Arctiin alleviates functional constipation by enhancing intestinal motility in mice
Exp Ther Med. 2023 Mar 20;25(5):199. doi: 10.3892/etm.2023.11898. eCollection 2023 May.ABSTRACTFunctional constipation (FC), a common symptom that is primarily associated with intestinal motility dysfunction, is a common problem worldwide. Arctiin (Arc) is a lignan glycoside isolated from the Chinese herbal medicine Arctium lappa L., which is a health food in China. The present study aimed to evaluate the laxative effects of Arc against FC in mice. A model of FC induced by loperamide (5 mg/kg) was established in male Institute of Cancer Research (ICR) mice. Arc was administered at a dose of 100 mg/kg as a protective agent....
Source: Experimental and Therapeutic Medicine - April 24, 2023 Category: General Medicine Authors: Yujin Wang Hua Jiang Lijun Wang Huiping Gan Xinchun Xiao Liangwu Huang Wenxin Li Zongrun Li Source Type: research
Pelvic floor muscle exercises alleviate symptoms and improve mental health and rectal function in patients with low anterior resection syndrome
ConclusionPelvic floor muscle exercises are an effective treatment that can alleviate symptoms and improve rectal function and mental health in patients with low anterior resection syndrome. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 20, 2023 Category: Cancer & Oncology Source Type: research
P13 Trametinib for chylothorax management in Noonan syndrome: discussion about efficacy, safety and tolerability
In conclusion, our experience has demonstrated that it is possible to manage the side effects of trametinib in a patient with multiple comorbidities using a patient centred and MDT approach.
References
Roberts AE, Allanson JE, Tartaglia M, Gelb BD. Noonan syndrome. Lancet 2013;381(9863):333–342.
Dori Y, Smith C, Pinto E, Snyder K, March ME, Hakonarson H, Belasco J. Severe lymphatic disorder resolved with MEK inhibition in a patient with Noonan syndrome and SOS1 mutation. Pediatrics 2020;146(6):e20200167. doi: 10.1542/peds.2020-0167. PMID: 33219052.
O’Hare P, Ahmed M, Samrin-Balch L. Guideline for the prescri...
Source: Archives of Disease in Childhood - April 19, 2023 Category: Pediatrics Authors: Brooks, T., Whiteley, S., Morris, S., Dunlop-Jones, A., Hribernik, I., Bentham, J. Tags: Abstract from the Neonatal and Paediatric Pharmacists Conference 2022 Source Type: research
75-Year-Old Woman With Deranged Liver Enzymes
A 75-year-old woman with a medical background of rheumatoid arthritis (treated with prednisone and leflunomide), secondary Sj ögren syndrome, irritable bowel syndrome, osteoporosis, hypertension, hyperlipidemia, chronic kidney disease stage 3, and hypoparathyroidism presented to the emergency department for right-sided neck pain. It radiated to the right side of her neck and was associated with subjective fevers and sweat s. She rated the pain 15 on a 10-point scale. On presentation, regular medications included acetaminophen, amlodipine, calcitriol, calcium carbonate, diclofenac 1% topical gel, duloxetine, folic acid, ir...
Source: Mayo Clinic Proceedings - April 5, 2023 Category: Internal Medicine Authors: Matthew L. Vincent, Robert M. Kraft, John T. Ratelle Tags: Residents ’ clinic Source Type: research
Rising toxicity of the antidiarrheal drug: loperamide in Pakistan
Ann Med Surg (Lond). 2023 Feb 17;85(3):569-570. doi: 10.1097/MS9.0000000000000170. eCollection 2023 Mar.ABSTRACTLoperamide, an opioid-based anti-diarrheal drug, frequently purchased without a prescription over-the-counter in Pakistan, the majority of the community thinks it is safe to use. It has been speculated that loperamide toxicity is greatly underreported since it is not frequently included in drug screening. The Pakistani government has to reevaluate its loperamide over-the-counter regulations. By media campaigns, the general population of Pakistan should be made aware of the risky consequences of high doses of lope...
Source: Annals of Medicine - March 16, 2023 Category: Internal Medicine Authors: Ashna Habib Arisha Mahfooz Zainab Nazir Source Type: research
Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model
Gastrointestinal (GI) motility is largely dependent upon activity within the enteric nervous system (ENS) and is an important part of the digestive process. Dysfunction of the ENS can impair GI motility as is seen in the case of constipation where gut transit time is prolonged. Animal models mimicking symptoms of constipation have been developed by way of pharmacological manipulations. Studies have reported an association between altered GI motility and gut microbial population. Little is known about the changes in gut microbiota profile resulting specifically from pharmacologically induced slowed GI motility in rats. More...
Source: Frontiers in cellular and infection microbiology - March 14, 2023 Category: Microbiology Source Type: research
Improvement of loperamide-hydrochloride-induced intestinal motility disturbance by Platycodon grandiflorum polysaccharides through effects on gut microbes and colonic serotonin
Constipation is a common gastrointestinal symptom characterized by intestinal motility disorder. The effects of Platycodon grandiflorum polysaccharides (PGP) on intestinal motility have not been confirmed. We established a rat model of constipation induced by loperamide hydrochloride to elucidate the therapeutic effect of PGP on intestinal motility disorder and to explore the possible mechanism. After PGP treatment (400 and 800 mg/kg) for 21 d, PGP clearly relieved gastrointestinal motility, including fecal water content, gastric emptying rate, and intestinal transit rate. Moreover, the secretion of motility-related hormo...
Source: Frontiers in cellular and infection microbiology - March 13, 2023 Category: Microbiology Source Type: research
Sticking to the Rules: Outcome and Success Rate of Guideline-Based Diarrhea Management in Metastatic Breast Cancer Patients Treated with Abemaciclib
J Clin Med. 2023 Feb 23;12(5):1775. doi: 10.3390/jcm12051775.ABSTRACTIn clinical trials testing abemaciclib in patients with hormone-receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer, diarrhea is a very common adverse event (occurring in approximately 85% of patients, any grade). Nonetheless, this toxicity leads to abemaciclib discontinuation in a small proportion of patients (approximately 2%) thanks to the use of effective loperamide-based supportive therapy. We aimed to determine whether the incidence of abemaciclib-induced diarrhea in real-world trials was higher than the one reported in clinical tr...
Source: Clinical Breast Cancer - March 11, 2023 Category: Cancer & Oncology Authors: Flavia Jacobs Elisa Agostinetto Alessandra Solferino Rosalba Torrisi Giovanna Masci Armando Santoro Rita De Sanctis Source Type: research
Sticking to the Rules: Outcome and Success Rate of Guideline-Based Diarrhea Management in Metastatic Breast Cancer Patients Treated with Abemaciclib
J Clin Med. 2023 Feb 23;12(5):1775. doi: 10.3390/jcm12051775.ABSTRACTIn clinical trials testing abemaciclib in patients with hormone-receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer, diarrhea is a very common adverse event (occurring in approximately 85% of patients, any grade). Nonetheless, this toxicity leads to abemaciclib discontinuation in a small proportion of patients (approximately 2%) thanks to the use of effective loperamide-based supportive therapy. We aimed to determine whether the incidence of abemaciclib-induced diarrhea in real-world trials was higher than the one reported in clinical tr...
Source: Clinical Genitourinary Cancer - March 11, 2023 Category: Cancer & Oncology Authors: Flavia Jacobs Elisa Agostinetto Alessandra Solferino Rosalba Torrisi Giovanna Masci Armando Santoro Rita De Sanctis Source Type: research
Sticking to the Rules: Outcome and Success Rate of Guideline-Based Diarrhea Management in Metastatic Breast Cancer Patients Treated with Abemaciclib
J Clin Med. 2023 Feb 23;12(5):1775. doi: 10.3390/jcm12051775.ABSTRACTIn clinical trials testing abemaciclib in patients with hormone-receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer, diarrhea is a very common adverse event (occurring in approximately 85% of patients, any grade). Nonetheless, this toxicity leads to abemaciclib discontinuation in a small proportion of patients (approximately 2%) thanks to the use of effective loperamide-based supportive therapy. We aimed to determine whether the incidence of abemaciclib-induced diarrhea in real-world trials was higher than the one reported in clinical tr...
Source: Clinical Breast Cancer - March 11, 2023 Category: Cancer & Oncology Authors: Flavia Jacobs Elisa Agostinetto Alessandra Solferino Rosalba Torrisi Giovanna Masci Armando Santoro Rita De Sanctis Source Type: research
Sticking to the Rules: Outcome and Success Rate of Guideline-Based Diarrhea Management in Metastatic Breast Cancer Patients Treated with Abemaciclib
J Clin Med. 2023 Feb 23;12(5):1775. doi: 10.3390/jcm12051775.ABSTRACTIn clinical trials testing abemaciclib in patients with hormone-receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer, diarrhea is a very common adverse event (occurring in approximately 85% of patients, any grade). Nonetheless, this toxicity leads to abemaciclib discontinuation in a small proportion of patients (approximately 2%) thanks to the use of effective loperamide-based supportive therapy. We aimed to determine whether the incidence of abemaciclib-induced diarrhea in real-world trials was higher than the one reported in clinical tr...
Source: Clinical Genitourinary Cancer - March 11, 2023 Category: Cancer & Oncology Authors: Flavia Jacobs Elisa Agostinetto Alessandra Solferino Rosalba Torrisi Giovanna Masci Armando Santoro Rita De Sanctis Source Type: research
Brucea javanica oil alleviates intestinal mucosal injury induced by chemotherapeutic agent 5-fluorouracil in mice
Conclusion: The present study provides new insights into the protective effects of BJO against CIM and suggests that BJO deserves to be applied as a potential therapeutic agent for the prevention of CIM. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 20, 2023 Category: Drugs & Pharmacology Source Type: research
UHPLC-MS profiles and antidiarrheal activity of Quercus coccinea m ünchh. and Quercus robur L. employing in vivo technique
Discussion: Twenty-five and twenty-six polyphenolic compounds were tentatively identified in Q. coccinea and Q. robur AME, respectively. The identified compounds are related to quercetin, kaempferol, isorhamnetin, and apigenin glycosides and their aglycones. In addition, hydrolyzable tannins, phenolic acid, phenyl propanoides derivatives, and cucurbitacin F were also identified in both species AME of Q. coccinea (250, 500, and 1000 mg/kg) exhibited a significant prolongation in the onset of diarrhea by 17.7 %, 42.6%, and 79.7% respectively while AME of Q. robur at the same doses significantly prolonged the onset of diarrh...
Source: Frontiers in Pharmacology - February 17, 2023 Category: Drugs & Pharmacology Source Type: research
