A Drug-drug Interaction Trial of Loperamide Pharmacokinetics Effect on Pyrotinib Maleate
Condition:   Healthy Participants Interventions:   Drug: pyrotinib maleate;   Drug: Loperamide Sponsor:   Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 19, 2020 Category: Research Source Type: clinical trials

Randomised, double-blind, placebo controlled multi-centre study to assess the efficacy, tolerability and safety of Enterosgel ® in the treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults
DiscussionThis is the first large scale randomised controlled trial investigating Enterosgel ® in IBS-D. A study design with blinded phase followed by an open-label phase was chosen to encourage participation and study completion. Demonstrating that Enterosgel® is effective and safe in IBS-D could encourage adoption by patients and healthcare professionals and foster future clinical trial s assessing its use in related conditions.Trial registrationISRCTN17149988. Prospectively registered on 14 November 2017. (Source: Trials)
Source: Trials - January 30, 2020 Category: Research Source Type: clinical trials

A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult Participants
Condition:   Healthy Participants Interventions:   Drug: Loperamide;   Other: Placebo;   Drug: Moxifloxacin Sponsor:   Janssen Research & Development, LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 13, 2020 Category: Research Source Type: clinical trials

A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers
Condition:   Healthy Interventions:   Drug: Combination Caplet with Loperamide HCl and Simethicone;   Drug: Loperamide HCl;   Drug: Simethicone Sponsor:   McNeil AB Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 5, 2019 Category: Research Source Type: clinical trials

Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients
Conditions:   Colitis;   Diarrhea;   Malignant Genitourinary System Neoplasm Interventions:   Procedure: Fecal Microbiota Transplantation;   Drug: Loperamide Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2019 Category: Research Source Type: clinical trials

Gut Transit Effect on Enterohepatic Circulation
Condition:   Intestinal Transit Interventions:   Drug: Loperamide;   Drug: Senna Sponsor:   University Hospital Plymouth NHS Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2018 Category: Research Source Type: clinical trials