Wu Xiaoli Wang Ran Sun Xiaoqian Fu Bin Zeng Fu Hang Qianyi Huang Li Jiang Qizhi Ou Aiping Qin Liuming Li Mujun Li Source Type: research
A Meta-analysis of the Efficacy and Safety of Traditional Chinese Medicine in Treating Endometriosis
CONCLUSION: The meta-analysis results confirmed that TCM treatment exhibited better efficacy in managing endometriosis, resulting in higher pregnancy rates, lower abortion rates, and a reduced probability of adverse reactions. These findings not only hold promise for improving the overall quality of life for patients but also offer practical implications for clinicians. The positive outcomes suggest that integrating TCM into endometriosis management could be considered as part of a comprehensive approach to enhance treatment effectiveness and minimize adverse effects, thereby providing clinicians and patients with valuable...
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Haiying Huang Yanshan Lin Huayang Ye Source Type: research
The significant improvement in ovarian PCOS syndrome using hydralazine and alendronate aromatase inhibitor FDA-approved drugs in Wistar rat models
Biomed Pharmacother. 2024 Mar 28;174:116504. doi: 10.1016/j.biopha.2024.116504. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The aim of this study was to investigate the therapeutic potential of vitamin C, glutamine, mesalazine, hydralazine, and alendronate as new drug candidates for the treatment of letrozole-induced PCOS in female Wistar rats. PCOS was induced in rats by intramuscular injection of estradiol valerate (2 mg/kg body weight for 28 days). The rats then received normal saline (PCOS group), letrozole (0.5 mg/kg), vitamin C (100 mg/kg), gluta...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Soudabeh Kavousipour Fahimeh Koohnavard Behzad Shahbazi Ebrahim Eftekhar Khadijeh Ahmadi Source Type: research
Individualized Weight Management and Its Impact on Pregnancy Outcomes in Overweight/Obese Infertile Women: A Retrospective Study
CONCLUSIONS: Individualized weight management enhances pregnancy outcomes in overweight/obese infertile women. Achieving a reduction in body weight by 10% or more, combined with effective control of visceral fat, proves important in improving pregnancy outcomes. Excess visceral fat emerges as an adverse factor impacting successful pregnancy.PMID:38551442 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Huimei Wu Xiaoli Wang Ran Sun Xiaoqian Fu Bin Zeng Fu Hang Qianyi Huang Li Jiang Qizhi Ou Aiping Qin Liuming Li Mujun Li Source Type: research
A Meta-analysis of the Efficacy and Safety of Traditional Chinese Medicine in Treating Endometriosis
CONCLUSION: The meta-analysis results confirmed that TCM treatment exhibited better efficacy in managing endometriosis, resulting in higher pregnancy rates, lower abortion rates, and a reduced probability of adverse reactions. These findings not only hold promise for improving the overall quality of life for patients but also offer practical implications for clinicians. The positive outcomes suggest that integrating TCM into endometriosis management could be considered as part of a comprehensive approach to enhance treatment effectiveness and minimize adverse effects, thereby providing clinicians and patients with valuable...
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Haiying Huang Yanshan Lin Huayang Ye Source Type: research
