Diarrhea and COVID-19 Infection
The global COVID-19 pandemic has caused significant morbidity and mortality, thoroughly affected daily living, and caused severe economic disruption throughout the world. Pulmonary symptoms predominate and account for most of the associated morbidity and mortality. However, extrapulmonary manifestations are common in COVID-19 infections, including gastrointestinal symptoms, such as diarrhea. Diarrhea affects about 10% to 20% of COVID-19 patients. Diarrhea can occasionally be the presenting and only COVID-19 symptom. Diarrhea in COVID-19 subjects is usually acute but is occasionally chronic. It is typically mild-to-moderate...
Source: Gastroenterology Clinics of North America - November 13, 2022 Category: Gastroenterology Authors: By David M. Friedel, Mitchell S. Cappell Source Type: research
Diarrhea and Coronavirus Disease 2019 Infection
The global coronavirus disease-2019 (COVID-19) pandemic has caused significant morbidity and mortality, thoroughly affected daily living, and caused severe economic disruption throughout the world. Pulmonary symptoms predominate and account for most of the associated morbidity and mortality. However, extrapulmonary manifestations are common in COVID-19 infections, including gastrointestinal (GI) symptoms, such as diarrhea. Diarrhea affects approximately 10% to 20% of COVID-19 patients. Diarrhea can occasionally be the presenting and only COVID-19 symptom. Diarrhea in COVID-19 subjects is usually acute but is occasionally c...
Source: Gastroenterology Clinics of North America - November 13, 2022 Category: Gastroenterology Authors: David M. Friedel, Mitchell S. Cappell Source Type: research
An automated online three-phase electro-extraction setup with machine-vision process monitoring hyphenated to LC-MS analysis
In this study, an automated three-phase electro-extraction (EE) method coupled to machine vision was developed, integrated with a robotic autosampler hyphenated to LC-MS. Eight model compounds, i.e. amitriptyline, clemastine, clomipramine, haloperidol, loperamide, propranolol, oxeladin, and verapamil were utilized for the optimization and evaluation of the automated EE setup. The stability of automated EE was evaluated by monitoring the acceptor droplet size by machine vision and recording the current during EE. A Design of Experiment approach (Box-Behnken design) was utilized to optimize the critical parameters of the EE ...
Source: Analytica Chimica Acta - November 11, 2022 Category: Chemistry Authors: Yupeng He Paul Miggiels Nicolas Drouin Peter W Lindenburg Bert Wouters Thomas Hankemeier Source Type: research
An automated online three-phase electro-extraction setup with machine-vision process monitoring hyphenated to LC-MS analysis
In this study, an automated three-phase electro-extraction (EE) method coupled to machine vision was developed, integrated with a robotic autosampler hyphenated to LC-MS. Eight model compounds, i.e. amitriptyline, clemastine, clomipramine, haloperidol, loperamide, propranolol, oxeladin, and verapamil were utilized for the optimization and evaluation of the automated EE setup. The stability of automated EE was evaluated by monitoring the acceptor droplet size by machine vision and recording the current during EE. A Design of Experiment approach (Box-Behnken design) was utilized to optimize the critical parameters of the EE ...
Source: Analytica Chimica Acta - November 11, 2022 Category: Chemistry Authors: Yupeng He Paul Miggiels Nicolas Drouin Peter W Lindenburg Bert Wouters Thomas Hankemeier Source Type: research
An automated online three-phase electro-extraction setup with machine-vision process monitoring hyphenated to LC-MS analysis
In this study, an automated three-phase electro-extraction (EE) method coupled to machine vision was developed, integrated with a robotic autosampler hyphenated to LC-MS. Eight model compounds, i.e. amitriptyline, clemastine, clomipramine, haloperidol, loperamide, propranolol, oxeladin, and verapamil were utilized for the optimization and evaluation of the automated EE setup. The stability of automated EE was evaluated by monitoring the acceptor droplet size by machine vision and recording the current during EE. A Design of Experiment approach (Box-Behnken design) was utilized to optimize the critical parameters of the EE ...
Source: Analytica Chimica Acta - November 11, 2022 Category: Chemistry Authors: Yupeng He Paul Miggiels Nicolas Drouin Peter W Lindenburg Bert Wouters Thomas Hankemeier Source Type: research
An automated online three-phase electro-extraction setup with machine-vision process monitoring hyphenated to LC-MS analysis
In this study, an automated three-phase electro-extraction (EE) method coupled to machine vision was developed, integrated with a robotic autosampler hyphenated to LC-MS. Eight model compounds, i.e. amitriptyline, clemastine, clomipramine, haloperidol, loperamide, propranolol, oxeladin, and verapamil were utilized for the optimization and evaluation of the automated EE setup. The stability of automated EE was evaluated by monitoring the acceptor droplet size by machine vision and recording the current during EE. A Design of Experiment approach (Box-Behnken design) was utilized to optimize the critical parameters of the EE ...
Source: Analytica Chimica Acta - November 11, 2022 Category: Chemistry Authors: Yupeng He Paul Miggiels Nicolas Drouin Peter W Lindenburg Bert Wouters Thomas Hankemeier Source Type: research
An automated online three-phase electro-extraction setup with machine-vision process monitoring hyphenated to LC-MS analysis
In this study, an automated three-phase electro-extraction (EE) method coupled to machine vision was developed, integrated with a robotic autosampler hyphenated to LC-MS. Eight model compounds, i.e. amitriptyline, clemastine, clomipramine, haloperidol, loperamide, propranolol, oxeladin, and verapamil were utilized for the optimization and evaluation of the automated EE setup. The stability of automated EE was evaluated by monitoring the acceptor droplet size by machine vision and recording the current during EE. A Design of Experiment approach (Box-Behnken design) was utilized to optimize the critical parameters of the EE ...
Source: Analytica Chimica Acta - November 11, 2022 Category: Chemistry Authors: Yupeng He Paul Miggiels Nicolas Drouin Peter W Lindenburg Bert Wouters Thomas Hankemeier Source Type: research
Beyond the Basics: How Should We Manage Acute Pain in Hospitalized Patients with OUD?
Case
A 23-year-old male with opioid use disorder (OUD) with intravenous use is hospitalized with a fever and several weeks of back pain. He is diagnosed with methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis of the cervical spine. He desires medication treatment for OUD (MOUD) but is afraid of inadequate pain management while hospitalized. During previous admissions, untreated pain and withdrawal led to in-hospital substance use.
Brief overview of issue
The opioid epidemic is increasing hospitalizations and inpatient mortality related to OUD.1 Patients with injection use can experience painful, lif...
Source: The Hospitalist - November 1, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Key Clinical Questions Pain Source Type: research
Antidiarrheal Activity of < em > Dialium guineense < /em > Willd Fruit Pulp in Wistar Rats
CONCLUSION: The fruit pulp of D. guineense has showed antidiarrheal activities in Wistar rats by reducing the frequency of defecation, the amount of diarrheal fecal matter emitted as well as the water content. It also delayed the onset of diarrhea and significantly reduced the purging index like loperamide.PMID:36317113 | PMC:PMC9617707 | DOI:10.1155/2022/4161714 (Source: Biomed Res)
Source: Biomed Res - November 1, 2022 Category: Research Authors: Tchar é Assiki Aboudoulatif Diallo Essotolom Badjaba ïssi Mind édé Assih Tchazou Kpatcha Kokou Idoh Kossivi Dosseh Amegnona Agbonon Source Type: research
Engineered 5-HT producing gut probiotic improves gastrointestinal motility and behavior disorder
Slow transit constipation is an intractable constipation with unknown aetiology and uncertain pathogenesis. The gut microbiota maintains a symbiotic relationship with the host and has an impact on host metabolism. Previous studies have reported that some gut microbes have the ability to produce 5-hydroxytryptamine (5-HT), an important neurotransmitter. However, there are scarce data exploiting the effects of gut microbiota-derived 5-HT in constipation-related disease. We genetically engineered the probiotic Escherichia coli Nissle 1917 (EcN-5-HT) for synthesizing 5-HT in situ. The ability of EcN-5-HT to secrete 5-HT in vit...
Source: Frontiers in cellular and infection microbiology - October 20, 2022 Category: Microbiology Source Type: research
Cymbopogon citratus (DC.) Stapf aqueous extract ameliorates loperamide-induced constipation in mice by promoting gastrointestinal motility and regulating the gut microbiota
In this study, the loperamide-induced STC mouse model was used to evaluate the laxative effect of the aqueous extract of CC (CCAE), and the laxative mechanism was systematically explored from the perspectives of the enteric nervous system (ENS), neurotransmitter secretion, gastrointestinal motility factors, intestinal inflammation, gut barrier and gut microbiota. The results showed that CCAE not only decreased the serum vasoactive intestinal polypeptide (VIP), induced nitric oxide synthases (iNOS), and acetylcholinesterase (AchE) in STC mice but also increased the expression of gastrointestinal motility factors in colonic ...
Source: Frontiers in Microbiology - October 4, 2022 Category: Microbiology Source Type: research
Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study
CONCLUSIONS: This study indicates that the use of trackers can be a tool to estimate the occurrence of adverse drug reactions and to establish adverse events related to the use of medications, which should be reported to the pharmacovigilance service, with a view to patient safety.PMID:36183207 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - October 2, 2022 Category: Drugs & Pharmacology Authors: Kely Corr êa Benedet Baesso Diego Zapelini do Nascimento Alessandra De S á Soares Fabiana Schuelter-Trevisol Source Type: research
Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study
CONCLUSIONS: This study indicates that the use of trackers can be a tool to estimate the occurrence of adverse drug reactions and to establish adverse events related to the use of medications, which should be reported to the pharmacovigilance service, with a view to patient safety.PMID:36183207 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - October 2, 2022 Category: Drugs & Pharmacology Authors: Kely Corr êa Benedet Baesso Diego Zapelini do Nascimento Alessandra De S á Soares Fabiana Schuelter-Trevisol Source Type: research
Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study
CONCLUSIONS: This study indicates that the use of trackers can be a tool to estimate the occurrence of adverse drug reactions and to establish adverse events related to the use of medications, which should be reported to the pharmacovigilance service, with a view to patient safety.PMID:36183207 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - October 2, 2022 Category: Drugs & Pharmacology Authors: Kely Corr êa Benedet Baesso Diego Zapelini do Nascimento Alessandra De S á Soares Fabiana Schuelter-Trevisol Source Type: research
Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study
CONCLUSIONS: This study indicates that the use of trackers can be a tool to estimate the occurrence of adverse drug reactions and to establish adverse events related to the use of medications, which should be reported to the pharmacovigilance service, with a view to patient safety.PMID:36183207 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - October 2, 2022 Category: Drugs & Pharmacology Authors: Kely Corr êa Benedet Baesso Diego Zapelini do Nascimento Alessandra De S á Soares Fabiana Schuelter-Trevisol Source Type: research
